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Select item 111582241.

Roles of AKT1 and AKT2 in non‐small cell lung cancer cell survival, growth, and migration

Myoung W. Lee, Dae S. Kim, Joo H. Lee, Bum S. Lee, Soo H. Lee, Hye L. Jung, Ki W. Sung, Heung T. Kim, Keon H. Yoo, Hong H. Koo

Cancer Sci. 2011 Oct; 102(10): 1822–1828. Published online 2011 Aug 5. doi: 10.1111/j.1349-7006.2011.02025.x

PMCID:: PMC11158224

Abstract Article PDF–1.7M

Select item 109637602.

Differential prognostic values of the three AKT isoforms in acute myeloid leukemia

Eulalie Corre, Cécile Soum, Romain Pfeifer, Chloé Bessière, Sandra Dailhau, Catherine Marbœuf, Fabienne Meggetto, Christian Touriol, Christian Récher, Marina Bousquet, Stéphane Pyronnet

Sci Rep. 2024; 14: 7070. Published online 2024 Mar 25. doi: 10.1038/s41598-024-57578-x

PMCID:: PMC10963760

Abstract Article PDF–2.2M

Select item 108897663.

All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines

Ling-Yu Tian, Daniel J. Smit, Nadezhda V. Popova, Stefan Horn, Lis Noelia Velasquez, Samuel Huber, Manfred Jücker

Int J Mol Sci. 2024 Feb; 25(4): 2168. Published online 2024 Feb 11. doi: 10.3390/ijms25042168

PMCID:: PMC10889766

Abstract Article PDF–2.4M

Select item 105999834.

Differential activation of AKT isoforms by growth factors in human myotubes

Brandon M. Roberts, Alyssa V. Geddis, Ronald W. Matheny, Jr

Physiol Rep. 2023 Oct; 11(20): e15805. Published online 2023 Oct 25. doi: 10.14814/phy2.15805

PMCID:: PMC10599983

Abstract Article PDF–1.7M

Select item 103719155.

CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis

Lilan Wu, Huiqin Xiao, Yaqin Hong, Meihua Xie, Yanxia Yu, Lijuan Jiang

Biochem Genet. 2023; 61(4): 1625–1644. Published online 2023 Jan 31. doi: 10.1007/s10528-023-10332-w

PMCID:: PMC10371915

Abstract Article PDF–4.2M

Select item 102374226.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100729067.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 98749768.

Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes

Selina Mäkinen, Neeta Datta, Savithri Rangarajan, Yen H Nguyen, Vesa M Olkkonen, Aino Latva-Rasku, Pirjo Nuutila, Markku Laakso, Heikki A Koistinen

J Mol Endocrinol. 2023 Feb 1; 70(2): e210285. Published online 2022 Jan 4. doi: 10.1530/JME-21-0285

PMCID:: PMC9874976

Abstract Article PDF–2.9M

Select item 95617139.

Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy

Haitao Liu, Nadezda A. Stepicheva, Sayan Ghosh, Peng Shang, Olivia Chowdhury, Rachel A. Daley, Meysam Yazdankhah, Urvi Gupta, Stacey L. Hose, Mallika Valapala, Christopher Scott Fitting, Anastasia Strizhakova, Yang Shan, Derrick Feenstra, José-Alain Sahel, Ashwath Jayagopal, James T. Handa, J. Samuel Zigler, Jr., Patrice E. Fort, Akrit Sodhi, Debasish Sinha

Nat Commun. 2022; 13: 6045. Published online 2022 Oct 13. doi: 10.1038/s41467-022-33773-0

PMCID:: PMC9561713

Abstract Article PDF–9.8M

Select item 948193310.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 927928511.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 926261412.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 911973613.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 904055614.

A protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066

PMCID:: PMC9040556

Abstract Article PDF–2.2M

Select item 889702215.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 852757816.

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity

Yuehui Zhang, Limin Shang, Jing Zhang, Yuchen Liu, Chaozhi Jin, Yanan Zhao, Xiaobo Lei, Wenjing Wang, Xia Xiao, Xiuyuan Zhang, Yujiao Liu, Linlin Liu, Meng-Wei Zhuang, Qingkun Mi, Chunyan Tian, Jianwei Wang, Fuchu He, Pei-Hui Wang, Jian Wang

Cell Chem Biol. 2022 Jan 20; 29(1): 5–18.e6. Published online 2021 Oct 20. doi: 10.1016/j.chembiol.2021.10.008

PMCID:: PMC8527578

Abstract Article PDF–4.5M

Select item 831454717.

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang

Cell Biosci. 2021; 11: 146. Published online 2021 Jul 27. doi: 10.1186/s13578-021-00659-5

PMCID:: PMC8314547

Abstract Article PDF–3.7M

Select item 827460318.

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome

Jérémy A. Ferreira Barbosa, Samantha Sparapani, Jonathan Boulais, Robert Lodge, Éric A. Cohen

J Virol. 2021 Aug; 95(15): e00971-20. Prepublished online 2021 May 19. Published online 2021 Jul 12. doi: 10.1128/JVI.00971-20

PMCID:: PMC8274603

Abstract Article PDF–4.2M

Select item 816503019.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 804264920.

Role of AMPK and Akt in triple negative breast cancer lung colonization

Jeremy Johnson, Zeta Chow, Eun Lee, Heidi L. Weiss, B. Mark Evers, Piotr Rychahou

Neoplasia. 2021 Apr; 23(4): 429–438. Published online 2021 Apr 8. doi: 10.1016/j.neo.2021.03.005

PMCID:: PMC8042649

Abstract Article PDF–1.6M

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