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Select item 111138061.

Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1

Wei Wang, Jinyang Cai, Yingliang Wu, Li Hu, Zongyun Chen, Jun Hu, Ze Chen, Wenxin Li, Mingxiong Guo, Zan Huang

Cell Mol Life Sci. 2013 Oct; 70(20): 3947–3958. Published online 2013 May 12. doi: 10.1007/s00018-013-1359-4

PMCID:: PMC11113806

Abstract Article PDF–2.3M

Select item 110922622.

KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m⁶A reader YTHDC1 protein degradation

Yi Yang, Yingwen Zhang, Guoyu Chen, Bowen Sun, Fei Luo, Yijin Gao, Haizhong Feng, Yanxin Li

J Exp Clin Cancer Res. 2024; 43: 141. Published online 2024 May 14. doi: 10.1186/s13046-024-03040-9

PMCID:: PMC11092262

Abstract Article PDF–3.7M

Select item 109032443.

TRIM28 suppresses cancer stem-like characteristics in gastric cancer cells through Wnt/β-catenin signaling pathways

Tingting Ning, Mengran Zhao, Nan Zhang, Zhaoqing Wang, Shutian Zhang, Mo Liu, Shengtao Zhu

Exp Biol Med (Maywood) 2023 Dec; 248(23): 2210–2218. Published online 2023 Dec 6. doi: 10.1177/15353702231211970

PMCID:: PMC10903244

Abstract Article PDF–7.6M

Select item 108195764.

Functional Analysis of KAP1/TRIM28 Requirements for HIV-1 Transcription Activation

Keyera Randolph, Usman Hyder, Ashwini Challa, Erick Perez, Iván D’Orso

Viruses. 2024 Jan; 16(1): 116. Published online 2024 Jan 13. doi: 10.3390/v16010116

PMCID:: PMC10819576

Abstract Article PDF–4.4M

Select item 107875425.

Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer

Shasha Li, Lulu Wang, Jing Shi, Yi Chen, Ang Xiao, Bingyue Huo, Wenjing Tian, Shilu Zhang, Gang Yang, Wensheng Gong, Huixia Zhang

PeerJ. 2024; 12: e16752. Published online 2024 Jan 10. doi: 10.7717/peerj.16752

PMCID:: PMC10787542

Abstract Article PDF–13M

Select item 107649586.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 106390657.

ATM, KAP1 and the Epstein–Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication

Huanzhou Xu, Ibukun A Akinyemi, John Haley, Michael T McIntosh, Sumita Bhaduri-McIntosh

Nucleic Acids Res. 2023 Nov 10; 51(20): 11104–11122. Published online 2023 Oct 19. doi: 10.1093/nar/gkad823

PMCID:: PMC10639065

Abstract Article PDF–1.8M

Select item 106176738.

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg

Science. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021

PMCID:: PMC10617673

Abstract Article PDF–3.6M

Select item 105899709.

E3 ligase TRIM28 promotes anti-PD-1 resistance in non-small cell lung cancer by enhancing the recruitment of myeloid-derived suppressor cells

Manman Liang, Zhengui Sun, Xingwu Chen, Lijing Wang, Hanli Wang, Lilong Qin, Wenying Zhao, Biao Geng

J Exp Clin Cancer Res. 2023; 42: 275. Published online 2023 Oct 21. doi: 10.1186/s13046-023-02862-3

PMCID:: PMC10589970

Abstract Article PDF–9.1M

Select item 1055659310.

A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells

Lucy Ginn, Joe Maltas, Martin J. Baker, Anshuman Chaturvedi, Leah Wilson, Ryan Guilbert, Fabio M. R. Amaral, Lynsey Priest, Holly Mole, Fiona Blackhall, Zoi Diamantopoulou, Tim C. P. Somervaille, Adam Hurlstone, Angeliki Malliri

Proc Natl Acad Sci U S A. 2023 Oct 3; 120(40): e2300489120. Published online 2023 Sep 25. doi: 10.1073/pnas.2300489120

PMCID:: PMC10556593

Abstract Article PDF–6.6M

Select item 1045414511.

