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Select item 109545501.

IL-10 constrains sphingolipid metabolism to limit inflammation

Autumn G. York, Mathias H. Skadow, Joonseok Oh, Rihao Qu, Quan D. Zhou, Wei-Yuan Hsieh, Walter K. Mowel, J. Richard Brewer, Eleanna Kaffe, Kevin J. Williams, Yuval Kluger, Stephen T. Smale, Jason M. Crawford, Steven J. Bensinger, Richard A. Flavell

Nature. 2024; 627(8004): 628–635. Published online 2024 Feb 21. doi: 10.1038/s41586-024-07098-5

PMCID:: PMC10954550

Abstract Article PDF–4.3M

Select item 104707842.

Loss of stearoyl-CoA desaturase 2 disrupts inflammatory response in macrophages

Joseph B. Lin, Amy Mora, Tzu Jui Wang, Andrea Santeford, Darksha Usmani, Marianne M. Ligon, Indira U. Mysorekar, Rajendra S. Apte

mBio. 2023 Jul-Aug; 14(4): e00925-23. Published online 2023 Jul 7. doi: 10.1128/mbio.00925-23

PMCID:: PMC10470784

Abstract Article PDF–4.3M

Select item 101673143.

Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis

Sonal Sinha, Satoka Aizawa, Yasuhiro Nakano, Alexander Rialdi, Hye Yeon Choi, Rajan Shrestha, Stephanie Q. Pan, Yibu Chen, Meng Li, Audrey Kapelanski-Lamoureux, Gregory Yochum, Linda Sher, Satdarshan Paul Monga, Anthoula Lazaris, Keigo Machida, Michael Karin, Ernesto Guccione, Hidekazu Tsukamoto

Nat Commun. 2023; 14: 2651. Published online 2023 May 8. doi: 10.1038/s41467-023-38406-8

PMCID:: PMC10167314

Abstract Article PDF–2.9M

Select item 82420234.

SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4⁺ T cells

Toshio Kanno, Takahiro Nakajima, Satoru Yokoyama, Hikari K. Asou, Shigemi Sasamoto, Yasuhiro Kamii, Koji Hayashizaki, Yasuo Ouchi, Taishi Onodera, Yoshimasa Takahashi, Kazutaka Ikeda, Yoshinori Hasegawa, Yuki Kinjo, Osamu Ohara, Toshinori Nakayama, Yusuke Endo

Commun Biol. 2021; 4: 820. Published online 2021 Jun 29. doi: 10.1038/s42003-021-02310-y

PMCID:: PMC8242023

Abstract Article PDF–3.7M

Select item 78911755.

Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome

Wei-Yuan Hsieh, Quan D. Zhou, Autumn G. York, Kevin J. Williams, Philip O. Scumpia, Eliza B. Kronenberger, Xen Ping Hoi, Baolong Su, Xun Chi, Viet L. Bui, Elvira Khialeeva, Amber Kaplan, Young Min Son, Ajit S. Divakaruni, Jie Sun, Stephen T. Smale, Richard A. Flavell, Steven J. Bensinger

Cell Metab. Author manuscript; available in PMC 2021 Jul 7.

Published in final edited form as: Cell Metab. 2020 Jul 7; 32(1): 128–143.e5. Published online 2020 Jun 8. doi: 10.1016/j.cmet.2020.05.003

PMCID:: PMC7891175

Abstract Article PDF–3.2M

Select item 76979996.

Stearoyl-CoA Desaturase-2 in Murine Development, Metabolism, and Disease

Lucas M. O’Neill, Chang-An Guo, Fang Ding, Yar Xin Phang, Zhaojin Liu, Sohel Shamsuzzaman, James M. Ntambi

Int J Mol Sci. 2020 Nov; 21(22): 8619. Published online 2020 Nov 16. doi: 10.3390/ijms21228619

PMCID:: PMC7697999

Abstract Article PDF–3.6M

Select item 75936317.

Transcriptional activation of the mouse Scd2 gene by interdependent enhancers and long noncoding RNAs in ovarian granulosa cells

Shota MAYAMA, Nobuhiko HAMAZAKI, Yuki MARUYAMA, Shin MATSUBARA, Atsushi P. KIMURA

J Reprod Dev. 2020 Oct; 66(5): 435–444. Published online 2020 Jun 5. doi: 10.1262/jrd.2019-161

PMCID:: PMC7593631

Abstract Article PDF–1.4M

Select item 74159918.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 73106749.

Global deficiency of stearoyl-CoA desaturase-2 protects against diet-induced adiposity

Lucas M. O’Neill, Yar Xin Phang, Majaliwa Matango, Sohel Shamsuzzaman, Chang-An Guo, David W. Nelson, Chi-Liang E. Yen, James M. Ntambi

Biochem Biophys Res Commun. Author manuscript; available in PMC 2021 Jun 30.

