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Select item 110796051.

Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3β-Srebp2 axis

Takahiro Toshima, Mikako Yagi, Yura Do, Haruka Hirai, Yuya Kunisaki, Dongchon Kang, Takeshi Uchiumi

Life Sci Alliance. 2024 Jul; 7(7): e202302423. Published online 2024 May 8. doi: 10.26508/lsa.202302423

PMCID:: PMC11079605

Abstract Article PDF–2.6M

Select item 106635052.

PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling

Yongfang Lin, Jing Yang, Qili Yang, Sha Zeng, Jiayu Zhang, Yuanxiang Zhu, Yuxin Tong, Lin Li, Weiqi Tan, Dahua Chen, Qinmiao Sun

Nat Commun. 2023; 14: 7567. Published online 2023 Nov 21. doi: 10.1038/s41467-023-43419-4

PMCID:: PMC10663505

Abstract Article PDF–2.1M

Select item 94251823.

PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas

Junling Shen, Jilong Yang, Lei Sang, Rui Sun, Weiyu Bai, Chao Wang, Yan Sun, Jianwei Sun

Cancer Biol Med. 2022 Aug 15; 19(8): 1211–1223. Published online 2021 Sep 28. doi: 10.20892/j.issn.2095-3941.2020.0294

PMCID:: PMC9425182

Abstract Article PDF–1.7M

Select item 91529724.

Proline-rich tyrosine kinase Pyk2 regulates deep vein thrombosis

Stefania Momi, Jessica Canino, Mauro Vismara, Luca Galgano, Emanuela Falcinelli, Giuseppe Guglielmini, Giulia Ciarrocca Taranta, Gianni Francesco Guidetti, Paolo Gresele, Mauro Torti, Ilaria Canobbio

Haematologica. 2022 Jun 1; 107(6): 1374–1383. Published online 2022 Feb 10. doi: 10.3324/haematol.2021.279703

PMCID:: PMC9152972

Abstract Article PDF–1.1M

Select item 90632995.

Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy

A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam, Stephen M. Strittmatter

Mol Neurodegener. 2022; 17: 32. Published online 2022 May 3. doi: 10.1186/s13024-022-00526-y

Correction in:: Mol Neurodegener. 2022; 17: 56.

PMCID:: PMC9063299

Abstract Article PDF–12M

Select item 89094716.

Pyk2 Regulates MAMs and Mitochondrial Dynamics in Hippocampal Neurons

Laura López-Molina, Joaquín Fernández-Irigoyen, Carmen Cifuentes-Díaz, Jordi Alberch, Jean-Antoine Girault, Enrique Santamaría, Silvia Ginés, Albert Giralt

Cells. 2022 Mar; 11(5): 842. Published online 2022 Mar 1. doi: 10.3390/cells11050842

PMCID:: PMC8909471

Abstract Article PDF–4.6M

Select item 87825907.

Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner

Jin Zheng, Lun Suo, Yuxiao Zhou, Liling Jia, Jingwei Li, Yanping Kuang, Donghong Cui, Xuehong Zhang, Qiang Wu

J Mol Cell Biol. 2021 Nov; 13(11): 808–821. Published online 2021 Sep 16. doi: 10.1093/jmcb/mjab057

PMCID:: PMC8782590

Abstract Article PDF–1.4M

Select item 87005928.

Pyk2 Stabilizes Striatal Medium Spiny Neuron Structure and Striatal-Dependent Action

Shannon L. Gourley, Kolluru D. Srikanth, Ellen P. Woon, Hava Gil-Henn

Cells. 2021 Dec; 10(12): 3442. Published online 2021 Dec 7. doi: 10.3390/cells10123442

PMCID:: PMC8700592

Abstract Article PDF–2.9M

Select item 86996429.

Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells

Richard N. Day, Kathleen H. Day, Fredrick M. Pavalko

PLoS One. 2021; 16(12): e0261660. Published online 2021 Dec 23. doi: 10.1371/journal.pone.0261660

PMCID:: PMC8699642

Abstract Article PDF–4.0M

Select item 869395310.

Pyk2 regulates cell-edge protrusion dynamics by interacting with Crk

Nikola Lukic, Stefanie Lapetina, Hanna Grobe, Kolluru D. Srikanth, Shams Twafra, Jonathan Solomon, Tal Sneh, Michal Gendler, Ronen Zaidel-Bar, Hava Gil-Henn

Mol Biol Cell. 2021 Nov 1; 32(21): ar17. doi: 10.1091/mbc.E20-10-0640

PMCID:: PMC8693953

Abstract Article PDF–5.5M

Select item 860232311.

Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation

Grigory Ryzhakov, Hannah Almuttaqi, Alastair L. Corbin, Dorothée L. Berthold, Tariq Khoyratty, Hayley L. Eames, Samuel Bullers, Claire Pearson, Zhichao Ai, Kristina Zec, Sarah Bonham, Roman Fischer, Luke Jostins-Dean, Simon P. L. Travis, Benedikt M. Kessler, Irina A. Udalova

Nat Commun. 2021; 12: 6702. Published online 2021 Nov 18. doi: 10.1038/s41467-021-27038-5

PMCID:: PMC8602323

Abstract Article PDF–2.2M

Select item 847719312.

Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β

Sarah Helena Nies, Hideyuki Takahashi, Charlotte S. Herber, Anita Huttner, Alison Chase, Stephen M. Strittmatter

J Biol Chem. 2021 Oct; 297(4): 101159. Published online 2021 Sep 2. doi: 10.1016/j.jbc.2021.101159

PMCID:: PMC8477193

Abstract Article PDF–6.8M

Select item 835801913.

Pyk2 in dorsal hippocampus plays a selective role in spatial memory and synaptic plasticity

Vincenzo Mastrolia, Omar al Massadi, Benoit de Pins, Jean-Antoine Girault

Sci Rep. 2021; 11: 16357. Published online 2021 Aug 11. doi: 10.1038/s41598-021-95813-x

PMCID:: PMC8358019

Abstract Article PDF–1.5M

Select item 818202414.

Sperm–oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding site

Huizhen Wang, Xiaoman Hong, William H Kinsey

Biol Reprod. 2021 Jun; 104(6): 1292–1301. Published online 2021 Mar 16. doi: 10.1093/biolre/ioab048

PMCID:: PMC8182024

Abstract Article PDF–925K

Select item 813806015.

Pyruvate Kinase M2 Contributes to TLR-Mediated Inflammation and Autoimmunity by Promoting Pyk2 Activation

Xin Zhang, Yonghong Yang, Lina Jing, Weiwei Zhai, Hui Zhang, Qun Ma, Chunxia Li, Fenglian Yan, Dalei Cheng, Junfeng Zhang, Zhaochen Ning, Hui Shi, Changying Wang, Mingsheng Zhao, Jun Dai, Zhihua Li, Jiankuo Ming, Meimei Yu, Haiyan Wang, Hongyan Cheng, Huabao Xiong, Guanjun Dong

Front Immunol. 2021; 12: 680068. Published online 2021 May 7. doi: 10.3389/fimmu.2021.680068

PMCID:: PMC8138060

Abstract Article PDF–8.1M

Select item 793877016.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003