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Items: 1 to 20 of 336

1.
PCSK9 E670G polymorphism increases risk of coronary artery disease in a Chinese Han population
Zhang Lin, Shi Hong Wang, Da Yong Wei, Lu Min Wang, Zhong Wu Zhang
J Int Med Res. 2024 Oct; 52(10): 0300060519892177. Published online 2019 Dec 16. doi: 10.1177/0300060519892177
PMCID:
PMC11465380
AbstractArticlePDF–669K
2.
Contrasting effects of intracellular and extracellular human PCSK9 on inflammation, lipid alteration and cell death
Aram Ghalali, Fahd Alhamdan, Swapna Upadhyay, Koustav Ganguly, Kjell Larsson, Lena Palmberg, Mizanur Rahman
Commun Biol. 2024; 7: 985. Published online 2024 Aug 13. doi: 10.1038/s42003-024-06674-9
PMCID:
PMC11322528
AbstractArticlePDF–1.6M
3.
Assessment of serum proprotein convertase subtilisin/kexin type 9 in pediatric sepsis syndrome
Suzan Omar Mousa, Mohamed Farouk Afifi, Noha Anwar Hassuna, Michael Fekry Yassa, Hend Mohamed Moness
Sci Rep. 2024; 14: 15634. Published online 2024 Jul 7. doi: 10.1038/s41598-024-65609-w
PMCID:
PMC11228027
AbstractArticlePDF–941K
4.
Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C
Sepideh Mikaeeli, Ali Ben Djoudi Ouadda, Alexandra Evagelidis, Rachid Essalmani, Oscar Henrique Pereira Ramos, Carole Fruchart-Gaillard, Nabil G. Seidah
Cells. 2024 May; 13(10): 857. Published online 2024 May 17. doi: 10.3390/cells13100857
PMCID:
PMC11119474
AbstractArticlePDF–14M
5.
Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis
Janne Pott, Azin Kheirkhah, Jesper R. Gadin, Marcus E. Kleber, Graciela E. Delgado, Holger Kirsten, Lukas Forer, Stefanie M. Hauck, Ralph Burkhardt, Hubert Scharnagl, Markus Loeffler, Winfried März, Joachim Thiery, Christian Gieger, Annette Peters, Angela Silveira, Ferdinand van’t Hooft, Florian Kronenberg, Markus Scholz
Biol Sex Differ. 2024; 15: 26. Published online 2024 Mar 26. doi: 10.1186/s13293-024-00602-6
PMCID:
PMC10964567
AbstractArticlePDF–1.6M
6.
PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells
Ran Xu, Tianhua Li, Jichang Luo, Xiao Zhang, Tao Wang, Yabing Wang, Yan Ma, Bin Yang, Jinzhu Jia, Adam A. Dmytriw, Wenjing Li, Liqun Jiao
CNS Neurosci Ther. 2024 Feb; 30(2): e14640. Published online 2024 Feb 25. doi: 10.1111/cns.14640
PMCID:
PMC10894644
AbstractArticlePDF–16M
7.
Proteome-wide mendelian randomization investigates potential associations in heart failure and its etiology: emphasis on PCSK9
Lichao Lin, Huizhen Yu, Yan Xue, Liman Wang, Pengli Zhu
BMC Med Genomics. 2024; 17: 59. Published online 2024 Feb 21. doi: 10.1186/s12920-024-01826-6
PMCID:
PMC10882912
AbstractArticlePDF–2.0M
8.
GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal
Ninna Karsbæk Senftleber, Mette K. Andersen, Emil Jørsboe, Frederik Filip Stæger, Anne Krogh Nøhr, Genis Garcia-Erill, Jonas Meisner, Cindy G. Santander, Renzo F. Balboa, Arthur Gilly, Peter Bjerregaard, Christina Viskum Lytken Larsen, Niels Grarup, Marit Eika Jørgensen, Eleftheria Zeggini, Ida Moltke, Torben Hansen, Anders Albrechtsen
Eur J Hum Genet. 2024 Feb; 32(2): 215–223. Published online 2023 Oct 30. doi: 10.1038/s41431-023-01485-8
PMCID:
PMC10853193
AbstractArticlePDF–2.1M
9.
Data-driven transcriptomics analysis identifies PCSK9 as a novel key regulator in liver aging
Muhammad Arif, Csaba Matyas, Partha Mukhopadhyay, Burhan Yokus, Eszter Trojnar, Janos Paloczi, Bruno Paes-Leme, Suxian Zhao, Falk W. Lohoff, György Haskó, Pal Pacher
GeroScience. 2023 Oct; 45(5): 3059–3077. Published online 2023 Sep 20. doi: 10.1007/s11357-023-00928-w
PMCID:
PMC10643490
AbstractArticlePDF–1.9M
10.
Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations
Jessica M. Cale, Kristin A. Ham, Dunhui Li, Craig S. McIntosh, Gerald F. Watts, Steve D. Wilton, May T. Aung-Htut
Sci Rep. 2023; 13: 19725. Published online 2023 Nov 13. doi: 10.1038/s41598-023-47005-y
PMCID:
PMC10643364
AbstractArticlePDF–3.0M
11.
