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Items: 1 to 20 of 48

1.
Cerebrotendinous Xanthomatosis patients with late diagnosed in single orthopedic clinic: two novel variants in the CYP27A1 gene
Muhammed Köroğlu, Mustafa Karakaplan, Enes Gündüz, Betül Kesriklioğlu, Emre Ergen, Okan Aslantürk, Zeynep Maraş Özdemir
Orphanet J Rare Dis. 2024; 19: 53. Published online 2024 Feb 9. doi: 10.1186/s13023-024-03082-4
PMCID:
PMC10858589
AbstractArticlePDF–2.8M
2.
27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor
Silia Ayadi, Silvia Friedrichs, Regis Soulès, Laly Pucheu, Dieter Lütjohann, Sandrine Silvente-Poirot, Marc Poirot, Philippe de Medina
J Lipid Res. 2023 Dec; 64(12): 100479. Published online 2023 Nov 20. doi: 10.1016/j.jlr.2023.100479
PMCID:
PMC10770617
AbstractArticlePDF–3.2M
3.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
4.
TUBB2B facilitates progression of hepatocellular carcinoma by regulating cholesterol metabolism through targeting HNF4A/CYP27A1
Xiaobo Wang, Jiawei Shi, Mingming Huang, Jiehong Chen, Jia Dan, Yunhua Tang, Zhiyong Guo, Xiaoshun He, Qiang Zhao
Cell Death Dis. 2023 Mar; 14(3): 179. Published online 2023 Mar 6. doi: 10.1038/s41419-023-05687-2
PMCID:
PMC9986231
AbstractArticlePDF–4.6M
5.
HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis
Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai
Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4
PMCID:
PMC9338313
AbstractArticlePDF–2.8M
6.
CYP27A1 dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism
Hyelim Cho, Qiong Shen, Lydia H. Zhang, Mikiko Okumura, Akinori Kawakami, Jessi Ambrose, Frederic Sigoillot, Howard R. Miller, Scott Gleim, Amanda Cobos-Correa, Ying Wang, Philippe Piechon, Guglielmo Roma, Fabian Eggimann, Charles Moore, Peter Aspesi, Jr., Felipa A. Mapa, Heather Burks, Nathan T. Ross, Philipp Krastel, Marc Hild, Thomas J. Maimone, David E. Fisher, Daniel K. Nomura, John A. Tallarico, Stephen M. Canham, Jeremy L. Jenkins, William C. Forrester
Cell Chem Biol. Author manuscript; available in PMC 2022 Oct 21.
Published in final edited form as: Cell Chem Biol. 2021 Oct 21; 28(10): 1407–1419.e6. Published online 2021 Mar 31. doi: 10.1016/j.chembiol.2021.03.004
PMCID:
PMC8481390
AbstractArticlePDF–1.5M
7.
Clinical and Genetic Characteristics of Splicing Variant in CYP27A1 in an Iranian Family with Cerebrotendinous xanthomatosis
Zahra Rashvand, Kimia Kahrizi, Hossein Najmabadi, Reza Najafipour, Mir Davood Omrani
Iran Biomed J. 2021 Mar; 25(2): 132–139. Published online 2021 Jan 19. doi: 10.29252/ibj.25.2.132
PMCID:
PMC7921520
AbstractArticlePDF–975K
8.
Dysregulation of vitamin D synthesis pathway genes in colorectal cancer: A case‐control study
Hossein Sadeghi, Zeeba Kamaliyan, Roohollah Mohseni, Unes Sahebi, Ehsan Nazemalhosseini‐Mojarad, Naser Aghaei, Mohammad Reza Zali, Hamid Asadzadeh Aghdaei, Reza Mirfakhraie, Arfa Moshiri
J Clin Lab Anal. 2021 Feb; 35(2): e23617. Published online 2020 Oct 14. doi: 10.1002/jcla.23617
PMCID:
PMC7891505
AbstractArticlePDF–469K
9.
CYP27A1 expression is associated with risk of late lethal estrogen receptor-positive breast cancer in postmenopausal patients
Siker Kimbung, Maria Inasu, Tor Stålhammar, Björn Nodin, Karin Elebro, Helga Tryggvadottir, Maria Ygland Rödström, Karin Jirström, Karolin Isaksson, Helena Jernström, Signe Borgquist
Breast Cancer Res. 2020; 22: 123. Published online 2020 Nov 11. doi: 10.1186/s13058-020-01347-x
PMCID:
PMC7656740
AbstractArticlePDF–1.2M
10.
Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding
Duc T. Tran, Anita Pottekat, Saiful A. Mir, Salvatore Loguercio, Insook Jang, Alexandre Rosa Campos, Kathleen M. Scully, Reyhaneh Lahmy, Ming Liu, Peter Arvan, William E. Balch, Randal J. Kaufman, Pamela Itkin-Ansari
Diabetes. 2020 Aug; 69(8): 1723–1734. Published online 2020 May 26. doi: 10.2337/db20-0245
PMCID:
PMC7372081
AbstractArticlePDF–2.0M
11.
