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Select item 114476911.

Bruton Tyrosine Kinase Inhibition Decreases Inflammation and Differentially Impacts Phagocytosis and Cellular Metabolism in Mouse- and Human-derived Myeloid Cells

Rochelle Y. Benoit, Jennifer L. Zagrodnik, Samantha J. Carew, Craig S. Moore

Immunohorizons. 2024 Sep; 8(9): 652–667. Published online 2024 Sep 11. doi: 10.4049/immunohorizons.2400045

PMCID:: PMC11447691

Abstract Article PDF–2.8M

Select item 111785472.

BTK drives neutrophil activation for sterilizing antifungal immunity

Jigar V. Desai, Marissa A. Zarakas, Andrew L. Wishart, Mark Roschewski, Mariano A. Aufiero, Agnes Donkò, Gustaf Wigerblad, Neta Shlezinger, Markus Plate, Matthew R. James, Jean K. Lim, Gulbu Uzel, Jenna R.E. Bergerson, Ivan Fuss, Robert A. Cramer, Luis M. Franco, Emily S. Clark, Wasif N. Khan, Daisuke Yamanaka, Georgios Chamilos, Jamel El-Benna, Mariana J. Kaplan, Louis M. Staudt, Thomas L. Leto, Steven M. Holland, Wyndham H. Wilson, Tobias M. Hohl, Michail S. Lionakis

J Clin Invest. 2024 Jun 17; 134(12): e176142. Published online 2024 May 2. doi: 10.1172/JCI176142

PMCID:: PMC11178547

Abstract Article PDF–2.3M

Select item 110249223.

In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function

H. Yesid Estupiñán, Thibault Bouderlique, Chenfei He, Anna Berglöf, Andrea Cappelleri, Nicolai Frengen, Rula Zain, Mikael C. I. Karlsson, Robert Månsson, C. I. Edvard Smith

Blood Adv. 2024 Apr 23; 8(8): 1981–1990. Published online 2024 Mar 22. doi: 10.1182/bloodadvances.2024012706

PMCID:: PMC11024922

Abstract Article PDF–4.1M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107402995.

Bruton’s tyrosine kinase-bearing B cells and microglia in neuromyelitis optica spectrum disorder

Ye Liu, Zhenning Huang, Tian-Xiang Zhang, Bin Han, Guili Yang, Dongmei Jia, Li Yang, Qiang Liu, Alexander Y. L. Lau, Friedemann Paul, Alexei Verkhratsky, Fu-Dong Shi, Chao Zhang

J Neuroinflammation. 2023; 20: 309. Published online 2023 Dec 21. doi: 10.1186/s12974-023-02997-2

PMCID:: PMC10740299

Abstract Article PDF–9.5M

Select item 106439016.

Bruton's Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae

Zhe Liu, Alexander P.N.A. De Porto, Regina De Beer, Joris J.T.H. Roelofs, Onno J. De Boer, Sandrine Florquin, Cornelis Van't Veer, Rudi W. Hendriks, Tom Van der Poll, Alex F. De Vos

J Innate Immun. 2023 Jan-Dec; 15(1): 1–15. Published online 2022 May 10. doi: 10.1159/000524583

PMCID:: PMC10643901

Abstract Article PDF–1.0M

Select item 104245677.

B cell receptor signaling in germinal centers prolongs survival and primes B cells for selection

Spencer T. Chen, Thiago Y. Oliveira, Anna Gazumyan, Melissa Cipolla, Michel C. Nussenzweig

Immunity. Author manuscript; available in PMC 2023 Aug 14.

Published in final edited form as: Immunity. 2023 Mar 14; 56(3): 547–561.e7. Published online 2023 Mar 6. doi: 10.1016/j.immuni.2023.02.003

PMCID:: PMC10424567

Abstract Article PDF–3.0M

Select item 93610098.

Bruton's TK regulates myeloid cell recruitment during acute inflammation

Gareth S. D. Purvis, Haidee Aranda‐Tavio, Keith M. Channon, David R. Greaves

Br J Pharmacol. 2022 Jun; 179(11): 2754–2770. Published online 2022 Mar 15. doi: 10.1111/bph.15778

PMCID:: PMC9361009

Abstract Article PDF–12M

Select item 92910199.

Bruton's tyrosine kinase inhibition induces rewiring of proximal and distal B‐cell receptor signaling in mice

Jasper Rip, Marjolein J. W. de Bruijn, Stefan F. H. Neys, Simar Pal Singh, Jonas Willar, Jennifer A. C. van Hulst, Rudi W. Hendriks, Odilia B. J. Corneth

Eur J Immunol. 2021 Sep; 51(9): 2251–2265. Published online 2021 Aug 16. doi: 10.1002/eji.202048968

PMCID:: PMC9291019

Abstract Article PDF–1.8M

Select item 900213810.

