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Select item 110314051.

Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system

Pingze Zhang, James H. Catterson, Sebastian Grönke, Linda Partridge

Nat Aging. 2024; 4(4): 491–509. Published online 2024 Feb 27. doi: 10.1038/s43587-024-00578-3

PMCID:: PMC11031405

Abstract Article PDF–12M

Select item 109455082.

DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response to oxidative stress

Fabian Hersperger, Tim Meyring, Pia Weber, Chintan Chhatbar, Gianni Monaco, Marc S Dionne, Katrin Paeschke, Marco Prinz, Olaf Groß, Anne-Kathrin Classen, Katrin Kierdorf

eLife. 2024; 12: RP86700. Published online 2024 Jan 8. doi: 10.7554/eLife.86700

PMCID:: PMC10945508

Abstract Article PDF–5.7M

Select item 109454003.

When the microbiome shapes the host: immune evolution implications for infectious disease

Mark A. Hanson

Philos Trans R Soc Lond B Biol Sci. May 6, 2024; 379(1901): 20230061. Published online March 18, 2024. doi: 10.1098/rstb.2023.0061

PMCID:: PMC10945400

Abstract Article PDF–667K

Select item 109359544.

Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila

Laura Vesala, Yuliya Basikhina, Tea Tuomela, Anssi Nurminen, Emilia Siukola, Pedro F. Vale, Tiina S. Salminen

BMC Biol. 2024; 22: 60. Published online 2024 Mar 13. doi: 10.1186/s12915-024-01858-5

PMCID:: PMC10935954

Abstract Article PDF–2.4M

Select item 109334775.

Drosophila eIF3f1 mediates host immune defense by targeting dTak1

Yixuan Hu, Fanrui Kong, Huimin Guo, Yongzhi Hua, Yangyang Zhu, Chuchu Zhang, Abdul Qadeer, Yihua Xiao, Qingshuang Cai, Shanming Ji

EMBO Rep. 2024 Mar; 25(3): 1415–1435. Published online 2024 Jan 26. doi: 10.1038/s44319-024-00067-z

PMCID:: PMC10933477

Abstract Article PDF–3.5M

Select item 108693626.

The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy

Shannon Nicolson, Jantina A. Manning, Yoon Lim, Xin Jiang, Erica Kolze, Sonia Dayan, Ruchi Umargamwala, Tianqi Xu, Jarrod J. Sandow, Andrew I. Webb, Sharad Kumar, Donna Denton

Commun Biol. 2024; 7: 183. Published online 2024 Feb 15. doi: 10.1038/s42003-024-05834-1

PMCID:: PMC10869362

Abstract Article PDF–6.1M

Select item 107871067.

Branched‐Chain Amino Acid Accumulation Fuels the Senescence‐Associated Secretory Phenotype

Yaosi Liang, Christopher Pan, Tao Yin, Lu Wang, Xia Gao, Ergang Wang, Holly Quang, De Huang, Lianmei Tan, Kun Xiang, Yu Wang, Peter B. Alexander, Qi‐Jing Li, Tso‐Pang Yao, Zhao Zhang, Xiao‐Fan Wang

Adv Sci (Weinh) 2024 Jan; 11(2): 2303489. Published online 2023 Nov 15. doi: 10.1002/advs.202303489

PMCID:: PMC10787106

Abstract Article PDF–5.0M

Select item 107773518.

Magnetic Yeast Glucan Particles for Antibody-Free Separation of Viable Macrophages from Drosophila melanogaster

Gabriela Krejčová, Ivan Saloň, Vojtěch Klimša, Pavel Ulbrich, Ayse Beyza Aysan, Adam Bajgar, František Štěpánek

ACS Biomater Sci Eng. 2024 Jan 8; 10(1): 355–364. Published online 2023 Dec 4. doi: 10.1021/acsbiomaterials.3c01199

PMCID:: PMC10777351

Abstract Article PDF–7.3M

Select item 107246949.

The adaptor protein 14-3-3zeta modulates intestinal immunity and aging in Drosophila

Xiaolan Fan, Tiantian Huang, Shuai Wang, Ziyue Yang, Wenhao Song, Yao Zeng, Yingdong Tong, Yujuan Cai, Deying Yang, Bo Zeng, Mingwang Zhang, Qingyong Ni, Yan Li, Diyan Li, Mingyao Yang

J Biol Chem. 2023 Dec; 299(12): 105414. Published online 2023 Oct 31. doi: 10.1016/j.jbc.2023.105414

PMCID:: PMC10724694

Abstract Article PDF–2.7M

Select item 1069741610.

Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging

Jia Huang, Fan Zhou, Huanchan Zhou, Xiaoqi Zheng, Zhengyi Huo, Meng Yang, Zihe Xu, Runzhou Liu, Luoluo Wang, Xiaoyun Wang

PNAS Nexus. 2023 Dec; 2(12): pgad390. Published online 2023 Dec 5. doi: 10.1093/pnasnexus/pgad390

PMCID:: PMC10697416

Abstract Article PDF–1.3M

Select item 1061648511.

Interactions between innate immunity and insulin signaling affect resistance to infection in insects

Andrea M. Darby, Brian P. Lazzaro

Front Immunol. 2023; 14: 1276357. Published online 2023 Oct 17. doi: 10.3389/fimmu.2023.1276357

Correction in:: Front Immunol. 2024; 15: 1400514.

PMCID:: PMC10616485

Abstract Article PDF–1.5M

Select item 1060910712.

The Sterol Transporter Npc2c Controls Intestinal Stem Cell Mitosis and Host–Microbiome Interactions in Drosophila

Constantina Neophytou, Euripides Soteriou, Chrysoula Pitsouli

Metabolites. 2023 Oct; 13(10): 1084. Published online 2023 Oct 16. doi: 10.3390/metabo13101084

PMCID:: PMC10609107

Abstract Article PDF–8.3M

Select item 1060166413.

Perilipin 1 Deficiency Prompts Lipolysis in Lipid Droplets and Aggravates the Pathogenesis of Persistent Immune Activation in Drosophila

Lei Wang, Jiaxin Lin, Kaiyan Yang, Weina Wang, Yan Lv, Xiangkang Zeng, Yaya Zhao, Junjing Yu, Lei Pan

J Innate Immun. 2023 Jan-Dec; 15(1): 697–708. Published online 2023 Sep 23. doi: 10.1159/000534099

PMCID:: PMC10601664

Abstract Article PDF–2.1M

Select item 1059070714.

Drosophila Gut Immune Pathway Suppresses Host Development-Promoting Effects of Acetic Acid Bacteria

Jaegeun Lee, Xinge Song, Bom Hyun, Che Ok Jeon, Seogang Hyun

Mol Cells. 2023 Oct 31; 46(10): 637–653. Published online 2023 Sep 22. doi: 10.14348/molcells.2023.0141

PMCID:: PMC10590707

Abstract Article PDF–1.1M

Select item 1059016115.

The reproductive status determines tolerance and resistance to Mycobacterium marinum in Drosophila melanogaster

Marta Arch, Maria Vidal, Esther Fuentes, Anmaw Shite Abat, Pere-Joan Cardona

Evol Med Public Health. 2023; 11(1): 332–347. Published online 2023 Sep 6. doi: 10.1093/emph/eoad029

PMCID:: PMC10590161

Abstract Article PDF–907K

Select item 1058097216.

Delayed host mortality and immune response upon infection with P. aeruginosa persister cells

Cody J. Hastings, Maya V. Keledjian, Laura Palanker Musselman, Cláudia N. H. Marques

Infect Immun. 2023 Oct; 91(10): e00246-23. Published online 2023 Sep 21. doi: 10.1128/iai.00246-23

PMCID:: PMC10580972

Abstract Article PDF–967K

Select item 1057942717.

Defective phagocytosis leads to neurodegeneration through systemic increased innate immune signaling

Johnny E. Elguero, Guangmei Liu, Katherine Tiemeyer, Shruthi Bandyadka, Heena Gandevia, Lauren Duro, Zhenhao Yan, Kimberly McCall

iScience. 2023 Oct 20; 26(10): 108052. Published online 2023 Sep 26. doi: 10.1016/j.isci.2023.108052

PMCID:: PMC10579427

Abstract Article PDF–4.3M

Select item 1056293418.

The nematode parasite Steinernema hermaphroditum is pathogenic to Drosophila melanogaster larvae without activating their immune response

Tien Huynh, Damien O'Halloran, John Hawdon, Ioannis Eleftherianos

MicroPubl Biol. 2023; 2023: 10.17912/micropub.biology.000944. Published online 2023 Sep 25. doi: 10.17912/micropub.biology.000944

PMCID:: PMC10562934

Abstract Article PDF–187K

Select item 1055668119.

Stilbenoid compounds inhibit NF-κB-mediated inflammatory responses in the Drosophila intestine

Anna L. Aalto, Atefeh Saadabadi, Fanny Lindholm, Christa Kietz, Emmy Himmelroos, Parthiban Marimuthu, Outi M. H. Salo-Ahen, Patrik Eklund, Annika Meinander

Front Immunol. 2023; 14: 1253805. Published online 2023 Sep 22. doi: 10.3389/fimmu.2023.1253805