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Select item 111212481.

MerTK Drives Proliferation and Metastatic Potential in Triple-Negative Breast Cancer

Mari Iida, Bridget E. Crossman, Kourtney L. Kostecki, Christine E. Glitchev, Carlene A. Kranjac, Madisen T. Crow, Jillian M. Adams, Peng Liu, Irene Ong, David T. Yang, Irene Kang, Ravi Salgia, Deric L. Wheeler

Int J Mol Sci. 2024 May; 25(10): 5109. Published online 2024 May 8. doi: 10.3390/ijms25105109

PMCID:: PMC11121248

Abstract Article PDF–13M

Select item 110501082.

Regulation of Mertk Surface Expression via ADAM17 and γ-Secretase Proteolytic Processing

Kevin C. Lahey, Christopher Varsanyi, Ziren Wang, Ahmed Aquib, Varsha Gadiyar, Alcina A. Rodrigues, Rachael Pulica, Samuel Desind, Viralkumar Davra, David C. Calianese, Dongfang Liu, Jong-Hyun Cho, Sergei V. Kotenko, Mariana S. De Lorenzo, Raymond B. Birge

Int J Mol Sci. 2024 Apr; 25(8): 4404. Published online 2024 Apr 17. doi: 10.3390/ijms25084404

PMCID:: PMC11050108

Abstract Article PDF–5.9M

Select item 109772543.

The Important Role of Phosphatidylserine, ADAM17, TNF-Alpha, and Soluble MER on Efferocytosis Activity in Central Obesity

Chandra Agung Purnama, Anna Meiliana, Melisa Intan Barliana, Keri Lestari, Andi Wijaya

J Obes. 2024; 2024: 1424404. Published online 2024 Mar 20. doi: 10.1155/2024/1424404

PMCID:: PMC10977254

Abstract Article PDF–782K

Select item 109444584.

Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis

Alessandra Nerviani, Marie-Astrid Boutet, Giulia Maria Ghirardi, Katriona Goldmann, Elisabetta Sciacca, Felice Rivellese, Elena Pontarini, Edoardo Prediletto, Federico Abatecola, Mattia Caliste, Sara Pagani, Daniele Mauro, Mattia Bellan, Cankut Cubuk, Rachel Lau, Sarah E. Church, Briana M. Hudson, Frances Humby, Michele Bombardieri, Myles J. Lewis, Costantino Pitzalis

Nat Commun. 2024; 15: 2398. Published online 2024 Mar 16. doi: 10.1038/s41467-024-46564-6

PMCID:: PMC10944458

Abstract Article PDF–5.4M

Select item 108976105.

Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma

Shun Wang, Le Zhu, Tianen Li, Xinxin Lin, Yan Zheng, Da Xu, Yu Guo, Ze Zhang, Yan Fu, Hao Wang, Xufeng Wang, Tiantian Zou, Xiaotian Shen, Lumin Zhang, Nannan Lai, Lu Lu, Lunxiu Qin, Qiongzhu Dong

Cell Rep Med. 2024 Feb 20; 5(2): 101415. Published online 2024 Feb 20. doi: 10.1016/j.xcrm.2024.101415

PMCID:: PMC10897610

Abstract Article PDF–9.0M

Select item 108692596.

Big data analytics for MerTK genomics reveals its double-edged sword functions in human diseases

Shijie Liu, Jinzi Wu, Daixuan Yang, Jianliang Xu, Hang Shi, Bingzhong Xue, Zufeng Ding

Redox Biol. 2024 Apr; 70: 103061. Published online 2024 Feb 5. doi: 10.1016/j.redox.2024.103061

PMCID:: PMC10869259

Abstract Article PDF–24M

Select item 108342567.

MerTK is a mediator of alpha-synuclein fibril uptake by human microglia

Marie-France Dorion, Moein Yaqubi, Konstantin Senkevich, Nicholas W Kieran, Adam MacDonald, Carol X Q Chen, Wen Luo, Amber Wallis, Irina Shlaifer, Jeffery A Hall, Roy W R Dudley, Ian A Glass, Birth Defects Research Laboratory, Jo Anne Stratton, Edward A Fon, Tim Bartels, Jack P Antel, Ziv Gan-or, Thomas M Durcan, Luke M Healy

Brain. 2024 Feb; 147(2): 427–443. Published online 2023 Sep 6. doi: 10.1093/brain/awad298

PMCID:: PMC10834256

Abstract Article PDF–4.1M

Select item 108111908.

Semaphorin3B promotes an anti-inflammatory and pro-resolving phenotype in macrophages from rheumatoid arthritis patients in a MerTK-dependent manner

Sara Martínez-Ramos, Carlos Rafael-Vidal, Beatriz Malvar-Fernández, Nair Pérez, Coral Mouriño, Sara García Pérez, Francisco J. Maceiras Pan, Carmen Conde, Jose María Pego-Reigosa, Samuel García

Front Immunol. 2023; 14: 1268144. Published online 2024 Jan 12. doi: 10.3389/fimmu.2023.1268144

PMCID:: PMC10811190

Abstract Article PDF–2.1M

Select item 107525769.

