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Items: 1 to 20 of 77

1.
Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7
Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537
PMCID:
PMC10850818
AbstractArticlePDF–2.7M
2.
The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma
Mitsuhiko Moriyama, Tatsuo Kanda, Yutaka Midorikawa, Hiroshi Matsumura, Ryota Masuzaki, Hitomi Nakamura, Masahiro Ogawa, Shunichi Matsuoka, Toshikatu Shibata, Motomi Yamazaki, Kazumichi Kuroda, Hisashi Nakayama, Tokio Higaki, Kazunori Kanemaru, Toshio Miki, Masahiko Sugitani, Tadatoshi Takayama
Sci Rep. 2022; 12: 20508. Published online 2022 Nov 28. doi: 10.1038/s41598-022-25201-6
PMCID:
PMC9705552
AbstractArticlePDF–3.2M
3.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
4.
Long non-coding RNA-PCGEM1 contributes to prostate cancer progression by sponging microRNA miR-129-5p to enhance chromatin licensing and DNA replication factor 1 expression
Qiao Fu, Fangfang Wang, Jun Yang, Wei Sun, Zhi Hu, Lv Xu, Hao Chu, Xiao Wang, Wei Zhang
Bioengineered. 2022; 13(4): 9411–9424. Published online 2022 Apr 12. doi: 10.1080/21655979.2022.2059936
PMCID:
PMC9162030
AbstractArticlePDF–4.3M
5.
An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity
Yuehui Zhang, Limin Shang, Jing Zhang, Yuchen Liu, Chaozhi Jin, Yanan Zhao, Xiaobo Lei, Wenjing Wang, Xia Xiao, Xiuyuan Zhang, Yujiao Liu, Linlin Liu, Meng-Wei Zhuang, Qingkun Mi, Chunyan Tian, Jianwei Wang, Fuchu He, Pei-Hui Wang, Jian Wang
Cell Chem Biol. 2022 Jan 20; 29(1): 5–18.e6. Published online 2021 Oct 20. doi: 10.1016/j.chembiol.2021.10.008
PMCID:
PMC8527578
AbstractArticlePDF–4.5M
6.
SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition
Jian Ma, Qing Shi, Gaofeng Cui, Haoyue Sheng, Maria Victoria Botuyan, Yingke Zhou, Yuqian Yan, Yundong He, Liguo Wang, Yuzhuo Wang, Georges Mer, Dingwei Ye, Chenji Wang, Haojie Huang
Nat Commun. 2021; 12: 5779. Published online 2021 Oct 1. doi: 10.1038/s41467-021-26049-6
PMCID:
PMC8486843
AbstractArticlePDF–4.1M
7.
HectD1 Controls Hematopoietic Stem Cell Regeneration by Coordinating Ribosome Assembly and Protein Synthesis
Kaosheng Lv, Chujie Gong, Charles Antony, Xu Han, Jian-Gang Ren, Ryan Donaghy, Ying Cheng, Simone Pellegrino, Alan J. Warren, Vikram R. Paralkar, Wei Tong
Cell Stem Cell. Author manuscript; available in PMC 2022 Jul 1.
Published in final edited form as: Cell Stem Cell. 2021 Jul 1; 28(7): 1275–1290.e9. Published online 2021 Mar 11. doi: 10.1016/j.stem.2021.02.008
PMCID:
PMC8254759
AbstractArticlePDF–2.8M
8.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
9.
Intermittent hypoxia-induced downregulation of microRNA-320b promotes lung cancer tumorigenesis by increasing CDT1 via USP37
Weihao Li, Kai Huang, Fengbiao Wen, Guanghui Cui, Haizhou Guo, Zhanfeng He, Song Zhao
Mol Ther Nucleic Acids. 2021 Jun 4; 24: 528–541. Published online 2021 Jan 1. doi: 10.1016/j.omtn.2020.12.023
PMCID:
PMC8056179
AbstractArticlePDF–2.5M
10.
SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors
Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier
Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2015654118. Published online 2021 Feb 3. doi: 10.1073/pnas.2015654118
PMCID:
PMC8017720
AbstractArticlePDF–1.9M
11.
In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators
Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele
PLoS Biol. 2020 Dec; 18(12): e3000975. Published online 2020 Dec 11. doi: 10.1371/journal.pbio.3000975
PMCID:
PMC7758050
AbstractArticlePDF–4.2M
12.