Bruton’s Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis

Rachel H. Bonami, Christina E. Thurman, Sonam Verma, Camille S. Westlake, Lindsay E. Nyhoff, Bridgette B. Barron, Andrea Reboldi, Peggy L. Kendall

Front Immunol. 2022; 13: 748284. Published online 2022 Mar 29. doi: 10.3389/fimmu.2022.748284

PMCID:: PMC9002138

Abstract Article PDF–22M

Select item 883246111.

DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis

Yanchuan Li, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y. Konopleva, Xuhong Cheng, Shao-Cong Sun

Blood. 2021 Dec 9; 138(23): 2360–2371. doi: 10.1182/blood.2021011247

PMCID:: PMC8832461

Abstract Article

Select item 866532412.

Bruton’s tyrosine kinase drives neuroinflammation and anxiogenic behavior in mouse models of stress

Simantini Ghosh, Zaidan Mohammed, Itender Singh

J Neuroinflammation. 2021; 18: 289. Published online 2021 Dec 11. doi: 10.1186/s12974-021-02322-9

PMCID:: PMC8665324

Abstract Article PDF–2.1M

Select item 866122713.

Knockout of Bruton’s tyrosine kinase in macrophages attenuates diabetic nephropathy in streptozotocin-induced mice

Zhe Fan, Yuanyuan Li, Lingling Xia, Yonggui Wu

Am J Transl Res. 2021; 13(11): 12352–12363. Published online 2021 Nov 15.

PMCID:: PMC8661227

Abstract Article PDF–1.7M

Select item 851671914.

Inhibition of a BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage inflammatory dendritic cells and enhances anti-tumor T cell immunity

Madhav D. Sharma, Rafal Pacholczyk, Huidong Shi, Zuzana J. Berrong, Yousef Zakharia, Austin Greco, Chang-Sheng S. Chang, Sudharshan Eathiraj, Eugene Kennedy, Thomas Cash, Roni J. Bollag, Ravindra Kolhe, Ramses Sadek, Tracy L. McGaha, Paulo Rodriguez, Jessica Mandula, Bruce R. Blazar, Theodore S. Johnson, David H. Munn

Immunity. Author manuscript; available in PMC 2022 Oct 12.

Published in final edited form as: Immunity. 2021 Oct 12; 54(10): 2354–2371.e8. Published online 2021 Oct 5. doi: 10.1016/j.immuni.2021.09.005

PMCID:: PMC8516719

Abstract Article PDF–1.6M

Select item 848067215.

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

Zsófia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellán, Sangeetha Shankar, Liudmila Andreeva, Matthew Mangan, Marianne Spalinger, Hubert Kalbacher, Peter Düwell, Marta Lovotti, Karlotta Bosch, Sabine Dickhöfer, Ana Marcu, Stefan Stevanović, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L. Greve, Markus W. Löffler, Olaf-Oliver Wolz, Nadine A. Schilling, Jasmin B. Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N.R. Weber

J Exp Med. 2021 Nov 1; 218(11): e20201656. Published online 2021 Sep 23. doi: 10.1084/jem.20201656

PMCID:: PMC8480672

Abstract Article PDF–6.7M

Select item 845057916.

Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia

Alexander P. de Porto, Zhe Liu, Regina de Beer, Sandrine Florquin, Joris J. T. H. Roelofs, Onno J. de Boer, Joke M. M. den Haan, Rudi W. Hendriks, Cornelis van ‘t Veer, Tom van der Poll, Alex F. de Vos

Front Immunol. 2021; 12: 723967. Published online 2021 Sep 6. doi: 10.3389/fimmu.2021.723967

PMCID:: PMC8450579

Abstract Article PDF–1.7M

Select item 835431117.

Bruton's tyrosine kinase regulates macrophage-induced inflammation in the diabetic kidney via NLRP3 inflammasome activation

Jing Zhao, Juan Chen, Yuan-Yuan Li, Ling-Ling Xia, Yong-Gui Wu

Int J Mol Med. 2021 Sep; 48(3): 177. Published online 2021 Jul 16. doi: 10.3892/ijmm.2021.5010

PMCID:: PMC8354311

Abstract Article PDF–3.6M

Select item 793877018.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 760844319.

T-cell expression of Bruton’s tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia

Simo Xia, Xiang Liu, Xuetao Cao, Sheng Xu

Cell Mol Immunol. 2020 Oct; 17(10): 1042–1052. Published online 2019 Aug 20. doi: 10.1038/s41423-019-0270-9

PMCID:: PMC7608443

Abstract Article PDF–3.0M

Select item 758025420.

X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure

Caroline E. O'Riordan, Gareth S. D. Purvis, Debora Collotta, Nadine Krieg, Bianka Wissuwa, Madeeha H. Sheikh, Gustavo Ferreira Alves, Shireen Mohammad, Lauren A. Callender, Sina M. Coldewey, Massimo Collino, David R. Greaves, Christoph Thiemermann

Front Immunol. 2020; 11: 581758. Published online 2020 Oct 7. doi: 10.3389/fimmu.2020.581758

PMCID:: PMC7580254

Abstract Article PDF–2.3M

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