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Select item 112394421.

The dualistic role of Lyn tyrosine kinase in immune cell signaling: implications for systemic lupus erythematosus

Elan L’Estrange-Stranieri, Timothy A. Gottschalk, Mark D. Wright, Margaret L. Hibbs

Front Immunol. 2024; 15: 1395427. Published online 2024 Jun 28. doi: 10.3389/fimmu.2024.1395427

PMCID:: PMC11239442

Abstract Article PDF–2.6M

Select item 110356502.

PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus

John TCHEN, Quentin SIMON, Léa CHAPART, Morgane K. THAMINY, Shamila VIBHUSHAN, Loredana SAVEANU, Yasmine LAMRI, Fanny SAIDOUNE, Emeline PACREAU, Christophe PELLEFIGUES, Julie BEX-COUDRAT, Hajime KARASUYAMA, Kensuke MIYAKE, Juan HIDALGO, Padraic G. FALLON, Thomas PAPO, Ulrich BLANK, Marc BENHAMOU, Guillaume HANOUNA, Karim SACRE, Eric DAUGAS, Nicolas CHARLES

Nat Commun. 2024; 15: 3389. Published online 2024 Apr 22. doi: 10.1038/s41467-024-47691-w

PMCID:: PMC11035650

Abstract Article PDF–6.1M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108465304.

Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model

Giusy Tornillo, Lauren Warrington, Howard Kendrick, Adam T. Higgins, Trevor Hay, Sam Beck, Matthew J. Smalley

Dis Model Mech. 2024 Jan 1; 17(1): dmm050211. Published online 2024 Jan 25. doi: 10.1242/dmm.050211

PMCID:: PMC10846530

Abstract Article

Select item 107958295.

Validation of a murine proteome-wide phage display library for identification of autoantibody specificities

Elze Rackaityte, Irina Proekt, Haleigh S. Miller, Akshaya Ramesh, Jeremy F. Brooks, Andrew F. Kung, Caleigh Mandel-Brehm, David Yu, Colin R. Zamecnik, Rebecca Bair, Sara E. Vazquez, Sara Sunshine, Clare L. Abram, Clifford A. Lowell, Gabrielle Rizzuto, Michael R. Wilson, Julie Zikherman, Mark S. Anderson, Joseph L. DeRisi

JCI Insight. 2023 Dec 8; 8(23): e174976. Published online 2023 Dec 8. doi: 10.1172/jci.insight.174976

PMCID:: PMC10795829

Abstract Article PDF–1.1M

Select item 105717956.

Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain

Erskine Chu, Richelle Mychasiuk, Evelyn Tsantikos, April L. Raftery, Elan L’Estrange-Stranieri, Larissa K. Dill, Bridgette D. Semple, Margaret L. Hibbs

Cells. 2023 Oct; 12(19): 2378. Published online 2023 Sep 28. doi: 10.3390/cells12192378

PMCID:: PMC10571795

Abstract Article PDF–11M

Select item 105249567.

T-bet-expressing B cells contribute to the autoreactive plasma cell pool in Lyn−/− mice

Kristina Ottens, Jalyn Schneider, Anne B. Satterthwaite

Eur J Immunol. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Eur J Immunol. 2023 Aug; 53(8): e2250300. Published online 2023 May 14. doi: 10.1002/eji.202250300

PMCID:: PMC10524956

Abstract Article PDF–1.5M

Select item 101176568.

Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors

Krisztina Futosi, Boglárka Bajza, Dorottya Deli, András Erdélyi, Simon Tusnády, Attila Mócsai

Front Pharmacol. 2023; 14: 1056154. Published online 2023 Apr 6. doi: 10.3389/fphar.2023.1056154

PMCID:: PMC10117656

Abstract Article PDF–3.0M

Select item 100062339.

LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1

Alexander F. vom Stein, Rocio Rebollido-Rios, Anna Lukas, Maximilian Koch, Anton von Lom, Sebastian Reinartz, Daniel Bachurski, France Rose, Katarzyna Bozek, Ali T. Abdallah, Viktoria Kohlhas, Julia Saggau, Rebekka Zölzer, Yue Zhao, Christiane Bruns, Paul J. Bröckelmann, Philipp Lohneis, Reinhard Büttner, Björn Häupl, Thomas Oellerich, Phuong-Hien Nguyen, Michael Hallek

Nat Commun. 2023; 14: 1330. Published online 2023 Mar 10. doi: 10.1038/s41467-023-36824-2

PMCID:: PMC10006233

Abstract Article PDF–7.6M

Select item 959252610.

Establishment of fetomaternal tolerance through glycan-mediated B cell suppression

G. Rizzuto, J. F. Brooks, S. T. Tuomivaara, T. I. McIntyre, S. Ma, D. Rideaux, J. Zikherman, S. J. Fisher, A. Erlebacher

Nature. Author manuscript; available in PMC 2022 Oct 25.

Published in final edited form as: Nature. 2022 Mar; 603(7901): 497–502. Published online 2022 Mar 2. doi: 10.1038/s41586-022-04471-0

PMCID:: PMC9592526

Abstract Article PDF–4.4M

Select item 919486711.

Brain-derived neurotrophic factor regulates LYN kinase–mediated myosin light chain kinase activation to modulate nonmuscle myosin II activity in hippocampal neurons

Xiaobing Li, Rong-Rong Yuan, Qixia Wang, Shouyu Chai, Zhengying Zhang, Yue Wang, Shu-Hong Huang

J Biol Chem. 2022 Jun; 298(6): 102054. Published online 2022 May 20. doi: 10.1016/j.jbc.2022.102054

PMCID:: PMC9194867

Abstract Article PDF–1.8M

Select item 913408312.

Loss of CD11b Accelerates Lupus Nephritis in Lyn-Deficient Mice Without Disrupting Glomerular Leukocyte Trafficking

Timothy A. Gottschalk, Pamela Hall, Evelyn Tsantikos, Elan L’Estrange-Stranieri, Michael J. Hickey, Margaret L. Hibbs

Front Immunol. 2022; 13: 875359. Published online 2022 May 12. doi: 10.3389/fimmu.2022.875359

PMCID:: PMC9134083

Abstract Article PDF–5.5M

Select item 903297613.

A dominant function of LynB kinase in preventing autoimmunity

Ben F. Brian, IV, Monica L. Sauer, Joseph T. Greene, S. Erandika Senevirathne, Anders J. Lindstedt, Olivia L. Funk, Brian L. Ruis, Luis A. Ramirez, Jennifer L. Auger, Whitney L. Swanson, Myra G. Nunez, Branden S. Moriarity, Clifford A. Lowell, Bryce A. Binstadt, Tanya S. Freedman

Sci Adv. 2022 Apr; 8(16): eabj5227. Published online 2022 Apr 22. doi: 10.1126/sciadv.abj5227

PMCID:: PMC9032976

Abstract Article PDF–2.8M

Select item 901426614.

AMG853, A Bispecific Prostaglandin D₂ Receptor 1 and 2 Antagonist, Dampens Basophil Activation and Related Lupus-Like Nephritis Activity in Lyn-Deficient Mice

Christophe Pellefigues, John Tchen, Chaimae Saji, Yasmine Lamri, Nicolas Charles

Front Immunol. 2022; 13: 824686. Published online 2022 Apr 4. doi: 10.3389/fimmu.2022.824686

PMCID:: PMC9014266

Abstract Article PDF–4.8M

Select item 871493915.