The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
Philippe Coulombe, Joelle Nassar, Isabelle Peiffer, Slavica Stanojcic, Yvon Sterkers, Axel Delamarre, Stéphane Bocquet, Marcel Méchali
Nat Commun. 2019; 10: 2426. Published online 2019 Jun 3. doi: 10.1038/s41467-019-10321-x
PMCID:
PMC6547688
AbstractArticlePDF–4.3M
13.
USP7 Regulates Cytokinesis through FBXO38 and KIF20B
Anna Georges, Etienne Coyaud, Edyta Marcon, Jack Greenblatt, Brian Raught, Lori Frappier
Sci Rep. 2019; 9: 2724. Published online 2019 Feb 25. doi: 10.1038/s41598-019-39368-y
PMCID:
PMC6389929
AbstractArticlePDF–4.0M
14.
Cdt1 variants reveal unanticipated aspects of interactions with cyclin/CDK and MCM important for normal genome replication
Pedro N. Pozo, Jacob P. Matson, Yasemin Cole, Katarzyna M. Kedziora, Gavin D. Grant, Brenda Temple, Jeanette Gowen Cook
Mol Biol Cell. 2018 Dec 1; 29(25): 2989–3002. doi: 10.1091/mbc.E18-04-0242
PMCID:
PMC6333176
AbstractArticlePDF–2.5M
15.
Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1
Akiyo Hayashi, Nickolaos Nikiforos Giakoumakis, Tatjana Heidebrecht, Takashi Ishii, Andreas Panagopoulos, Christophe Caillat, Michiyo Takahara, Richard G Hibbert, Naohiro Suenaga, Magda Stadnik-Spiewak, Tatsuro Takahashi, Yasushi Shiomi, Stavros Taraviras, Eleonore von Castelmur, Zoi Lygerou, Anastassis Perrakis, Hideo Nishitani
Life Sci Alliance. 2018 Dec; 1(6): e201800238. Published online 2018 Dec 31. doi: 10.26508/lsa.201800238
PMCID:
PMC6312923
AbstractArticlePDF–3.2M
16.
Proliferating cell nuclear antigen interacts with the CRL4 ubiquitin ligase subunit CDT2 in DNA synthesis–induced degradation of CDT1
Feng Leng, Lovely Saxena, Nam Hoang, Chunxiao Zhang, Logan Lee, Wenjing Li, Xiaoshan Gong, Fei Lu, Hong Sun, Hui Zhang
J Biol Chem. 2018 Dec 7; 293(49): 18879–18889. Published online 2018 Oct 9. doi: 10.1074/jbc.RA118.003049
PMCID:
PMC6295734
AbstractArticlePDF–2.6M
17.
Cdt1 stabilizes kinetochore–microtubule attachments via an Aurora B kinase–dependent mechanism
Shivangi Agarwal, Kyle Paul Smith, Yizhuo Zhou, Aussie Suzuki, Richard J. McKenney, Dileep Varma
J Cell Biol. 2018 Oct 1; 217(10): 3446–3463. doi: 10.1083/jcb.201705127
PMCID:
PMC6168275
AbstractArticlePDF–3.1M
18.
The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin
Sang-Min Jang, Ya Zhang, Koichi Utani, Haiqing Fu, Christophe E. Redon, Anna B. Marks, Owen K. Smith, Catherine J. Redmond, Adrian M. Baris, Danielle A. Tulchinsky, Mirit I. Aladjem
Nat Commun. 2018; 9: 2782. Published online 2018 Jul 17. doi: 10.1038/s41467-018-05177-6
PMCID:
PMC6050238
AbstractArticlePDF–3.8M
19.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
20.
The prognostic significance of Cdc6 and Cdt1 in breast cancer
Ravikiran Mahadevappa, Henrique Neves, Shun Ming Yuen, Yuchen Bai, Cian M. McCrudden, Hiu Fung Yuen, Qing Wen, Shu Dong Zhang, Hang Fai Kwok
Sci Rep. 2017; 7: 985. Published online 2017 Apr 20. doi: 10.1038/s41598-017-00998-9
PMCID:
PMC5430515
AbstractArticlePDF–2.7M

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