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Select item 111138101.

FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation

Abdulrzag F. Ahmed, Charles E. de Bock, Lisa F. Lincz, Jay Pundavela, Ihssane Zouikr, Estelle Sontag, Hubert Hondermarck, Rick F. Thorne

Cell Mol Life Sci. 2015 Dec; 72(23): 4653–4669. Published online 2015 Jun 24. doi: 10.1007/s00018-015-1955-6

PMCID:: PMC11113810

Abstract Article PDF–2.2M

Select item 109902772.

ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton

Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012

PMCID:: PMC10990277

Abstract Article PDF–3.9M

Select item 105658763.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 104607324.

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4

Wenhu Chen, Liqiang Hu, Xuemei Lu, Xiaofei Wang, Changan Zhao, Chen Guo, Xiaoyan Li, Yuqin Ding, Hongguang Zhao, Dongdong Tong, Lifang Wang, Chen Huang

Breast Cancer Res Treat. 2023; 201(3): 353–366. Published online 2023 Jul 11. doi: 10.1007/s10549-023-07028-5

PMCID:: PMC10460732

Abstract Article PDF–5.6M

Select item 102977095.

The FAT1 Cadherin Drives Vascular Smooth Muscle Cell Migration

Dario F. Riascos-Bernal, Gaia Ressa, Anish Korrapati, Nicholas E. S. Sibinga

Cells. 2023 Jun; 12(12): 1621. Published online 2023 Jun 14. doi: 10.3390/cells12121621

PMCID:: PMC10297709

Abstract Article PDF–1.2M

Select item 102809406.

CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability

Feifei Yang, Qiang Ma, Bo Huang, Xiaolin Wang, Xiaojuan Pan, Ting Yu, Lingyu Ran, Shan Jiang, Haiping Li, Ye Chen, Yuying Liu, Ce Liang, Junwu Ren, Yuying Zhang, Shimin Wang, Wei Li, Bin Xiao

J Transl Med. 2023; 21: 402. Published online 2023 Jun 20. doi: 10.1186/s12967-023-04235-y

PMCID:: PMC10280940

Abstract Article PDF–11M

Select item 100410567.

Analysis of scRNA-seq and bulk RNA-seq demonstrates the effects of EVI2B or CD361 on CD8⁺ T cells in osteosarcoma

Tianyu Xie, Wenyu Feng, Mingwei He, Xinli Zhan, Shijie Liao, Juliang He, Zhaojie Qin, Feicui Li, Jiake Xu, Yun Liu, Qingjun Wei

Exp Biol Med (Maywood) 2023 Jan; 248(2): 130–145. Published online 2022 Dec 13. doi: 10.1177/15353702221142607

PMCID:: PMC10041056

Abstract Article PDF–9.1M

Select item 98494528.

FAT1 expression in T-cell acute lymphoblastic leukemia (T-ALL) modulates proliferation and WNT signaling

Sven Liebig, Martin Neumann, Patricia Silva, Jutta Ortiz-Tanchez, Veronika Schulze, Konstandina Isaakidis, Cornelia Schlee, Michael P. Schroeder, Thomas Beder, Luc G. T. Morris, Timothy A. Chan, Lorenz Bastian, Thomas Burmeister, Stefan Schwartz, Nicola Gökbuget, Liliana H. Mochmann, Claudia D. Baldus

Sci Rep. 2023; 13: 972. Published online 2023 Jan 18. doi: 10.1038/s41598-023-27792-0

PMCID:: PMC9849452

Abstract Article PDF–1.7M

Select item 98075109.

Oncogenic LINC00857 recruits TFAP2C to elevate FAT1 expression in gastric cancer

Wenqing Zhang, Kaiyue Ji, Congcong Min, Cuiping Zhang, Lin Yang, Qi Zhang, Zibin Tian, Mengyuan Zhang, Xinyu Wang, Xiaoyu Li

Cancer Sci. 2023 Jan; 114(1): 63–74. Published online 2022 Nov 8. doi: 10.1111/cas.15394

PMCID:: PMC9807510

Abstract Article PDF–1.8M

Select item 975114210.

A pan-cancer analysis of the FAT1 in human tumors

Ziyao Wang, Kang Lin, Hai Xiao

Sci Rep. 2022; 12: 21598. Published online 2022 Dec 14. doi: 10.1038/s41598-022-26008-1

PMCID:: PMC9751142

Abstract Article PDF–13M

Select item 943393811.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

Select item 927448312.

CircFAT1 Promotes Lung Adenocarcinoma Progression by Sequestering miR-7 from Repressing IRS2-ERK-mediated CCND1 Expression

Hang Peng, Wan Zhang, Huanhuan Dong, Jialan Yuan, Yankun Li, Fanni Li, Daping Yu, Yingjie Guan, Feng Zhang

Int J Biol Sci. 2022; 18(10): 3944–3960. Published online 2022 Jun 13. doi: 10.7150/ijbs.70889

PMCID:: PMC9274483

Abstract Article PDF–3.2M

Select item 926261413.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 923162314.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 920520615.

Upregulation of Atypical Cadherin FAT1 Promotes an Immunosuppressive Tumor Microenvironment via TGF-β

Khushboo Irshad, Chitrangda Srivastava, Nargis Malik, Manvi Arora, Yakhlesh Gupta, Sanjeev Goswami, Chitra Sarkar, Vaishali Suri, Swati Mahajan, Deepak Kumar Gupta, Ashish Suri, Parthaprasad Chattopadhyay, Subrata Sinha, Kunzang Chosdol

Front Immunol. 2022; 13: 813888. Published online 2022 May 26. doi: 10.3389/fimmu.2022.813888

PMCID:: PMC9205206

Abstract Article PDF–8.6M

Select item 917141116.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 910523517.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 901990718.

Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma

Su Il Kim, Seon Rang Woo, Joo Kyung Noh, Min Kyeong Lee, Young Chan Lee, Jung Woo Lee, Seong‐Gyu Ko, Young‐Gyu Eun

Mol Oncol. 2022 Apr; 16(8): 1661–1679. Published online 2022 Jan 13. doi: 10.1002/1878-0261.13171

PMCID:: PMC9019907

Abstract Article PDF–2.0M

Select item 882889519.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 873228220.

Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer

Chune Yu, Dan Luo, Jing Yu, Min Zhang, Xiaobo Zheng, Guangchao Xu, Jiaxin Wang, Huiling Wang, Yufei Xu, Ke Jiang, Jie Xu, Xuelei Ma, Jing Jing, Hubing Shi

Oncogene. 2022; 41(2): 191–203. Published online 2021 Oct 30. doi: 10.1038/s41388-021-02077-w