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Select item 111583681.

Nemo‐like kinase suppresses a wide range of transcription factors, including nuclear factor‐kB

Jun Yasuda, Hideki Yokoo, Tesshi Yamada, Issay Kitabayashi, Takao Sekiya, Hitoshi Ichikawa

Cancer Sci. 2004 Jan; 95(1): 52–57. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2004.tb03170.x

PMCID:: PMC11158368

Abstract Article PDF–509K

Select item 104252132.

Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43–related neurodegeneration

Leon Tejwani, Youngseob Jung, Hiroshi Kokubu, Sowmithra Sowmithra, Luhan Ni, Changwoo Lee, Benjamin Sanders, Paul J. Lee, Yangfei Xiang, Kimberly Luttik, Armand Soriano, Jennifer Yoon, Junhyun Park, Hannah H. Ro, Hyoungseok Ju, Clara Liao, Sofia Massaro Tieze, Frank Rigo, Paymaan Jafar-Nejad, Janghoo Lim

J Clin Invest. 2023 Aug 15; 133(16): e138207. Published online 2023 Aug 15. doi: 10.1172/JCI138207

PMCID:: PMC10425213

Abstract Article PDF–19M

Select item 102297433.

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN

Kaini Zhang, Chen Yang, Xin Zhou, Jin Liang, Jianjin Guo, Min Li, Yi Zhang, Shulin Shao, Peng Sun, Kai Li, Jingjing Huang, Fang Chen, Xiubin Liang, Dongming Su

Cell Mol Life Sci. 2023 Jun; 80(6): 168. Published online 2023 May 30. doi: 10.1007/s00018-023-04820-w

PMCID:: PMC10229743

Abstract Article PDF–2.9M

Select item 91813604.

The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway

Bin Zhao, Claudia Schlesiger, Maria G. Masucci, Kristina Lindsten

J Cell Mol Med. 2009 Aug; 13(8b): 1886–1895. Published online 2009 Nov 26. doi: 10.1111/j.1582-4934.2008.00682.x

PMCID:: PMC9181360

Abstract Article PDF–947K

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73342206.

Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase

M. C. Wilkes, K. Siva, J. Chen, G. Varetti, M. Y. Youn, H. Chae, F. Ek, R. Olsson, T. Lundbäck, D. P. Dever, T. Nishimura, A. Narla, B. Glader, H. Nakauchi, M. H. Porteus, C. E. Repellin, H. T. Gazda, S. Lin, M. Serrano, J. Flygare, K. M. Sakamoto

Nat Commun. 2020; 11: 3344. Published online 2020 Jul 3. doi: 10.1038/s41467-020-17100-z

PMCID:: PMC7334220

Abstract Article PDF–2.4M

Select item 72548507.

Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington’s disease

Mali Jiang, Xiaoyan Zhang, Hongshuai Liu, Jared LeBron, Athanasios Alexandris, Qi Peng, Hao Gu, Fanghan Yang, Yuchen Li, Ruiling Wang, Zhipeng Hou, Nicolas Arbez, Qianwei Ren, Jen-Li Dong, Emma Whela, Ronald Wang, Tamara Ratovitski, Juan C Troncoso, Susumu Mori, Christopher A Ross, Janghoo Lim, Wenzhen Duan

Hum Mol Genet. 2020 May 28; 29(8): 1340–1352. Published online 2020 Apr 2. doi: 10.1093/hmg/ddaa061

PMCID:: PMC7254850

Abstract Article PDF–1.3M

Select item 71699838.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 71605569.

NLK interacts with 14-3-3ζ to restore the expression of E-cadherin

Jie Chen, Qingfeng Lin, Tingting Ni, Jiyi Zhao, Feng Lin, Xiangdong Lu, Ye Lv, Shujuan Ren, Zhili Liu, Ting Zhang, Shuyan He, Dong Shen, Weidong Mao

Oncol Rep. 2020 Jun; 43(6): 1845–1852. Published online 2020 Mar 20. doi: 10.3892/or.2020.7557

PMCID:: PMC7160556

Abstract Article PDF–1.1M

Select item 674264610.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 666792411.

