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Select item 114252641.

TRIM65/NF2/YAP1 Signaling Coordinately Orchestrates Metabolic and Immune Advantages in Hepatocellular Carcinoma

Zhixuan Bian, Chang Xu, Xiaoying Wang, Baohua Zhang, Yixuan Xiao, Li Liu, Shasha Zhao, Nan Huang, Fengjiao Yang, Yue Zhang, Shaobo Xue, Xiongjun Wang, Qiuhui Pan, Fenyong Sun

Adv Sci (Weinh) 2024 Sep; 11(35): 2402578. Published online 2024 Jul 15. doi: 10.1002/advs.202402578

PMCID:: PMC11425264

Abstract Article PDF–9.0M

Select item 112090812.

Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription

Sheng Shen, Ran Yan, Zhanglian Xie, Xiaoyang Yu, Hongyan Liang, Qiuhong You, Hu Zhang, Jinlin Hou, Xiaoyong Zhang, Yuanjie Liu, Jian Sun, Haitao Guo

Viruses. 2024 Jun; 16(6): 890. Published online 2024 May 31. doi: 10.3390/v16060890

PMCID:: PMC11209081

Abstract Article PDF–3.7M

Select item 103719873.

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development

Anthony J. Asmar, Shaun R. Abrams, Jenny Hsin, Jason C. Collins, Rita M. Yazejian, Youmei Wu, Jean Cho, Andrew D. Doyle, Samhitha Cinthala, Marleen Simon, Richard H. van Jaarsveld, David B. Beck, Laura Kerosuo, Achim Werner

Nat Commun. 2023; 14: 4499. Published online 2023 Jul 26. doi: 10.1038/s41467-023-40223-y

PMCID:: PMC10371987

Abstract Article PDF–3.9M

Select item 102794724.

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

Julie K. Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A. Donovan, Michelle W. Ma, Cyrus Y. Jin, Marilyn Leonard, Eric S. Fischer, Eric J. Bennett

Cell Rep. Author manuscript; available in PMC 2023 Jun 19.

Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112496. Published online 2023 May 9. doi: 10.1016/j.celrep.2023.112496

PMCID:: PMC10279472

Abstract Article PDF–2.9M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 94023076.

TRIM65 Promotes Malignant Cell Behaviors in Triple-Negative Breast Cancer by Impairing the Stability of LATS1 Protein

Yongbin Lu, Yi Xiao, Jingru Yang, Hongxin Su, Xiaobin Zhang, Fei Su, Baohong Tian, Da Zhao, Xiaoling Ling, Tao Zhang

Oxid Med Cell Longev. 2022; 2022: 4374978. Published online 2022 Aug 17. doi: 10.1155/2022/4374978

PMCID:: PMC9402307

Abstract Article PDF–3.2M

Select item 93406367.

TRIM65 determines the fate of a novel subtype of pituitary neuroendocrine tumors via ubiquitination and degradation of TPIT

Hong Yao, Wanqun Xie, Yuting Dai, Yanting Liu, Weiting Gu, Jianfeng Li, Liang Wu, Jing Xie, Weiwei Rui, Bohan Ren, Li Xue, Yijun Cheng, Shaojian Lin, Changsheng Li, Hao Tang, Yu Wang, Meiqing Lou, Xiaobiao Zhang, Ronggui Hu, Hanbing Shang, Jinyan Huang, Zhe Bao Wu

Neuro Oncol. 2022 Aug; 24(8): 1286–1297. Published online 2022 Feb 26. doi: 10.1093/neuonc/noac053

PMCID:: PMC9340636

Abstract Article PDF–21M

Select item 91052358.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 84362059.

LncRNA LINC00963 promotes colorectal cancer cell proliferation and metastasis by regulating miR-1281 and TRIM65

Haidong Lv, Dixia Zhou, Guoqing Liu

Mol Med Rep. 2021 Nov; 24(5): 781. Published online 2021 Sep 7. doi: 10.3892/mmr.2021.12421

PMCID:: PMC8436205

Abstract Article PDF–11M

Select item 842743010.