Children with Chronic Immune Thrombocytopenia Exhibit High Expression of Human Endogenous Retroviruses TRIM28 and SETDB1

Pier-Angelo Tovo, Ilaria Galliano, Emilia Parodi, Cristina Calvi, Stefano Gambarino, Francesco Licciardi, Maddalena Dini, Paola Montanari, Margherita Branca, Ugo Ramenghi, Massimiliano Bergallo

Genes (Basel) 2023 Aug; 14(8): 1569. Published online 2023 Aug 1. doi: 10.3390/genes14081569

PMCID:: PMC10454145

Abstract Article PDF–2.0M

Select item 1040690512.

N6-methyladenosine hypomethylation of circGPATCH2L regulates DNA damage and apoptosis through TRIM28 in intervertebral disc degeneration

Zhenhao Chen, Jian Song, Lin Xie, Guangyu Xu, Chaojun Zheng, Xinlei Xia, Feizhou Lu, Xiaosheng Ma, Fei Zou, Jianyuan Jiang, Hongli Wang

Cell Death Differ. 2023 Aug; 30(8): 1957–1972. Published online 2023 Jul 12. doi: 10.1038/s41418-023-01190-5

PMCID:: PMC10406905

Abstract Article PDF–5.9M

Select item 1029808713.

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells

Yao-Jen Chang, Steven Lin, Zhi-Fu Kang, Bin-Jon Shen, Wen-Hai Tsai, Wen-Ching Chen, Hsin-Pin Lu, Yu-Lun Su, Shu-Jen Chou, Shu-Yu Lin, Sheng-Wei Lin, Yin-Jung Huang, Hsin-Hui Wang, Ching-Jin Chang

Int J Mol Sci. 2023 Jun; 24(12): 9830. Published online 2023 Jun 6. doi: 10.3390/ijms24129830

PMCID:: PMC10298087

Abstract Article PDF–4.3M

Select item 1023742214.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1020143715.

A novel role of TRIM28 B box domain in L1 retrotransposition and ORF2p-mediated cDNA synthesis

Qianhui Du, Emily C Stow, Dawn LaCoste, Benjamin Freeman, Melody Baddoo, Afzaal M Shareef, Kyle M Miller, Victoria P Belancio

Nucleic Acids Res. 2023 May 22; 51(9): 4429–4450. Published online 2023 Apr 18. doi: 10.1093/nar/gkad247

PMCID:: PMC10201437

Abstract Article PDF–6.4M

Select item 1016456416.

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing

Yingxiao Chen, Yanping Li, Roselyn S Dai, Jonathan C Savage, Ujwal Shinde, John Klimek, Larry L David, Emma A Young, Markus Hafner, Rosalie C Sears, Xiao-Xin Sun, Mu-Shui Dai

Nucleic Acids Res. 2023 May 8; 51(8): 3934–3949. Published online 2023 Mar 13. doi: 10.1093/nar/gkad140

PMCID:: PMC10164564

Abstract Article PDF–3.8M

Select item 1014152217.

TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy

Tanjing Song, Suli Lv, Xianyun Ma, Xuefeng Zhao, Li Fan, Qingli Zou, Neng Li, Yingying Yan, Wen Zhang, Lidong Sun

J Biol Chem. 2023 May; 299(5): 104621. Published online 2023 Mar 18. doi: 10.1016/j.jbc.2023.104621

PMCID:: PMC10141522

Abstract Article PDF–2.5M

Select item 1013893118.

Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage

Sanna Abbasi, Laila Bayat, Caroline Schild-Poulter

Int J Mol Sci. 2023 Apr; 24(8): 7041. Published online 2023 Apr 11. doi: 10.3390/ijms24087041

PMCID:: PMC10138931

Abstract Article PDF–4.0M

Select item 1007290619.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 1005111620.

Pregnancy Is Associated with Impaired Transcription of Human Endogenous Retroviruses and of TRIM28 and SETDB1, Particularly in Mothers Affected by Multiple Sclerosis

Pier-Angelo Tovo, Luca Marozio, Giancarlo Abbona, Cristina Calvi, Federica Frezet, Stefano Gambarino, Maddalena Dini, Chiara Benedetto, Ilaria Galliano, Massimiliano Bergallo

Viruses. 2023 Mar; 15(3): 710. Published online 2023 Mar 9. doi: 10.3390/v15030710