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Select item 115884271.

Sinomenine Ameliorated Microglial Activation and Neuropathic Pain After Chronic Constriction Injury Via TGF‐β1/ALK5/Smad3 Signalling Pathway

Ling Ling, Min Luo, Haolin Yin, Yunyun Tian, Tao Wang, Bangjian Zhang, Li Yin, Yuehui Zhang, Jiang Bian

J Cell Mol Med. 2024 Nov; 28(22): e70214. Published online 2024 Nov 25. doi: 10.1111/jcmm.70214

PMCID:: PMC11588427

Abstract Article PDF–19M

Select item 115650402.

Single-cell RNA transcriptomics in mice reveals embryonic origin of fibrosis due to maternal obesity

Md Nazmul Hossain, Yao Gao, Xinrui Li, Liang Zhao, Xiangdong Liu, Jeanene Marie de Avila, Mei-Jun Zhu, Min Du

eBioMedicine. 2024 Nov; 109: 105421. Published online 2024 Oct 30. doi: 10.1016/j.ebiom.2024.105421

PMCID:: PMC11565040

Abstract Article PDF–4.9M

Select item 114405123.

MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells

Yun-Ji Lim, Sang-A Park, Dandan Wang, Wenwen Jin, Wai Lim Ku, Dunfang Zhang, Junji Xu, Liliana C. Patiño, Na Liu, Weiwei Chen, Rida Kazmi, Keji Zhao, Ying E. Zhang, Lingyun Sun, WanJun Chen

Cell Rep. Author manuscript; available in PMC 2024 Sep 30.

Published in final edited form as: Cell Rep. 2024 Aug 27; 43(8): 114565. Published online 2024 Jul 30. doi: 10.1016/j.celrep.2024.114565

PMCID:: PMC11440512

Abstract Article PDF–2.6M

Select item 113030514.

Taz/Tead1 Promotes Alternative Macrophage Activation and Kidney Fibrosis via Transcriptional Upregulation of Smad3

Yizhi Ren, Lu Zhou, Xinyuan Li, Xingwen Zhu, Zhiheng Zhang, Xiaoli Sun, Xian Xue, Chunsun Dai

J Immunol Res. 2024; 2024: 9512251. Published online 2024 Jul 30. doi: 10.1155/2024/9512251

PMCID:: PMC11303051

Abstract Article PDF–5.5M

Select item 112958845.

Suppression of NUPR1 in fibroblast-like synoviocytes reduces synovial fibrosis via the Smad3 pathway

Taiyang Liao, Lei Shi, Chenglong He, Deren Liu, Yibao Wei, Zhenyuan Ma, Peimin Wang, Jun Mao, Peng Wu

J Transl Med. 2024; 22: 715. Published online 2024 Aug 1. doi: 10.1186/s12967-024-05540-w

PMCID:: PMC11295884

Abstract Article PDF–9.2M

Select item 112226596.

Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation

Jeong-Hwan Yoon, Eunjin Bae, Yasuo Nagafuchi, Katsuko Sudo, Jin Soo Han, Seok Hee Park, Susumu Nakae, Tadashi Yamashita, Ji Hyeon Ju, Isao Matsumoto, Takayuki Sumida, Keiji Miyazawa, Mitsuyasu Kato, Masahiko Kuroda, In-Kyu Lee, Keishi Fujio, Mizuko Mamura

Life Sci Alliance. 2024 Sep; 7(9): e201900581. Published online 2024 Jul 3. doi: 10.26508/lsa.201900581

PMCID:: PMC11222659

Abstract Article PDF–5.3M

Select item 112177837.

Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

Davy Vanhoutte, Tobias G. Schips, Rachel A. Minerath, Jiuzhou Huo, Naga Swathi Sree Kavuri, Vikram Prasad, Suh-Chin Lin, Michael J. Bround, Michelle A. Sargent, Christopher M. Adams, Jeffery D. Molkentin

Cell Rep. Author manuscript; available in PMC 2024 Jul 2.

Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114149. Published online 2024 Apr 26. doi: 10.1016/j.celrep.2024.114149

PMCID:: PMC11217783

Abstract Article PDF–3.2M

Select item 112172818.

The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function

Yana Kibalnyk, Elia Afanasiev, Ronan M. N. Noble, Adrianne E. S. Watson, Irina Poverennaya, Nicole L. Dittmann, Maria Alexiou, Kara Goodkey, Amanda A. Greenwell, John R. Ussher, Igor Adameyko, James Massey, Daniel Graf, Stephane L. Bourque, Jo Anne Stratton, Anastassia Voronova

Nat Commun. 2024; 15: 4632. Published online 2024 Jul 1. doi: 10.1038/s41467-024-48955-1

PMCID:: PMC11217281

Abstract Article PDF–6.8M

Select item 111458629.

miR-27b-3p reduces muscle fibrosis during chronic skeletal muscle injury by targeting TGF-βR1/Smad pathway

Hang Yao, Jin Qian, Xu-ting Bian, Lin Guo, Kang-lai Tang, Xu Tao

J Orthop Surg Res. 2024; 19: 329. Published online 2024 Jun 2. doi: 10.1186/s13018-024-04733-9

PMCID:: PMC11145862

Abstract Article PDF–2.1M

Select item 1093334410.

A lncRNA Dleu2-encoded peptide relieves autoimmunity by facilitating Smad3-mediated Treg induction

Sibei Tang, Junxun Zhang, Fangzhou Lou, Hong Zhou, Xiaojie Cai, Zhikai Wang, Libo Sun, Yang Sun, Xiangxiao Li, Li Fan, Yan Li, Xinping Jin, Siyu Deng, Qianqian Yin, Jing Bai, Hong Wang, Honglin Wang

EMBO Rep. 2024 Mar; 25(3): 1208–1232. Published online 2024 Jan 30. doi: 10.1038/s44319-024-00070-4

PMCID:: PMC10933344

Abstract Article PDF–4.9M

Select item 1091766011.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 1086374912.

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Zhuoran Yin, Neta Rosenzweig, Kilian L. Kleemann, Xiaoming Zhang, Wesley Brandão, Milica A. Margeta, Caitlin Schroeder, Kisha N. Sivanathan, Sebastian Silveira, Christian Gauthier, Dania Mallah, Kristen M. Pitts, Ana Durao, Shawn Herron, Hannah Shorey, Yiran Cheng, Jen-Li Barry, Rajesh K. Krishnan, Sam Wakelin, Jared Rhee, Anthony Yung, Michael Aronchik, Chao Wang, Nimansha Jain, Xin Bao, Emma Gerrits, Nieske Brouwer, Amy Deik, Daniel G. Tenen, Tsuneya Ikezu, Nicolas G. Santander, Gabriel L. McKinsey, Caroline Baufeld, Dean Sheppard, Susanne Krasemann, Roni Nowarski, Bart J.L. Eggen, Clary Clish, Rudolph E. Tanzi, Charlotte Madore, Thomas D. Arnold, David M. Holtzman, Oleg Butovsky

Nat Immunol. Author manuscript; available in PMC 2024 Nov 1.

Published in final edited form as: Nat Immunol. 2023 Nov; 24(11): 1839–1853. Published online 2023 Sep 25. doi: 10.1038/s41590-023-01627-6

PMCID:: PMC10863749

Abstract Article PDF–8.5M

Select item 1065591813.

The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis

Jingyue Xu, Han Liu, Yu Lan, Rulang Jiang

Development. 2022 Nov 1; 149(21): dev200667. Published online 2022 Oct 28. doi: 10.1242/dev.200667

PMCID:: PMC10655918

Abstract Article

Select item 1064623314.

