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Items: 1 to 20 of 85

1.
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
Mathias Linnerbauer, Lena Lößlein, Oliver Vandrey, Anne Peter, Yanan Han, Thanos Tsaktanis, Emile Wogram, Maria Needhamsen, Lara Kular, Lisa Nagel, Julia Zissler, Marie Andert, Lisa Meszaros, Jannis Hanspach, Finnja Zuber, Ulrike J. Naumann, Martin Diebold, Michael A. Wheeler, Tobias Beyer, Lucy Nirschl, Ana Cirac, Frederik B. Laun, Claudia Günther, Jürgen Winkler, Tobias Bäuerle, Maja Jagodic, Bernhard Hemmer, Marco Prinz, Francisco J. Quintana, Veit Rothhammer
Nat Immunol. 2024; 25(3): 432–447. Published online 2024 Feb 26. doi: 10.1038/s41590-024-01756-6
PMCID:
PMC10907300
AbstractArticlePDF–22M
2.
Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer
Valentina Cigliola, Adam Shoffner, Nutishia Lee, Jianhong Ou, Trevor J. Gonzalez, Jiaul Hoque, Clayton J. Becker, Yanchao Han, Grace Shen, Timothy D. Faw, Muhammad M. Abd-El-Barr, Shyni Varghese, Aravind Asokan, Kenneth D. Poss
Nat Commun. 2023; 14: 4857. Published online 2023 Aug 11. doi: 10.1038/s41467-023-40486-5
PMCID:
PMC10421883
AbstractArticlePDF–4.6M
3.
HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids
Manuela Völkner, Felix Wagner, Lisa Maria Steinheuer, Madalena Carido, Thomas Kurth, Ali Yazbeck, Jana Schor, Stephanie Wieneke, Lynn J. A. Ebner, Claudia Del Toro Runzer, David Taborsky, Katja Zoschke, Marlen Vogt, Sebastian Canzler, Andreas Hermann, Shahryar Khattak, Jörg Hackermüller, Mike O. Karl
Nat Commun. 2022; 13: 6183. Published online 2022 Oct 19. doi: 10.1038/s41467-022-33848-y
PMCID:
PMC9581928
AbstractArticlePDF–16M
4.
microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor
Yi-xuan Wu, Yan-shan Lin, Si-chen Li, Xi Yao, Mingwei Cheng, Lin Zhu, Hai-ying Liu
Reprod Biol Endocrinol. 2021; 19: 170. Published online 2021 Nov 23. doi: 10.1186/s12958-021-00850-w
PMCID:
PMC8609843
AbstractArticlePDF–4.1M
5.
Potentially Functional Variants of HBEGF and ITPR3 in GnRH Signaling Pathway Genes Predict Survival of Non-Small Cell Lung Cancer Patients
Yufeng Wu, Zhensheng Liu, Dongfang Tang, Hongliang Liu, Sheng Luo, Thomas E. Stinchcombe, Carolyn Glass, Li Su, Lijuan Lin, David C. Christiani, Qiming Wang, Qingyi Wei
Transl Res. Author manuscript; available in PMC 2021 Jul 1.
Published in final edited form as: Transl Res. 2021 Jul; 233: 92–103. Published online 2021 Jan 2. doi: 10.1016/j.trsl.2020.12.009
PMCID:
PMC8184605
AbstractArticlePDF–1.1M
6.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
7.
s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand–foot skin reaction that can be reversed by nicotinamide
Peihua Luo, Hao Yan, Xueqin Chen, Ying Zhang, Ziying Zhao, Ji Cao, Yi Zhu, Jiangxia Du, Zhifei Xu, Xiaochen Zhang, Su Zeng, Bo Yang, Shenglin Ma, Qiaojun He
Cell Res. 2020 Sep; 30(9): 779–793. Published online 2020 Apr 15. doi: 10.1038/s41422-020-0309-6
PMCID:
PMC7608389
AbstractArticlePDF–5.0M
8.
