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Items: 1 to 20 of 32

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
In Search of Small Molecules That Selectively Inhibit MBOAT4
Emily S. Murzinski, Ishika Saha, Hui Ding, David Strugatsky, Ryan A. Hollibaugh, Haixia Liu, Peter Tontonoz, Patrick G. Harran
Molecules. 2021 Dec; 26(24): 7599. Published online 2021 Dec 15. doi: 10.3390/molecules26247599
PMCID:
PMC8709388
AbstractArticlePDF–1.8M
3.
Gfi1 Loss Protects against Two Models of Induced Diabetes
Tiziana Napolitano, Fabio Avolio, Serena Silvano, Sara Forcisi, Anja Pfeifer, Andhira Vieira, Sergi Navarro-Sanz, Marika Elsa Friano, Chaïma Ayachi, Anna Garrido-Utrilla, Josipa Atlija, Biljana Hadzic, Jérôme Becam, Anette Sousa-De-Veiga, Magali Dodille Plaisant, Shruti Balaji, Didier F. Pisani, Magali Mondin, Philippe Schmitt-Kopplin, Ez-Zoubir Amri, Patrick Collombat
Cells. 2021 Nov; 10(11): 2805. Published online 2021 Oct 20. doi: 10.3390/cells10112805
PMCID:
PMC8616283
AbstractArticlePDF–11M
4.
Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson’s Dementia in Humans
Amanda K.E. Hornsby, Luke Buntwal, Maria Carla Carisi, Vanessa V. Santos, Fionnuala Johnston, Luke D. Roberts, Martina Sassi, Mathieu Mequinion, Romana Stark, Alex Reichenbach, Sarah H. Lockie, Mario Siervo, Owain Howell, Alwena H. Morgan, Timothy Wells, Zane B. Andrews, David J. Burn, Jeffrey S. Davies
Cell Rep Med. 2020 Oct 20; 1(7): 100120. Published online 2020 Oct 20. doi: 10.1016/j.xcrm.2020.100120
PMCID:
PMC7575905
AbstractArticlePDF–4.8M
5.
Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis
Grzegorz Godlewski, Resat Cinar, Nathan J. Coffey, Jie Liu, Tony Jourdan, Bani Mukhopadhyay, Lee Chedester, Ziyi Liu, Douglas Osei-Hyiaman, Malliga R. Iyer, Joshua K. Park, Roy G. Smith, Hiroshi Iwakura, George Kunos
Cell Metab. Author manuscript; available in PMC 2020 Jun 4.
Published in final edited form as: Cell Metab. 2019 Jun 4; 29(6): 1320–1333.e8. Published online 2019 May 16. doi: 10.1016/j.cmet.2019.04.012
PMCID:
PMC6551287
AbstractArticlePDF–2.3M
6.
Acylated Ghrelin Supports the Ovarian Transcriptome and Follicles in the Mouse: Implications for Fertility
Luba Sominsky, Jeferson F. Goularte, Zane B. Andrews, Sarah J. Spencer
Front Endocrinol (Lausanne) 2018; 9: 815. Published online 2019 Jan 15. doi: 10.3389/fendo.2018.00815
PMCID:
PMC6340924
AbstractArticlePDF–2.6M
7.
Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus
Mohammad I. Murtuza, Masako Isokawa
J Neurochem. Author manuscript; available in PMC 2019 Jan 1.
Published in final edited form as: J Neurochem. 2018 Jan; 144(1): 58–67. Published online 2017 Nov 20. doi: 10.1111/jnc.14244
PMCID:
PMC5832437
AbstractArticlePDF–1.8M
8.
Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice
Parinaz Mahbod, Eric P. Smith, Maureen E. Fitzgerald, Rachel L. Morano, Benjamin A. Packard, Sriparna Ghosal, Jessie R. Scheimann, Diego Perez-Tilve, James P. Herman, Jenny Tong
Endocrinology. 2018 Jan; 159(1): 388–399. Published online 2017 Nov 15. doi: 10.1210/en.2017-00540
PMCID:
PMC5761608
AbstractArticle
9.
The Ghrelin/GOAT System Regulates Obesity-Induced Inflammation in Male Mice
Rebecca E. Harvey, Victor G. Howard, Moyra B. Lemus, Tara Jois, Zane B. Andrews, Mark W. Sleeman
Endocrinology. 2017 Jul 1; 158(7): 2179–2189. Published online 2017 Mar 29. doi: 10.1210/en.2016-1832
PMCID:
PMC5505216
AbstractArticle
10.
Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R1a activity: evidence for target cell-induced acylation
Anna L. Hopkins, Timothy A. S. Nelson, Irina A. Guschina, Lydia C. Parsons, Charlotte L. Lewis, Richard C. Brown, Helen C. Christian, Jeffrey S. Davies, Timothy Wells
Sci Rep. 2017; 7: 45541. Published online 2017 Mar 31. doi: 10.1038/srep45541
PMCID:
PMC5374529
AbstractArticlePDF–2.1M
11.