Btg2 Promotes Focal Segmental Glomerulosclerosis via Smad3‐Dependent Podocyte‐Mesenchymal Transition

Qiong‐ Dan Hu, Hong‐Lian Wang, Jian Liu, Tao He, Rui‐Zhi Tan, Qiong Zhang, Hong‐Wei Su, Fahsai Kantawong, Hui‐Yao Lan, Li Wang

Adv Sci (Weinh) 2023 Nov; 10(32): 2304360. Published online 2023 Sep 25. doi: 10.1002/advs.202304360

PMCID:: PMC10646233

Abstract Article PDF–10M

Select item 1049230615.

circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer

Zhongjie Zhao, Wenbo Yang, Rui Kong, Yangyang Zhang, Le Li, Zengfu Song, Hongze Chen, Yan Luo, Tao Zhang, Chundong Cheng, Guanqun Li, Danxi Liu, Xinglong Geng, Hua Chen, Yongwei Wang, Shangha Pan, Jisheng Hu, Bei Sun

Mol Cancer. 2023; 22: 152. Published online 2023 Sep 9. doi: 10.1186/s12943-023-01847-2

PMCID:: PMC10492306

Abstract Article PDF–16M

Select item 1038049216.

Smad3 Mediates Diabetic Dyslipidemia and Fatty Liver in db/db Mice by Targeting PPARδ

Huijun He, Yu Zhong, Honglian Wang, Patrick Ming-Kuen Tang, Vivian Weiwen Xue, Xiaocui Chen, Jiaoyi Chen, Xiaoru Huang, Cheng Wang, Huiyao Lan

Int J Mol Sci. 2023 Jul; 24(14): 11396. Published online 2023 Jul 13. doi: 10.3390/ijms241411396

PMCID:: PMC10380492

Abstract Article PDF–5.3M

Select item 1033483117.

Tsp-1⁺ microglia attenuate retinal neovascularization by maintaining the expression of Smad3 in endothelial cells through exosomes with decreased miR-27a-5p

Qian Luo, Zihua Jiang, Jingyi Jiang, Linxi Wan, Yan Li, Yuke Huang, Jin Qiu, Keming Yu, Jing Zhuang

Theranostics. 2023; 13(11): 3689–3706. Published online 2023 Jun 26. doi: 10.7150/thno.84236

PMCID:: PMC10334831

Abstract Article PDF–12M

Select item 1030952718.

Elevated FBXL18 promotes RPS15A ubiquitination and SMAD3 activation to drive HCC

Hong-Qiang Yu, Feng Li, HaoJun Xiong, Lei Fang, Jie Zhang, Ping Bie, Chuan-Ming Xie

Hepatol Commun. 2023 Jul; 7(7): e00198. Published online 2023 Jun 28. doi: 10.1097/HC9.0000000000000198

PMCID:: PMC10309527

Abstract Article PDF–2.1M

Select item 1011912119.

Topologically associating domain boundaries are required for normal genome function

Sudha Rajderkar, Iros Barozzi, Yiwen Zhu, Rong Hu, Yanxiao Zhang, Bin Li, Ana Alcaina Caro, Yoko Fukuda-Yuzawa, Guy Kelman, Adyam Akeza, Matthew J. Blow, Quan Pham, Anne N. Harrington, Janeth Godoy, Eman M. Meky, Kianna von Maydell, Riana D. Hunter, Jennifer A. Akiyama, Catherine S. Novak, Ingrid Plajzer-Frick, Veena Afzal, Stella Tran, Javier Lopez-Rios, Michael E. Talkowski, K. C. Kent Lloyd, Bing Ren, Diane E. Dickel, Axel Visel, Len A. Pennacchio

Commun Biol. 2023; 6: 435. Published online 2023 Apr 20. doi: 10.1038/s42003-023-04819-w

PMCID:: PMC10119121

Abstract Article PDF–3.2M

Select item 1006636620.

Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma

Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Vivian Weiwen Xue, Xiao-Ru Huang, Calvin Sze-Hang Ng, Dongmei Zhang, Kam-Tong Leung, Chun-Kwok Wong, Tin-Lap Lee, Eric W-F Lam, David J. Nikolic-Paterson, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang

Nat Commun. 2023; 14: 1794. Published online 2023 Mar 31. doi: 10.1038/s41467-023-37515-8

PMCID:: PMC10066366

Abstract Article PDF–14M

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