M2 macrophages reduce the radiosensitivity of head and neck cancer by releasing HB-EGF
Enhui Fu, Tianyang Liu, Siyang Yu, Xiaohang Chen, Lianhao Song, Huihuang Lou, Fen Ma, Siwei Zhang, Sajjad Hussain, Junnan Guo, Ji Sun, Pingyang Yu, Xionghui Mao, Lanlan Wei
Oncol Rep. 2020 Aug; 44(2): 698–710. Published online 2020 May 29. doi: 10.3892/or.2020.7628
PMCID:
PMC7336513
AbstractArticlePDF–1.0M
9.
Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases
Seonwook Kim, Venkateswaran Subramanian, Ahmed Abdel-Latif, Sangderk Lee
Metab Syndr Relat Disord. May 2020; 18(4): 186–196. Published online 2020 Apr 28. doi: 10.1089/met.2019.0120
PMCID:
PMC7196370
AbstractArticlePDF–492K
10.
HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats
Hasna Maachi, Grace Fergusson, Melanie Ethier, Gabriel N. Brill, Liora S. Katz, Lee B. Honig, Mallikarjuna R. Metukuri, Donald K. Scott, Julien Ghislain, Vincent Poitout
Diabetes. 2020 Mar; 69(3): 369–380. Published online 2020 Dec 27. doi: 10.2337/db19-0643
PMCID:
PMC7034189
AbstractArticlePDF–2.1M
11.
TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile
Karen Dendoncker, Steven Timmermans, Jolien Vandewalle, Melanie Eggermont, Joanna Lempiäinen, Evelien Van Hamme, Sylviane Dewaele, Sofie Vandevyver, Marlies Ballegeer, Jolien Souffriau, Lise Van Wyngene, Kelly Van Looveren, Tineke Vanderhaeghen, Rudi Beyaert, Karolien De Bosscher, Jorma J. Palvimo, Marc Van Montagu, Claude Libert
Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26): 12942–12951. Published online 2019 Jun 10. doi: 10.1073/pnas.1821565116
Correction in:
Proc Natl Acad Sci U S A. 2019 Jul 30; 116(31): 15745.
PMCID:
PMC6600915
AbstractArticlePDF–1.7M
12.
Soluble Heparin Binding Epidermal Growth Factor-Like Growth Factor Is a Regulator of GALGT2 Expression and GALGT2-Dependent Muscle and Neuromuscular Phenotypes
Megan L. Cramer, Rui Xu, Paul T. Martin
Mol Cell Biol. 2019 Jul 15; 39(14): e00140-19. Prepublished online 2019 Apr 29. Published online 2019 Jun 27. doi: 10.1128/MCB.00140-19
PMCID:
PMC6597879
AbstractArticlePDF–4.5M
13.
Amino‐terminal deletion of heparin‐binding epidermal growth factor‐like growth factor4−127 stimulates cell proliferation but lacks insulin‐like activity
Z. Zhou, P. A. Harding
Cell Prolif. 2007 Apr; 40(2): 213–230. Published online 2007 Mar 9. doi: 10.1111/j.1365-2184.2007.00425.x
PMCID:
PMC6496231
AbstractArticlePDF–494K
14.
Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling
Yifang Xie, Anyun Ma, Boshi Wang, Rui Peng, Yingchun Jing, Deqian Wang, Richard H. Finnell, Bin Qiao, Yongming Wang, Hongyan Wang, Yufang Zheng
Clin Sci (Lond) 2019 Jan 31; 133(2): 225–238. Prepublished online 2019 Jan 4. Published online 2019 Jan 22. doi: 10.1042/CS20180842
PMCID:
PMC6365624
AbstractArticlePDF–1.8M
15.
BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion
Aarti Sethuraman, Martin Brown, Raya Krutilina, Zhao-Hui Wu, Tiffany N. Seagroves, Lawrence M. Pfeffer, Meiyun Fan
Breast Cancer Res. 2018; 20: 117. Published online 2018 Oct 1. doi: 10.1186/s13058-018-1046-3
PMCID:
PMC6167787
AbstractArticlePDF–6.6M
16.
