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Select item 111601591.

Identification of candidate predictive markers of anticancer drug sensitivity using a panel of human cancer cell lines

Shingo Dan, Mieko Shirakawa, Yumiko Mukai, Yoko Yoshida, Kanami Yamazaki, Tokuichi Kawaguchi, Masaaki Matsuura, Yusuke Nakamura, Takao Yamori

Cancer Sci. 2003 Dec; 94(12): 1074–1082. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2003.tb01403.x

PMCID:: PMC11160159

Abstract Article PDF–512K

Select item 105169882.

Functional genomics identify causal variant underlying the protective CTSH locus for Alzheimer’s disease

Yu Li, Min Xu, Bo-Lin Xiang, Xiao Li, Deng-Feng Zhang, Hui Zhao, Rui Bi, Yong-Gang Yao

Neuropsychopharmacology. 2023 Oct; 48(11): 1555–1566. Published online 2023 Feb 4. doi: 10.1038/s41386-023-01542-2

PMCID:: PMC10516988

Abstract Article PDF–2.0M

Select item 92792853.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 91631884.

USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c

Ye Yao, Weijie Ma, Yonghua Guo, Yingyi Liu, Peng Xia, Xiaoling Wu, Yiran Chen, Kunlei Wang, Chengjie Mei, Ganggang Wang, Xiaomian Li, Zhonglin Zhang, Xi Chen, Yufeng Yuan

Oncogenesis. 2022 Dec; 11(1): 31. Published online 2022 Jun 2. doi: 10.1038/s41389-022-00404-8

Correction in:: Oncogenesis. 2023 Dec; 12(1): 27.

PMCID:: PMC9163188

Abstract Article PDF–8.2M

Select item 91197365.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 89305156.

Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination

Angelo Cirinelli, Justin Wheelan, Christopher Grieg, Carlos A. Molina

Exp Cell Res. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Exp Cell Res. 2022 May 1; 414(1): 113083. Published online 2022 Feb 26. doi: 10.1016/j.yexcr.2022.113083

PMCID:: PMC8930515

Abstract Article PDF–1.9M

Select item 81913117.

Genetic and environmental factors regulate the type 1 diabetes gene CTSH via differential DNA methylation

Jody Ye, Mihaela Stefan-Lifshitz, Yaron Tomer

J Biol Chem. 2021 Jan-Jun; 296: 100774. Published online 2021 May 14. doi: 10.1016/j.jbc.2021.100774

PMCID:: PMC8191311

Abstract Article PDF–1.3M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 69277549.

Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong

eLife. 2019; 8: e50223. Published online 2019 Nov 19. doi: 10.7554/eLife.50223

PMCID:: PMC6927754

Abstract Article PDF–5.1M

Select item 607772210.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115

PMCID:: PMC6077722

Abstract Article PDF–2.4M

Select item 605944011.

Crystal structures of human procathepsin H

Yue Hao, Whitney Purtha, Christa Cortesio, Huan Rui, Yan Gu, Hao Chen, E. Allen Sickmier, Paolo Manzanillo, Xin Huang

PLoS One. 2018; 13(7): e0200374. Published online 2018 Jul 25. doi: 10.1371/journal.pone.0200374

Correction in:: PLoS One. 2019; 14(6): e0218063.

PMCID:: PMC6059440

Abstract Article PDF–6.9M

Select item 553161112.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 539772113.

Cathepsin H–Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases

Zemin Yang, Yu Liu, Lan Qin, Pengfei Wu, Zanxian Xia, Mei Luo, Yilan Zeng, Hidekazu Tsukamoto, Zongyun Ju, Danmei Su, Han Kang, Zhixiong Xiao, Sujun Zheng, Zhongping Duan, Richard Hu, Qiang Wang, Stephen J. Pandol, Yuan-Ping Han

Am J Pathol. 2017 Apr; 187(4): 781–797. doi: 10.1016/j.ajpath.2016.12.001

PMCID:: PMC5397721

Abstract Article PDF–2.8M

Select item 478474114.

Exogenous Thyropin from p41 Invariant Chain Diminishes Cysteine Protease Activity and Affects IL-12 Secretion during Maturation of Human Dendritic Cells

Tina Zavašnik-Bergant, Martina Bergant Marušič

PLoS One. 2016; 11(3): e0150815. Published online 2016 Mar 9. doi: 10.1371/journal.pone.0150815

PMCID:: PMC4784741

Abstract Article PDF–8.6M

Select item 461721115.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 422362716.

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver

Alexandra Naba, Karl R Clauser, Charles A Whittaker, Steven A Carr, Kenneth K Tanabe, Richard O Hynes

BMC Cancer. 2014; 14: 518. Published online 2014 Jul 18. doi: 10.1186/1471-2407-14-518

PMCID:: PMC4223627

Abstract Article PDF–1.5M

Select item 410487217.

CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients

Tina Fløyel, Caroline Brorsson, Lotte B. Nielsen, Michela Miani, Claus Heiner Bang-Berthelsen, Martin Friedrichsen, Anne Julie Overgaard, Lukas A. Berchtold, Anna Wiberg, Pernille Poulsen, Lars Hansen, Silke Rosinger, Bernhard O. Boehm, Ramesh Ram, Quang Nguyen, Munish Mehta, Grant Morahan, Patrick Concannon, Regine Bergholdt, Jens H. Nielsen, Thomas Reinheckel, Matthias von Herrath, Allan Vaag, Decio Laks Eizirik, Henrik B. Mortensen, Joachim Størling, Flemming Pociot

Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28): 10305–10310. Published online 2014 Jun 30. doi: 10.1073/pnas.1402571111

PMCID:: PMC4104872

Abstract Article PDF–1.0M

Select item 377350518.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

Simona Principe, E. Ellen Jones, Yunee Kim, Ankit Sinha, Julius O. Nyalwidhe, Jasmin Brooks, O. John Semmes, Dean A. Troyer, Raymond S. Lance, Thomas Kislinger, Richard R. Drake

Proteomics. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Proteomics. 2013 May; 13(0): 1667–1671. Published online 2013 Apr 23. doi: 10.1002/pmic.201200561

PMCID:: PMC3773505

Abstract Article PDF–630K

Select item 370996619.

HIV-1 Vpr Modulates Macrophage Metabolic Pathways: A SILAC-Based Quantitative Analysis

Carlos A. Barrero, Prasun K. Datta, Satarupa Sen, Satish Deshmane, Shohreh Amini, Kamel Khalili, Salim Merali

PLoS One. 2013; 8(7): e68376. Published online 2013 Jul 12. doi: 10.1371/journal.pone.0068376

PMCID:: PMC3709966

Abstract Article PDF–1.3M

Select item 359018320.

The Expression and Activity of Cathepsins D, H and K in Asthmatic Airways

Alen Faiz, Gavin Tjin, Louise Harkness, Markus Weckmann, Shisan Bao, Judith L. Black, Brian G. G. Oliver, Janette K. Burgess

PLoS One. 2013; 8(3): e57245. Published online 2013 Mar 6. doi: 10.1371/journal.pone.0057245

Correction in:: PLoS One. 2014; 9(1): 10.1371/annotation/d2be9c62-8d74-4cfb-b49c-b900ea8cd17c.

PMCID:: PMC3590183

Abstract Article PDF–633K

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