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Select item 65801701.

Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle

Dandan Xu, Kevin L. Shimkus, Holly A. Lacko, Lydia Kutzler, Leonard S. Jefferson, Scot R. Kimball

Am J Physiol Endocrinol Metab. 2019 May 1; 316(5): E817–E828. Published online 2019 Mar 5. doi: 10.1152/ajpendo.00522.2018

PMCID:: PMC6580170

Abstract Article

Select item 60794592.

Knockdown of Sestrin2 Increases Lipopolysaccharide-Induced Oxidative Stress, Apoptosis, and Fibrotic Reactions in H9c2 Cells and Heart Tissues of Mice via an AMPK-Dependent Mechanism

Hwan-Jin Hwang, Joo Won Kim, Hye Soo Chung, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo

Mediators Inflamm. 2018; 2018: 6209140. Published online 2018 Jul 5. doi: 10.1155/2018/6209140

Correction in:: Mediators Inflamm. 2019; 2019: 1905313.

PMCID:: PMC6079459

Abstract Article PDF–2.8M

Select item 50673003.

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

Deborah C.I. Goberdhan, Clive Wilson, Adrian L. Harris

Cell Metab. 2016 Apr 12; 23(4): 580–589. doi: 10.1016/j.cmet.2016.03.013

PMCID:: PMC5067300

Abstract Article PDF–2.2M

Select item 49589974.

Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats

Lingyu Li, Lina Xiao, Yanghao Hou, Qi He, Jin Zhu, Yixin Li, Jingxian Wu, Jing Zhao, Shanshan Yu, Yong Zhao

Sci Rep. 2016; 6: 30272. Published online 2016 Jul 25. doi: 10.1038/srep30272

PMCID:: PMC4958997

Abstract Article PDF–2.9M

Select item 46980395.

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

Robert A. Saxton, Kevin E. Knockenhauer, Rachel L. Wolfson, Lynne Chantranupong, Michael E. Pacold, Tim Wang, Thomas U. Schwartz, David M. Sabatini

Science. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: Science. 2016 Jan 1; 351(6268): 53–58. Published online 2015 Nov 19. doi: 10.1126/science.aad2087

PMCID:: PMC4698039

Abstract Article PDF–827K

Select item 46980176.

Sestrin2 is a leucine sensor for the mTORC1 pathway

Rachel L. Wolfson, Lynne Chantranupong, Robert A. Saxton, Kuang Shen, Sonia M. Scaria, Jason R. Cantor, David M. Sabatini

Science. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: Science. 2016 Jan 1; 351(6268): 43–48. Published online 2015 Oct 8. doi: 10.1126/science.aab2674

PMCID:: PMC4698017

Abstract Article PDF–1.4M

Select item 46746877.

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

Hanseong Kim, Sojin An, Seung-Hyun Ro, Filipa Teixeira, Gyeong Jin Park, Cheal Kim, Chun-Seok Cho, Jeong-Sig Kim, Ursula Jakob, Jun Hee Lee, Uhn-Soo Cho

Nat Commun. 2015; 6: 10025. Published online 2015 Nov 27. doi: 10.1038/ncomms10025

PMCID:: PMC4674687

Abstract Article PDF–2.5M

Select item 46618228.

Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury

Yao-Chung Chuang, Jenq-Lin Yang, Ding-I Yang, Tsu-Kung Lin, Chia-Wei Liou, Shang-Der Chen

Int J Mol Sci. 2015 Nov; 16(11): 26406–26416. Published online 2015 Nov 4. doi: 10.3390/ijms161125963

PMCID:: PMC4661822

Abstract Article PDF–3.5M

Select item 45083259.

Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation

Yi-Sheng Hou, Jun-Jie Guan, Hai-Dong Xu, Feng Wu, Rui Sheng, Zheng-Hong Qin

Mol Cell Biol. 2015 Aug; 35(16): 2740–2751. Prepublished online 2015 Jun 1. Published online 2015 Jul 20. doi: 10.1128/MCB.00285-15

PMCID:: PMC4508325

Abstract Article PDF–2.7M

Select item 437508210.

Sestrin 3 Protein Enhances Hepatic Insulin Sensitivity by Direct Activation of the mTORC2-Akt Signaling

Rongya Tao, Xiwen Xiong, Suthat Liangpunsakul, X. Charlie Dong

Diabetes. 2015 Apr; 64(4): 1211–1223. Published online 2014 Nov 4. doi: 10.2337/db14-0539

PMCID:: PMC4375082

Abstract Article PDF–2.1M

Select item 430354611.

Sestrins Inhibit mTORC1 Kinase Activation Through the GATOR Complex

Anita Parmigiani, Aida Nourbakhsh, Boxiao Ding, Wei Wang, Young Chul Kim, Konstantin Akopiants, Kun-Liang Guan, Michael Karin, Andrei V. Budanov

Cell Rep. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell Rep. 2014 Nov 20; 9(4): 1281–1291. doi: 10.1016/j.celrep.2014.10.019

PMCID:: PMC4303546

Abstract Article PDF–1.9M

Select item 422386612.

