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Items: 1 to 20 of 134

1.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
2.
ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced Transcription through Genome-Wide Binding of Phosphorylated and Unphosphorylated Complexes to Common ISRE-Containing ISGs
Hanna Nowicka, Agata Sekrecka, Katarzyna Blaszczyk, Katarzyna Kluzek, Chan-Yu Chang, Joanna Wesoly, Chien-Kuo Lee, Hans A. R. Bluyssen
Int J Mol Sci. 2023 Dec; 24(24): 17635. Published online 2023 Dec 18. doi: 10.3390/ijms242417635
PMCID:
PMC10743977
AbstractArticlePDF–8.9M
3.
Human inherited complete STAT2 deficiency underlies inflammatory viral diseases
Giorgia Bucciol, Leen Moens, Masato Ogishi, Darawan Rinchai, Daniela Matuozzo, Mana Momenilandi, Nacim Kerrouche, Catherine M. Cale, Elsa R. Treffeisen, Mohammad Al Salamah, Bandar K. Al-Saud, Alain Lachaux, Remi Duclaux-Loras, Marie Meignien, Aziz Bousfiha, Ibtihal Benhsaien, Anna Shcherbina, Anna Roppelt, COVID Human Genetic Effort, Florian Gothe, Nadhira Houhou-Fidouh, Scott J. Hackett, Lisa M. Bartnikas, Michelle C. Maciag, Mohammed F. Alosaimi, Janet Chou, Reem W. Mohammed, Bishara J. Freij, Emmanuelle Jouanguy, Shen-Ying Zhang, Stephanie Boisson-Dupuis, Vivien Béziat, Qian Zhang, Christopher J.A. Duncan, Sophie Hambleton, Jean-Laurent Casanova, Isabelle Meyts
J Clin Invest. 2023 Jun 15; 133(12): e168321. Published online 2023 Jun 15. doi: 10.1172/JCI168321
PMCID:
PMC10266780
AbstractArticlePDF–11M
4.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
5.
STAT2 act a prognostic biomarker and associated with immune infiltration in kidney renal clear cell carcinoma
Tao Zeng, Jianzhong Ye, Heng Wang, Wen Tian
Medicine (Baltimore) 2023 Apr 28; 102(17): e33662. Published online 2023 Apr 28. doi: 10.1097/MD.0000000000033662
PMCID:
PMC10146042
AbstractArticlePDF–2.6M
6.
Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2
Gaofeng Zhu, Mihaly Badonyi, Lina Franklin, Luis Seabra, Gillian I. Rice, Anne-Boland-Auge, Jean-François Deleuze, Salima El-Chehadeh, Mathieu Anheim, Anne de Saint-Martin, Sandra Pellegrini, Joseph A. Marsh, Yanick J. Crow, Marie-Therese El-Daher
J Clin Immunol. 2023; 43(4): 808–818. Published online 2023 Feb 8. doi: 10.1007/s10875-023-01445-3
PMCID:
PMC10110676
AbstractArticlePDF–1.3M
7.
African Swine Fever Virus Cysteine Protease pS273R Inhibits Type I Interferon Signaling by Mediating STAT2 Degradation
Yu-Hui Li, Jiang-Ling Peng, Zhi-Sheng Xu, Mei-Guang Xiong, Huang-Ning Wu, Su-Yun Wang, Dan Li, Guo-Qiang Zhu, Yong Ran, Yan-Yi Wang
J Virol. 2023 Mar; 97(3): e01942-22. Published online 2023 Mar 1. doi: 10.1128/jvi.01942-22
PMCID:
PMC10062137
AbstractArticlePDF–2.5M
8.
circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer
Yufei Yang, Dakui Luo, Yang Shao, Zezhi Shan, Qi Liu, Junyong Weng, Weijing He, Ruoxin Zhang, Qingguo Li, Ziliang Wang, Xinxiang Li
Cancer Commun (Lond) 2023 Jan; 43(1): 100–122. Published online 2022 Nov 3. doi: 10.1002/cac2.12380
PMCID:
PMC9859733
AbstractArticlePDF–4.1M
9.
Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis
Kei-ichiro Arimoto, Sayuri Miyauchi, Ty D. Troutman, Yue Zhang, Mengdan Liu, Samuel A. Stoner, Amanda G. Davis, Jun-Bao Fan, Yi-Jou Huang, Ming Yan, Christopher K. Glass, Dong-Er Zhang
Nat Commun. 2023; 14: 251. Published online 2023 Jan 17. doi: 10.1038/s41467-022-35348-5
PMCID:
PMC9842760
AbstractArticlePDF–4.8M
10.
Exposing the Two Contrasting Faces of STAT2 in Inflammation
Philip Duodu, Geohaira Sosa, Jorge Canar, Olivia Chhugani, Ana M. Gamero
J Interferon Cytokine Res. September 2022; 42(9): 467–481. Published online 2022 Sep 15. doi: 10.1089/jir.2022.0117
PMCID:
PMC9527059
AbstractArticlePDF–587K
11.
Initial activation of STAT2 induced by IAV infection is critical for innate antiviral immunity
Xinxin Li, Siya Liu, Kul Raj Rai, Wenzhuo Zhou, Song Wang, Xiaojuan Chi, Guijie Guo, Ji-Long Chen, Shasha Liu
Front Immunol. 2022; 13: 960544. Published online 2022 Sep 5. doi: 10.3389/fimmu.2022.960544
PMCID:
PMC9486978
AbstractArticlePDF–6.1M
12.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
13.
