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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 102937412.

Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis

Polly A. Machin, Anna-Karin E. Johnsson, Ellie J. Massey, Chiara Pantarelli, Stephen A. Chetwynd, Julia Y. Chu, Hanneke Okkenhaug, Anne Segonds-Pichon, Simon Walker, Angeliki Malliri, Yoshinori Fukui, Heidi C. E. Welch

Front Immunol. 2023; 14: 1180886. Published online 2023 Jun 13. doi: 10.3389/fimmu.2023.1180886

PMCID:: PMC10293741

Abstract Article PDF–22M

Select item 102125303.

DOCK2 deficiency attenuates abdominal aortic aneurysm formation

Xia Guo, Dunpeng Cai, Kun Dong, Chenxiao Li, Zaiyan Xu, Shi-You Chen

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 Jun; 43(6): e210–e217. Published online 2023 Apr 6. doi: 10.1161/ATVBAHA.122.318400

PMCID:: PMC10212530

Abstract Article PDF–991K

Select item 96270444.

DOCK2 and phosphoinositide-3 kinase δ mediate two complementary signaling pathways for CXCR5-dependent B cell migration

Stefanie Wissmann, Bettina Stolp, Ana Marcos Jímenez, Jens V. Stein

Front Immunol. 2022; 13: 982383. Published online 2022 Oct 19. doi: 10.3389/fimmu.2022.982383

PMCID:: PMC9627044

Abstract Article PDF–4.0M

Select item 92801905.

Naïve Primary Mouse CD8⁺ T Cells Retain In Vivo Immune Responsiveness After Electroporation-Based CRISPR/Cas9 Genetic Engineering

Petra Pfenninger, Laura Yerly, Jun Abe

Front Immunol. 2022; 13: 777113. Published online 2022 Jun 30. doi: 10.3389/fimmu.2022.777113

PMCID:: PMC9280190

Abstract Article PDF–15M

Select item 92732796.

DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition

Xia Guo, Oluwaseun Adeyanju, Christudas Sunil, Venkatakirankumar Mandlem, Ayobami Olajuyin, Steven Huang, Shi-You Chen, Steven Idell, Torry A. Tucker, Guoqing Qian

Am J Physiol Cell Physiol. 2022 Jul 1; 323(1): C133–C144. Published online 2022 May 18. doi: 10.1152/ajpcell.00067.2022

PMCID:: PMC9273279

Abstract Article

Select item 88834397.

Dedicator of Cytokinesis 2 (DOCK2) Deficiency Attenuates Lung Injury Associated with Chronic High-Fat and High-Fructose Diet–Induced Obesity

Guoqing Qian, Oluwaseun Adeyanju, Christudas Sunil, Steven K. Huang, Shi-You Chen, Torry A. Tucker, Steven Idell, Xia Guo

Am J Pathol. 2022 Feb; 192(2): 226–238. doi: 10.1016/j.ajpath.2021.10.011

PMCID:: PMC8883439

Abstract Article PDF–2.1M

Select item 88451308.

DOCK2 Promotes Pleural Fibrosis by Modulating Mesothelial to Mesenchymal Transition

Guoqing Qian, Oluwaseun Adeyanju, Saptarshi Roy, Christudas Sunil, Ann Jeffers, Xia Guo, Mitsuo Ikebe, Steven Idell, Torry A. Tucker

Am J Respir Cell Mol Biol. 2022 Feb; 66(2): 171–182. Published online 2021 Oct 28. doi: 10.1165/rcmb.2021-0175OC

PMCID:: PMC8845130

Abstract Article PDF–1.7M

Select item 87874519.

DOCK2 regulates antifungal immunity by regulating RAC GTPase activity

Xiaojian Ma, Xi Tan, Bingbing Yu, Wanwei Sun, Heping Wang, Huijun Hu, Yanyun Du, Ruirui He, Ru Gao, Qianwen Peng, Zhihui Cui, Ting Pan, Xiong Feng, Junhan Wang, Chengqi Xu, Bin Zhu, Wei Liu, Chenhui Wang

Cell Mol Immunol. 2022 May; 19(5): 602–618. Published online 2022 Jan 25. doi: 10.1038/s41423-021-00835-0

PMCID:: PMC8787451

Abstract Article PDF–6.7M

Select item 811983010.

The role of Dock2 on macrophage migration and functions during Citrobacter rodentium infection

L. Ji, Y. Chen, L. Xie, Z. Liu

Clin Exp Immunol. 2021 Jun; 204(3): 361–372. Published online 2021 Mar 22. doi: 10.1111/cei.13590

PMCID:: PMC8119830

Abstract Article PDF–1.2M

Select item 793877011.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 692054312.

DOCK2 sets the threshold for entry into the virtual memory CD8⁺ T cell compartment by negatively regulating tonic TCR triggering

Vinay S Mahajan, Ezana Demissie, Faisal Alsufyani, Sudha Kumari, Grace J Yuen, Vinayak Viswanadham, Andrew Huang, Johnson Q. Tran, James J. Moon, Darrell J Irvine, Shiv Pillai

J Immunol. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: J Immunol. 2020 Jan 1; 204(1): 49–57. Published online 2019 Nov 18. doi: 10.4049/jimmunol.1900440

PMCID:: PMC6920543

Abstract Article PDF–1.6M

Select item 633346013.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

Select item 610385014.

B cell defects observed in Nod2 knockout mice are a consequence of a Dock2 mutation frequently found in inbred strains

Serre-Yu Wong, Maryaline Coffre, Deepshika Ramanan, Marcus J. Hines, Luis E. Gomez, Lauren Peters, Eric Schadt, Sergei B. Koralov, Ken Cadwell

J Immunol. Author manuscript; available in PMC 2019 Mar 1.

Published in final edited form as: J Immunol. 2018 Sep 1; 201(5): 1442–1451. Published online 2018 Jul 16. doi: 10.4049/jimmunol.1800014

PMCID:: PMC6103850

Abstract Article PDF–1.5M

Select item 582029215.

The Rac Activator DOCK2 Mediates Plasma Cell Differentiation and IgG Antibody Production

Miho Ushijima, Takehito Uruno, Akihiko Nishikimi, Fumiyuki Sanematsu, Yasuhisa Kamikaseda, Kazufumi Kunimura, Daiji Sakata, Takaharu Okada, Yoshinori Fukui

Front Immunol. 2018; 9: 243. Published online 2018 Feb 16. doi: 10.3389/fimmu.2018.00243

PMCID:: PMC5820292

Abstract Article PDF–7.8M

Select item 566060716.

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

Lauren A Peters, Jacqueline Perrigoue, Arthur Mortha, Alina Iuga, Won-min Song, Eric M Neiman, Sean R Llewellyn, Antonio Di Narzo, Brian A Kidd, Shannon E Telesco, Yongzhong Zhao, Aleksandar Stojmirovic, Jocelyn Sendecki, Khader Shameer, Riccardo Miotto, Bojan Losic, Hardik Shah, Eunjee Lee, Minghui Wang, Jeremiah J Faith, Andrew Kasarskis, Carrie Brodmerkel, Mark Curran, Anuk Das, Joshua R Friedman, Yoshinori Fukui, Mary Beth Humphrey, Brian M Iritani, Nicholas Sibinga, Teresa K Tarrant, Carmen Argmann, Ke Hao, Panos Roussos, Jun Zhu, Bin Zhang, Radu Dobrin, Lloyd F Mayer, Eric E Schadt

Nat Genet. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Nat Genet. 2017 Oct; 49(10): 1437–1449. Published online 2017 Sep 11. doi: 10.1038/ng.3947