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Select item 101937821.

PKD2/polycystin-2 inhibits LPS-induced acute lung injury in vitro and in vivo by activating autophagy

Fan Pan, Lina Bu, Kaixuan Wu, Aizhong Wang, Xiaotao Xu

BMC Pulm Med. 2023; 23: 171. Published online 2023 May 18. doi: 10.1186/s12890-023-02449-w

PMCID:: PMC10193782

Abstract Article PDF–4.0M

Select item 95291742.

KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency–Related Polycystic Kidney Disease

Gyuyeong Rah, Hwayeon Cha, Joohee Kim, Jieun Song, Hyunho Kim, Yun Kyu Oh, Curie Ahn, Minyong Kang, Jongmin Kim, Kyung Hyun Yoo, Min Jung Kim, Hyuk Wan Ko, Je Yeong Ko, Jong Hoon Park

J Am Soc Nephrol. 2022 Sep; 33(9): 1726–1741. Published online 2022 Sep. doi: 10.1681/ASN.2021111455

PMCID:: PMC9529174

Abstract Article

Select item 93761833.

PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression

Ronak Lakhia, Harini Ramalingam, Chun-Mien Chang, Patricia Cobo-Stark, Laurence Biggers, Andrea Flaten, Jesus Alvarez, Tania Valencia, Darren P. Wallace, Edmund C. Lee, Vishal Patel

Nat Commun. 2022; 13: 4765. Published online 2022 Aug 15. doi: 10.1038/s41467-022-32543-2

PMCID:: PMC9376183

Abstract Article PDF–9.0M

Select item 93426404.

Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease

Biswajit Padhy, Jian Xie, Runping Wang, Fang Lin, Chou-Long Huang

J Am Soc Nephrol. 2022 Aug; 33(8): 1501–1516. Published online 2022 Aug. doi: 10.1681/ASN.2022010053

PMCID:: PMC9342640

Abstract Article

Select item 92914215.

Polycystin-2 (PC2) is a key determinant of in vitro myogenesis

Karla M. Márquez-Nogueras, Virdjinija Vuchkovska, Elisabeth DiNello, Sara Osorio-Valencia, Ivana Y. Kuo

Am J Physiol Cell Physiol. 2022 Aug 1; 323(2): C333–C346. Published online 2022 Jun 8. doi: 10.1152/ajpcell.00159.2021

PMCID:: PMC9291421

Abstract Article

Select item 92794146.

A SOX17-PDGFB signaling axis regulates aortic root development

Pengfei Lu, Ping Wang, Bingruo Wu, Yidong Wang, Yang Liu, Wei Cheng, Xuhui Feng, Xinchun Yuan, Miriam M. Atteya, Haleigh Ferro, Yukiko Sugi, Grant Rydquist, Mahdi Esmaily, Jonathan T. Butcher, Ching-Pin Chang, Jack Lenz, Deyou Zheng, Bin Zhou

Nat Commun. 2022; 13: 4065. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31815-1

PMCID:: PMC9279414

Abstract Article PDF–11M

Select item 89330037.

A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation

Charles E MacKay, Miranda Floen, M Dennis Leo, Raquibul Hasan, Tessa AC Garrud, Carlos Fernández-Peña, Purnima Singh, Kafait U Malik, Jonathan H Jaggar

eLife. 2022; 11: e74765. Published online 2022 Mar 1. doi: 10.7554/eLife.74765

PMCID:: PMC8933003

Abstract Article PDF–8.9M

Select item 84352928.

A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts

Melanie Grosch, Katrin Brunner, Alexandr V. Ilyaskin, Michael Schober, Tobias Staudner, Denise Schmied, Tina Stumpp, Kerstin N. Schmidt, M. Gregor Madej, Thaissa D. Pessoa, Helga Othmen, Marion Kubitza, Larissa Osten, Uwe de Vries, Magdalena M. Mair, Stefan Somlo, Markus Moser, Karl Kunzelmann, Christine Ziegler, Silke Haerteis, Christoph Korbmacher, Ralph Witzgall

J Cell Sci. 2021 Aug 15; 134(16): jcs259013. Published online 2021 Aug 23. doi: 10.1242/jcs.259013

PMCID:: PMC8435292

Abstract Article

Select item 82493889.

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Katsura Minegishi, Benjamin Rothé, Kaoru R. Komatsu, Hiroki Ono, Yayoi Ikawa, Hiromi Nishimura, Takanobu A. Katoh, Eriko Kajikawa, Xiaorei Sai, Emi Miyashita, Katsuyoshi Takaoka, Kana Bando, Hiroshi Kiyonari, Tadashi Yamamoto, Hirohide Saito, Daniel B. Constam, Hiroshi Hamada

Nat Commun. 2021; 12: 4071. Published online 2021 Jul 1. doi: 10.1038/s41467-021-24295-2

PMCID:: PMC8249388

Abstract Article PDF–4.7M

Select item 819972010.

Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca²⁺ Signals

Khaoula Talbi, Inês Cabrita, Rainer Schreiber, Karl Kunzelmann

Int J Mol Sci. 2021 Jun; 22(11): 6019. Published online 2021 Jun 2. doi: 10.3390/ijms22116019

PMCID:: PMC8199720

Abstract Article PDF–5.9M

Select item 812647911.

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

Leticia L. Niborski, Mélanie Paces-Fessy, Pierbruno Ricci, Adeline Bourgeois, Pedro Magalhães, Maria Kuzma-Kuzniarska, Celine Lesaulnier, Martin Reczko, Edwige Declercq, Petra Zürbig, Alain Doucet, Muriel Umbhauer, Silvia Cereghini

Dis Model Mech. 2021 May 1; 14(5): dmm047498. Published online 2021 May 4. doi: 10.1242/dmm.047498

PMCID:: PMC8126479

Abstract Article

Select item 793877012.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 789465413.

Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease

Chao Zhang, Bruno Balbo, Ming Ma, Jun Zhao, Xin Tian, Yuval Kluger, Stefan Somlo

J Am Soc Nephrol. 2021 Jan; 32(1): 41–51. Published online 2020 Oct 12. doi: 10.1681/ASN.2020040511

PMCID:: PMC7894654

Abstract Article

Select item 778997014.

Deletion of cardiac polycystin 2/PC2 results in increased SR calcium release and blunted adrenergic reserve

Elisabeth DiNello, Elisa Bovo, Paula Thuo, Thomas G. Martin, Jonathan A. Kirk, Aleksey V. Zima, Quan Cao, Ivana Y. Kuo

Am J Physiol Heart Circ Physiol. 2020 Nov 1; 319(5): H1021–H1035. Published online 2020 Sep 18. doi: 10.1152/ajpheart.00302.2020

PMCID:: PMC7789970

Abstract Article

Select item 745752715.

TRPP2 and STIM1 form a microdomain to regulate store-operated Ca²⁺ entry and blood vessel tone

Jizheng Guo, Ren Zhao, Muyao Zhou, Jie Li, Xiaoqiang Yao, Juan Du, Jiexia Chen, Bing Shen

Cell Commun Signal. 2020; 18: 138. Published online 2020 Aug 31. doi: 10.1186/s12964-020-00560-7

PMCID:: PMC7457527

Abstract Article PDF–3.2M

Select item 741599116.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 736809717.

Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway

Vasileios Gerakopoulos, Peter Ngo, Leonidas Tsiokas

Life Sci Alliance. 2020 Sep; 3(9): e202000750. Published online 2020 Jul 10. doi: 10.26508/lsa.202000750

PMCID:: PMC7368097

Abstract Article PDF–3.1M

Select item 728635718.

Renal tubular cell spliced X-box binding protein-1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation

Silvia Ferrè, Yingfeng Deng, Sarah C. Huen, Christopher Y. Lu, Philipp E. Scherer, Peter Igarashi, Orson W. Moe

Kidney Int. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Kidney Int. 2019 Dec; 96(6): 1359–1373. Published online 2019 Aug 1. doi: 10.1016/j.kint.2019.06.023

PMCID:: PMC7286357

Abstract Article PDF–2.3M

Select item 722876419.

Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure

Charles E MacKay, M Dennis Leo, Carlos Fernández-Peña, Raquibul Hasan, Wen Yin, Alejandro Mata-Daboin, Simon Bulley, Jesse Gammons, Salvatore Mancarella, Jonathan H Jaggar

eLife. 2020; 9: e56655. Published online 2020 May 4. doi: 10.7554/eLife.56655

Correction in:: eLife. 2020; 9: e60401.

PMCID:: PMC7228764

Abstract Article PDF–2.4M

Select item 720527620.

Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression

Ronak Lakhia, Matanel Yheskel, Andrea Flaten, Harini Ramalingam, Karam Aboudehen, Silvia Ferrè, Laurence Biggers, Abheepsa Mishra, Christopher Chaney, Darren P. Wallace, Thomas Carroll, Peter Igarashi, Vishal Patel

JCI Insight. 2020 Apr 9; 5(7): e133785. Published online 2020 Apr 9. doi: 10.1172/jci.insight.133785

PMCID:: PMC7205276

Abstract Article PDF–18M

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