Published in final edited form as: Biochem Biophys Res Commun. 2020 Jun 30; 527(3): 589–595. Published online 2020 May 15. doi: 10.1016/j.bbrc.2020.04.077

PMCID:: PMC7310674

Abstract Article PDF–1.0M

Select item 629804010.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 582402411.

PPARα-Target Gene Expression Requires TIS21^/BTG2 Gene in Liver of the C57BL/6 Mice under Fasting Condition

Allen Eugene Hong, Min Sook Ryu, Seung Jun Kim, Seung Yong Hwang, In Kyoung Lim

Mol Cells. 2018 Feb 28; 41(2): 140–149. Published online 2018 Jan 29. doi: 10.14348/molcells.2018.2257

PMCID:: PMC5824024

Abstract Article PDF–3.2M

Select item 486590112.

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development

Bernice H. Wong, Jia Pei Chan, Amaury Cazenave-Gassiot, Rebecca W. Poh, Juat Chin Foo, Dwight L. A. Galam, Sujoy Ghosh, Long N. Nguyen, Veluchamy A. Barathi, Sia W. Yeo, Chi D. Luu, Markus R. Wenk, David L. Silver

J Biol Chem. 2016 May 13; 291(20): 10501–10514. Published online 2016 Mar 22. doi: 10.1074/jbc.M116.721340

PMCID:: PMC4865901

Abstract Article PDF–5.4M

Select item 466579513.

Saturated phosphatidic acids mediate saturated fatty acid–induced vascular calcification and lipotoxicity

Masashi Masuda, Shinobu Miyazaki-Anzai, Audrey L. Keenan, Kayo Okamura, Jessica Kendrick, Michel Chonchol, Stefan Offermanns, James M. Ntambi, Makoto Kuro-o, Makoto Miyazaki

J Clin Invest. 2015 Dec 1; 125(12): 4544–4558. Published online 2015 Oct 26. doi: 10.1172/JCI82871

PMCID:: PMC4665795

Abstract Article PDF–2.2M

Select item 414181914.

Cartilage-Specific Ablation of Site-1 Protease in Mice Results in the Endoplasmic Reticulum Entrapment of Type IIB Procollagen and Down-Regulation of Cholesterol and Lipid Homeostasis

Debabrata Patra, Elizabeth DeLassus, Guosheng Liang, Linda J. Sandell

PLoS One. 2014; 9(8): e105674. Published online 2014 Aug 22. doi: 10.1371/journal.pone.0105674

PMCID:: PMC4141819

Abstract Article PDF–21M

Select item 384523615.

Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins

Jessica Rios-Esteves, Marilyn D. Resh

Cell Rep. Author manuscript; available in PMC 2014 Sep 26.

Published in final edited form as: Cell Rep. 2013 Sep 26; 4(6): 10.1016/j.celrep.2013.08.027. Published online 2013 Sep 19. doi: 10.1016/j.celrep.2013.08.027

PMCID:: PMC3845236

Abstract Article PDF–3.3M

Select item 381794616.

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates

Jeremy A. Miller, Jason Nathanson, Daniel Franjic, Sungbo Shim, Rachel A. Dalley, Sheila Shapouri, Kimberly A. Smith, Susan M. Sunkin, Amy Bernard, Jeffrey L. Bennett, Chang-Kyu Lee, Michael J. Hawrylycz, Allan R. Jones, David G. Amaral, Nenad Sestan, Fred H. Gage, Ed S. Lein

Development. 2013 Nov 15; 140(22): 4633–4644. doi: 10.1242/dev.097212

PMCID:: PMC3817946

Abstract Article

Select item 376377417.

Susceptibility of Podocytes to Palmitic Acid Is Regulated by Stearoyl-CoA Desaturases 1 and 2

Jonas Sieber, Astrid Weins, Kapil Kampe, Stefan Gruber, Maja T. Lindenmeyer, Clemens D. Cohen, Jana M. Orellana, Peter Mundel, Andreas W. Jehle

Am J Pathol. 2013 Sep; 183(3): 735–744. doi: 10.1016/j.ajpath.2013.05.023

PMCID:: PMC3763774

Abstract Article PDF–1.3M

Select item 357241018.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 347934319.

Placental PPARγ Regulates Spatiotemporally Diverse Genes And A Unique Metabolic Network

Tali Shalom-Barak, Xiaowen Zhang, Tianjiao Chu, W. Timothy Schaiff, Janardan K. Reddy, Jianming Xu, Yoel Sadovsky, Yaacov Barak

Dev Biol. Author manuscript; available in PMC 2013 Dec 1.

Published in final edited form as: Dev Biol. 2012 Dec 1; 372(1): 143–155. Published online 2012 Aug 29. doi: 10.1016/j.ydbio.2012.08.021

PMCID:: PMC3479343

Abstract Article PDF–3.8M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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