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Select item 109915531.

Dbf4-dependent kinase promotes cell cycle controlled resection of DNA double-strand breaks and repair by homologous recombination

Lorenzo Galanti, Martina Peritore, Robert Gnügge, Elda Cannavo, Johannes Heipke, Maria Dilia Palumbieri, Barbara Steigenberger, Lorraine S. Symington, Petr Cejka, Boris Pfander

Nat Commun. 2024; 15: 2890. Published online 2024 Apr 3. doi: 10.1038/s41467-024-46951-z

PMCID:: PMC10991553

Abstract Article PDF–4.7M

Select item 109544702.

Rif2 interaction with Rad50 counteracts Tel1 functions in checkpoint signalling and DNA tethering by releasing Tel1 from MRX binding

Paolo Pizzul, Erika Casari, Carlo Rinaldi, Marco Gnugnoli, Marco Mangiagalli, Renata Tisi, Maria Pia Longhese

Nucleic Acids Res. 2024 Mar 21; 52(5): 2355–2371. Published online 2024 Jan 5. doi: 10.1093/nar/gkad1246

PMCID:: PMC10954470

Abstract Article PDF–2.4M

Select item 107001383.

The social and structural architecture of the yeast protein interactome

André C. Michaelis, Andreas-David Brunner, Maximilian Zwiebel, Florian Meier, Maximilian T. Strauss, Isabell Bludau, Matthias Mann

Nature. 2023; 624(7990): 192–200. Published online 2023 Nov 15. doi: 10.1038/s41586-023-06739-5

PMCID:: PMC10700138

Abstract Article PDF–20M

Select item 106225114.

Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ-dependent mechanism

Amr M. Al-Zain, Mattie R. Nester, Iffat Ahmed, Lorraine S. Symington

Nat Commun. 2023; 14: 7020. Published online 2023 Nov 2. doi: 10.1038/s41467-023-42640-5

PMCID:: PMC10622511

Abstract Article PDF–5.4M

Select item 99768775.

The Ku complex promotes DNA end-bridging and this function is antagonized by Tel1/ATM kinase

Carlo Rinaldi, Paolo Pizzul, Erika Casari, Marco Mangiagalli, Renata Tisi, Maria Pia Longhese

Nucleic Acids Res. 2023 Feb 28; 51(4): 1783–1802. Published online 2023 Feb 10. doi: 10.1093/nar/gkad062

PMCID:: PMC9976877

Abstract Article PDF–6.3M

Select item 96309866.

A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans

Phoebe Y T Lu, Alyssa C Kirlin, Maria J Aristizabal, Hilary T Brewis, Nancy Lévesque, Dheva T Setiaputra, Nikita Avvakumov, Joris J Benschop, Marian Groot Koerkamp, Frank C P Holstege, Nevan J Krogan, Calvin K Yip, Jacques Côté, Michael S Kobor

Genetics. 2022 Nov; 222(3): iyac136. Published online 2022 Sep 6. doi: 10.1093/genetics/iyac136

PMCID:: PMC9630986

Abstract Article PDF–2.2M

Select item 92098117.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources

Stacia R Engel, Edith D Wong, Robert S Nash, Suzi Aleksander, Micheal Alexander, Eric Douglass, Kalpana Karra, Stuart R Miyasato, Matt Simison, Marek S Skrzypek, Shuai Weng, J Michael Cherry

Genetics. 2022 Apr; 220(4): iyab224. Published online 2021 Dec 13. doi: 10.1093/genetics/iyab224

PMCID:: PMC9209811

Abstract Article PDF–818K

Select item 91175468.

Nej1 interacts with Sae2 at DNA double-stranded breaks to inhibit DNA resection

Aditya Mojumdar, Nancy Adam, Jennifer A. Cobb

J Biol Chem. 2022 Jun; 298(6): 101937. Published online 2022 Apr 13. doi: 10.1016/j.jbc.2022.101937

PMCID:: PMC9117546

Abstract Article PDF–2.7M

Select item 90617539.

