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Select item 111144981.

PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling

Kai Kysenius, Pranuthi Muggalla, Kert Mätlik, Urmas Arumäe, Henri J. Huttunen

Cell Mol Life Sci. 2012 Jun; 69(11): 1903–1916. Published online 2012 Apr 6. doi: 10.1007/s00018-012-0977-6

PMCID:: PMC11114498

Abstract Article PDF–1.0M

Select item 92233542.

Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Deletion but Not Inhibition of Extracellular PCSK9 Reduces Infarct Sizes Ex Vivo but Not In Vivo

Rolf Schreckenberg, Annemarie Wolf, Tamara Szabados, Kamilla Gömöri, István Adorján Szabó, Gergely Ágoston, Gábor Brenner, Péter Bencsik, Péter Ferdinandy, Rainer Schulz, Klaus-Dieter Schlüter

Int J Mol Sci. 2022 Jun; 23(12): 6512. Published online 2022 Jun 10. doi: 10.3390/ijms23126512

PMCID:: PMC9223354

Abstract Article PDF–1.5M

Select item 89766003.

Protective Mechanism of Proprotein Convertase Subtilisin-Like Kexin Type 9 Inhibitor on Rats with Middle Cerebral Artery Occlusion-Induced Cerebral Ischemic Infarction

Shengxiong Pu, Chaojun Jia, Zhimin Li, Yunhua Zang

Comput Intell Neurosci. 2022; 2022: 4964262. Published online 2022 Mar 26. doi: 10.1155/2022/4964262

PMCID:: PMC8976600

Abstract Article PDF–2.1M

Select item 88403524.

Comparative Effect of Bergamot Polyphenolic Fraction and Red Yeast Rice Extract in Rats Fed a Hyperlipidemic Diet: Role of Antioxidant Properties and PCSK9 Expression

Rocco Mollace, Roberta Macrì, Annamaria Tavernese, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Jessica Maiuolo, Massimo Fini, Maurizio Volterrani, Vincenzo Mollace

Nutrients. 2022 Feb; 14(3): 477. Published online 2022 Jan 22. doi: 10.3390/nu14030477

PMCID:: PMC8840352

Abstract Article PDF–656K

Select item 84651185.

Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells

Chiara Barisione, Daniela Verzola, Silvano Garibaldi, Pier Francesco Ferrari, Giacomo Garibotto, Pietro Ameri, Bianca Pane, Giovanni Spinella, Giovanni Pratesi, Domenico Palombo

Int J Mol Sci. 2021 Sep; 22(18): 9884. Published online 2021 Sep 13. doi: 10.3390/ijms22189884

PMCID:: PMC8465118

Abstract Article PDF–7.4M

Select item 77190846.

Secretion of the epithelial sodium channel chaperone PCSK9 from the cortical collecting duct links sodium retention with hypercholesterolemia in nephrotic syndrome.

Eduardo Molina-Jijon, Stéphanie Gambut, Camille Macé, Carmen Avila-Casado, Lionel C. Clement

Kidney Int. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Kidney Int. 2020 Dec; 98(6): 1449–1460. Published online 2020 Aug 1. doi: 10.1016/j.kint.2020.06.045

PMCID:: PMC7719084

Abstract Article PDF–2.3M

Select item 76527477.

Autocrine effects of PCSK9 on cardiomyocytes

Annemarie Wolf, Hanna Sarah Kutsche, Rolf Schreckenberg, Martin Weber, Ling Li, Susanne Rohrbach, Rainer Schulz, Klaus-Dieter Schlüter

Basic Res Cardiol. 2020; 115(6): 65. Published online 2020 Nov 10. doi: 10.1007/s00395-020-00824-w

PMCID:: PMC7652747

Abstract Article PDF–944K

Select item 68682408.

PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease

Ji Soo Lee, Partha Mukhopadhyay, Csaba Matyas, Eszter Trojnar, Janos Paloczi, Yuan Ru Yang, Brandon A. Blank, Cody Savage, Alexander V. Sorokin, Nehal N. Mehta, Janaina C. M. Vendruscolo, George F. Koob, Leandro F. Vendruscolo, Pal Pacher, Falk W. Lohoff

Sci Rep. 2019; 9: 17167. Published online 2019 Nov 20. doi: 10.1038/s41598-019-53603-6

PMCID:: PMC6868240

Abstract Article PDF–2.8M

Select item 64458069.