HLA-DRB1*15:01 and the MERTK Gene Interact to Selectively Influence the Profile of MERTK-Expressing Monocytes in Both Health and MS

Michele D. Binder, Eze C. Nwoke, Ellen Morwitch, Chris Dwyer, Vivien Li, Alexandre Xavier, Rodney A. Lea, Jeannette Lechner-Scott, Bruce V. Taylor, Anne-Louise Ponsonby, Trevor J. Kilpatrick, for the Ausimmune Investigator Group

Neurol Neuroimmunol Neuroinflamm. 2024 Mar; 11(2): e200190. Published online 2023 Dec 27. doi: 10.1212/NXI.0000000000200190

PMCID:: PMC10752576

Abstract Article PDF–551K

Select item 1048297710.

Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer

Kaisa E. Happonen, Patrick G. Burrola, Greg Lemke

Commun Biol. 2023; 6: 916. Published online 2023 Sep 7. doi: 10.1038/s42003-023-05287-y

PMCID:: PMC10482977

Abstract Article PDF–1.6M

Select item 1014843311.

Elevated expression of macrophage MERTK exhibits profibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis

Yixin She, Xin Xu, Qingyang Yu, Xiangsheng Yang, Jianxing He, Xiao Xiao Tang

Respir Res. 2023; 24: 118. Published online 2023 Apr 29. doi: 10.1186/s12931-023-02424-3

PMCID:: PMC10148433

Abstract Article PDF–3.7M

Select item 1007290612.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 999420713.

Mertk: An emerging target in cancer biology and immuno-oncology

Kevin C. Lahey, Varsha Gadiyar, Amanda Hill, Samuel Desind, Ziren Wang, Viralkumar Davra, Radhey Patel, Ahnaf Zaman, David Calianese, Raymond B. Birge

Int Rev Cell Mol Biol. Author manuscript; available in PMC 2023 Mar 8.

Published in final edited form as: Int Rev Cell Mol Biol. 2022; 368: 35–59. Published online 2022 May 5. doi: 10.1016/bs.ircmb.2022.04.004

PMCID:: PMC9994207

Abstract Article PDF–1.2M

Select item 963914214.

Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease

Sule Yavuz, Pascal Pucholt, Johanna K Sandling, Matteo Bianchi, Dag Leonard, Karin Bolin, Juliana Imgenberg-Kreuz, Maija-Leena Eloranta, Sergey V Kozyrev, Cristina M Lanata, Andreas Jönsen, Anders A Bengtsson, Christopher Sjöwall, Elisabet Svenungsson, Iva Gunnarsson, Solbritt Rantapää-Dahlqvist, ImmunoArray Development Consortium, DISSECT Consortium, Joanne Nititham, Lindsey A Criswell, Kerstin Lindblad-Toh, Lars Rönnblom

Lupus Sci Med. 2022; 9(1): e000752. Published online 2022 Nov 4. doi: 10.1136/lupus-2022-000752

PMCID:: PMC9639142

Abstract Article PDF–1.1M

Select item 961555815.

MERTK missense variants in three patients with retinitis pigmentosa

Federica E. Poli, Imran H. Yusuf, Penny Clouston, Morag Shanks, Jennifer Whitfield, Peter Charbel Issa, Robert E. MacLaren

Ophthalmic Genet. 2022 Aug 29 : 1–9. doi: 10.1080/13816810.2022.2113541 [Epub ahead of print]

PMCID:: PMC9615558

Abstract Article PDF–13M

Select item 939445316.

Mer Tyrosine Kinase (MERTK) modulates liver fibrosis progression and hepatocellular carcinoma development

Rosaria Maria Pipitone, Vincenza Calvaruso, Lorenza Di Marco, Francesca Di Salvo, Miriam Gaggianesi, Giulia Lupo, Rossella Zito, Claudia La Mantia, Matteo Ramazzotti, Salvatore Petta, Vito Di Marco, Antonio Craxì, Stefania Grimaudo

Front Immunol. 2022; 13: 926236. Published online 2022 Aug 8. doi: 10.3389/fimmu.2022.926236

PMCID:: PMC9394453

Abstract Article PDF–886K

Select item 934857617.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 917141118.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 883559119.

High Glucose Impairs Expression and Activation of MerTK in ARPE-19 Cells

Alessandra Puddu, Silvia Ravera, Isabella Panfoli, Nadia Bertola, Davide Maggi

Int J Mol Sci. 2022 Feb; 23(3): 1144. Published online 2022 Jan 20. doi: 10.3390/ijms23031144

PMCID:: PMC8835591

Abstract Article PDF–3.3M

Select item 875747120.

MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression

Jinti Lin, Ankai Xu, Jiakang Jin, Man Zhang, Jianan Lou, Chao Qian, Jian Zhu, Yitian Wang, Zhengming Yang, Xiumao Li, Wei Yu, Bing Liu, Huimin Tao

Oncoimmunology. 2022; 11(1): 2024941. Published online 2022 Jan 12. doi: 10.1080/2162402X.2021.2024941

PMCID:: PMC8757471

Abstract Article PDF–3.5M

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