PMC Links for GEO Profiles (Select 36815519) - PMC

Select item 64306581.

A chemoproteomic portrait of the oncometabolite fumarate

Rhushikesh A. Kulkarni, Daniel W. Bak, Darmood Wei, Sarah E. Bergholtz, Chloe A. Briney, Jonathan H. Shrimp, Aktan Alpsoy, Abigail L. Thorpe, Arissa E. Bavari, Daniel R. Crooks, Michaella Levy, Laurence Florens, Michael P. Washburn, Norma Frizzell, Emily C. Dykhuizen, Eranthie Weerapana, W. Marston Linehan, Jordan L. Meier

Nat Chem Biol. Author manuscript; available in PMC 2019 Aug 4.

Published in final edited form as: Nat Chem Biol. 2019 Apr; 15(4): 391–400. Published online 2019 Feb 4. doi: 10.1038/s41589-018-0217-y

PMCID:: PMC6430658

Abstract Article PDF–2.1M

Select item 58604412.

Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance

Hao Yang, Jiang W. Wu, Shu P. Wang, Ilenia Severi, Loris Sartini, Norma Frizzell, Saverio Cinti, Gongshe Yang, Grant A. Mitchell

Diabetes. 2016 Nov; 65(11): 3396–3409. Published online 2016 Aug 23. doi: 10.2337/db16-0136

PMCID:: PMC5860441

Abstract Article PDF–3.0M

Select item 58061933.

Biochemical Characterization of Two Clinically-Relevant Human Fumarase Variants Defective for Oligomerization

Artemisa Bulku, Todd M. Weaver, Melanie B. Berkmen

Open Biochem J. 2018; 12: 1–15. Published online 2018 Jan 29. doi: 10.2174/1874091X01812010001

PMCID:: PMC5806193

Abstract Article PDF–1.8M

Select item 56252674.

Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain

Kristie Usa, Yong Liu, Aron M. Geurts, Yuan Cheng, Jozef Lazar, Maria Angeles Baker, Michael Grzybowski, Yongcheng He, Zhongmin Tian, Mingyu Liang

Physiol Genomics. 2017 Sep 1; 49(9): 496–504. Published online 2017 Jul 28. doi: 10.1152/physiolgenomics.00063.2017

PMCID:: PMC5625267

Abstract Article

Select item 53086805.

Generation of TALEN-mediated FH knockout rat model

Dandan Yu, Yali Zhong, Xiaoran Li, Yaqing Li, Xiaoli Li, Jing Cao, Zhirui Fan, Huijie Fan, Long Yuan, Benling Xu, Yuan Yuan, Hongquan Zhang, Zhenyu Ji, Jian-Guo Wen, Mingzhi Zhang, Jahn M. Nesland, Zhenhe Suo

Oncotarget. 2016 Sep 20; 7(38): 61656–61669. Published online 2016 Aug 19. doi: 10.18632/oncotarget.11429

PMCID:: PMC5308680

Abstract Article PDF–4.7M

Select item 48009906.

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

Yuhui Jiang, Xu Qian, Jianfeng Shen, Yugang Wang, Xinjian Li, Rui Liu, Yan Xia, Qianming Chen, Guang Peng, Shiaw-Yih Lin, Zhimin Lu

Nat Cell Biol. Author manuscript; available in PMC 2016 Mar 21.

Published in final edited form as: Nat Cell Biol. 2015 Sep; 17(9): 1158–1168. Published online 2015 Aug 3. doi: 10.1038/ncb3209

PMCID:: PMC4800990

Abstract Article PDF–2.7M

Select item 36756757.

A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

Julie Adam, Ming Yang, Christina Bauerschmidt, Mitsuhiro Kitagawa, Linda O’Flaherty, Pratheesh Maheswaran, Gizem Özkan, Natasha Sahgal, Dilair Baban, Keiko Kato, Kaori Saito, Keiko Iino, Kaori Igarashi, Michael Stratford, Christopher Pugh, Daniel A. Tennant, Christian Ludwig, Benjamin Davies, Peter J. Ratcliffe, Mona El-Bahrawy, Houman Ashrafian, Tomoyoshi Soga, Patrick J. Pollard

Cell Rep. 2013 May 30; 3(5): 1440–1448. doi: 10.1016/j.celrep.2013.04.006

PMCID:: PMC3675675

Abstract Article PDF–3.0M

Select item 31780598.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 31221719.

Identification of the Catalytic Mechanism and Estimation of Kinetic Parameters for Fumarase

Muriel Mescam, Kalyan C. Vinnakota, Daniel A. Beard

J Biol Chem. 2011 Jun 17; 286(24): 21100–21109. Published online 2011 Apr 15. doi: 10.1074/jbc.M110.214452

PMCID:: PMC3122171

Abstract Article PDF–2.1M

Select item 301344210.

Phosphoproteome Analysis of Functional Mitochondria Isolated from Resting Human Muscle Reveals Extensive Phosphorylation of Inner Membrane Protein Complexes and Enzymes

Xiaolu Zhao, Ileana R. León, Steffen Bak, Martin Mogensen, Krzysztof Wrzesinski, Kurt Højlund, Ole Nørregaard Jensen

Mol Cell Proteomics. 2011 Jan; 10(1): M110.000299. Published online 2010 Sep 10. doi: 10.1074/mcp.M110.000299

PMCID:: PMC3013442

Abstract Article PDF–310K

Select item 283471211.

Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response

Ohad Yogev, Orli Yogev, Esti Singer, Eitan Shaulian, Michal Goldberg, Thomas D. Fox, Ophry Pines

PLoS Biol. 2010 Mar; 8(3): e1000328. Published online 2010 Mar 9. doi: 10.1371/journal.pbio.1000328

PMCID:: PMC2834712

Abstract Article PDF–1.9M

Select item 277884412.

A mitochondrial protein compendium elucidates complex I disease biology

David J. Pagliarini, Sarah E. Calvo, Betty Chang, Sunil A. Sheth, Scott B. Vafai, Shao-En Ong, Geoffrey A. Walford, Canny Sugiana, Avihu Boneh, William K. Chen, David E. Hill, Marc Vidal, James G. Evans, David R. Thorburn, Steven A. Carr, Vamsi K. Mootha

Cell. Author manuscript; available in PMC 2009 Nov 18.

Published in final edited form as: Cell. 2008 Jul 11; 134(1): 112–123. doi: 10.1016/j.cell.2008.06.016

PMCID:: PMC2778844

Abstract Article PDF–1.2M

Select item 256449913.

Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer

M‐H Wei, O Toure, G M Glenn, M Pithukpakorn, L Neckers, C Stolle, P Choyke, R Grubb, L Middelton, M L Turner, M M Walther, M J Merino, B Zbar, W M Linehan, J R Toro

J Med Genet. 2006 Jan; 43(1): 18–27. Published online 2005 Jun 10. doi: 10.1136/jmg.2005.033506