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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 110434122.

Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria

Sarah V. Schweighofer, Daniel C. Jans, Jan Keller-Findeisen, Anne Folmeg, Peter Ilgen, Mark Bates, Stefan Jakobs

Cell Death Differ. 2024 Apr; 31(4): 469–478. Published online 2024 Mar 19. doi: 10.1038/s41418-024-01273-x

PMCID:: PMC11043412

Abstract Article PDF–2.0M

Select item 103756373.

Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia

Jizi Zhou, Ying Zhao, Ping An, Huanqiang Zhao, Xiaotian Li, Yu Xiong

J Transl Med. 2023; 21: 509. Published online 2023 Jul 28. doi: 10.1186/s12967-023-04240-1

PMCID:: PMC10375637

Abstract Article PDF–9.6M

Select item 103126744.

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Philipp Trepte, Christopher Secker, Simona Kostova, Sibusiso B. Maseko, Soon Gang Choi, Jeremy Blavier, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J. Liebich, Nadine Scharek, Anja Schütz, Marcel Sperling, Michael Lisurek, Yang Wang, Kerstin Spirohn, Tong Hao, Michael A. Calderwood, David E. Hill, Markus Landthaler, Julien Olivet, Jean-Claude Twizere, Marc Vidal, Erich E. Wanker

Version 1. bioRxiv. Preprint. 2023 Jun 14. doi: 10.1101/2023.06.14.544560

Published in:: Mol Syst Biol. 2024 Apr; 20(4): 428–457.

PMCID:: PMC10312674

Abstract Article PDF–9.6M

Select item 98522245.

Mechanisms of MCL-1 protein stability induced by MCL-1 antagonists in B-cell malignancies

Shady I. Tantawy, Aloke Sarkar, Stefan Hubner, Zhi Tan, William G. Wierda, Abdelraouf Eldeib, Shuxing Zhang, Steven Kornblau, Varsha Gandhi

Clin Cancer Res. Author manuscript; available in PMC 2023 Jul 17.

Published in final edited form as: Clin Cancer Res. 2023 Jan 17; 29(2): 446–457. doi: 10.1158/1078-0432.CCR-22-2088

PMCID:: PMC9852224

Abstract Article PDF–2.1M

Select item 95619606.

NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles

Md Imam Faizan, Rituparna Chaudhuri, Shakti Sagar, Sarah Albogami, Nisha Chaudhary, Iqbal Azmi, Areej Akhtar, Syed Mansoor Ali, Rohit Kumar, Jawed Iqbal, Mohan C. Joshi, Gaurav Kharya, Pankaj Seth, Soumya Sinha Roy, Tanveer Ahmad

Cells. 2022 Oct; 11(19): 2969. Published online 2022 Sep 23. doi: 10.3390/cells11192969

PMCID:: PMC9561960

Abstract Article PDF–52M

Select item 93461287.

A common deletion at BAK1 reduces enhancer activity and confers risk of intracranial germ cell tumors

Kyuto Sonehara, Yui Kimura, Yoshiko Nakano, Tatsuya Ozawa, Meiko Takahashi, Ken Suzuki, Takashi Fujii, Yuko Matsushita, Arata Tomiyama, Toshihiro Kishikawa, Kenichi Yamamoto, Tatsuhiko Naito, Tomonari Suzuki, Shigeru Yamaguchi, Tomoru Miwa, Hikaru Sasaki, Masashi Kitagawa, Naoyuki Ohe, Junya Fukai, Hideki Ogiwara, Atsufumi Kawamura, Satoru Miyawaki, Fumihiko Matsuda, Nobutaka Kiyokawa, Koichi Ichimura, Ryo Nishikawa, Yukinori Okada, Keita Terashima

Nat Commun. 2022; 13: 4478. Published online 2022 Aug 2. doi: 10.1038/s41467-022-32005-9

PMCID:: PMC9346128

Abstract Article PDF–2.7M

Select item 93083748.

CD36 and ERK5 link dyslipidemia to apoptotic-like platelet procoagulant function

Moua Yang, Roy L. Silverstein

Curr Opin Hematol. Author manuscript; available in PMC 2022 Jul 23.

Published in final edited form as: Curr Opin Hematol. 2019 Sep; 26(5): 357–365. doi: 10.1097/MOH.0000000000000522

PMCID:: PMC9308374

Abstract Article PDF–1.1M

Select item 89014419.

