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Items: 1 to 20 of 102

1.
Proximal Binding Pocket Arg717 Substitutions in Escherichia coli AcrB Cause Clinically Relevant Divergencies in Resistance Profiles
Martijn Zwama, Kunihiko Nishino
Antimicrob Agents Chemother. 2022 Apr; 66(4): e02392-21. Published online 2022 Mar 21. doi: 10.1128/aac.02392-21
PMCID:
PMC9017336
AbstractArticlePDF–2.2M
2.
Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
Coline Plé, Heng-Keat Tam, Anais Vieira Da Cruz, Nina Compagne, Juan-Carlos Jiménez-Castellanos, Reinke T. Müller, Elizabeth Pradel, Wuen Ee Foong, Giuliano Malloci, Alexia Ballée, Moritz A. Kirchner, Parisa Moshfegh, Adrien Herledan, Andrea Herrmann, Benoit Deprez, Nicolas Willand, Attilio Vittorio Vargiu, Klaas M. Pos, Marion Flipo, Ruben C. Hartkoorn
Nat Commun. 2022; 13: 115. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27726-2
PMCID:
PMC8749003
AbstractArticlePDF–1.6M
3.
In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution
Muyuan Chen, Xiaodong Shi, Zhili Yu, Guizhen Fan, Irina I. Serysheva, Matthew L. Baker, Ben F. Luisi, Steven J. Ludtke, Zhao Wang
Structure. Author manuscript; available in PMC 2023 Jan 6.
Published in final edited form as: Structure. 2022 Jan 6; 30(1): 107–113.e3. Published online 2021 Sep 9. doi: 10.1016/j.str.2021.08.008
PMCID:
PMC8741639
AbstractArticlePDF–1.1M
4.
Allosteric drug transport mechanism of multidrug transporter AcrB
Heng-Keat Tam, Wuen Ee Foong, Christine Oswald, Andrea Herrmann, Hui Zeng, Klaas M. Pos
Nat Commun. 2021; 12: 3889. Published online 2021 Jun 29. doi: 10.1038/s41467-021-24151-3
PMCID:
PMC8242077
AbstractArticlePDF–2.6M
5.
Metabolomics Reveal Potential Natural Substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium
Xuan Wang-Kan, Giovanny Rodríguez-Blanco, Andrew D. Southam, Catherine L. Winder, Warwick B. Dunn, Alasdair Ivens, Laura J. V. Piddock
mBio. 2021 Mar-Apr; 12(2): e00109-21. Published online 2021 Mar 30. doi: 10.1128/mBio.00109-21
PMCID:
PMC8092203
AbstractArticlePDF–2.1M
6.
Cryo-EM analysis of a membrane protein embedded in the liposome
Xia Yao, Xiao Fan, Nieng Yan
Proc Natl Acad Sci U S A. 2020 Aug 4; 117(31): 18497–18503. Published online 2020 Jul 17. doi: 10.1073/pnas.2009385117
PMCID:
PMC7414195
AbstractArticlePDF–2.5M
7.
Conformational dynamics of AcrA govern multidrug efflux pump assembly
Anthony J. Hazel, Narges Abdali, Inga V. Leus, Jerry M. Parks, Jeremy C. Smith, Helen I. Zgurskaya, James C. Gumbart
ACS Infect Dis. Author manuscript; available in PMC 2020 Nov 8.
Published in final edited form as: ACS Infect Dis. 2019 Nov 8; 5(11): 1926–1935. Published online 2019 Sep 26. doi: 10.1021/acsinfecdis.9b00273
PMCID:
PMC7301636
AbstractArticlePDF–1.7M
8.
Substrate Dependent Transport Mechanism in AcrB of Multidrug Resistance Bacteria
Yead Jewel, Quyen Van Dinh, Jin Liu, Prashanta Dutta
Proteins. Author manuscript; available in PMC 2021 Jul 1.
Published in final edited form as: Proteins. 2020 Jul; 88(7): 853–864. Published online 2020 Feb 8. doi: 10.1002/prot.25877
PMCID:
PMC7292753
AbstractArticlePDF–1.6M
9.
Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment
Dijun Du, Arthur Neuberger, Mona Wu Orr, Catherine E. Newman, Pin-Chia Hsu, Firdaus Samsudin, Andrzej Szewczak-Harris, Leana M. Ramos, Mekdes Debela, Syma Khalid, Gisela Storz, Ben F. Luisi
Structure. 2020 Jun 2; 28(6): 625–634.e6. doi: 10.1016/j.str.2020.03.013
PMCID:
PMC7267776
AbstractArticle
10.
Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold
Adam T. Green, Mohammad Moniruzzaman, Connor J. Cooper, John K. Walker, Jeremy C. Smith, Jerry M. Parks, Helen I. Zgurskaya
Biochim Biophys Acta Gen Subj. Author manuscript; available in PMC 2021 Jun 1.
