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Items: 1 to 20 of 76

1.
DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity
Pinhua Wang, Sunayana Sarkar, Menghuan Zhang, Tingting Xiao, Fenhua Kong, Zhe Zhang, Deepa Balasubramanian, Nandan Jayaram, Sayantan Datta, Ruyu He, Ping Wu, Peng Chao, Ying Zhang, Michael Washburn, Laurence A Florens, Sonal Nagarkar-Jaiswal, Manish Jaiswal, Man Mohan
eLife. 2024; 12: RP88318. Published online 2024 Oct 22. doi: 10.7554/eLife.88318
PMCID:
PMC11495841
AbstractArticlePDF–2.1M
2.
Rational Design and Identification of Harmine-Inspired, N-Heterocyclic DYRK1A Inhibitors Employing a Functional Genomic In Vivo Drosophila Model System
Francisco J. Huizar, Harrison M. Hill, Emily P. Bacher, Kaitlyn E. Eckert, Eva M. Gulotty, Kevin X. Rodriguez, Zachary D. Tucker, Monimoy Banerjee, Olaf Wiest, Jeremiah Zartman, Brandon L. Ashfeld
ChemMedChem. Author manuscript; available in PMC 2024 Aug 21.
Published in final edited form as: ChemMedChem. 2022 Feb 16; 17(4): e202100512. Published online 2022 Jan 27. doi: 10.1002/cmdc.202100512
PMCID:
PMC11337134
AbstractArticlePDF–1.2M
3.
Numerous Serine/Threonine Kinases Affect Blood Cell Homeostasis in Drosophila melanogaster
Sebastian Deichsel, Bernd M. Gahr, Helena Mastel, Anette Preiss, Anja C. Nagel
Cells. 2024 Apr; 13(7): 576. Published online 2024 Mar 26. doi: 10.3390/cells13070576
PMCID:
PMC11011202
AbstractArticlePDF–5.5M
4.
A transcriptomics-based RNAi screen for regulators of meiosis and early stages of oocyte development in Drosophila melanogaster
Stacie E Hughes, Andrew Price, Salam Briggs, Cynthia Staber, Morgan James, Madelyn Anderson, R Scott Hawley
G3 (Bethesda) 2024 Apr; 14(4): jkae028. Published online 2024 Feb 9. doi: 10.1093/g3journal/jkae028
PMCID:
PMC10989863
AbstractArticlePDF–1.3M
5.
Loss of the DYRK1A Protein Kinase Results in the Reduction in Ribosomal Protein Gene Expression, Ribosome Mass and Reduced Translation
Chiara Di Vona, Laura Barba, Roberto Ferrari, Susana de la Luna
Biomolecules. 2024 Jan; 14(1): 31. Published online 2023 Dec 25. doi: 10.3390/biom14010031
PMCID:
PMC10813206
AbstractArticlePDF–2.9M
6.
Excess glutamate release triggers subunit-specific homeostatic receptor scaling
Yifu Han, Pragya Goel, Jiawen Chen, Sarah Perry, Nancy Tran, Samantha Nishimura, Manisha Sanjani, Chun Chien, Dion Dickman
Cell Rep. Author manuscript; available in PMC 2023 Sep 27.
Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112775. Published online 2023 Jul 11. doi: 10.1016/j.celrep.2023.112775
PMCID:
PMC10529671
AbstractArticlePDF–2.1M
7.
Analysis of asymptomatic Drosophila models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degeneration
Marina L. Garcia-Vaquero, Marjorie Heim, Barbara Flix, Marcelo Pereira, Lucile Palin, Tânia M. Marques, Francisco R. Pinto, Javier de Las Rivas, Aaron Voigt, Florence Besse, Margarida Gama-Carvalho
BMC Genomics. 2023; 24: 576. Published online 2023 Sep 27. doi: 10.1186/s12864-023-09562-4
PMCID:
PMC10523761
AbstractArticlePDF–3.2M
8.
The mitochondrial ribosomal protein mRpL4 regulates Notch signaling
Dongqing Mo, Chenglin Liu, Yao Chen, Xinkai Cheng, Jie Shen, Long Zhao, Junzheng Zhang
EMBO Rep. 2023 Jun; 24(6): e55764. Published online 2023 Apr 3. doi: 10.15252/embr.202255764
PMCID:
PMC10240210
AbstractArticlePDF–2.5M
9.
DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity
Bangfu Zhu, Tom Parsons, Christopher Foley, Yeng Shaw, Travis Dunckley, Christopher Hulme, James J. L. Hodge
Sci Rep. 2022; 12: 15847. Published online 2022 Sep 23. doi: 10.1038/s41598-022-19967-y
PMCID:
PMC9508268
AbstractArticlePDF–3.6M
10.
DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer’s Disease-Down Syndrome Phenotypes
Bangfu Zhu, Tom Parsons, Wenche Stensen, John S. Mjøen Svendsen, Anders Fugelli, James J. L. Hodge
Front Pharmacol. 2022; 13: 881385. Published online 2022 Jul 19. doi: 10.3389/fphar.2022.881385
PMCID:
PMC9345315
AbstractArticlePDF–2.3M
11.
Genetic variation of macronutrient tolerance in Drosophila melanogaster
E. Havula, S. Ghazanfar, N. Lamichane, D. Francis, K. Hasygar, Y. Liu, L. A. Alton, J. Johnstone, E. J. Needham, T. Pulpitel, T. Clark, H. N. Niranjan, V. Shang, V. Tong, N. Jiwnani, G. Audia, A. N. Alves, L. Sylow, C. Mirth, G. G. Neely, J. Yang, V. Hietakangas, S. J. Simpson, A. M. Senior
Nat Commun. 2022; 13: 1637. Published online 2022 Mar 28. doi: 10.1038/s41467-022-29183-x
PMCID:
PMC8960806
AbstractArticlePDF–3.3M
12.
Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes
Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis
G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349
PMCID:
PMC8664486
AbstractArticlePDF–3.1M
13.
Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing
Cristina M Ostalé, Nuria Esteban, Ana López-Varea, Jose F de Celis
G3 (Bethesda) 2021 Dec; 11(12): jkab348. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab348
PMCID:
PMC8664455
AbstractArticlePDF–2.9M
14.
Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin
Yi-Jheng Peng, Junhua Geng, Ying Wu, Cristian Pinales, Jennifer Langen, Yen-Ching Chang, Christopher Buser, Karen T. Chang
J Cell Biol. 2021 Dec 6; 220(12): e202011028. Published online 2021 Oct 1. doi: 10.1083/jcb.202011028
PMCID:
PMC8491876
AbstractArticlePDF–7.6M
15.
All Creatures Great and Small: New Approaches for Understanding Down syndrome Genetics
Anna J. Moyer, Katheleen Gardiner, Roger H. Reeves
Trends Genet. Author manuscript; available in PMC 2021 Jun 16.
Published in final edited form as: Trends Genet. 2021 May; 37(5): 444–459. Published online 2020 Oct 20. doi: 10.1016/j.tig.2020.09.017
PMCID:
PMC8208824
AbstractArticlePDF–864K
16.
Leucokinin and Associated Neuropeptides Regulate Multiple Aspects of Physiology and Behavior in Drosophila
Dick R. Nässel
Int J Mol Sci. 2021 Feb; 22(4): 1940. Published online 2021 Feb 16. doi: 10.3390/ijms22041940
PMCID:
PMC7920058
AbstractArticlePDF–7.7M
17.
A single-cell atlas and lineage analysis of the adult Drosophila ovary
Katja Rust, Lauren E. Byrnes, Kevin Shengyang Yu, Jason S. Park, Julie B. Sneddon, Aaron D. Tward, Todd G. Nystul
Nat Commun. 2020; 11: 5628. Published online 2020 Nov 6. doi: 10.1038/s41467-020-19361-0
Correction in:
Nat Commun. 2021; 12: 5951.
PMCID:
PMC7648648
AbstractArticlePDF–6.1M
18.
De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay
Lisenka E.L.M. Vissers, Sreehari Kalvakuri, Elke de Boer, Sinje Geuer, Machteld Oud, Inge van Outersterp, Michael Kwint, Melde Witmond, Simone Kersten, Daniel L. Polla, Dilys Weijers, Amber Begtrup, Kirsty McWalter, Anna Ruiz, Elisabeth Gabau, Jenny E.V. Morton, Christopher Griffith, Karin Weiss, Candace Gamble, James Bartley, Hilary J. Vernon, Kendra Brunet, Claudia Ruivenkamp, Sarina G. Kant, Paul Kruszka, Austin Larson, Alexandra Afenjar, Thierry Billette de Villemeur, Kimberly Nugent, the DDD Study, F. Lucy Raymond, Hanka Venselaar, Florence Demurger, Claudia Soler-Alfonso, Dong Li, Elizabeth Bhoj, Ian Hayes, Nina Powell Hamilton, Ayesha Ahmad, Rachel Fisher, Myrthe van den Born, Marjolaine Willems, Arthur Sorlin, Julian Delanne, Sebastien Moutton, Philippe Christophe, Frederic Tran Mau-Them, Antonio Vitobello, Himanshu Goel, Lauren Massingham, Chanika Phornphutkul, Jennifer Schwab, Boris Keren, Perrine Charles, Maaike Vreeburg, Lenika De Simone, George Hoganson, Maria Iascone, Donatella Milani, Lucie Evenepoel, Nicole Revencu, D. Isum Ward, Kaitlyn Burns, Ian Krantz, Sarah E. Raible, Jill R. Murrell, Kathleen Wood, Megan T. Cho, Hans van Bokhoven, Maximilian Muenke, Tjitske Kleefstra, Rolf Bodmer, Arjan P.M. de Brouwer
Am J Hum Genet. 2020 Jul 2; 107(1): 164–172. Published online 2020 Jun 17. doi: 10.1016/j.ajhg.2020.05.017
PMCID:
PMC7332645
AbstractArticlePDF–1.0M
19.
A novel de novo heterozygous DYRK1A mutation causes complete loss of DYRK1A function and developmental delay
Kyu-Sun Lee, Miri Choi, Dae-Woo Kwon, Doyoun Kim, Jong-Moon Choi, Ae-Kyeong Kim, Youngwook Ham, Sang-Bae Han, Sungchan Cho, Chong Kun Cheon
Sci Rep. 2020; 10: 9849. Published online 2020 Jun 17. doi: 10.1038/s41598-020-66750-y
PMCID:
PMC7299959
AbstractArticlePDF–1.9M
20.
A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis
Allison Jevitt, Deeptiman Chatterjee, Gengqiang Xie, Xian-Feng Wang, Taylor Otwell, Yi-Chun Huang, Wu-Min Deng
PLoS Biol. 2020 Apr; 18(4): e3000538. Published online 2020 Apr 27. doi: 10.1371/journal.pbio.3000538
PMCID:
PMC7205450
AbstractArticlePDF–6.2M

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