EGFR ligands differentially stabilize receptor dimers to specify signaling kinetics
Daniel M. Freed, Nicholas J. Bessman, Anatoly Kiyatkin, Emanuel Salazar-Cavazos, Patrick O. Byrne, Jason O. Moore, Christopher C. Valley, Kathryn M. Ferguson, Daniel J. Leahy, Diane S. Lidke, Mark A. Lemmon
Cell. Author manuscript; available in PMC 2018 Oct 19.
Published in final edited form as: Cell. 2017 Oct 19; 171(3): 683–695.e18. Published online 2017 Oct 5. doi: 10.1016/j.cell.2017.09.017
PMCID:
PMC5650921
AbstractArticlePDF–1.6M
17.
Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding
Chandni V Jain, Philip Jessmon, Charbel T Barrak, Alan D Bolnick, Brian A Kilburn, Michael Hertz, D Randall Armant
Cell Death Differ. 2017 Oct; 24(10): 1772–1783. Published online 2017 Jul 21. doi: 10.1038/cdd.2017.104
PMCID:
PMC5596420
AbstractArticlePDF–2.8M
18.
HBEGF promotes gliomagenesis in the context of Ink4a/Arf and Pten loss
Clifford H. Shin, James P. Robinson, Joshua A. Sonnen, Adam E. Welker, Diana X. Yu, Matthew W. VanBrocklin, Sheri L. Holmen
Oncogene. Author manuscript; available in PMC 2017 Oct 3.
Published in final edited form as: Oncogene. 2017 Aug 10; 36(32): 4610–4618. Published online 2017 Apr 3. doi: 10.1038/onc.2017.83
PMCID:
PMC5552427
AbstractArticlePDF–972K
19.
Transethnic genome-wide scan identifies novel Alzheimer disease loci
Gyungah R. Jun, Jaeyoon Chung, Jesse Mez, Robert Barber, Gary W. Beecham, David A. Bennett, Joseph D. Buxbaum, Goldie S. Byrd, Minerva M. Carrasquillo, Paul K. Crane, Carlos Cruchaga, Philip De Jager, Nilufer Ertekin-Taner, Denis Evans, M. Danielle Fallin, Tatiana M. Foroud, Robert P. Friedland, Alison M. Goate, Neill R. Graff-Radford, Hugh Hendrie, Kathleen S. Hall, Kara L. Hamilton-Nelson, Rivka Inzelberg, M. Ilyas Kamboh, John SK Kauwe, Walter A. Kukull, Brian W. Kunkle, Ryozo Kuwano, Eric B. Larson, Mark W. Logue, Jennifer J. Manly, Eden R. Martin, Thomas J. Montine, Shubhabrata Mukherjee, Adam Naj, Eric M. Reiman, Christiane Reitz, Richard Sherva, St. Peter H. George-Hyslop, Timothy Thornton, Steven G. Younkin, Badri N. Vardarajan, Li-San Wang, Jens R. Wendlund, Ashley R. Winslow, Alzheimer Disease Genetics Consortium, Jonathan Haines, Richard Mayeux, Margaret A. Pericak-Vance, Gerard Schellenberg, Kathryn L. Lunetta, Lindsay A. Farrer
Alzheimers Dement. Author manuscript; available in PMC 2018 Jul 1.
Published in final edited form as: Alzheimers Dement. 2017 Jul; 13(7): 727–738. Published online 2017 Feb 7. doi: 10.1016/j.jalz.2016.12.012
PMCID:
PMC5496797
AbstractArticlePDF–1.2M
20.
Autocrine expression of the epidermal growth factor receptor ligand heparin-binding EGF-like growth factor in cervical cancer
Marlies Schrevel, E. Michelle Osse, Frans A. Prins, J. Baptist M.Z. Trimbos, Gert Jan Fleuren, Arko Gorter, Ekaterina S. Jordanova
Int J Oncol. 2017 Jun; 50(6): 1947–1954. Published online 2017 May 3. doi: 10.3892/ijo.2017.3980
PMCID:
PMC5435322
AbstractArticlePDF–701K

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