Elevated circulating PCSK9 level is associated with 28-day mortality in patients with sepsis: a prospective cohort study
Yuanlu Shu, Ziwei Deng, Ye Deng, Jianliang Zhou, Jin Wang, Zhenxing Duan, Tao Jiang, Xiang Zhao, Zhihua Shi, Chengfeng Qiu
BMC Emerg Med. 2023; 23: 127. Published online 2023 Oct 31. doi: 10.1186/s12873-023-00896-6
PMCID:
PMC10617046
AbstractArticlePDF–1.9M
12.
Screening and verifying the mutations in the LDLR and APOB genes in a Chinese family with familial hypercholesterolemia
Xian Lv, Chunyue Wang, Lu Liu, Guoqing Yin, Wen Zhang, Fuad A. Abdu, Tingting Shi, Qingfeng Zhang, Wenliang Che
Lipids Health Dis. 2023; 22: 175. Published online 2023 Oct 18. doi: 10.1186/s12944-023-01935-8
PMCID:
PMC10585857
AbstractArticlePDF–1.8M
13.
Exploring PCSK9 Genetic Impact on Lipoprotein(a) via Dual Approaches: Association and Mendelian Randomization
Ya-Ching Chang, Lung-An Hsu, Yu-Lin Ko
Int J Mol Sci. 2023 Oct; 24(19): 14668. Published online 2023 Sep 28. doi: 10.3390/ijms241914668
PMCID:
PMC10572552
AbstractArticlePDF–819K
14.
Exploring the Link between Plasma Levels of PCSK9, Immune Dysregulation and Atherosclerosis in Patients with Primary Sjögren’s Syndrome
Vanessa Bianconi, Giacomo Cafaro, Massimo Raffaele Mannarino, Carlo Perricone, Elena Cosentini, Onelia Bistoni, Rita Paltriccia, Rita Lombardini, Roberto Gerli, Matteo Pirro, Elena Bartoloni
Biomolecules. 2023 Sep; 13(9): 1384. Published online 2023 Sep 12. doi: 10.3390/biom13091384
PMCID:
PMC10527459
AbstractArticlePDF–1.1M
15.
PCSK9 and the nervous system: a no-brainer?
Ali K. Jaafar, Romuald Techer, Kévin Chemello, Gilles Lambert, Steeve Bourane
J Lipid Res. 2023 Sep; 64(9): 100426. Published online 2023 Aug 14. doi: 10.1016/j.jlr.2023.100426
PMCID:
PMC10491654
AbstractArticlePDF–1.3M
16.
Plasma Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) as a Possible Biomarker for Severe COVID-19
Patricia Mester, Pablo Amend, Stephan Schmid, Martina Müller, Christa Buechler, Vlad Pavel
Viruses. 2023 Jul; 15(7): 1511. Published online 2023 Jul 6. doi: 10.3390/v15071511
PMCID:
PMC10385877
AbstractArticlePDF–1.1M
17.
PCSK9 inhibition interrupts the cross-talk between keratinocytes and macrophages and prevents UVB-induced skin damage
Chao Luan, Yingxue He, Wen Liu, Yicheng Rong, Jian Gao, Kang Xu, Hui Yu, Yu Hu, Jiaan Zhang, Kun Chen, Wenjie Guo
J Biol Chem. 2023 Jul; 299(7): 104895. Published online 2023 Jun 6. doi: 10.1016/j.jbc.2023.104895
PMCID:
PMC10331474
AbstractArticlePDF–6.0M
18.
Relationship between Serum Proprotein Convertase Subtilisin/Kexin Type 9 Concentration and Prevalence of Coronary Artery Calcium in a Community-Based Sample of Japanese Men
Ayako Kunimura, Katsuyuki Miura, Hiroyoshi Segawa, Sayuki Torii, Keiko Kondo, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Yuichiro Yano, Yoshihisa Nakagawa, Tomonori Okamura, Hirotsugu Ueshima
J Atheroscler Thromb. 2023 Jul 1; 30(7): 767–777. Published online 2022 Sep 17. doi: 10.5551/jat.63549
PMCID:
PMC10322734
AbstractArticlePDF–388K
19.
Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1
Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Patrick Lahni, Scarlett Ripberger, Adesuwa Ekunwe, Kyle R. Campbell, Keith R. Walley, Stephen W. Standage
Crit Care. 2023; 27: 250. Published online 2023 Jun 26. doi: 10.1186/s13054-023-04535-1
PMCID:
PMC10291783
AbstractArticlePDF–10M
20.
PCSK9 promotes T helper 1 and T helper 17 cell differentiation by activating the nuclear factor‐κB pathway in ankylosing spondylitis
Jianfei Cai, Yinghui Jiang, Fucai Chen, Shubin Wu, Hongjun Ren, Pingping Wang, Jiayong Wang, Wei Liu
Immun Inflamm Dis. 2023 May; 11(5): e870. Published online 2023 May 26. doi: 10.1002/iid3.870
PMCID:
PMC10214583
AbstractArticlePDF–3.2M

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