Up-regulation of PCSK9 gene expression and diminished level of LDL-receptor in rat liver as a potential cause of post-lipectomy hypercholesterolemia

Agnieszka Dettlaff-Pokora, Elzbieta Sucajtys-Szulc, Tomasz Sledzinski

Mol Cell Biochem. 2019; 455(1): 207–217. Published online 2018 Nov 27. doi: 10.1007/s11010-018-3484-8

PMCID:: PMC6445806

Abstract Article PDF–1010K

Select item 559947010.

Oxidized low-density lipoprotein (oxLDL) affects load-free cell shortening of cardiomyocytes in a proprotein convertase subtilisin/kexin 9 (PCSK9)-dependent way

Klaus-Dieter Schlüter, Annemarie Wolf, Martin Weber, Rolf Schreckenberg, Rainer Schulz

Basic Res Cardiol. 2017; 112(6): 63. Published online 2017 Sep 14. doi: 10.1007/s00395-017-0650-1

PMCID:: PMC5599470

Abstract Article PDF–755K

Select item 473778711.

Up-regulation of liver Pcsk9 gene expression as a possible cause of hypercholesterolemia in experimental chronic renal failure

Elzbieta Sucajtys-Szulc, Marek Szolkiewicz, Julian Swierczynski, Boleslaw Rutkowski

Mol Cell Biochem. 2016; 411: 281–287. Published online 2015 Oct 19. doi: 10.1007/s11010-015-2590-0

PMCID:: PMC4737787

Abstract Article PDF–583K

Select item 468691312.

Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics

Dong An, Xiaowei Wei, Hui Li, Hui Gu, Tianchu Huang, Guifeng Zhao, Bo Liu, Weilin Wang, Lizhu Chen, Wei Ma, Henan Zhang, Songying Cao, Zhengwei Yuan

Sci Rep. 2015; 5: 17559. Published online 2015 Dec 22. doi: 10.1038/srep17559

PMCID:: PMC4686913

Abstract Article PDF–1.9M

Select item 400053313.

Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats

Yan-Jun Jia, Rui-Xa Xu, Jing Sun, Yue Tang, Jian-Jun Li

J Transl Med. 2014; 12: 103. Published online 2014 Apr 23. doi: 10.1186/1479-5876-12-103

PMCID:: PMC4000533

Abstract Article PDF–657K

Select item 393127614.

Impact of currently prescribed lipid-lowering drugs on plasma PCSK9 concentration: single or in combination study in rats

Yan Zhang, Jun Liu, Sha Li, Rui-Xia Xu, Jing Sun, Jian-Jun Li

Lipids Health Dis. 2014; 13: 35. Published online 2014 Feb 18. doi: 10.1186/1476-511X-13-35

PMCID:: PMC3931276

Abstract Article PDF–538K

Select item 362217715.

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion

Xiao-Wei Chen, He Wang, Kanika Bajaj, Pengcheng Zhang, Zhuo-Xian Meng, Danjun Ma, Yongsheng Bai, Hui-Hui Liu, Elizabeth Adams, Andrea Baines, Genggeng Yu, Maureen A Sartor, Bin Zhang, Zhengping Yi, Jiandie Lin, Stephen G Young, Randy Schekman, David Ginsburg

eLife. 2013; 2: e00444. Published online 2013 Apr 9. doi: 10.7554/eLife.00444

PMCID:: PMC3622177

Abstract Article PDF–5.3M

Select item 340713116.

Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation

Nabil G. Seidah, Steve Poirier, Maxime Denis, Rex Parker, Bowman Miao, Claudio Mapelli, Annik Prat, Hanny Wassef, Jean Davignon, Katherine A. Hajjar, Gaétan Mayer

PLoS One. 2012; 7(7): e41865. Published online 2012 Jul 27. doi: 10.1371/journal.pone.0041865

PMCID:: PMC3407131

Abstract Article PDF–683K

Select item 336595817.

Regulation of Epithelial Sodium Channel Trafficking by Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

Vikas Sharotri, Daniel M. Collier, Diane R. Olson, Ruifeng Zhou, Peter M. Snyder

J Biol Chem. 2012 Jun 1; 287(23): 19266–19274. Published online 2012 Apr 9. doi: 10.1074/jbc.M112.363382

PMCID:: PMC3365958

Abstract Article PDF–1.8M

Select item 324569518.

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

Paola Lo Surdo, Matthew J Bottomley, Alessandra Calzetta, Ethan C Settembre, Agostino Cirillo, Shilpa Pandit, Yan G Ni, Brian Hubbard, Ayesha Sitlani, Andrea Carfí

EMBO Rep. 2011 Dec; 12(12): 1300–1305. Published online 2011 Nov 11. doi: 10.1038/embor.2011.205