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Select item 111085191.

Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases

Lorraine Springuel, Elisabeth Losdyck, Pascale Saussoy, Béatrice Turcq, François-Xavier Mahon, Laurent Knoops, Jean-Christophe Renauld

Cell Mol Life Sci. 2016 Dec; 73(24): 4739–4748. Published online 2016 Jul 19. doi: 10.1007/s00018-016-2310-2

PMCID:: PMC11108519

Abstract Article PDF–1.2M

Select item 110067542.

Omenn Syndrome in Two Infants with Different Hypomorphic Variants in Janus Kinase 3

Christo Tsilifis, Jarmila Stremenova Spegarova, Ross Good, Helen Griffin, Karin R. Engelhardt, Sophie Graham, Stephen Hughes, Peter D. Arkwright, Sophie Hambleton, Andrew R. Gennery

J Clin Immunol. 2024; 44(4): 98. Published online 2024 Apr 10. doi: 10.1007/s10875-024-01699-5

PMCID:: PMC11006754

Abstract Article PDF–1.1M

Select item 109324053.

Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity Disrupted in Immune Cell Cancer and Immunodeficiency

Clifford Liongue, Tarindhi Ratnayake, Faiza Basheer, Alister C. Ward

Int J Mol Sci. 2024 Mar; 25(5): 2977. Published online 2024 Mar 4. doi: 10.3390/ijms25052977

PMCID:: PMC10932405

Abstract Article PDF–1.2M

Select item 107814894.

Conjoint research of WGCNA, single-cell transcriptome and structural biology reveals the potential targets of IDD development and treatment and JAK3 involvement

Yingjing Zhao, Yuxue Mu, Yujia Zou, Zhijian He, Tianxing Lu, Xinhui Wang, Weihang Li, Bo Gao

Aging (Albany NY) 2023 Dec 31; 15(24): 14764–14790. Published online 2023 Dec 12. doi: 10.18632/aging.205289

PMCID:: PMC10781489

Abstract Article PDF–3.3M

Select item 105720115.

New JAK3-INSL3 Fusion Transcript—An Oncogenic Event in Cutaneous T-Cell Lymphoma

Loka Reddy Velatooru, Cheng Hui Hu, Pedram Bijani, Xiaohong Wang, Pierr Bojaxhi, Hao Chen, Madeleine Duvic, Xiao Ni

Cells. 2023 Oct; 12(19): 2381. Published online 2023 Sep 29. doi: 10.3390/cells12192381

PMCID:: PMC10572011

Abstract Article PDF–2.9M

Select item 95996166.

Zebrafish Model of Severe Combined Immunodeficiency (SCID) Due to JAK3 Mutation

Faiza Basheer, Effie Lee, Clifford Liongue, Alister C. Ward

Biomolecules. 2022 Oct; 12(10): 1521. Published online 2022 Oct 20. doi: 10.3390/biom12101521

PMCID:: PMC9599616

Abstract Article PDF–5.5M

Select item 94819627.

Prognostic value of JAK3 promoter methylation and mRNA expression in clear cell renal cell carcinoma

Qian Long, Chunyu Huang, Jinsheng Huang, Qi Meng, Yanjun Cheng, Yilin Li, Liru He, Miao Chen, Changlin Zhang, Xiaonan Wang, Wancui Zhu, Jin Peng, Dingbo Shi, Fufu Zheng, Pei Dong, Wuguo Deng

J Adv Res. 2022 Sep; 40: 153–166. Published online 2021 Dec 4. doi: 10.1016/j.jare.2021.11.016

PMCID:: PMC9481962

Abstract Article PDF–6.4M

Select item 92626148.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 91776799.

JAK3 Mutations and Mitochondrial Apoptosis Resistance in T-Cell Acute Lymphoblastic Leukemia

Kimberly Bodaar, Natsuko Yamagata, Anais Barthe, Jack Landrigan, Triona Ni Chonghaile, Melissa Burns, Kristen E. Stevenson, Meenakshi Devidas, Mignon L. Loh, Stephen P. Hunger, Brent Wood, Lewis B. Silverman, David T. Teachey, Jules P. Meijerink, Anthony Letai, Alejandro Gutierrez

Leukemia. Author manuscript; available in PMC 2022 Oct 11.

Published in final edited form as: Leukemia. 2022 Jun; 36(6): 1499–1507. Published online 2022 Apr 11. doi: 10.1038/s41375-022-01558-5

PMCID:: PMC9177679

Abstract Article PDF–1.4M

Select item 917141110.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 855126311.

Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling

Jiajia Wang, Jiaying Wang, Wenxiang Hong, Lulu Zhang, Liqian Song, Qi Shi, Yanfei Shao, Guifeng Hao, Chunyan Fang, Yueping Qiu, Lijun Yang, Zhaoxu Yang, Jincheng Wang, Ji Cao, Bo Yang, Qiaojun He, Qinjie Weng

Nat Commun. 2021; 12: 6198. Published online 2021 Oct 27. doi: 10.1038/s41467-021-26477-4

PMCID:: PMC8551263

Abstract Article PDF–3.0M

Select item 811561912.