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia
Qian Zhang, Daniela Matuozzo, Jérémie Le Pen, Danyel Lee, Leen Moens, Takaki Asano, Jonathan Bohlen, Zhiyong Liu, Marcela Moncada-Velez, Yasemin Kendir-Demirkol, Huie Jing, Lucy Bizien, Astrid Marchal, Hassan Abolhassani, Selket Delafontaine, Giorgia Bucciol, COVID Human Genetic Effort, Gulsum Ical Bayhan, Sevgi Keles, Ayca Kiykim, Selda Hancerli, Filomeen Haerynck, Benoit Florkin, Nevin Hatipoglu, Tayfun Ozcelik, Guillaume Morelle, Mayana Zatz, Lisa F.P. Ng, David Chien Lye, Barnaby Edward Young, Yee-Sin Leo, Clifton L. Dalgard, Richard P. Lifton, Laurent Renia, Isabelle Meyts, Emmanuelle Jouanguy, Lennart Hammarström, Qiang Pan-Hammarström, Bertrand Boisson, Paul Bastard, Helen C. Su, Stéphanie Boisson-Dupuis, Laurent Abel, Charles M. Rice, Shen-Ying Zhang, Aurélie Cobat, Jean-Laurent Casanova
J Exp Med. 2022 Aug 1; 219(8): e20220131. Published online 2022 Jun 16. doi: 10.1084/jem.20220131
PMCID:
PMC9206114
AbstractArticlePDF–2.6M
14.
Physical and functional interactome atlas of human receptor tyrosine kinases
Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo
EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041
PMCID:
PMC9171411
AbstractArticlePDF–1.9M
15.
A partial form of inherited human USP18 deficiency underlies infection and inflammation
Marta Martin-Fernandez, Sofija Buta, Tom Le Voyer, Zhi Li, Lasse Toftdal Dynesen, Françoise Vuillier, Lina Franklin, Fatima Ailal, Alice Muglia Amancio, Louise Malle, Conor Gruber, Ibtihal Benhsaien, Jennie Altman, Justin Taft, Caroline Deswarte, Manon Roynard, Alejandro Nieto-Patlan, Kunihiko Moriya, Jérémie Rosain, Nathalie Boddaert, Aziz Bousfiha, Yanick J. Crow, Dragana Jankovic, Alan Sher, Jean-Laurent Casanova, Sandra Pellegrini, Jacinta Bustamante, Dusan Bogunovic
J Exp Med. 2022 Apr 4; 219(4): e20211273. Published online 2022 Mar 8. doi: 10.1084/jem.20211273
PMCID:
PMC8908790
AbstractArticlePDF–6.1M
16.
Human transcription factor protein interaction networks
Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo
Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5
PMCID:
PMC8828895
AbstractArticlePDF–1.7M
17.
The Human STAT2 Coiled-Coil Domain Contains a Degron for Zika Virus Interferon Evasion
Jean-Patrick Parisien, Jessica J. Lenoir, Gloria Alvarado, Curt M. Horvath
J Virol. 2022 Jan; 96(1): e01301-21. Prepublished online 2021 Oct 13. Published online 2022 Jan 12. doi: 10.1128/JVI.01301-21
PMCID:
PMC8754212
AbstractArticlePDF–3.8M
18.
A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
Megan R. Reed, A. Geoffrey Lyle, Annick De Loose, Leena Maddukuri, Katrina Learned, Holly C. Beale, Ellen T. Kephart, Allison Cheney, Anouk van den Bout, Madison P. Lee, Kelsey N. Hundley, Ashley M. Smith, Teresa M. DesRochers, Cecile Rose T. Vibat, Murat Gokden, Sofie Salama, Christopher P. Wardell, Robert L. Eoff, Olena M. Vaske, Analiz Rodriguez
Cells. 2021 Dec; 10(12): 3400. Published online 2021 Dec 2. doi: 10.3390/cells10123400
PMCID:
PMC8699481
AbstractArticlePDF–3.5M
19.
An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity
Yuehui Zhang, Limin Shang, Jing Zhang, Yuchen Liu, Chaozhi Jin, Yanan Zhao, Xiaobo Lei, Wenjing Wang, Xia Xiao, Xiuyuan Zhang, Yujiao Liu, Linlin Liu, Meng-Wei Zhuang, Qingkun Mi, Chunyan Tian, Jianwei Wang, Fuchu He, Pei-Hui Wang, Jian Wang
Cell Chem Biol. 2022 Jan 20; 29(1): 5–18.e6. Published online 2021 Oct 20. doi: 10.1016/j.chembiol.2021.10.008
PMCID:
PMC8527578
AbstractArticlePDF–4.5M
20.
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response
Yinghua Zhao, Liyan Sui, Ping Wu, Wenfang Wang, Zedong Wang, Yang Yu, Zhijun Hou, Guangyun Tan, Quan Liu, Guoqing Wang
Signal Transduct Target Ther. 2021; 6: 331. Published online 2021 Sep 1. doi: 10.1038/s41392-021-00742-w
PMCID:
PMC8409078
AbstractArticlePDF–4.4M

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