The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation

Katia Cosentino, Vanessa Hertlein, Andreas Jenner, Timo Dellmann, Milos Gojkovic, Aida Peña-Blanco, Shashank Dadsena, Noel Wajngarten, John S.H. Danial, Jervis Vermal Thevathasan, Markus Mund, Jonas Ries, Ana J. Garcia-Saez

Mol Cell. 2022 Mar 3; 82(5): 933–949.e9. doi: 10.1016/j.molcel.2022.01.008

PMCID:: PMC8901441

Abstract Article

Select item 875283710.

Structural basis of BAK activation in mitochondrial apoptosis initiation

Geetika Singh, Cristina D. Guibao, Jayaraman Seetharaman, Anup Aggarwal, Christy R. Grace, Dan E. McNamara, Sivaraja Vaithiyalingam, M. Brett Waddell, Tudor Moldoveanu

Nat Commun. 2022; 13: 250. Published online 2022 Jan 11. doi: 10.1038/s41467-021-27851-y

PMCID:: PMC8752837

Abstract Article PDF–6.5M

Select item 856087111.

Paradoxical implication of BAX/BAK in the persistence of tetraploid cells

Jiayin Deng, Lucía G. Gutiérrez, Gautier Stoll, Omar Motiño, Isabelle Martins, Lucía Núñez, José Manuel Bravo-San Pedro, Juliette Humeau, Chloé Bordenave, Juncheng Pan, Hélène Fohrer-Ting, Sylvie Souquere, Gerard Pierron, Claudio Hetz, Carlos Villalobos, Guido Kroemer, Laura Senovilla

Cell Death Dis. 2021 Nov; 12(11): 1039. Published online 2021 Nov 1. doi: 10.1038/s41419-021-04321-3

PMCID:: PMC8560871

Abstract Article PDF–6.0M

Select item 852130512.

High‐resolution analysis of the conformational transition of pro‐apoptotic Bak at the lipid membrane

Laura E Sperl, Florian Rührnößl, Anita Schiller, Martin Haslbeck, Franz Hagn

EMBO J. 2021 Oct 18; 40(20): e107159. Published online 2021 Sep 15. doi: 10.15252/embj.2020107159

PMCID:: PMC8521305

Abstract Article PDF–2.9M

Select item 852127513.

Dynamic reconfiguration of pro‐apoptotic BAK on membranes

Jarrod J Sandow, Iris KL Tan, Alan S Huang, Shashank Masaldan, Jonathan P Bernardini, Ahmad Z Wardak, Richard W Birkinshaw, Robert L Ninnis, Ziyan Liu, Destiny Dalseno, Daisy Lio, Giuseppi Infusini, Peter E Czabotar, Andrew I Webb, Grant Dewson

EMBO J. 2021 Oct 18; 40(20): e107237. Published online 2021 Sep 15. doi: 10.15252/embj.2020107237

PMCID:: PMC8521275

Abstract Article PDF–2.0M

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 756688115.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 733505016.

Characterization of an alternative BAK-binding site for BH3 peptides

Kaiqin Ye, Wei X. Meng, Hongbin Sun, Bo Wu, Meng Chen, Yuan-Ping Pang, Jia Gao, Hongzhi Wang, Junfeng Wang, Scott H. Kaufmann, Haiming Dai

Nat Commun. 2020; 11: 3301. Published online 2020 Jul 3. doi: 10.1038/s41467-020-17074-y

PMCID:: PMC7335050

Abstract Article PDF–3.4M

Select item 728023317.

Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1

Li Dong, David L. Vaux

Cell Death Dis. 2020 Jun; 11(6): 442. Published online 2020 Jun 8. doi: 10.1038/s41419-020-2599-5

PMCID:: PMC7280233

Abstract Article PDF–5.5M

Select item 716998318.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 709792519.

Inflammation-dependent downregulation of miR-532-3p mediates apoptotic signaling in human sarcopenia through targeting BAK1

Fa-Xiu Chen, Yi Shen, Yang Liu, Hai-Feng Wang, Chen-Yu Liang, Ming Luo

Int J Biol Sci. 2020; 16(9): 1481–1494. Published online 2020 Feb 24. doi: 10.7150/ijbs.41641

PMCID:: PMC7097925

Abstract Article PDF–2.4M

Select item 705917220.

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity

Yonghan He, Wen Li, Dongwen Lv, Xin Zhang, Xuan Zhang, Yuma T. Ortiz, Vivekananda Budamagunta, Judith Campisi, Guangrong Zheng, Daohong Zhou

Aging Cell. 2020 Mar; 19(3): e13117. Published online 2020 Feb 16. doi: 10.1111/acel.13117

PMCID:: PMC7059172

Abstract Article PDF–1.0M

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