Generation of a chemical genetic model for JAK3

Judit Remenyi, Rangeetha Jayaprakash Naik, Jinhua Wang, Momchil Razsolkov, Alyssa Verano, Quan Cai, Li Tan, Rachel Toth, Samantha Raggett, Carla Baillie, Ryan Traynor, C. James Hastie, Nathanael S. Gray, J. Simon C. Arthur

Sci Rep. 2021; 11: 10093. Published online 2021 May 12. doi: 10.1038/s41598-021-89356-4

PMCID:: PMC8115619

Abstract Article PDF–4.2M

Select item 787483913.

Whole‐exome sequencing of T^‐B⁺ severe combined immunodeficiency in Egyptian infants, JAK3 predominance and novel variants

R. El Hawary, S. Meshaal, A.A. Mauracher, L. Opitz, D. Abd Elaziz, S. Lotfy, A. Eldash, J. Boutros, N. Galal, J. Pachlopnik Schmid, A. Elmarsafy

Clin Exp Immunol. 2021 Mar; 203(3): 448–457. Published online 2020 Nov 2. doi: 10.1111/cei.13536

PMCID:: PMC7874839

Abstract Article PDF–374K

Select item 771980814.

RNA Sequencing Keloid Transcriptome Associates Keloids With Th2, Th1, Th17/Th22, and JAK3-Skewing

Jianni Wu, Ester Del Duca, Michael Espino, Alyssa Gontzes, Inna Cueto, Ning Zhang, Yeriel D. Estrada, Ana B. Pavel, James G. Krueger, Emma Guttman-Yassky

Front Immunol. 2020; 11: 597741. Published online 2020 Nov 23. doi: 10.3389/fimmu.2020.597741

PMCID:: PMC7719808

Abstract Article PDF–6.8M

Select item 755925815.

JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma

Lingkai Meng, Ling Ding, Yue Yu, Wang Li

Biomed Res Int. 2020; 2020: 7973568. Published online 2020 Sep 19. doi: 10.1155/2020/7973568

PMCID:: PMC7559258

Abstract Article PDF–1.3M

Select item 742732716.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 734316017.

Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene

Lorenza Mittempergher, Anna M. Piskorz, Astrid J. Bosma, Magali Michaut, G. Bea A. Wisman, Roelof J. C. Kluin, Marja Nieuwland, Wim Brugman, Kevin J. W. van der Ven, Francesco Marass, James Morris, Nitzan Rosenfeld, Mercedes Jimenez-Linan, Steven de Jong, Ate G. J. van der Zee, James D. Brenton, René Bernards

PLoS One. 2020; 15(7): e0235766. Published online 2020 Jul 8. doi: 10.1371/journal.pone.0235766

PMCID:: PMC7343160

Abstract Article PDF–2.1M

Select item 701590918.

A Targeted Quantitative Proteomic Method Revealed a Substantial Reprogramming of Kinome during Melanoma Metastasis

Weili Miao, Lin Li, Xiaochuan Liu, Tianyu F. Qi, Lei Guo, Ming Huang, Yinsheng Wang

Sci Rep. 2020; 10: 2485. Published online 2020 Feb 12. doi: 10.1038/s41598-020-59572-5

PMCID:: PMC7015909

Abstract Article PDF–2.1M

Select item 688814319.

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

Michael Broux, Cristina Prieto, Sofie Demeyer, Marlies Vanden Bempt, Llucia Alberti-Servera, Inge Lodewijckx, Roel Vandepoel, Nicole Mentens, Olga Gielen, Kris Jacobs, Ellen Geerdens, Carmen Vicente, Charles E. de Bock, Jan Cools

Blood. 2019 Oct 17; 134(16): 1323–1336. Prepublished online 2019 Sep 6. doi: 10.1182/blood.2019000015

PMCID:: PMC6888143

Abstract Article

Select item 680003720.

JAK3 variant, immune signatures, DNA methylation, and social determinants linked to survival racial disparities in head and neck cancer patients

Rafael Guerrero-Preston, Fahcina Lawson, Sebastian Rodriguez-Torres, Maartje G. Noordhuis, Francesca Pirini, Laura Manuel, Blanca Valle, Tal Hadar, Bianca Rivera, Oluwasina Folawiyo, Adriana Baez Bermejo, Luigi Marchionni, Wayne Koch, William H. Westra, Young Kim, James Eshleman, David Sidransky

Cancer Prev Res (Phila) Author manuscript; available in PMC 2020 Apr 1.

Published in final edited form as: Cancer Prev Res (Phila). 2019 Apr; 12(4): 255–270. Published online 2019 Feb 18. doi: 10.1158/1940-6207.CAPR-17-0356

Correction in:: Cancer Prev Res (Phila). 2019 Jul; 12(7): 491–492.

PMCID:: PMC6800037

Abstract Article PDF–982K

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