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Select item 106879041.

Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells

Zhaohui Ruan, Guosheng Cao, Yisong Qian, Longsheng Fu, Jinfang Hu, Tiantian Xu, Yaoqi Wu, Yanni Lv

J Neuroinflammation. 2023; 20: 285. Published online 2023 Nov 30. doi: 10.1186/s12974-023-02941-4

PMCID:: PMC10687904

Abstract Article PDF–8.9M

Select item 102383932.

Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation

Jimin Yang, Guo Nan Yin, Do-Kyun Kim, Ah-reum Han, Dong Sun Lee, Kwang Wook Min, Yaoyao Fu, Jeongwon Yun, Jun-Kyu Suh, Ji-Kan Ryu, Ho Min Kim

Exp Mol Med. 2023 May; 55(5): 1013–1022. Published online 2023 May 1. doi: 10.1038/s12276-023-00992-4

PMCID:: PMC10238393

Abstract Article PDF–5.9M

Select item 96743483.

LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation

Chan Hee J Choi, William Barr, Samir Zaman, Corey Model, Annsea Park, Mascha Koenen, Zeran Lin, Sarah K Szwed, Francois Marchildon, Audrey Crane, Thomas S Carroll, Henrik Molina, Paul Cohen

eLife. 2022; 11: e81559. Published online 2022 Nov 8. doi: 10.7554/eLife.81559

PMCID:: PMC9674348

Abstract Article PDF–9.2M

Select item 89737604.

Leucine rich alpha-2-glycoprotein 1 (Lrg1) silencing protects against sepsis-mediated brain injury by inhibiting transforming growth factor beta1 (TGFβ1)/SMAD signaling pathway

Youhan Miao, Meihua Wang, Xiaojuan Cai, Qiqi Zhu, Liping Mao

Bioengineered. 2022; 13(3): 7316–7327. Published online 2022 Mar 10. doi: 10.1080/21655979.2022.2048775

PMCID:: PMC8973760

Abstract Article PDF–3.4M

Select item 89387205.

Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway

Athina Dritsoula, Laura Dowsett, Camilla Pilotti, Marie N. O’Connor, Stephen E. Moss, John Greenwood

Sci Rep. 2022; 12: 4867. Published online 2022 Mar 22. doi: 10.1038/s41598-022-08516-2

Correction in:: Sci Rep. 2022; 12: 5347.

PMCID:: PMC8938720

Abstract Article PDF–3.0M

Select item 87922366.

Modulation of Transforming Growth Factor-β-induced kidney fibrosis by leucine-rich α-2 glycoprotein-1

Quan Hong, Hong Cai, Lu Zhang, Zhengzhe Li, Fang Zhong, Zhaohui Ni, Guangyan Cai, Xiang-Mei Chen, John Cijiang He, Kyung Lee

Kidney Int. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: Kidney Int. 2022 Feb; 101(2): 299–314. Published online 2021 Nov 10. doi: 10.1016/j.kint.2021.10.023

PMCID:: PMC8792236

Abstract Article PDF–4.6M

Select item 86708377.

LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance

Sijia He, Jiyoon Ryu, Juanhong Liu, Hairong Luo, Ying Lv, Paul R. Langlais, Jie Wen, Feng Dong, Zhe Sun, Wenjuan Xia, Jane L. Lynch, Ravindranath Duggirala, Bruce J. Nicholson, Mengwei Zang, Yuguang Shi, Fang Zhang, Feng Liu, Juli Bai, Lily Q. Dong

J Clin Invest. 2021 Dec 15; 131(24): e148545. Published online 2021 Dec 15. doi: 10.1172/JCI148545

PMCID:: PMC8670837

Abstract Article PDF–7.4M

Select item 82880758.

Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor

Kuin Tian Pang, Mean Ghim, Chenghao Liu, Hui Min Tay, Chee Wai Fhu, Rui Ning Chia, Beiying Qiu, Padmini Sarathchandra, Adrian H. Chester, Magdi H. Yacoub, Fiona L. Wilkinson, Ria Weston, Christina M. Warboys, Han Wei Hou, Peter D. Weinberg, Xiaomeng Wang

Front Cell Dev Biol. 2021; 9: 706143. Published online 2021 Jul 5. doi: 10.3389/fcell.2021.706143

PMCID:: PMC8288075

Abstract Article PDF–3.7M

Select item 82692869.

