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Select item 113167091.

Inhibition of the ubiquitin-proteasome system reduces the abundance of pyruvate dehydrogenase kinase 1 in cultured myotubes

Blaž Kociper, Nives Škorja Milić, Ivana Ogrizek, Katarina Miš, Sergej Pirkmajer

J Muscle Res Cell Motil. 2024; 45(3): 155–169. Published online 2024 Jul 31. doi: 10.1007/s10974-024-09679-3

PMCID:: PMC11316709

Abstract Article PDF–4.9M

Select item 112099352.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 110878163.

Long non‐coding RNA NEAT1 promotes aerobic glycolysis and progression of cervical cancer through WNT/β‐catenin/PDK1 axis

Min Su, Ziyan Liang, Shidong Shan, Yang Gao, Li He, Xuelian Liu, Anjin Wang, Hua Wang, Hongbing Cai

Cancer Med. 2024 May; 13(9): e7221. Published online 2024 May 11. doi: 10.1002/cam4.7221

PMCID:: PMC11087816

Abstract Article PDF–29M

Select item 108753654.

RP11-495P10.1 promotes HCC cell proliferation by regulating reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis: RP11-495P10.1 promotes HCC cell proliferation

Chi Liu, Jie Shi, Zhengyuan Jiang, Shan Jiang, Yuan Wu, Dongqian Peng, Jiebing Tang, Linchi Guo

Acta Biochim Biophys Sin (Shanghai) 2024 Jan 25; 56(1): 44–53. Published online 2023 Oct 30. doi: 10.3724/abbs.2023242

PMCID:: PMC10875365

Abstract Article PDF–1.8M

Select item 108692645.

Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression

Yi-Ying Chiou, Cing-Yun Lee, Hao-Wei Yang, Wei-Cheng Cheng, Kun-Da Ji

J Biol Chem. 2024 Feb; 300(2): 105637. Published online 2024 Jan 8. doi: 10.1016/j.jbc.2024.105637

PMCID:: PMC10869264

Abstract Article PDF–2.7M

Select item 105009386.

SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes

Juli Liu, Shiyong Wu, Yucheng Zhang, Cheng Wang, Sheng Liu, Jun Wan, Lei Yang

Stem Cell Res Ther. 2023; 14: 249. Published online 2023 Sep 13. doi: 10.1186/s13287-023-03485-3

PMCID:: PMC10500938

Abstract Article PDF–5.0M

Select item 103675557.

SDC2 Stabilization by USP14 Promotes Gastric Cancer Progression through Co-option of PDK1

Li You, Yi Dou, Yu Zhang, Hongwei Xiao, Hong Lv, Gong-Hong Wei, Dazhi Xu

Int J Biol Sci. 2023; 19(11): 3483–3498. Published online 2023 Jul 9. doi: 10.7150/ijbs.84331

PMCID:: PMC10367555

Abstract Article PDF–10M

Select item 103459638.

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald

Clin Cancer Res. 2023 Jul 14; 29(14): 2686–2701. Published online 2023 Mar 28. doi: 10.1158/1078-0432.CCR-22-2535

PMCID:: PMC10345963

Abstract Article PDF–13M

Select item 103183889.

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk

Maria J Forteza, Martin Berg, Andreas Edsfeldt, Jangming Sun, Roland Baumgartner, Ilona Kareinen, Felipe Beccaria Casagrande, Ulf Hedin, Song Zhang, Ivan Vuckovic, Petras P Dzeja, Konstantinos A Polyzos, Anton Gisterå, Mette Trauelsen, Thue W Schwartz, Lea Dib, Joerg Herrmann, Claudia Monaco, Ljubica Matic, Isabel Gonçalves, Daniel F J Ketelhuth

Cardiovasc Res. 2023 Jun; 119(7): 1524–1536. Published online 2023 Mar 2. doi: 10.1093/cvr/cvad038

PMCID:: PMC10318388

Abstract Article PDF–83M

Select item 1024470310.

The transcription factor Foxp1 regulates aerobic glycolysis in adipocytes and myocytes

Haixia Ma, Valentina Sukonina, Wei Zhang, Fang Meng, Santhilal Subhash, Henrik Palmgren, Ida Alexandersson, Huiming Han, Shuping Zhou, Stefano Bartesaghi, Chandrasekhar Kanduri, Sven Enerbäck

J Biol Chem. 2023 Jun; 299(6): 104795. Published online 2023 May 5. doi: 10.1016/j.jbc.2023.104795

PMCID:: PMC10244703

Abstract Article PDF–3.8M

Select item 1023742211.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1007894912.

CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis

Qiancheng He, Qiongyu Hao, Yanyuan Wu, Jaydutt V. Vadgama, Yiyan Jiang

Life Sci. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Life Sci. 2023 Jan 1; 312: 121128. Published online 2022 Nov 2. doi: 10.1016/j.lfs.2022.121128

PMCID:: PMC10078949

Abstract Article PDF–2.1M

Select item 988777113.

PKCβII activation requires nuclear trafficking for phosphorylation and Mdm2-mediated ubiquitination

Xiao Min, Shujie Wang, Xiaohan Zhang, Ningning Sun, Kyeong-Man Kim

Life Sci Alliance. 2023 Apr; 6(4): e202201748. Published online 2023 Jan 30. doi: 10.26508/lsa.202201748

PMCID:: PMC9887771

Abstract Article PDF–2.6M

Select item 945037414.

Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1

Jiewei Lin, Xinjing Wang, Shuyu Zhai, Minmin Shi, Chenghong Peng, Xiaxing Deng, Da Fu, Jiancheng Wang, Baiyong Shen

J Hematol Oncol. 2022; 15: 128. Published online 2022 Sep 6. doi: 10.1186/s13045-022-01348-7

PMCID:: PMC9450374

Abstract Article PDF–10M

Select item 925870615.

FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1

Qing Yang, Fang Wu, Yong Zhang, Rensheng Wang

J Cell Mol Med. 2022 Jul; 26(13): 3783–3796. Published online 2022 Jun 3. doi: 10.1111/jcmm.17413

PMCID:: PMC9258706

Abstract Article PDF–9.6M

Select item 913694316.

Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy

Bhaskar Saha, Michelle Salemi, Geneva L. Williams, Seeun Oh, Michael L. Paffett, Brett Phinney, Michael A. Mandell

Cell Rep. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell Rep. 2022 May 10; 39(6): 110797. doi: 10.1016/j.celrep.2022.110797

PMCID:: PMC9136943

Abstract Article PDF–3.2M

Select item 905883617.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 898544318.

Proximity-dependent labeling of Cysteines

Sudeshna Sen, Nadia Sultana, Scott A. Shaffer, Paul R. Thompson

J Am Chem Soc. Author manuscript; available in PMC 2022 Apr 6.

Published in final edited form as: J Am Chem Soc. 2021 Nov 24; 143(46): 19257–19261. Published online 2021 Nov 11. doi: 10.1021/jacs.1c07069

PMCID:: PMC8985443

Abstract Article PDF–1.4M

Select item 889702219.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 889438020.

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing

Alexandra Bergfort, Marco Preußner, Benno Kuropka, İbrahim Avşar Ilik, Tarek Hilal, Gert Weber, Christian Freund, Tuğçe Aktaş, Florian Heyd, Markus C. Wahl

Nat Commun. 2022; 13: 1132. Published online 2022 Mar 3. doi: 10.1038/s41467-022-28754-2

PMCID:: PMC8894380

Abstract Article PDF–5.6M

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