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Select item 110931971.

RB1 loss induces quiescent state through downregulation of RAS signaling in mammary epithelial cells

Linxiang Gong, Dominic Chih‐Cheng Voon, Joji Nakayama, Chiaki Takahashi, Susumu Kohno

Cancer Sci. 2024 May; 115(5): 1576–1586. Published online 2024 Mar 11. doi: 10.1111/cas.16122

PMCID:: PMC11093197

Abstract Article PDF–3.4M

Select item 105656432.

Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors

Sudarshan R Iyer, Kevin Nusser, Kristen Jones, Pushkar Shinde, Clare Keddy, Catherine Z Beach, Erin Aguero, Jeremy Force, Ujwal Shinde, Monika A Davare

EMBO Mol Med. 2023 Oct; 15(10): e17367. Published online 2023 Aug 17. doi: 10.15252/emmm.202217367

PMCID:: PMC10565643

Abstract Article PDF–2.6M

Select item 103804553.

Therapeutical Options in ROS1—Rearranged Advanced Non Small Cell Lung Cancer

Brigida Stanzione, Alessandro Del Conte, Elisa Bertoli, Elisa De Carlo, Alberto Revelant, Michele Spina, Alessandra Bearz

Int J Mol Sci. 2023 Jul; 24(14): 11495. Published online 2023 Jul 15. doi: 10.3390/ijms241411495

PMCID:: PMC10380455

Abstract Article PDF–533K

Select item 102245794.

“Evaluation of ROS1 expression and rearrangements in a large cohort of early-stage lung cancer”

Anne Pernille Harlem Dyrbekk, Abdirashid Ali Warsame, Pål Suhrke, Marianne Odnakk Ludahl, Joakim Oliu Moe, Inger Johanne Zwicky Eide, Marius Lund-Iversen, Odd Terje Brustugun

Diagn Pathol. 2023; 18: 70. Published online 2023 May 27. doi: 10.1186/s13000-023-01357-1

PMCID:: PMC10224579

Abstract Article PDF–1.1M

Select item 99243435.

SNP rs9387478 at ROS1-DCBLD1 Locus is Significantly Associated with Lung Cancer Risk and Poor Survival in Indian Population

Jonita Chongtham, Namita Pandey, Lokesh Kumar Sharma, Anant Mohan, Tapasya Srivastava

Asian Pac J Cancer Prev. 2022 Oct; 23(10): 3553–3561. doi: 10.31557/APJCP.2022.23.10.3553

PMCID:: PMC9924343

Abstract Article PDF–523K

Select item 98044126.

ROS1 genomic rearrangements are rare actionable drivers in microsatellite stable colorectal cancer

Dilara Akhoundova, Saskia Hussung, Smruthy Sivakumar, Antonia Töpfer, Markus Rechsteiner, Abdullah Kahraman, Fabian Arnold, Florian Angst, Christian Britschgi, Martin Zoche, Holger Moch, Achim Weber, Ethan Sokol, Ralph M. Fritsch

Int J Cancer. 2022 Dec 15; 151(12): 2161–2171. Published online 2022 Aug 30. doi: 10.1002/ijc.34257

PMCID:: PMC9804412

Abstract Article PDF–4.2M

Select item 97725587.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 93383138.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 91714119.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 906010110.

Clinical characteristics of non‐small cell lung cancer patients with EGFR mutations and ALK&ROS1 fusions

Qinghua Liu, Qingyan Huang, Zhikang Yu, Heming Wu

Clin Respir J. 2022 Mar; 16(3): 216–225. Published online 2022 Jan 26. doi: 10.1111/crj.13472

PMCID:: PMC9060101

Abstract Article PDF–1.0M

Select item 893389611.

Clinical and economic impact of ‘ROS1-testing’ strategy compared to a ‘no-ROS1-testing’ strategy in advanced NSCLC in Spain

Federico Rojo, Esther Conde, Héctor Torres, Luis Cabezón-Gutiérrez, Dolores Bautista, Inmaculada Ramos, David Carcedo, Natalia Arrabal, J. Francisco García, Raquel Galán, Ernest Nadal

BMC Cancer. 2022; 22: 292. Published online 2022 Mar 19. doi: 10.1186/s12885-022-09397-4

PMCID:: PMC8933896

Abstract Article PDF–1.9M

Select item 888083512.

Comparison of PD-L1, EGFR, ALK, and ROS1 Status Between Surgical Samples and Cytological Samples in Non-Small Cell Lung Carcinoma

Zübeyde Ekin, Deniz Nart, Pınar Savaş, Ali Veral

Balkan Med J. 2021 Sep; 38(5): 287–295. Published online 2021 Sep 1. doi: 10.5152/balkanmedj.2021.20086

PMCID:: PMC8880835

Abstract Article PDF–1.6M

Select item 865749713.

Deepening the Knowledge of ROS1 Rearrangements in Non-Small Cell Lung Cancer: Diagnosis, Treatment, Resistance and Concomitant Alterations

Giorgia Guaitoli, Federica Bertolini, Stefania Bettelli, Samantha Manfredini, Michela Maur, Lucia Trudu, Beatrice Aramini, Valentina Masciale, Giulia Grisendi, Massimo Dominici, Fausto Barbieri

Int J Mol Sci. 2021 Dec; 22(23): 12867. Published online 2021 Nov 28. doi: 10.3390/ijms222312867

PMCID:: PMC8657497

Abstract Article PDF–1.0M

Select item 856885514.

GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types

Philipp Sievers, Damian Stichel, Martin Sill, Daniel Schrimpf, Dominik Sturm, Florian Selt, Jonas Ecker, Daniel Kazdal, Evelina Miele, Mariëtte E. G. Kranendonk, Bastiaan B. J. Tops, Patricia Kohlhof-Meinecke, Rudi Beschorner, Christof M. Kramm, Martin Hasselblatt, Guido Reifenberger, David Capper, Pieter Wesseling, Albrecht Stenzinger, Till Milde, Andrey Korshunov, Olaf Witt, Stefan M. Pfister, Wolfgang Wick, Andreas von Deimling, David T. W. Jones, Felix Sahm

Acta Neuropathol. 2021; 142(6): 1065–1069. Published online 2021 Sep 18. doi: 10.1007/s00401-021-02369-1

PMCID:: PMC8568855

Article PDF–1.7M

Select item 853672115.

Crizotinib efficacy in advanced non-squamous NSCLC patients with ALK or ROS1 rearrangement

Paweł Krawczyk, Anna Grenda, Paulina Terlecka, Justyna Błach, Kamila Wojas-Krawczyk, Tomasz Kucharczyk, Izabela Chmielewska, Robert Kieszko, Bożena Jarosz, Michał Gil, Katarzyna Reszka, Janusz Milanowski

Sci Rep. 2021; 11: 20939. Published online 2021 Oct 22. doi: 10.1038/s41598-021-00309-3

PMCID:: PMC8536721

Abstract Article PDF–1.1M

Select item 848618716.

Highly sensitive fusion detection using plasma cell‐free RNA in non‐small‐cell lung cancers

Nobuhiko Hasegawa, Shinji Kohsaka, Kana Kurokawa, Yuki Shinno, Ikuko Takeda Nakamura, Toshihide Ueno, Shinya Kojima, Masahito Kawazu, Yoshiyuki Suehara, Muneaki Ishijima, Yasushi Goto, Yuki Kojima, Kan Yonemori, Takuo Hayashi, Tsuyoshi Saito, Takehito Shukuya, Fumiyuki Takahashi, Kazuhisa Takahashi, Hiroyuki Mano

Cancer Sci. 2021 Oct; 112(10): 4393–4403. Published online 2021 Aug 18. doi: 10.1111/cas.15084

PMCID:: PMC8486187

Abstract Article PDF–751K

Select item 839551517.

Reflex ROS1 IHC Screening with FISH Confirmation for Advanced Non-Small Cell Lung Cancer—A Cost-Efficient Strategy in a Public Healthcare System

Maisam Makarem, Doreen A. Ezeife, Adam C. Smith, Janice J. N. Li, Jennifer H. Law, Ming-Sound Tsao, Natasha B. Leighl

Curr Oncol. 2021 Oct; 28(5): 3268–3279. Published online 2021 Aug 25. doi: 10.3390/curroncol28050284

PMCID:: PMC8395515

Abstract Article PDF–2.9M

Select item 812738318.

Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion-Positive Lung Cancer

Jessica J. Lin, Noura J. Choudhury, Satoshi Yoda, Viola W. Zhu, Ted W. Johnson, Ramin Sakhtemani, Ibiayi Dagogo-Jack, Subba R. Digumarthy, Charlotte Lee, Andrew Do, Jennifer Peterson, Kylie Prutisto-Chang, Wafa Malik, Harper G. Hubbeling, Adam Langenbucher, Adam J. Schoenfeld, Christina J. Falcon, Jennifer S. Temel, Lecia V. Sequist, Beow Y. Yeap, Jochen K. Lennerz, Alice T. Shaw, Michael S. Lawrence, Sai-Hong Ignatius Ou, Aaron N. Hata, Alexander Drilon, Justin F. Gainor

Clin Cancer Res. Author manuscript; available in PMC 2021 Nov 15.

Published in final edited form as: Clin Cancer Res. 2021 May 15; 27(10): 2899–2909. Published online 2021 Mar 8. doi: 10.1158/1078-0432.CCR-21-0032

PMCID:: PMC8127383

Abstract Article PDF–1.5M

Select item 808390719.

Identification of a Novel MAN1A1-ROS1 Fusion Gene Through mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a Patient with Leiomyosarcoma

Yoshiyuki Suehara, Shinji Kohsaka, Takuo Hayashi, Keisuke Akaike, Aiko Kurisaki-Arakawa, Shingo Sato, Eisuke Kobayashi, Sho Mizuno, Toshihide Ueno, Takeshi Morii, Tomotake Okuma, Taisei Kurihara, Nobuhiko Hasegawa, Kei Sano, Keita Sasa, Taketo Okubo, Youngji Kim, Hiroyuki Mano, Tsuyoshi Saito

Clin Orthop Relat Res. 2021 Apr; 479(4): 838–852. Published online 2020 Nov 12. doi: 10.1097/CORR.0000000000001548

PMCID:: PMC8083907

Abstract Article PDF–1.3M

Select item 797440620.

Cigarette smoke extract stimulates PCSK9 production in HepG2 cells via ROS/NF-κB signaling

Baitao Ma, Xuebin Wang, Rui Zhang, Shuai Niu, Zhihua Rong, Leng Ni, Xiao Di, Qin Han, Changwei Liu

Mol Med Rep. 2021 May; 23(5): 331. Published online 2021 Mar 8. doi: 10.3892/mmr.2021.11970

PMCID:: PMC7974406

Abstract Article PDF–2.0M

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