The Sestrins interact with GATOR2 to negatively regulate the amino acid sensing pathway upstream of mTORC1

Lynne Chantranupong, Rachel L. Wolfson, Jose M. Orozco, Robert A. Saxton, Sonia M. Scaria, Liron Bar-Peled, Eric Spooner, Marta Isasa, Steven P. Gygi, David M. Sabatini

Cell Rep. Author manuscript; available in PMC 2014 Nov 7.

Published in final edited form as: Cell Rep. 2014 Oct 9; 9(1): 1–8. Published online 2014 Sep 25. doi: 10.1016/j.celrep.2014.09.014

PMCID:: PMC4223866

Abstract Article PDF–616K

Select item 418135213.

Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling

Min Peng, Na Yin, Ming O. Li

Cell. Author manuscript; available in PMC 2015 Sep 25.

Published in final edited form as: Cell. 2014 Sep 25; 159(1): 122–133. doi: 10.1016/j.cell.2014.08.038

PMCID:: PMC4181352

Abstract Article PDF–2.7M

Select item 416673214.

Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells

Hiroko Hamatani, Keiju Hiromura, Toru Sakairi, Satoshi Takahashi, Mitsuharu Watanabe, Akito Maeshima, Takamoto Ohse, Jeffery W. Pippin, Stuart J. Shankland, Yoshihisa Nojima

Am J Physiol Renal Physiol. 2014 Sep 15; 307(6): F708–F717. Published online 2014 Jul 23. doi: 10.1152/ajprenal.00625.2013

PMCID:: PMC4166732

Abstract Article

Select item 415653215.

Sestrin2 Promotes Unc-51-like Kinase 1 (ULK1)-Mediated Phosphorylation of p62/sequestosome-1

Seung-Hyun Ro, Ian A. Semple, Haewon Park, Haeli Park, Hwan-Woo Park, Myungjin Kim, Jeong Sig Kim, Jun Hee Lee

FEBS J. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: FEBS J. 2014 Sep; 281(17): 3816–3827. Published online 2014 Jul 28. doi: 10.1111/febs.12905

PMCID:: PMC4156532

Abstract Article PDF–2.0M

Select item 407470716.

Hepatoprotective role of Sestrin2 against chronic ER stress

Hwan-Woo Park, Haeli Park, Seung-Hyun Ro, Insook Jang, Ian A. Semple, David N. Kim, Myungjin Kim, Myeongjin Nam, Deqiang Zhang, Lei Yin, Jun Hee Lee

Nat Commun. Author manuscript; available in PMC 2014 Dec 20.

Published in final edited form as: Nat Commun. 2014; 5: 4233. Published online 2014 Jun 20. doi: 10.1038/ncomms5233

PMCID:: PMC4074707

Abstract Article PDF–2.2M

Select item 375384517.

Sestrin 2 and AMPK Connect Hyperglycemia to Nox4-Dependent Endothelial Nitric Oxide Synthase Uncoupling and Matrix Protein Expression

Assaad A. Eid, Doug-Yoon Lee, Linda J. Roman, Khaled Khazim, Yves Gorin

Mol Cell Biol. 2013 Sep; 33(17): 3439–3460. doi: 10.1128/MCB.00217-13

PMCID:: PMC3753845

Abstract Article PDF–4.6M

Select item 368736518.

Maintenance of metabolic homeostasis by Sestrin 2 and 3

Jun Hee Lee, Andrei V. Budanov, Saswata Talukdar, Eek Joong Park, Hae Li Park, Hwan-Woo Park, Gautam Bandyopadhyay, Ning Li, Mariam Aghajan, Insook Jang, Amber M. Wolfe, Guy A. Perkins, Mark H. Ellisman, Ethan Bier, Miriam Scadeng, Marc Foretz, Benoit Viollet, Jerrold Olefsky, Michael Karin

Cell Metab. Author manuscript; available in PMC 2013 Jun 20.

Published in final edited form as: Cell Metab. 2012 Sep 5; 16(3): 311–321. doi: 10.1016/j.cmet.2012.08.004

PMCID:: PMC3687365

Abstract Article PDF–5.0M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 286663220.

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

Jun Hee Lee, Andrei V. Budanov, Eek Joong Park, Ryan Birse, Teddy E. Kim, Guy A. Perkins, Karen Ocorr, Mark H. Ellisman, Rolf Bodmer, Ethan Bier, Michael Karin

Science. Author manuscript; available in PMC 2011 Mar 5.

Published in final edited form as: Science. 2010 Mar 5; 327(5970): 1223–1228. doi: 10.1126/science.1182228