Knockdown of Nemo-like kinase promotes metastasis in non-small-cell lung cancer

Cui Shi, Liqin Xu, Zhiyuan Tang, Weishuai Zhang, Yulin Wei, Jun Ni, Shuwen Zhang, Jian Feng

Oncol Rep. 2019 Sep; 42(3): 1090–1100. Published online 2019 Jul 9. doi: 10.3892/or.2019.7226

PMCID:: PMC6667924

Abstract Article PDF–1.0M

Select item 664220512.

Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response

Shang-Ze Li, Qi-Peng Shu, Yang Song, Hui-Hui Zhang, Yi Liu, Bing-Xue Jin, Tian-Zi Liuyu, Chao Li, Xi-Chen Huang, Run-Lei Du, Wei Song, Bo Zhong, Xiao-Dong Zhang

Nat Commun. 2019; 10: 3233. Published online 2019 Jul 19. doi: 10.1038/s41467-019-11258-x

PMCID:: PMC6642205

Abstract Article PDF–2.9M

Select item 644400113.

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

Veerle Fleskens, Carlos M. Minutti, Xingmei Wu, Ping Wei, Cornelieke E.G.M. Pals, James McCrae, Saskia Hemmers, Vincent Groenewold, Harm-Jan Vos, Alexander Rudensky, Fan Pan, Huabin Li, Dietmar M. Zaiss, Paul J. Coffer

Cell Rep. 2019 Mar 26; 26(13): 3600–3612.e6. Published online 2019 Mar 26. doi: 10.1016/j.celrep.2019.02.087

PMCID:: PMC6444001

Abstract Article

Select item 570387814.

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

Ramesh Kumar, Román González-Prieto, Zhenyu Xiao, Matty Verlaan-de Vries, Alfred C. O. Vertegaal

Nat Commun. 2017; 8: 1809. Published online 2017 Nov 27. doi: 10.1038/s41467-017-01900-x

PMCID:: PMC5703878

Abstract Article PDF–3.7M

Select item 553161115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549522516.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 521012217.

Phosphorylation by NLK inhibits YAP‐14‐3‐3‐interactions and induces its nuclear localization

Sungho Moon, Wantae Kim, Soyoung Kim, Youngeun Kim, Yonghee Song, Oleksii Bilousov, Jiyoung Kim, Taebok Lee, Boksik Cha, Minseong Kim, Hanjun Kim, Vladimir L Katanaev, Eek‐hoon Jho

EMBO Rep. 2017 Jan; 18(1): 61–71. Published online 2016 Dec 15. doi: 10.15252/embr.201642683

PMCID:: PMC5210122

Abstract Article PDF–2.1M

Select item 496838018.

Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34⁺ cells

Kshama Gupta, Inna Kuznetsova, Olga Klimenkova, Maksim Klimiankou, Johann Meyer, Malcolm A. S. Moore, Cornelia Zeidler, Karl Welte, Julia Skokowa

Blood. 2014 Apr 17; 123(16): 2550–2561. Prepublished online 2014 Jan 6. doi: 10.1182/blood-2012-09-456889

PMCID:: PMC4968380

Abstract Article

Select item 481750719.

Nemo-like kinase regulates the expression of vascular endothelial growth factor (VEGF) in alveolar epithelial cells

Hengning Ke, Katarzyna Chmielarska Masoumi, Kristofer Ahlqvist, Michael J. Seckl, Kristina Rydell-Törmänen, Ramin Massoumi

Sci Rep. 2016; 6: 23987. Published online 2016 Apr 1. doi: 10.1038/srep23987

PMCID:: PMC4817507

Abstract Article PDF–1.5M

Select item 481526720.

Nemo-like kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate cancer

Jian Wang, Zhi-Hong Yang, Hua Chen, Hua-Hui Li, Li-Yong Chen, Zhu Zhu, Ying Zou, Cong-Cong Ding, Jing Yang, Zhi-Wei He

BMC Cancer. 2016; 16: 257. Published online 2016 Mar 31. doi: 10.1186/s12885-016-2291-4

PMCID:: PMC4815267

Abstract Article PDF–2.3M

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