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Select item 114455141.

Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3—their sensing mediator—is tumor suppressive

Ido Livneh, Bertrand Fabre, Gilad Goldhirsh, Chen Lulu, Adar Zinger, Yael Shammai Vainer, Maya Kaduri, Aviva Dahan, Tamar Ziv, Avi Schroeder, Yinon Ben-Neriah, Yaniv Zohar, Victoria Cohen-Kaplan, Aaron Ciechanover

Cell Death Differ. 2024 Oct; 31(10): 1242–1254. Published online 2024 Sep 12. doi: 10.1038/s41418-024-01370-x

PMCID:: PMC11445514

Abstract Article PDF–5.1M

Select item 93485762.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 88970223.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 88065694.

Oncogenic role of early growth response-1 in liver cancer through the regulation of the microRNA-675/sestrin 3 and the Wnt/β-catenin signaling pathway

Lingling Zhang, Ran Ren, Xue Yang, Yiman Ge, Xiajun Zhang, Hongping Yuan

Bioengineered. 2021; 12(1): 5305–5322. Published online 2021 Aug 19. doi: 10.1080/21655979.2021.1964889

PMCID:: PMC8806569

Abstract Article PDF–6.0M

Select item 87211915.

The functions and roles of sestrins in regulating human diseases

Yitong Chen, Tingben Huang, Zhou Yu, Qiong Yu, Ying Wang, Ji’an Hu, Jiejun Shi, Guoli Yang

Cell Mol Biol Lett. 2022; 27: 2. Published online 2022 Jan 3. doi: 10.1186/s11658-021-00302-8

PMCID:: PMC8721191

Abstract Article PDF–2.1M

Select item 83766396.

Colon and liver tissue damage detection using methylated SESN3 and PTK2B genes in circulating cell-free DNA in patients with acute graft-versus-host disease

Miguel Waterhouse, Sandra Pennisi, Dietmar Pfeifer, Max Deuter, Nikolas von Bubnoff, Florian Scherer, Tim Strüssmann, Claudia Wehr, Justus Duyster, Hartmut Bertz, Jürgen Finke, Jesus Duque-Afonso

Bone Marrow Transplant. 2021; 56(2): 327–333. Published online 2020 Oct 20. doi: 10.1038/s41409-020-01090-z

Correction in:: Bone Marrow Transplant. 2021; 56(10): 2616.

PMCID:: PMC8376639

Abstract Article PDF–709K

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73068538.

Circulating Sestrin Levels Are Increased in Hypertension Patients

Cao Fang, Zicong Yang, Lei Shi, Tao Zeng, Ying Shi, Ling Liu, Hongtao Liu, Yingzhong Lin

Dis Markers. 2020; 2020: 3787295. Published online 2020 Jun 12. doi: 10.1155/2020/3787295

PMCID:: PMC7306853

Abstract Article PDF–629K

Select item 66798359.

Interactions between microRNA-200 family and Sestrin proteins in endometrial cancer cell lines and their significance to anoikis

Joanna Kozak, Paulina Wdowiak, Ryszard Maciejewski, Anna Torres

Mol Cell Biochem. 2019; 459(1): 21–34. Published online 2019 May 9. doi: 10.1007/s11010-019-03547-2

PMCID:: PMC6679835

Abstract Article PDF–1.6M

Select item 607551510.

Sestrin-3 modulation is essential for therapeutic efficacy of cucurbitacin B in lung cancer cells

Naghma Khan, Farah Jajeh, Mohammad Imran Khan, Eiman Mukhtar, Sameh M. Shabana, Hasan Mukhtar

Carcinogenesis. 2017 Feb; 38(2): 184–195. Published online 2016 Nov 23. doi: 10.1093/carcin/bgw124

PMCID:: PMC6075515

Abstract Article PDF–6.9M

Select item 580449011.

Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an exploratory study

Velda J. Gonzalez, Leorey N. Saligan, Brooke L. Fridley, Humberto Ortiz-Zuazaga, Lauren S. Aaronson

P R Health Sci J. Author manuscript; available in PMC 2018 Feb 8.

Published in final edited form as: P R Health Sci J. 2017 Dec; 36(4): 223–231.

PMCID:: PMC5804490

Abstract Article PDF–883K

Select item 567194412.