LRG1 Promotes Metastatic Dissemination of Melanoma through Regulating EGFR/STAT3 Signalling

Yuet Ping Kwan, Melissa Hui Yen Teo, Jonathan Chee Woei Lim, Michelle Siying Tan, Graciella Rosellinny, Walter Wahli, Xiaomeng Wang

Cancers (Basel) 2021 Jul; 13(13): 3279. Published online 2021 Jun 30. doi: 10.3390/cancers13133279

PMCID:: PMC8269286

Abstract Article PDF–24M

Select item 767665210.

Evaluation of leucine-rich alpha-2 glycoprotein as a biomarker of fetal infection

Etsuko Kajimoto, Masayuki Endo, Minoru Fujimoto, Shinya Matsuzaki, Makoto Fujii, Kazunobu Yagi, Aiko Kakigano, Kazuya Mimura, Takuji Tomimatsu, Satoshi Serada, Makoto Takeuchi, Kiyoshi Yoshino, Yutaka Ueda, Tadashi Kimura, Tetsuji Naka

PLoS One. 2020; 15(11): e0242076. Published online 2020 Nov 19. doi: 10.1371/journal.pone.0242076

PMCID:: PMC7676652

Abstract Article PDF–2.3M

Select item 761490211.

Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis

Mahak Singhal, Nicolas Gengenbacher, Ashik Ahmed Abdul Pari, Miki Kamiyama, Ling Hai, Bianca J. Kuhn, David M. Kallenberg, Shubhada R. Kulkarni, Carlotta Camilli, Stephanie F. Preuß, Barbara Leuchs, Carolin Mogler, Elisa Espinet, Eva Besemfelder, Danijela Heide, Mathias Heikenwalder, Martin R. Sprick, Andreas Trumpp, Jeroen Krijgsveld, Matthias Schlesner, Junhao Hu, Stephen E. Moss, John Greenwood, Hellmut G. Augustin

Sci Transl Med. Author manuscript; available in PMC 2023 Aug 9.

Published in final edited form as: Sci Transl Med. 2021 Sep 1; 13(609): eabe6805. Published online 2021 Sep 1. doi: 10.1126/scitranslmed.abe6805

PMCID:: PMC7614902

Abstract Article PDF–2.6M

Select item 761475712.

LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency

Marie N. O’Connor, David M. Kallenberg, Carlotta Camilli, Camilla Pilotti, Athina Dritsoula, Rene Jackstadt, Chantelle E. Bowers, H. Angharad Watson, Markella Alatsatianos, Julia Ohme, Laura Dowsett, Jestin George, Jack W.D. Blackburn, Xiaomeng Wang, Mahak Singhal, Hellmut G. Augustin, Ann Ager, Owen J. Sansom, Stephen E. Moss, John Greenwood

Med. Author manuscript; available in PMC 2023 Jul 15.

Published in final edited form as: Med. 2021 Nov 12; 2(11): 1231–1252.e10. Published online 2021 Nov 3. doi: 10.1016/j.medj.2021.10.002

PMCID:: PMC7614757

Abstract Article PDF–3.1M

Select item 757657013.

A Multifunctional Role of Leucine-Rich α-2-Glycoprotein 1 in Cutaneous Wound Healing Under Normal and Diabetic Conditions

Chenghao Liu, Melissa Hui Yen Teo, Sharon Li Ting Pek, Xiaoting Wu, Mei Ling Leong, Hui Min Tay, Han Wei Hou, Christiane Ruedl, Stephen E. Moss, John Greenwood, Subramaniam Tavintharan, Wanjin Hong, Xiaomeng Wang

Diabetes. 2020 Nov; 69(11): 2467–2480. Published online 2020 Sep 4. doi: 10.2337/db20-0585

PMCID:: PMC7576570

Abstract Article PDF–1.9M

Select item 709293214.