The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3

Tiantian Tang, Ping Li, Xinhui Zhou, Rui Wang, Xiuqin Fan, Mengyi Yang, Kemin Qi

Front Immunol. 2021; 12: 741839. Published online 2021 Aug 26. doi: 10.3389/fimmu.2021.741839

PMCID:: PMC8427430

Abstract Article PDF–2.1M

Select item 818367611.

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

Kazuki Kato, Sadeem Ahmad, Zixiang Zhu, Janet M. Young, Xin Mu, Sehoon Park, Harmit S. Malik, Sun Hur

Mol Cell. Author manuscript; available in PMC 2021 Jun 7.

Published in final edited form as: Mol Cell. 2021 Feb 4; 81(3): 599–613.e8. Published online 2020 Dec 28. doi: 10.1016/j.molcel.2020.11.047

PMCID:: PMC8183676

Abstract Article PDF–3.6M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 812022713.

KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1

Wenxue Liu, Zhiyan Zhan, Meiying Zhang, Bowen Sun, Qiqi Shi, Fei Luo, Mingda Zhang, Weiwei Zhang, Yanli Hou, Xiuying Xiao, Yanxin Li, Haizhong Feng

Theranostics. 2021; 11(13): 6278–6292. Published online 2021 Apr 15. doi: 10.7150/thno.57455

PMCID:: PMC8120227

Abstract Article PDF–2.7M

Select item 718172214.

TRIM65 E3 ligase targets VCAM-1 degradation to limit LPS-induced lung inflammation

Yong Li, Xuan Huang, Fang Guo, Tianhua Lei, Shitao Li, Paula Monaghan-Nichols, Zhisheng Jiang, Hong-Bo Xin, Mingui Fu

J Mol Cell Biol. 2020 Mar; 12(3): 190–201. Published online 2019 Jul 16. doi: 10.1093/jmcb/mjz077

PMCID:: PMC7181722

Abstract Article PDF–1.6M

Select item 677813715.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 675623616.

Ubiquitin ligase TRIM65 promotes colorectal cancer metastasis by targeting ARHGAP35 for protein degradation

Daici Chen, Yichen Li, Xiaowen Zhang, Haiyong Wu, Qian Wang, Jian Cai, Yanmei Cui, Huanliang Liu, Ping Lan, Jianping Wang, Zihuan Yang, Lei Wang

Oncogene. 2019; 38(37): 6429–6444. Published online 2019 Jul 22. doi: 10.1038/s41388-019-0891-6

PMCID:: PMC6756236

Abstract Article PDF–5.6M

Select item 659455117.

PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling

Adnan Shami Shah, Alex G. Batrouni, Dongsung Kim, Amith Punyala, Wendy Cao, Chun Han, Michael L. Goldberg, Marcus B. Smolka, Jeremy M. Baskin

Cell Rep. Author manuscript; available in PMC 2019 Jun 26.

Published in final edited form as: Cell Rep. 2019 May 14; 27(7): 2157–2170.e8. doi: 10.1016/j.celrep.2019.04.060

PMCID:: PMC6594551

Abstract Article PDF–1.4M

Select item 654668318.

Knockdown of TRIM65 inhibits autophagy and cisplatin resistance in A549/DDP cells by regulating miR-138-5p/ATG7

Xufeng Pan, Yong Chen, Yuzhou Shen, Jicheng Tantai

Cell Death Dis. 2019 Jun; 10(6): 429. Published online 2019 Jun 3. doi: 10.1038/s41419-019-1660-8

PMCID:: PMC6546683

Abstract Article PDF–3.8M

Select item 554841319.

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling

Parveen Kumar, Prathyusha Munnangi, KVS Rammohan Chowdary, Varun J. Shah, Swapnil R. Shinde, Nanci R. Kolli, Rachita R. Halehalli, Hampapathalu A. Nagarajaram, Subbareddy Maddika

J Proteome Res. 2017 Aug 4; 16(8): 2789–2801. Published online 2017 Jul 4. doi: 10.1021/acs.jproteome.7b00065

PMCID:: PMC5548413

Abstract Article PDF–5.2M

Select item 553161120.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

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