Synthetic triterpenoid inhibition of human ghrelin O-acyltransferase: Involvement of a functionally required cysteine provides mechanistic insight into ghrelin acylation
Kayleigh R. McGovern-Gooch, Nivedita S. Mahajani, Ariana Garagozzo, Anthony J. Schramm, Lauren G. Hannah, Michelle A. Sieburg, John D. Chisholm, James L. Hougland
Biochemistry. Author manuscript; available in PMC 2018 Feb 21.
Published in final edited form as: Biochemistry. 2017 Feb 21; 56(7): 919–931. Published online 2017 Feb 7. doi: 10.1021/acs.biochem.6b01008
PMCID:
PMC5319884
AbstractArticlePDF–1.4M
12.
Acylated but not des‐acyl ghrelin is neuroprotective in an MPTP mouse model of Parkinson's disease
Jacqueline A. Bayliss, Moyra Lemus, Vanessa V. Santos, Minh Deo, John D. Elsworth, Zane B. Andrews
J Neurochem. 2016 May; 137(3): 460–471. Published online 2016 Mar 11. doi: 10.1111/jnc.13576
PMCID:
PMC4836972
AbstractArticlePDF–1.4M
13.
Role of the clock gene Bmal1 and the gastric ghrelin-secreting cell in the circadian regulation of the ghrelin-GOAT system
J. Laermans, L. Vancleef, J. Tack, I. Depoortere
Sci Rep. 2015; 5: 16748. Published online 2015 Nov 18. doi: 10.1038/srep16748
PMCID:
PMC4649743
AbstractArticlePDF–1.0M
14.
Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: Reversal by growth hormone
Yuanyuan Zhang, Fei Fang, Joseph L. Goldstein, Michael S. Brown, Tong-Jin Zhao
Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4): 1226–1231. Published online 2015 Jan 12. doi: 10.1073/pnas.1423643112
PMCID:
PMC4313810
AbstractArticlePDF–1.5M
15.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
16.
Architectural Organization of the Metabolic Regulatory Enzyme Ghrelin O-Acyltransferase
Martin S. Taylor, Travis R. Ruch, Po-Yuan Hsiao, Yousang Hwang, Pingfeng Zhang, Lixin Dai, Cheng Ran Lisa Huang, Christopher E. Berndsen, Min-Sik Kim, Akhilesh Pandey, Cynthia Wolberger, Ronen Marmorstein, Carolyn Machamer, Jef D. Boeke, Philip A. Cole
J Biol Chem. 2013 Nov 8; 288(45): 32211–32228. Published online 2013 Sep 17. doi: 10.1074/jbc.M113.510313
PMCID:
PMC3820860
AbstractArticlePDF–7.1M
17.
Altered Lipid and Salt Taste Responsivity in Ghrelin and GOAT Null Mice
Huan Cai, Wei-na Cong, Caitlin M. Daimon, Rui Wang, Matthias H. Tschöp, Jean Sévigny, Bronwen Martin, Stuart Maudsley
PLoS One. 2013; 8(10): e76553. Published online 2013 Oct 4. doi: 10.1371/journal.pone.0076553
PMCID:
PMC3790684
AbstractArticlePDF–9.8M
18.
Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa
Andreas Stengel, Miriam Goebel, Lixin Wang, Yvette Taché, George Sachs, Nils W.G. Lambrecht
Biochem Biophys Res Commun. Author manuscript; available in PMC 2013 Jun 25.
Published in final edited form as: Biochem Biophys Res Commun. 2010 Jan 29; 392(1): 67–71. Published online 2010 Jan 7. doi: 10.1016/j.bbrc.2009.12.169
PMCID:
PMC3692737
AbstractArticlePDF–1.0M
19.
Ablation of Ghrelin O-Acyltransferase Does Not Improve Glucose Intolerance or Body Adiposity in Mice on a Leptin-Deficient ob/ob Background
Henriette Kirchner, Kristy M. Heppner, Jenna Holland, Dhiraj Kabra, Matthias H. Tschöp, Paul T. Pfluger
PLoS One. 2013; 8(4): e61822. Published online 2013 Apr 22. doi: 10.1371/journal.pone.0061822
PMCID:
PMC3632576
AbstractArticlePDF–1013K
20.
GOAT induced Ghrelin Acylation Regulates Hedonic Feeding
JF. Davis, M. Perello, DL. Choi, IJ. Magrisso, H. Kirchner, PT. Pfluger, M. Tschoep, JM. Zigman, SC. Benoit
Horm Behav. Author manuscript; available in PMC 2013 Nov 1.
Published in final edited form as: Horm Behav. 2012 Nov; 62(5): 598–604. Published online 2012 Sep 8. doi: 10.1016/j.yhbeh.2012.08.009
PMCID:
PMC3489978
AbstractArticlePDF–649K

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