Up-regulation of the expression of leucine-rich α₂-glycoprotein in hepatocytes by the mediators of acute-phase response

Ryoichi Shirai, Fumiyasu Hirano, Naoki Ohkura, Kiyoshi Ikeda, Seiji Inoue

Biochem Biophys Res Commun. 2009 May 15; 382(4): 776–779. Published online 2009 Mar 24. doi: 10.1016/j.bbrc.2009.03.104

PMCID:: PMC7092932

Abstract Article PDF–381K

Select item 677811415.

Mechanical strain promotes skin fibrosis through LRG-1 induction mediated by ELK1 and ERK signalling

Ya Gao, Jia Zhou, Zhibo Xie, Jing Wang, Chia-kang Ho, Yifan Zhang, Qingfeng Li

Commun Biol. 2019; 2: 359. Published online 2019 Oct 4. doi: 10.1038/s42003-019-0600-6

PMCID:: PMC6778114

Abstract Article PDF–6.3M

Select item 644234916.

LRG1 Promotes Diabetic Kidney Disease Progression by Enhancing TGF-β–Induced Angiogenesis

Quan Hong, Lu Zhang, Jia Fu, Divya A. Verghese, Kinsuk Chauhan, Girish N. Nadkarni, Zhengzhe Li, Wenjun Ju, Matthias Kretzler, Guang-Yan Cai, Xiang-Mei Chen, Vivette D. D’Agati, Steven G. Coca, Detlef Schlondorff, John C. He, Kyung Lee

J Am Soc Nephrol. 2019 Apr; 30(4): 546–562. Published online 2019 Mar 11. doi: 10.1681/ASN.2018060599

PMCID:: PMC6442349

Abstract Article

Select item 623697417.

Early Enhanced Leucine-Rich α-2-Glycoprotein-1 Expression in Glomerular Endothelial Cells of Type 2 Diabetic Nephropathy Model Mice

Sona haku, Hiromichi Wakui, Kengo Azushima, Kotaro Haruhara, Sho Kinguchi, Kohji Ohki, Kazushi Uneda, Ryu Kobayashi, Miyuki Matsuda, Takahiro Yamaji, Takayuki Yamada, Shintaro Minegishi, Tomoaki Ishigami, Akio Yamashita, Kenichi Ohashi, Kouichi Tamura

Biomed Res Int. 2018; 2018: 2817045. Published online 2018 Nov 1. doi: 10.1155/2018/2817045

PMCID:: PMC6236974

Abstract Article PDF–2.9M

Select item 574270818.

Leucine‐rich α‐2 glycoprotein promotes lung fibrosis by modulating TGF‐β signaling in fibroblasts

Hiromi Honda, Minoru Fujimoto, Satoshi Serada, Hayato Urushima, Takashi Mishima, Hyun Lee, Tomoharu Ohkawara, Nobuoki Kohno, Noboru Hattori, Akihito Yokoyama, Tetsuji Naka

Physiol Rep. 2017 Dec; 5(24): e13556. Published online 2017 Dec 26. doi: 10.14814/phy2.13556

PMCID:: PMC5742708

Abstract Article PDF–2.6M

Select item 547195619.

Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells

Hayato Urushima, Minoru Fujimoto, Takashi Mishima, Tomoharu Ohkawara, Hiromi Honda, Hyun Lee, Hirohisa Kawahata, Satoshi Serada, Tetsuji Naka

Arthritis Res Ther. 2017; 19: 137. Published online 2017 Jun 14. doi: 10.1186/s13075-017-1349-2

PMCID:: PMC5471956

Abstract Article PDF–1.6M

Select item 538653220.

TNF-α-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis

Yiyun Wang, Jiajia Xu, Xudong Zhang, Chuandong Wang, Yan Huang, Kerong Dai, Xiaoling Zhang

Cell Death Dis. 2017 Mar; 8(3): e2715. Published online 2017 Mar 30. doi: 10.1038/cddis.2017.129

PMCID:: PMC5386532

Abstract Article PDF–2.7M

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