FOXO3-mediated chemo-protection in high-stage neuroblastoma depends on wild-type TP53 and SESN3

M Rupp, J Hagenbuchner, B Rass, H Fiegl, U Kiechl-Kohlendorfer, P Obexer, M J Ausserlechner

Oncogene. 2017 Nov 2; 36(44): 6190–6203. Published online 2017 Sep 4. doi: 10.1038/onc.2017.288

PMCID:: PMC5671944

Abstract Article PDF–6.1M

Select item 553161113.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 496505114.

Prediction and Validation of Transcription Factors Modulating the Expression of Sestrin3 Gene Using an Integrated Computational and Experimental Approach

Rajneesh Srivastava, Yang Zhang, Xiwen Xiong, Xiaoning Zhang, Xiaoyan Pan, X. Charlie Dong, Suthat Liangpunsakul, Sarath Chandra Janga

PLoS One. 2016; 11(7): e0160228. Published online 2016 Jul 28. doi: 10.1371/journal.pone.0160228

PMCID:: PMC4965051

Abstract Article PDF–4.7M

Select item 469801715.

Sestrin2 is a leucine sensor for the mTORC1 pathway

Rachel L. Wolfson, Lynne Chantranupong, Robert A. Saxton, Kuang Shen, Sonia M. Scaria, Jason R. Cantor, David M. Sabatini

Science. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: Science. 2016 Jan 1; 351(6268): 43–48. Published online 2015 Oct 8. doi: 10.1126/science.aab2674

PMCID:: PMC4698017

Abstract Article PDF–1.4M

Select item 462757616.

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

Michael R. Johnson, Jacques Behmoaras, Leonardo Bottolo, Michelle L. Krishnan, Katharina Pernhorst, Paola L. Meza Santoscoy, Tiziana Rossetti, Doug Speed, Prashant K. Srivastava, Marc Chadeau-Hyam, Nabil Hajji, Aleksandra Dabrowska, Maxime Rotival, Banafsheh Razzaghi, Stjepana Kovac, Klaus Wanisch, Federico W. Grillo, Anna Slaviero, Sarah R. Langley, Kirill Shkura, Paolo Roncon, Tisham De, Manuel Mattheisen, Pitt Niehusmann, Terence J. O’Brien, Slave Petrovski, Marec von Lehe, Per Hoffmann, Johan Eriksson, Alison J. Coffey, Sven Cichon, Matthew Walker, Michele Simonato, Bénédicte Danis, Manuela Mazzuferi, Patrik Foerch, Susanne Schoch, Vincenzo De Paola, Rafal M. Kaminski, Vincent T. Cunliffe, Albert J. Becker, Enrico Petretto

Nat Commun. Author manuscript; available in PMC 2015 Oct 30.

Published in final edited form as: Nat Commun. 2015; 6: 6031. Published online 2015 Jan 23. doi: 10.1038/ncomms7031

PMCID:: PMC4627576

Abstract Article PDF–1.7M

Select item 461721117.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 422386618.

The Sestrins interact with GATOR2 to negatively regulate the amino acid sensing pathway upstream of mTORC1

Lynne Chantranupong, Rachel L. Wolfson, Jose M. Orozco, Robert A. Saxton, Sonia M. Scaria, Liron Bar-Peled, Eric Spooner, Marta Isasa, Steven P. Gygi, David M. Sabatini

Cell Rep. Author manuscript; available in PMC 2014 Nov 7.

Published in final edited form as: Cell Rep. 2014 Oct 9; 9(1): 1–8. Published online 2014 Sep 25. doi: 10.1016/j.celrep.2014.09.014

PMCID:: PMC4223866

Abstract Article PDF–616K

Select item 408016319.

The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury

Xinqin Kang, Kateryna Petyaykina, Rongya Tao, Xiwen Xiong, X. Charlie Dong, Suthat Liangpunsakul

Am J Physiol Gastrointest Liver Physiol. 2014 Jul 1; 307(1): G58–G65. Published online 2014 May 15. doi: 10.1152/ajpgi.00373.2013

PMCID:: PMC4080163

Abstract Article

Select item 407349420.

The Central Role of EED in the Orchestration of Polycomb Group Complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan

Nat Commun. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Nat Commun. 2014; 5: 3127. doi: 10.1038/ncomms4127

PMCID:: PMC4073494

Abstract Article PDF–2.1M

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