Published in final edited form as: Biochim Biophys Acta Gen Subj. 2020 Jun; 1864(6): 129546. Published online 2020 Feb 4. doi: 10.1016/j.bbagen.2020.129546
PMCID:
PMC7153915
AbstractArticlePDF–1.5M
11.
Mapping the Dynamic Functions and Structural Features of AcrB Efflux Pump Transporter Using Accelerated Molecular Dynamics Simulations
Shirin Jamshidi, J. Mark Sutton, Khondaker Miraz Rahman
Sci Rep. 2018; 8: 10470. Published online 2018 Jul 11. doi: 10.1038/s41598-018-28531-6
Correction in:
Sci Rep. 2019; 9: 18260.
PMCID:
PMC6041327
AbstractArticlePDF–2.3M
12.
Energetics and conformational pathways of functional rotation in the multidrug transporter AcrB
Yasuhiro Matsunaga, Tsutomu Yamane, Tohru Terada, Kei Moritsugu, Hiroshi Fujisaki, Satoshi Murakami, Mitsunori Ikeguchi, Akinori Kidera
eLife. 2018; 7: e31715. Published online 2018 Mar 6. doi: 10.7554/eLife.31715
PMCID:
PMC5839741
AbstractArticlePDF–4.1M
13.
Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition
Martijn Zwama, Seiji Yamasaki, Ryosuke Nakashima, Keisuke Sakurai, Kunihiko Nishino, Akihito Yamaguchi
Nat Commun. 2018; 9: 124. Published online 2018 Jan 9. doi: 10.1038/s41467-017-02493-1
PMCID:
PMC5760665
AbstractArticlePDF–2.0M
14.
CsrA maximizes expression of the AcrAB multidrug resistance transporter
Vito Ricci, Victoria Attah, Tim Overton, David C. Grainger, Laura J.V. Piddock
Nucleic Acids Res. 2017 Dec 15; 45(22): 12798–12807. Published online 2017 Oct 13. doi: 10.1093/nar/gkx929
PMCID:
PMC5727465
AbstractArticlePDF–2.1M
15.
Energy-coupling mechanism of the multidrug resistance transporter AcrB: Evidence for membrane potential-driving hypothesis through mutagenic analysis
Min Liu, Xuejun C. Zhang
Protein Cell. 2017 Aug; 8(8): 623–627. Published online 2017 May 11. doi: 10.1007/s13238-017-0417-3
PMCID:
PMC5546932
ArticlePDF–1021K
16.
An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
Zhao Wang, Guizhen Fan, Corey F Hryc, James N Blaza, Irina I Serysheva, Michael F Schmid, Wah Chiu, Ben F Luisi, Dijun Du
eLife. 2017; 6: e24905. Published online 2017 Mar 29. doi: 10.7554/eLife.24905
PMCID:
PMC5404916
AbstractArticlePDF–2.9M
17.
Effect of site-directed mutations in multidrug efflux pump AcrB examined by quantitative efflux assays
Alfred D. Kinana, Attilio V. Vargiu, Hiroshi Nikaido
Biochem Biophys Res Commun. Author manuscript; available in PMC 2017 Nov 25.
Published in final edited form as: Biochem Biophys Res Commun. 2016 Nov 25; 480(4): 552–557. Published online 2016 Oct 24. doi: 10.1016/j.bbrc.2016.10.083
PMCID:
PMC5137507
AbstractArticlePDF–1.1M
18.
Design of New Antibacterial Enhancers Based on AcrB’s Structure and the Evaluation of Their Antibacterial Enhancement Activity
Yi Song, Rongxin Qin, Xichun Pan, Qin Ouyang, Tianyu Liu, Zhaoxia Zhai, Yingchun Chen, Bin Li, Hong Zhou
Int J Mol Sci. 2016 Nov; 17(11): 1934. Published online 2016 Nov 18. doi: 10.3390/ijms17111934
PMCID:
PMC5133929
AbstractArticlePDF–3.5M
19.
Study of the degradation of a multidrug transporter using a non-radioactive pulse chase method
Qian Chai, Stacy R. Webb, Zhaoshuai Wang, Rebecca E. Dutch, Yinan Wei
Anal Bioanal Chem. Author manuscript; available in PMC 2017 Nov 1.
Published in final edited form as: Anal Bioanal Chem. 2016 Nov; 408(27): 7745–7751. Published online 2016 Aug 22. doi: 10.1007/s00216-016-9871-7
PMCID:
PMC5063704
AbstractArticlePDF–605K
20.
Substrate-dependent dynamics of the multidrug efflux transporter AcrB of Escherichia coli
Kentaro Yamamoto, Rei Tamai, Megumi Yamazaki, Takehiko Inaba, Yoshiyuki Sowa, Ikuro Kawagishi
Sci Rep. 2016; 6: 21909. Published online 2016 Feb 26. doi: 10.1038/srep21909
PMCID:
PMC4768149
AbstractArticlePDF–1.1M

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