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Select item 109535651.

Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes

Changzhu Li, Yang Zhang, Jingling Shen, Hairong Bao, Yue Zhao, Desheng Li, Sijia Li, Yining Liu, Jiming Yang, Zhiwen Zhou, Kangyi Gao, Lexin Zhao, Yao Pei, Yanjie Lu, Zhenwei Pan, Benzhi Cai

Adv Sci (Weinh) 2024 Mar; 11(11): 2305992. Published online 2024 Jan 9. doi: 10.1002/advs.202305992

PMCID:: PMC10953565

Abstract Article PDF–5.8M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105206373.

NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte‐to‐Embryo Transition

Tie‐Gang Meng, Jia‐Ni Guo, Liu Zhu, Yike Yin, Feng Wang, Zhi‐Ming Han, Lei Lei, Xue‐Shan Ma, Yue Xue, Wei Yue, Xiao‐Qing Nie, Zheng‐Hui Zhao, Hong‐Yong Zhang, Si‐Min Sun, Ying‐Chun Ouyang, Yi Hou, Heide Schatten, Zhenyu Ju, Xiang‐Hong Ou, Zhen‐Bo Wang, Catherine C. L. Wong, Zhonghan Li, Qing‐Yuan Sun

Adv Sci (Weinh) 2023 Sep; 10(27): 2301940. Published online 2023 Jul 26. doi: 10.1002/advs.202301940

PMCID:: PMC10520637

Abstract Article PDF–6.6M

Select item 98229264.

Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation

Andrea Irazoki, Isabel Gordaliza-Alaguero, Emma Frank, Nikolaos Nikiforos Giakoumakis, Jordi Seco, Manuel Palacín, Anna Gumà, Lykke Sylow, David Sebastián, Antonio Zorzano

Nat Commun. 2023; 14: 108. Published online 2023 Jan 6. doi: 10.1038/s41467-022-35732-1

PMCID:: PMC9822926

Abstract Article PDF–5.4M

Select item 98123845.

Lactate metabolism is essential in early-onset mitochondrial myopathy

Zhenkang Chen, Bogdan Bordieanu, Rushendhiran Kesavan, Nicholas P. Lesner, Siva Sai Krishna Venigalla, Spencer D. Shelton, Ralph J. DeBerardinis, Prashant Mishra

Sci Adv. 2023 Jan; 9(1): eadd3216. Published online 2023 Jan 4. doi: 10.1126/sciadv.add3216

PMCID:: PMC9812384

Abstract Article PDF–2.8M

Select item 97270366.

Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion

Xiu-Yi Kwek, Andrew R. Hall, Wei-Wen Lim, Khairunnisa Katwadi, Poh Loong Soong, Elina Grishina, Kun-Han Lin, Gustavo Crespo-Avilan, En Ping Yap, Nur Izzah Ismail, Kroekkiat Chinda, Ying Ying Chung, Heming Wei, Winston Shim, David Montaigne, Andrew Tinker, Sang-Bing Ong, Derek J. Hausenloy

Sci Rep. 2022; 12: 21049. Published online 2022 Dec 6. doi: 10.1038/s41598-022-25625-0

PMCID:: PMC9727036

Abstract Article PDF–1.7M

Select item 97118837.

A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle

Xun Wang, Yuemeng Jia, Jiawei Zhao, Nicholas P. Lesner, Cameron J. Menezes, Spencer D. Shelton, Siva Sai Krishna Venigalla, Jian Xu, Chunyu Cai, Prashant Mishra

J Clin Invest. 2022 Dec 1; 132(23): e161638. Published online 2022 Dec 1. doi: 10.1172/JCI161638

PMCID:: PMC9711883

Abstract Article PDF–56M

Select item 95151448.

Mitochondrial function and intracellular distribution is severely affected in in vitro cultured mouse embryos

Marta Czernik, Dawid Winiarczyk, Silvestre Sampino, Paweł Gręda, Salvatore Parillo, Jacek Andrzej Modliński, Pasqualino Loi

Sci Rep. 2022; 12: 16152. Published online 2022 Sep 27. doi: 10.1038/s41598-022-20374-6

Correction in:: Sci Rep. 2022; 12: 21276.

PMCID:: PMC9515144

Abstract Article PDF–1.6M

Select item 94369579.

Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism

Yohko Yoshida, Ippei Shimizu, Atsuhiro Shimada, Keita Nakahara, Sachiko Yanagisawa, Minoru Kubo, Shinji Fukuda, Chiharu Ishii, Hiromitsu Yamamoto, Takamasa Ishikawa, Kuniyuki Kano, Junken Aoki, Goro Katsuumi, Masayoshi Suda, Kazuyuki Ozaki, Yutaka Yoshida, Shujiro Okuda, Shigeo Ohta, Shiki Okamoto, Yasuhiko Minokoshi, Kanako Oda, Toshikuni Sasaoka, Manabu Abe, Kenji Sakimura, Yoshiaki Kubota, Norihiko Yoshimura, Shingo Kajimura, Maria Zuriaga, Kenneth Walsh, Tomoyoshi Soga, Tohru Minamino

Sci Rep. 2022; 12: 14883. Published online 2022 Sep 1. doi: 10.1038/s41598-022-19245-x

PMCID:: PMC9436957

Abstract Article PDF–8.2M

Select item 932773710.

Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice

Esteban Salazar-Petres, Daniela Pereira-Carvalho, Jorge Lopez-Tello, Amanda Nancy Sferruzzi-Perri

Biol Reprod. 2022 Jun; 106(6): 1292–1311. Published online 2022 Mar 16. doi: 10.1093/biolre/ioac056

PMCID:: PMC9327737

Abstract Article PDF–3.0M

Select item 923329811.

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Eleni Georgiadou, Charanya Muralidharan, Michelle Martinez, Pauline Chabosseau, Elina Akalestou, Alejandra Tomas, Fiona Yong Su Wern, Theodoros Stylianides, Asger Wretlind, Cristina Legido-Quigley, Ben Jones, Livia Lopez-Noriega, Yanwen Xu, Guoqiang Gu, Nour Alsabeeh, Céline Cruciani-Guglielmacci, Christophe Magnan, Mark Ibberson, Isabelle Leclerc, Yusuf Ali, Scott A. Soleimanpour, Amelia K. Linnemann, Tristan A. Rodriguez, Guy A. Rutter

Diabetes. 2022 Jul; 71(7): 1472–1489. Published online 2022 Apr 26. doi: 10.2337/db21-0800

PMCID:: PMC9233298

Abstract Article PDF–82M

Select item 903869212.

Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis

Divya Bhatia, Allyson Capili, Kiichi Nakahira, Thangamani Muthukumar, Lisa K. Torres, Augustine M. K. Choi, Mary E. Choi

Kidney Int. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Kidney Int. 2022 May; 101(5): 963–986. Published online 2022 Feb 26. doi: 10.1016/j.kint.2022.01.030

PMCID:: PMC9038692

Abstract Article PDF–5.3M

Select item 870793213.

MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice

Junru Miao, Wei Chen, Pengxiang Wang, Xin Zhang, Lei Wang, Shuai Wang, Yuan Wang

Int J Mol Sci. 2021 Dec; 22(24): 13507. Published online 2021 Dec 16. doi: 10.3390/ijms222413507

PMCID:: PMC8707932

Abstract Article PDF–2.1M

Select item 807039814.

Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson’s Disease

Philipp Portz, Michael K. Lee

Cells. 2021 Apr; 10(4): 885. Published online 2021 Apr 13. doi: 10.3390/cells10040885

PMCID:: PMC8070398

Abstract Article PDF–3.0M

Select item 799092415.

Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy

Yung Ting Hsiao, Ippei Shimizu, Takayuki Wakasugi, Yohko Yoshida, Ryutaro Ikegami, Yuka Hayashi, Masayoshi Suda, Goro Katsuumi, Masaaki Nakao, Takuya Ozawa, Daisuke Izumi, Takeshi Kashimura, Kazuyuki Ozaki, Tomoyoshi Soga, Tohru Minamino

Sci Rep. 2021; 11: 6722. Published online 2021 Mar 24. doi: 10.1038/s41598-021-86209-y

PMCID:: PMC7990924

Abstract Article PDF–7.4M

Select item 765510116.

Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A

Antonietta Franco, Xiawei Dang, Emily K Walton, Joshua N Ho, Barbara Zablocka, Cindy Ly, Timothy M Miller, Robert H Baloh, Michael E Shy, Andrew S Yoo, Gerald W Dorn, II

eLife. 2020; 9: e61119. Published online 2020 Oct 19. doi: 10.7554/eLife.61119

PMCID:: PMC7655101

Abstract Article PDF–6.2M

Select item 722110317.

MFN2 Plays a Distinct Role from MFN1 in Regulating Spermatogonial Differentiation

Wei Chen, Yun Sun, Qi Sun, Jingjing Zhang, Manxi Jiang, Chingwen Chang, Xiaoli Huang, Chuanyun Wang, Pengxiang Wang, Zhaoran Zhang, Xuejin Chen, Yuan Wang

Stem Cell Reports. 2020 May 12; 14(5): 803–817. Published online 2020 Apr 23. doi: 10.1016/j.stemcr.2020.03.024

PMCID:: PMC7221103

Abstract Article PDF–6.3M

Select item 721263218.

The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca²⁺–NFATc1 axis

Anna Ballard, Rong Zeng, Allahdad Zarei, Christine Shao, Linda Cox, Hui Yan, Antonietta Franco, Gerald W. Dorn, II, Roberta Faccio, Deborah J. Veis

J Biol Chem. 2020 May 8; 295(19): 6629–6640. Published online 2020 Mar 12. doi: 10.1074/jbc.RA119.012023

PMCID:: PMC7212632

Abstract Article PDF–4.2M

Select item 719986219.

Mitochondrial fragmentation enables localized signaling required for cell repair

Adam Horn, Shreya Raavicharla, Sonna Shah, Dan Cox, Jyoti K. Jaiswal

J Cell Biol. 2020 May 4; 219(5): e201909154. Published online 2020 Apr 1. doi: 10.1083/jcb.201909154

PMCID:: PMC7199862

Abstract Article PDF–3.9M

Select item 713920020.

Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling

Jana Gӧbel, Esther Engelhardt, Patric Pelzer, Vignesh Sakthivelu, Hannah M. Jahn, Milica Jevtic, Kat Folz-Donahue, Christian Kukat, Astrid Schauss, Christian K. Frese, Patrick Giavalisco, Alexander Ghanem, Karl-Klaus Conzelmann, Elisa Motori, Matteo Bergami

Cell Metab. 2020 Apr 7; 31(4): 791–808.e8. doi: 10.1016/j.cmet.2020.03.005

PMCID:: PMC7139200

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