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Select item 108308981.

DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors

Daria Ostroverkhova, Kathrin Tyryshkin, Annette K. Beach, Elizabeth A. Moore, Yosef Masoudi-Sobhanzadeh, Stephanie R. Barbari, Igor B. Rogozin, Konstantin V. Shaitan, Anna R. Panchenko, Polina V. Shcherbakova

Cell Rep. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Cell Rep. 2024 Jan 23; 43(1): 113655. Published online 2024 Jan 13. doi: 10.1016/j.celrep.2023.113655

PMCID:: PMC10830898

Abstract Article PDF–1.8M

Select item 108123832.

Exploring Co-occurring POLE Exonuclease and Non-exonuclease Domain Mutations and Their Impact on Tumor Mutagenicity

Shreya M. Shah, Elena V. Demidova, Salena Ringenbach, Bulat Faezov, Mark Andrake, Arjun Gandhi, Pilar Mur, Julen Viana-Errasti, Joanne Xiu, Jeffrey Swensen, Laura Valle, Roland L. Dunbrack, Jr, Michael J. Hall, Sanjeevani Arora

Cancer Res Commun. 2024 Jan; 4(1): 213–225. Published online 2024 Jan 26. doi: 10.1158/2767-9764.CRC-23-0312

Correction in:: Cancer Res Commun. 2024 May; 4(5): 1398.

PMCID:: PMC10812383

Abstract Article PDF–4.4M

Select item 107969173.

The P286R mutation of DNA polymerase ε activates cancer-cell-intrinsic immunity and suppresses endometrial tumorigenesis via the cGAS-STING pathway

Ming Tang, Shasha Yin, Hongliang Zeng, Ao Huang, Yujia Huang, Zhiyi Hu, Ab Rauf Shah, Shuyong Zhang, Haisen Li, Guofang Chen

Cell Death Dis. 2024 Jan; 15(1): 69. Published online 2024 Jan 18. doi: 10.1038/s41419-023-06418-3

PMCID:: PMC10796917

Abstract Article PDF–9.8M

Select item 107949414.

Race, Prevalence of POLE and POLD1 Alterations, and Survival Among Patients With Endometrial Cancer

Shuhua Zheng, Eric D. Donnelly, Jonathan B. Strauss

JAMA Netw Open. 2024 Jan; 7(1): e2351906. Published online 2024 Jan 17. doi: 10.1001/jamanetworkopen.2023.51906

PMCID:: PMC10794941

Abstract Article

Select item 107564815.

Cervical Cytology Preserves Histologically Detected Surface Epithelial Slackening, Unique to the POLE Mutation-subtype in Endometrial Cancer

IKUMI KITAZONO, TOSHIAKI AKAHANE, SEIYA YOKOYAMA, EMI KUBOTA, YUKARI NISHIDA-KIRITA, HIROTSUGU NOGUCHI, MIKI MURAKAMI, SHINTARO YANAZUME, HIROAKI KOBAYASHI, AKIHIDE TANIMOTO

In Vivo. 2024 Jan-Feb; 38(1): 321–333. Published online 2024 Jan 3. doi: 10.21873/invivo.13442

PMCID:: PMC10756481

Abstract Article PDF–3.6M

Select item 106643776.

Rare germline variants in POLE and POLD1 encoding the catalytic subunits of DNA polymerases ε and δ in glioma families

Christine A. M. Weber, Nicole Krönke, Valery Volk, Bernd Auber, Alisa Förster, Detlef Trost, Robert Geffers, Majid Esmaeilzadeh, Michael Lalk, Arya Nabavi, Amir Samii, Joachim K. Krauss, Friedrich Feuerhake, Christian Hartmann, Bettina Wiese, Frank Brand, Ruthild G. Weber

Acta Neuropathol Commun. 2023; 11: 184. Published online 2023 Nov 21. doi: 10.1186/s40478-023-01689-5

PMCID:: PMC10664377

Abstract Article PDF–10M

Select item 106100227.

Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants

Janick Selves, Helena de Castro e Gloria, Anne-Cécile Brunac, Jenifer Saffi, Rosine Guimbaud, Pierre Brousset, Jean-Sébastien Hoffmann

Life Sci Alliance. 2024 Jan; 7(1): e202302290. Published online 2023 Oct 27. doi: 10.26508/lsa.202302290

PMCID:: PMC10610022

Abstract Article PDF–1.2M

Select item 102374228.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101810959.

Functional Landscapes of POLE and POLD1 Mutations in Checkpoint Blockade-Dependent Anti-Tumor Immunity

Xiaoxiao Ma, Nadeem Riaz, Robert M. Samstein, Mark Lee, Vladimir Makarov, Cristina Valero, Diego Chowell, Fengshen Kuo, Douglas Hoen, Conall W.R. Fitzgerald, Hui Jiang, Jonathan Alektiar, Tyler J. Alban, Ivan Juric, Prerana Bangalore Parthasarathy, Yu Zhao, Erich Y. Sabio, Richa Verma, Raghvendra M. Srivastava, Lynda Vuong, Wei Yang, Xiao Zhang, Jingming Wang, Lawrence K. Chu, Stephen L. Wang, Daniel W. Kelly, Xin Pei, Jiapeng Chen, Rona Yaeger, Dmitriy Zamarin, Ahmet Zehir, Mithat Gönen, Luc GT Morris, Timothy A. Chan

Nat Genet. Author manuscript; available in PMC 2023 May 12.

Published in final edited form as: Nat Genet. 2022 Jul; 54(7): 996–1012. Published online 2022 Jul 11. doi: 10.1038/s41588-022-01108-w

PMCID:: PMC10181095

Abstract Article PDF–5.2M

Select item 995018310.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 976969811.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 958197812.

The iron-sulfur cluster is essential for DNA binding by human DNA polymerase ε

Alisa E. Lisova, Andrey G. Baranovskiy, Lucia M. Morstadt, Nigar D. Babayeva, Elena I. Stepchenkova, Tahir H. Tahirov

Sci Rep. 2022; 12: 17436. Published online 2022 Oct 19. doi: 10.1038/s41598-022-21550-4

PMCID:: PMC9581978

Abstract Article PDF–1.6M

Select item 948193313.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 934345514.

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis

Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi

Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y

PMCID:: PMC9343455

Abstract Article PDF–3.7M

Select item 927928515.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 926261416.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 926083917.

Pathological complete response to immune checkpoint inhibitor in patients with colorectal cancer liver metastases harboring POLE exonuclease domain mutation

Lei Wen, Zhigang Chen, Xiaomeng Ji, William Pat Fong, Qiong Shao, Chao Ren, Yanyu Cai, Binkui Li, Yunfei Yuan, Deshen Wang, Yuhong Li

J Immunother Cancer. 2022; 10(7): e004487. Published online 2022 Jul 6. doi: 10.1136/jitc-2022-004487

PMCID:: PMC9260839

Abstract Article PDF–3.3M

Select item 925017618.

POLE/POLD1 mutation and tumor immunotherapy

Xiaoting Ma, Lin Dong, Xiu Liu, Kai Ou, Lin Yang

J Exp Clin Cancer Res. 2022; 41: 216. Published online 2022 Jul 2. doi: 10.1186/s13046-022-02422-1

PMCID:: PMC9250176

Abstract Article PDF–1.1M

Select item 920588819.

Efficient discrimination against RNA-containing primers by human DNA polymerase ε

Alisa E. Lisova, Andrey G. Baranovskiy, Lucia M. Morstadt, Nigar D. Babayeva, Tahir H. Tahirov

Sci Rep. 2022; 12: 10163. Published online 2022 Jun 17. doi: 10.1038/s41598-022-14602-2

PMCID:: PMC9205888

Abstract Article PDF–1.6M

Select item 911973620.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

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