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Select item 113198251.

In vitro and in vivo inhibition of the host TRPC4 channel attenuates Zika virus infection

Xingjuan Chen, Yunzheng Yan, Zhiqiang Liu, Shaokang Yang, Wei Li, Zhuang Wang, Mengyuan Wang, Juan Guo, Zhenyang Li, Weiyan Zhu, Jingjing Yang, Jiye Yin, Qingsong Dai, Yuexiang Li, Cui Wang, Lei Zhao, Xiaotong Yang, Xiaojia Guo, Ling Leng, Jiaxi Xu, Alexander G Obukhov, Ruiyuan Cao, Wu Zhong

EMBO Mol Med. 2024 Aug; 16(8): 1817–1839. Published online 2024 Jul 15. doi: 10.1038/s44321-024-00103-4

PMCID:: PMC11319825

Abstract Article PDF–6.4M

Select item 99531802.

Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4, and Its Expression Correlated with Prognosis, Tumor Microenvironment, and Treatment Sensitivity

Zhenghao Chen, Youquan Zhao, Ye Tian, Rui Cao, Donghao Shang

Biomolecules. 2023 Feb; 13(2): 282. Published online 2023 Feb 2. doi: 10.3390/biom13020282

PMCID:: PMC9953180

Abstract Article PDF–6.4M

Select item 98626513.

Expression of pH-Sensitive TRPC4 in Common Skin Tumors

Bernadett Kurz, Hannah Philine Michael, Antonia Förch, Susanne Wallner, Florian Zeman, Sonja-Maria Decking, Ines Ugele, Constantin Hintschich, Frank Haubner, Tobias Ettl, Kathrin Renner, Christoph Brochhausen, Stephan Schreml

Int J Mol Sci. 2023 Jan; 24(2): 1037. Published online 2023 Jan 5. doi: 10.3390/ijms24021037

PMCID:: PMC9862651

Abstract Article PDF–2.8M

Select item 86432554.

Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation

Wenjun Zeng, Yinan Ji, Haiping Zhang, Liusheng Chen, Li Du, Ruiwei Guo

Genet Res (Camb) 2021; 2021: 2949986. Published online 2021 Nov 27. doi: 10.1155/2021/2949986

PMCID:: PMC8643255

Abstract Article PDF–1.1M

Select item 82318925.

Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma

Osama M. Elzamzamy, Brandon E. Johnson, Wei-Chih Chen, Gangqing Hu, Reinhold Penner, Lori A. Hazlehurst

Cells. 2021 Jun; 10(6): 1490. Published online 2021 Jun 13. doi: 10.3390/cells10061490

PMCID:: PMC8231892

Abstract Article PDF–5.3M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 67335377.

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation

Cristina Guardia-Laguarta, Yuhui Liu, Knut H. Lauritzen, Hediye Erdjument-Bromage, Brittany Martin, Theresa C. Swayne, Xuejun Jiang, Serge Przedborski

J Neurosci. 2019 Sep 4; 39(36): 7074–7085. doi: 10.1523/JNEUROSCI.1691-18.2019

PMCID:: PMC6733537

Abstract Article PDF–3.0M

Select item 63727168.

Differential PI(4,5)P₂ sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels

Juyeon Ko, Jongyun Myeong, Young-Cheul Shin, Insuk So

Sci Rep. 2019; 9: 1849. Published online 2019 Feb 12. doi: 10.1038/s41598-018-38443-0

PMCID:: PMC6372716

Abstract Article PDF–4.9M

Select item 61666829.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 609239410.

Dual action of the Gα_q-PLCβ-PI(4,5)P₂ pathway on TRPC1/4 and TRPC1/5 heterotetramers

Jongyun Myeong, Juyeon Ko, Misun Kwak, Jinsung Kim, Joohan Woo, Kotdaji Ha, Chansik Hong, Dongki Yang, Hyun Jin Kim, Ju-Hong Jeon, Insuk So

Sci Rep. 2018; 8: 12117. Published online 2018 Aug 14. doi: 10.1038/s41598-018-30625-0

PMCID:: PMC6092394

Abstract Article PDF–3.5M

Select item 582387311.

Gα_i-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation

Misun Kwak, Chansik Hong, Jongyun Myeong, Eunice Yon June Park, Ju-Hong Jeon, Insuk So

Sci Rep. 2018; 8: 3480. Published online 2018 Feb 22. doi: 10.1038/s41598-018-21873-1

PMCID:: PMC5823873

Abstract Article PDF–5.2M

Select item 559980012.

Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory

Jenny Bröker‐Lai, Astrid Kollewe, Barbara Schindeldecker, Jörg Pohle, Vivan Nguyen Chi, Ilka Mathar, Raul Guzman, Yvonne Schwarz, Alan Lai, Petra Weißgerber, Herbert Schwegler, Alexander Dietrich, Martin Both, Rolf Sprengel, Andreas Draguhn, Georg Köhr, Bernd Fakler, Veit Flockerzi, Dieter Bruns, Marc Freichel

EMBO J. 2017 Sep 15; 36(18): 2770–2789. Published online 2017 Aug 8. doi: 10.15252/embj.201696369

PMCID:: PMC5599800

Abstract Article PDF–4.2M

Select item 555616713.

