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Select item 111806591.

Targeted therapy for capillary-venous malformations

Lola Zerbib, Sophia Ladraa, Antoine Fraissenon, Charles Bayard, Marina Firpion, Quitterie Venot, Sanela Protic, Clément Hoguin, Amandine Thomas, Sylvie Fraitag, Jean-Paul Duong, Sophie Kaltenbach, Estelle Balducci, Coline Lefevre, Patrick Villarese, Vahid Asnafi, Christine Broissand, Nicolas Goudin, Ivan Nemazanyy, Gwennhael Autret, Bertrand Tavitian, Christophe Legendre, Nadia Arzouk, Veronique Minard-Colin, Caroline Chopinet, Michael Dussiot, Denise M. Adams, Tristan Mirault, Laurent Guibaud, Paul Isenring, Guillaume Canaud

Signal Transduct Target Ther. 2024; 9: 146. Published online 2024 Jun 17. doi: 10.1038/s41392-024-01862-9

PMCID:: PMC11180659

Abstract Article PDF–15M

Select item 111415262.

Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis

Ling Huang, Yilei Ma, Hui Guo, Na Tang, Song Ouyang, Patrick Nuro-Gyina, Lijian Tao, Yusen Liu, Matthew C. O’Brien, Wallace Y. Langdon, Jian Zhang

J Immunol. Author manuscript; available in PMC 2024 May 31.

Published in final edited form as: J Immunol. 2022 Sep 1; 209(5): 991–1000. Published online 2022 Aug 5. doi: 10.4049/jimmunol.2101003

PMCID:: PMC11141526

Abstract Article PDF–3.0M

Select item 110323183.

Spontaneous Akt2 deficiency in a colony of NOD mice exhibiting early diabetes

Julie Hervé, Karine Haurogné, Marie Allard, Sophie Sourice, Pierre Lindenbaum, Jean-Marie Bach, Blandine Lieubeau

Sci Rep. 2024; 14: 9100. Published online 2024 Apr 20. doi: 10.1038/s41598-024-60021-w

PMCID:: PMC11032318

Abstract Article PDF–1.3M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105848115.

Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis

Kotaro Soeda, Takayoshi Sasako, Kenichiro Enooku, Naoto Kubota, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Ryotaro Bouchi, Gotaro Toda, Tomoharu Yamada, Takuma Nakatsuka, Ryosuke Tateishi, Miwako Kakiuchi, Shogo Yamamoto, Kenji Tatsuno, Koji Atarashi, Wataru Suda, Kenya Honda, Hiroyuki Aburatani, Toshimasa Yamauchi, Mitsuhiro Fujishiro, Tetsuo Noda, Kazuhiko Koike, Takashi Kadowaki, Kohjiro Ueki

Nat Commun. 2023; 14: 6584. Published online 2023 Oct 18. doi: 10.1038/s41467-023-42334-y

PMCID:: PMC10584811

Abstract Article PDF–4.4M

Select item 103719156.

CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis

Lilan Wu, Huiqin Xiao, Yaqin Hong, Meihua Xie, Yanxia Yu, Lijuan Jiang

Biochem Genet. 2023; 61(4): 1625–1644. Published online 2023 Jan 31. doi: 10.1007/s10528-023-10332-w

PMCID:: PMC10371915

Abstract Article PDF–4.2M

Select item 95617137.

Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy

Haitao Liu, Nadezda A. Stepicheva, Sayan Ghosh, Peng Shang, Olivia Chowdhury, Rachel A. Daley, Meysam Yazdankhah, Urvi Gupta, Stacey L. Hose, Mallika Valapala, Christopher Scott Fitting, Anastasia Strizhakova, Yang Shan, Derrick Feenstra, José-Alain Sahel, Ashwath Jayagopal, James T. Handa, J. Samuel Zigler, Jr., Patrice E. Fort, Akrit Sodhi, Debasish Sinha

Nat Commun. 2022; 13: 6045. Published online 2022 Oct 13. doi: 10.1038/s41467-022-33773-0

PMCID:: PMC9561713

Abstract Article PDF–9.8M

Select item 95350088.

Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice

Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko, Miho Suzuki, Naoki Kobayashi, Yukiko Okazaki, Miwa Tamura-Nakano, Tomoki Chiba, Domenico Accili, C. Ronald Kahn, Tetsuo Noda, Hiroshi Asahara, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki

Nat Commun. 2022; 13: 5655. Published online 2022 Oct 5. doi: 10.1038/s41467-022-33008-2

PMCID:: PMC9535008

Abstract Article PDF–3.1M

Select item 94407569.

TWIST1 interacts with β/δ-catenins during neural tube development and regulates fate transition in cranial neural crest cells

Jessica W. Bertol, Shelby Johnston, Rabia Ahmed, Victoria K. Xie, Kelsea M. Hubka, Lissette Cruz, Larissa Nitschke, Marta Stetsiv, Jeremy P. Goering, Paul Nistor, Sally Lowell, Hanne Hoskens, Peter Claes, Seth M. Weinberg, Irfan Saadi, Mary C. Farach-Carson, Walid D. Fakhouri

Development. 2022 Aug 1; 149(15): dev200068. Published online 2022 Aug 8. doi: 10.1242/dev.200068

PMCID:: PMC9440756

Abstract Article

Select item 939691610.

Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake

Song-Hua Hu, Xia-Di He, Ji Nie, Jun-Li Hou, Jiang Wu, Xiao-Yan Liu, Yun Wei, Hui-Ru Tang, Wen-Xing Sun, Shu-Xian Zhou, Yi-Yuan Yuan, Yan-Peng An, Guo-Quan Yan, Yan Lin, Peng-Cheng Lin, Jean J. Zhao, Ming-Liang Ye, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao

Cell Rep. Author manuscript; available in PMC 2022 Aug 23.

Published in final edited form as: Cell Rep. 2022 Mar 15; 38(11): 110509. doi: 10.1016/j.celrep.2022.110509

PMCID:: PMC9396916

Abstract Article PDF–3.1M

Select item 935431811.

An integrin axis induces IFN-β production in plasmacytoid dendritic cells

Davina Camargo Madeira Simoes, Nikolaos Paschalidis, Evangelia Kourepini, Vily Panoutsakopoulou

J Cell Biol. 2022 Sep 5; 221(9): e202102055. Published online 2022 Jul 22. doi: 10.1083/jcb.202102055

PMCID:: PMC9354318

Abstract Article PDF–4.0M

Select item 915694412.

Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity

Dominic Santoleri, Hee-Woong Lim, Matthew J. Emmett, Julian Stoute, Matthew J. Gavin, Jaimarie Sostre-Colón, Kahealani Uehara, Jaclyn E. Welles, Kathy Fange Liu, Mitchell A. Lazar, Paul M. Titchenell

iScience. 2022 Jun 17; 25(6): 104410. Published online 2022 May 16. doi: 10.1016/j.isci.2022.104410

PMCID:: PMC9156944

Abstract Article PDF–3.6M

Select item 899509213.

Acute Deletion of the FOXO1-dependent Hepatokine FGF21 Does not Alter Basal Glucose Homeostasis or Lipolysis in Mice

Jaimarie Sostre-Colón, Matthew J Gavin, Dominic Santoleri, Paul M Titchenell

Endocrinology. 2022 May; 163(5): bqac035. Published online 2022 Mar 18. doi: 10.1210/endocr/bqac035

PMCID:: PMC8995092

Abstract Article

Select item 883611414.

Protein Kinase B2 (PKB2/AKT2) Is Essential for Host Protection in CVB3-Induced Acute Viral Myocarditis

So-Hee Kim, Ha-Hyeon Shin, Jin-Ho Kim, Jung-Ho Park, Eun-Seok Jeon, Byung-Kwan Lim

Int J Mol Sci. 2022 Feb; 23(3): 1489. Published online 2022 Jan 27. doi: 10.3390/ijms23031489

PMCID:: PMC8836114

Abstract Article PDF–2.2M

Select item 881865415.

AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology

Natasha Jaiswal, Matthew Gavin, Emanuele Loro, Jaimarie Sostre‐Colón, Paul A. Roberson, Kahealani Uehara, Nicole Rivera‐Fuentes, Michael Neinast, Zoltan Arany, Scot R. Kimball, Tejvir S. Khurana, Paul M. Titchenell

J Cachexia Sarcopenia Muscle. 2022 Feb; 13(1): 495–514. Published online 2021 Nov 9. doi: 10.1002/jcsm.12846

PMCID:: PMC8818654

Abstract Article PDF–11M

Select item 864245016.

Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy

Shuyi Wang, Jun Tao, Huaguo Chen, Machender R. Kandadi, Mingming Sun, Haixia Xu, Gary D. Lopaschuk, Yan Lu, Junmeng Zheng, Hu Peng, Jun Ren

Acta Pharm Sin B. 2021 Nov; 11(11): 3508–3526. Published online 2021 Jul 14. doi: 10.1016/j.apsb.2021.07.006

Correction in:: Acta Pharm Sin B. 2023 Feb; 13(2): 897–898.

PMCID:: PMC8642450

Abstract Article PDF–8.0M

Select item 848286217.

Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1

He Wang, Mengjia Liu, Zhuoyang Ye, Cuihua Zhou, Huiru Bi, Long Wang, Chen Zhang, Hui Fu, Ying Shen, Jian-Jun Yang, Yimin Hu, Guiquan Chen

J Neurosci. 2021 Sep 29; 41(39): 8163–8180. doi: 10.1523/JNEUROSCI.2432-20.2021

PMCID:: PMC8482862

Abstract Article PDF–10M

Select item 831323918.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 829175419.

Cell autonomous versus systemic Akt isoform deletions uncovered new roles for Akt1 and Akt2 in breast cancer

Xinyu Chen, Majd M. Ariss, Gopalakrishnan Ramakrishnan, Veronique Nogueira, Catherine Blaha, William Putzbach, Abul B. M. M. K. Islam, Maxim V. Frolov, Nissim Hay

Mol Cell. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Mol Cell. 2020 Oct 1; 80(1): 87–101.e5. Published online 2020 Sep 14. doi: 10.1016/j.molcel.2020.08.017

PMCID:: PMC8291754

Abstract Article PDF–2.9M

Select item 827811920.

Cardiac metallothionein overexpression rescues diabetic cardiomyopathy in Akt2‐knockout mice

Shan Huang, Jiqun Wang, Hongbo Men, Yi Tan, Qian Lin, Evelyne Gozal, Yang Zheng, Lu Cai

J Cell Mol Med. 2021 Jul; 25(14): 6828–6840. Published online 2021 May 30. doi: 10.1111/jcmm.16687

PMCID:: PMC8278119

Abstract Article PDF–2.1M

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