Intratumoral sterol-27-hydroxylase (CYP27A1) expression in relation to cholesterol synthesis and vitamin D signaling and its association with lethal prostate cancer
Nabeela A. Khan, Konrad H. Stopsack, Emma H. Allott, Travis Gerke, Edward L. Giovannucci, Lorelei A. Mucci, Philip W. Kantoff
Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2020 Jun 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2019 Jun; 28(6): 1052–1058. Published online 2019 Mar 13. doi: 10.1158/1055-9965.EPI-18-1083
PMCID:
PMC6548616
AbstractArticlePDF–415K
12.
Vitamin D supplementation decreases serum 27-hydroxycholesterol in a pilot breast cancer trial
Catherine C. Going, Ludmila Alexandrova, Kenneth Lau, Christine Y. Yeh, David Feldman, Sharon J. Pitteri
Breast Cancer Res Treat. Author manuscript; available in PMC 2019 Feb 20.
Published in final edited form as: Breast Cancer Res Treat. 2018 Feb; 167(3): 797–802. Published online 2017 Nov 7. doi: 10.1007/s10549-017-4562-4
PMCID:
PMC6381934
AbstractArticlePDF–664K
13.
CYP27A1 inhibits bladder cancer cells proliferation by regulating cholesterol homeostasis
Zhijuan Liang, Yuanbin Chen, Liping Wang, Dan Li, Xuecheng Yang, Guofeng Ma, Yonghua Wang, Yongxin Li, Han Zhao, Ye Liang, Haitao Niu
Cell Cycle. 2019; 18(1): 34–45. Published online 2018 Dec 30. doi: 10.1080/15384101.2018.1558868
PMCID:
PMC6343703
AbstractArticlePDF–1.7M
14.
Prominent Tendon Xanthomas and Abdominal Aortic Aneurysm Associated with Cerebrotendinous Xanthomatosis Identified Using Whole Exome Sequencing
Hayato Tada, Syota Inaba, Daria Pozharitckaia, Masa-aki Kawashiri
Intern Med. 2018 Apr 15; 57(8): 1119–1122. Published online 2017 Dec 21. doi: 10.2169/internalmedicine.9687-17
PMCID:
PMC5938503
AbstractArticlePDF–576K
15.
CYP27A1 loss dysregulates cholesterol homeostasis in prostate cancer
Mahmoud A. Alfaqih, Erik R. Nelson, Wen Liu, Rachid Safi, Jeffery S. Jasper, Everardo Macias, Joseph Geradts, J. Will Thompson, Laura G. Dubois, Michael R. Freeman, Ching-yi Chang, Jen-Tsan Chi, Donald P. McDonnell, Stephen J. Freedland
Cancer Res. Author manuscript; available in PMC 2018 Apr 1.
Published in final edited form as: Cancer Res. 2017 Apr 1; 77(7): 1662–1673. Published online 2017 Jan 27. doi: 10.1158/0008-5472.CAN-16-2738
PMCID:
PMC5687884
AbstractArticlePDF–818K
16.
Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia
Hiten D. Mistry, Lesia O. Kurlak, Yosef T. Mansour, Line Zurkinden, Markus G. Mohaupt, Geneviève Escher
J Lipid Res. 2017 Jun; 58(6): 1186–1195. Published online 2017 Apr 10. doi: 10.1194/jlr.M071985
PMCID:
PMC5454503
AbstractArticlePDF–1.0M
17.
Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum
Natalia Mast, Kyle W. Anderson, Joseph B. Lin, Yong Li, Illarion V. Turko, Curtis Tatsuoka, Ingemar Bjorkhem, Irina A. Pikuleva
J Biol Chem. 2017 Mar 24; 292(12): 4913–4924. Published online 2017 Feb 11. doi: 10.1074/jbc.M116.774760
PMCID:
PMC5377805
AbstractArticlePDF–2.5M
18.
Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients
Lai Fun Thean, Yu Hui Wong, Michelle Lo, Carol Loi, Min Hoe Chew, Choong Leong Tang, Peh Yean Cheah
PLoS One. 2017; 12(3): e0173772. Published online 2017 Mar 17. doi: 10.1371/journal.pone.0173772
PMCID:
PMC5357012
AbstractArticlePDF–1.6M
19.
Panorama of ancient metazoan macromolecular complexes
Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili
Nature. Author manuscript; available in PMC 2016 Sep 26.
Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877
PMCID:
PMC5036527
AbstractArticlePDF–4.7M
20.
Apparent underdiagnosis of Cerebrotendinous Xanthomatosis revealed by analysis of ~60,000 human exomes
Vivek Appadurai, Andrea DeBarber, Pei-Wen Chiang, Shailendra B. Patel, Robert D Steiner, Charles Tyler, Penelope E. Bonnen
Mol Genet Metab. Author manuscript; available in PMC 2016 Dec 1.
Published in final edited form as: Mol Genet Metab. 2015 Dec; 116(4): 298–304. Published online 2015 Oct 26. doi: 10.1016/j.ymgme.2015.10.010
PMCID:
PMC4767010
AbstractArticlePDF–701K

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