Functional expression of calcium‐permeable canonical transient receptor potential 4‐containing channels promotes migration of medulloblastoma cells

Wei‐Chun Wei, Wan‐Chen Huang, Yu‐Ping Lin, Esther B. E. Becker, Olaf Ansorge, Veit Flockerzi, Daniele Conti, Giovanna Cenacchi, Maike D. Glitsch

J Physiol. 2017 Aug 15; 595(16): 5525–5544. Published online 2017 Jul 20. doi: 10.1113/JP274659

PMCID:: PMC5556167

Abstract Article PDF–896K

Select item 543722514.

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels

Hussein N. Rubaiy, Melanie J. Ludlow, Matthias Henrot, Hannah J. Gaunt, Katarina Miteva, Sin Ying Cheung, Yasuyuki Tanahashi, Nurasyikin Hamzah, Katie E. Musialowski, Nicola M. Blythe, Hollie L. Appleby, Marc A. Bailey, Lynn McKeown, Roger Taylor, Richard Foster, Herbert Waldmann, Peter Nussbaumer, Mathias Christmann, Robin S. Bon, Katsuhiko Muraki, David J. Beech

J Biol Chem. 2017 May 19; 292(20): 8158–8173. Published online 2017 Mar 21. doi: 10.1074/jbc.M116.773556

PMCID:: PMC5437225

Abstract Article PDF–3.8M

Select item 516739015.

TRPC4α and TRPC4β Similarly Affect Neonatal Cardiomyocyte Survival during Chronic GPCR Stimulation

Nadine Kirschmer, Sandra Bandleon, Viktor von Ehrlich-Treuenstätt, Sonja Hartmann, Alice Schaaf, Anna-Karina Lamprecht, Erick Miranda-Laferte, Tanja Langsenlehner, Oliver Ritter, Petra Eder

PLoS One. 2016; 11(12): e0168446. Published online 2016 Dec 19. doi: 10.1371/journal.pone.0168446

PMCID:: PMC5167390

Abstract Article PDF–2.0M

Select item 500613216.

Identification of TRPCs genetic variants that modify risk for lung cancer based on the pathway and two-stage study

Zili Zhang, Jian Wang, Jianxing He, Xiansheng Zeng, Xindong Chen, Mingmei Xiong, Qipeng Zhou, Meihua Guo, Defu Li, Wenju Lu

Meta Gene. 2016 Sep; 9: 191–196. Published online 2016 Jul 8. doi: 10.1016/j.mgene.2016.07.005

PMCID:: PMC5006132

Abstract Article PDF–271K

Select item 480513917.

Silencing of Transient Receptor Potential Channel 4 Alleviates oxLDL-induced Angiogenesis in Human Coronary Artery Endothelial Cells by Inhibition of VEGF and NF-κB

Wen Qin, Wei Xie, Ning Xia, Qinglin He, Tianwei Sun

Med Sci Monit. 2016; 22: 930–936. Published online 2016 Mar 21. doi: 10.12659/MSM.897634

PMCID:: PMC4805139

Abstract Article PDF–1.1M

Select item 474381618.

Critical roles of G_i/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels

Dhananjay P. Thakur, Jin-bin Tian, Jaepyo Jeon, Jian Xiong, Yu Huang, Veit Flockerzi, Michael X. Zhu

Proc Natl Acad Sci U S A. 2016 Jan 26; 113(4): 1092–1097. Published online 2016 Jan 11. doi: 10.1073/pnas.1522294113

PMCID:: PMC4743816

Abstract Article PDF–1.3M

Select item 459451019.

The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels

Jinhong Wie, Byung Joo Kim, Jongyun Myeong, Kotdaji Ha, Seung Joo Jeong, Dongki Yang, Euiyong Kim, Ju-Hong Jeon, Insuk So

Channels (Austin) 2015 Jul-Aug; 9(4): 186–195. Published online 2015 Jun 17. doi: 10.1080/19336950.2015.1058454

Correction in:: Channels (Austin). 2016 Jul-Aug; 10(4): 332.

PMCID:: PMC4594510

Abstract Article PDF–820K

Select item 444721620.

TRUSS, TNF-R1, and TRPC Ion Channels Synergistically Reverse Endoplasmic Reticulum Ca²⁺ Storage Reduction in Response to m1 Muscarinic Acetylcholine Receptor Signaling

Kimberly E. Mace, Marc P. Lussier, Guylain Boulay, Jennifer L. Terry-Powers, Helen Parfrey, Anne-Laure Perraud, David W.H. Riches

J Cell Physiol. Author manuscript; available in PMC 2015 May 28.

Published in final edited form as: J Cell Physiol. 2010 Nov; 225(2): 444–453. doi: 10.1002/jcp.22221

PMCID:: PMC4447216

Abstract Article PDF–3.3M

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