Mre11-Rad50 oligomerization promotes DNA double-strand break repair

Vera M. Kissling, Giordano Reginato, Eliana Bianco, Kristina Kasaciunaite, Janny Tilma, Gea Cereghetti, Natalie Schindler, Sung Sik Lee, Raphaël Guérois, Brian Luke, Ralf Seidel, Petr Cejka, Matthias Peter

Nat Commun. 2022; 13: 2374. Published online 2022 May 2. doi: 10.1038/s41467-022-29841-0

PMCID:: PMC9061753

Abstract Article PDF–4.3M

Select item 872476710.

Sir3 heterochromatin protein promotes non‐homologous end joining by direct inhibition of Sae2

Hélène Bordelet, Rafaël Costa, Clémentine Brocas, Jordane Dépagne, Xavier Veaute, Didier Busso, Amandine Batté, Raphaël Guérois, Stéphane Marcand, Karine Dubrana

EMBO J. 2022 Jan 4; 41(1): e108813. Published online 2021 Nov 24. doi: 10.15252/embj.2021108813

PMCID:: PMC8724767

Abstract Article PDF–1.5M

Select item 834656011.

Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes

Erika Casari, Elisa Gobbini, Marco Gnugnoli, Marco Mangiagalli, Michela Clerici, Maria Pia Longhese

Nat Commun. 2021; 12: 4750. Published online 2021 Aug 6. doi: 10.1038/s41467-021-25090-9

PMCID:: PMC8346560

Abstract Article PDF–5.7M

Select item 828479912.

NuA4 and SAGA acetyltransferase complexes cooperate for repair of DNA breaks by homologous recombination

Xue Cheng, Valérie Côté, Jacques Côté

PLoS Genet. 2021 Jul; 17(7): e1009459. Published online 2021 Jul 6. doi: 10.1371/journal.pgen.1009459

PMCID:: PMC8284799

Abstract Article PDF–2.1M

Select item 816555113.

Catalysis-dependent and redundant roles of Dma1 and Dma2 in maintenance of genome stability in Saccharomyces cerevisiae

Andrew R. Yoblinski, Seoyoung Chung, Sophie B. Robinson, Kaitlyn E. Forester, Brian D. Strahl, Raghuvar Dronamraju

J Biol Chem. 2021 Jan-Jun; 296: 100721. Published online 2021 Apr 29. doi: 10.1016/j.jbc.2021.100721

PMCID:: PMC8165551

Abstract Article PDF–2.6M

Select item 805309414.

Structural parameters of palindromic repeats determine the specificity of nuclease attack of secondary structures

Anissia Ait Saada, Alex B Costa, Ziwei Sheng, Wenying Guo, James E Haber, Kirill S Lobachev

Nucleic Acids Res. 2021 Apr 19; 49(7): 3932–3947. Published online 2021 Mar 27. doi: 10.1093/nar/gkab168

PMCID:: PMC8053094

Abstract Article PDF–3.1M

Select item 802831415.

Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners

Antonio Marsella, Elisa Gobbini, Corinne Cassani, Renata Tisi, Elda Cannavo, Giordano Reginato, Petr Cejka, Maria Pia Longhese

Cell Rep. 2021 Mar 30; 34(13): 108906. Published online 2021 Mar 30. doi: 10.1016/j.celrep.2021.108906

PMCID:: PMC8028314

Abstract Article

Select item 796698216.

Rad52 SUMOylation functions as a molecular switch that determines a balance between the Rad51- and Rad59-dependent survivors

Ferose Charifi, Dmitri Churikov, Nadine Eckert-Boulet, Christopher Minguet, Frédéric Jourquin, Julien Hardy, Michael Lisby, Marie-Noëlle Simon, Vincent Géli

iScience. 2021 Mar 19; 24(3): 102231. Published online 2021 Feb 25. doi: 10.1016/j.isci.2021.102231

PMCID:: PMC7966982

Abstract Article PDF–12M

Select item 778828517.

A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans

Marie Chansel-Da Cruz, Marcel Hohl, Ilaria Ceppi, Laëtitia Kermasson, Laurence Maggiorella, Mauro Modesti, Jean-Pierre de Villartay, Talia Ileri, Petr Cejka, John H.J. Petrini, Patrick Revy

Cell Rep. 2020 Dec 29; 33(13): 108559. Published online 2020 Dec 29. doi: 10.1016/j.celrep.2020.108559