Deletions in VANGL1 are a risk factor for antibody-mediated kidney disease

Simon H. Jiang, Sevcan Mercan, Ilenia Papa, Max Moldovan, Giles D. Walters, Mark Koina, Mitali Fadia, Maurice Stanley, Tom Lea-Henry, Amelia Cook, Julia Ellyard, Brendan McMorran, Madhivanan Sundaram, Russell Thomson, Pablo F. Canete, Wendy Hoy, Holly Hutton, Monika Srivastava, Kathryn McKeon, Iñigo de la Rúa Figueroa, Ricard Cervera, Raquel Faria, Sandra D’Alfonso, Mariele Gatto, Vicki Athanasopoulos, Matthew Field, John Mathews, Eun Cho, Thomas D. Andrews, A. Richard Kitching, Matthew C. Cook, Marta Alarcon Riquelme, Melanie Bahlo, Carola G. Vinuesa

Cell Rep Med. 2021 Dec 21; 2(12): 100475. Published online 2021 Dec 21. doi: 10.1016/j.xcrm.2021.100475

PMCID:: PMC8714939

Abstract Article PDF–4.3M

Select item 863816216.

Signal integration by translocation and phosphorylation of PKCδ in the B cell alternate pathway

Naeem Khan, Yongmei Hu, Clifford A. Lowell, Thomas L. Rothstein

J Immunol. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: J Immunol. 2021 Nov 1; 207(9): 2288–2296. Published online 2021 Sep 29. doi: 10.4049/jimmunol.2100295

PMCID:: PMC8638162

Abstract Article PDF–1.7M

Select item 863397817.

Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases

Yuxiu Xu, Erlong Liu, Xialin Xie, Jiuru Wang, Huaguo Zheng, Ying Ju, Lizhao Chen, Changfei Li, Xuyu Zhou, Zihai Li, Xin Li, Songdong Meng

iScience. 2021 Dec 17; 24(12): 103445. Published online 2021 Nov 17. doi: 10.1016/j.isci.2021.103445

PMCID:: PMC8633978

Abstract Article PDF–6.8M

Select item 829000318.

Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease

Tatsuma Ban, Masako Kikuchi, Go R. Sato, Akio Manabe, Noriko Tagata, Kayo Harita, Akira Nishiyama, Kenichi Nishimura, Ryusuke Yoshimi, Yohei Kirino, Hideyuki Yanai, Yoshiko Matsumoto, Shuichi Suzuki, Hiroe Hihara, Masashi Ito, Kappei Tsukahara, Kentaro Yoshimatsu, Tadashi Yamamoto, Tadatsugu Taniguchi, Hideaki Nakajima, Shuichi Ito, Tomohiko Tamura

Nat Commun. 2021; 12: 4379. Published online 2021 Jul 19. doi: 10.1038/s41467-021-24609-4

PMCID:: PMC8290003

Abstract Article PDF–1.9M

Select item 821846819.

Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling

Koshu Okubo, Michael D. Brenner, Xavier Cullere, Gurpanna Saggu, Myra L. Patchen, Nandita Bose, Saki Mihori, Zhou Yuan, Clifford A. Lowell, Cheng Zhu, Tanya N. Mayadas

Cell Rep. Author manuscript; available in PMC 2021 Jun 22.

Published in final edited form as: Cell Rep. 2021 May 18; 35(7): 109142. doi: 10.1016/j.celrep.2021.109142

PMCID:: PMC8218468

Abstract Article PDF–2.1M

Select item 809168720.

Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis

Kevin Peikert, Enrica Federti, Alessandro Matte, Gabriela Constantin, Enrica Caterina Pietronigro, Paolo Francesco Fabene, Paola Defilippi, Emilia Turco, Federico Del Gallo, Pietro Pucci, Angela Amoresano, Anna Illiano, Flora Cozzolino, Maria Monti, Francesca Garello, Enzo Terreno, Seth Leo Alper, Hannes Glaß, Lisann Pelzl, Katja Akgün, Tjalf Ziemssen, Rainer Ordemann, Florian Lang, Anna Maria Brunati, Elena Tibaldi, Immacolata Andolfo, Achille Iolascon, Giuseppe Bertini, Mario Buffelli, Carlo Zancanaro, Erika Lorenzetto, Angela Siciliano, Massimiliano Bonifacio, Adrian Danek, Ruth Helen Walker, Andreas Hermann, Lucia De Franceschi

Acta Neuropathol Commun. 2021; 9: 81. Published online 2021 May 3. doi: 10.1186/s40478-021-01181-y

PMCID:: PMC8091687

Abstract Article PDF–6.7M

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