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Select item 112343841.

KRAP regulates mitochondrial Ca²⁺ uptake by licensing IP₃ receptor activity and stabilizing ER–mitochondrial junctions

Peace Atakpa-Adaji, Adelina Ivanova, Karolina Kujawa, Colin W. Taylor

J Cell Sci. 2024 Jun 15; 137(12): jcs261728. Published online 2024 Jun 27. doi: 10.1242/jcs.261728

PMCID:: PMC11234384

Abstract Article

Select item 109528452.

Detailed Analysis of ITPR1 Missense Variants Guides Diagnostics and Therapeutic Design

Jussi Pekka Tolonen, Ricardo Parolin Schnekenberg, Simon McGowan, David Sims, Meriel McEntagart, Frances Elmslie, Debbie Shears, Helen Stewart, George K. Tofaris, Tabib Dabir, Patrick J. Morrison, Diana Johnson, Marios Hadjivassiliou, Sian Ellard, Charles Shaw‐Smith, Anna Znaczko, Abhijit Dixit, Mohnish Suri, Ajoy Sarkar, Rachel E. Harrison, Gabriela Jones, Henry Houlden, Giorgia Ceravolo, Joanna Jarvis, Jonathan Williams, Morag E. Shanks, Penny Clouston, Julia Rankin, Lubov Blumkin, Tally Lerman‐Sagie, Penina Ponger, Salmo Raskin, Katariina Granath, Johanna Uusimaa, Hector Conti, Emma McCann, Shelagh Joss, Alexander J.M. Blakes, Kay Metcalfe, Helen Kingston, Marta Bertoli, Rachel Kneen, Sally Ann Lynch, Inmaculada Martínez Albaladejo, Austen Peter Moore, Wendy D. Jones, Genomics England Research Consortium, Esther B.E. Becker, Andrea H. Németh

Mov Disord. 2024 Jan; 39(1): 141–151. Published online 2023 Nov 14. doi: 10.1002/mds.29651

PMCID:: PMC10952845

Abstract Article PDF–3.0M

Select item 107109983.

Identification of ITPR1 gene as a novel target for hsa-miR-34b-5p in non-obstructive azoospermia: a Ca²⁺/apoptosis pathway cross-talk

Bahareh Maleki, Parastoo Modarres, Peyman Salehi, Sadeq Vallian

Sci Rep. 2023; 13: 21873. Published online 2023 Dec 10. doi: 10.1038/s41598-023-49155-5

Correction in:: Sci Rep. 2024; 14: 3722.

PMCID:: PMC10710998

Abstract Article PDF–1.6M

Select item 106473434.

The Complex Effects of PKM2 and PKM2:IP₃R Disruption on Intracellular Ca²⁺ Handling and Cellular Functions

Fernanda O. Lemos, Ian de Ridder, Martin D. Bootman, Geert Bultynck, Jan B. Parys

Cells. 2023 Nov; 12(21): 2527. Published online 2023 Oct 26. doi: 10.3390/cells12212527

PMCID:: PMC10647343

Abstract Article PDF–4.1M

Select item 106415245.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 98519736.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0

PMCID:: PMC9851973

Abstract Article PDF–4.0M

Select item 97979887.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 96635198.

Conformational motions and ligand-binding underlying gating and regulation in IP₃R channel

Guizhen Fan, Mariah R. Baker, Lara E. Terry, Vikas Arige, Muyuan Chen, Alexander B. Seryshev, Matthew L. Baker, Steven J. Ludtke, David I. Yule, Irina I. Serysheva

Nat Commun. 2022; 13: 6942. Published online 2022 Nov 14. doi: 10.1038/s41467-022-34574-1

PMCID:: PMC9663519

Abstract Article PDF–5.5M

Select item 95886789.

KRAP is required for diffuse and punctate IP₃-mediated Ca²⁺ liberation and determines the number of functional IP₃R channels within clusters

Irene Vorontsova, Jeffrey T. Lock, Ian Parker

Cell Calcium. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: Cell Calcium. 2022 Nov; 107: 102638. Published online 2022 Aug 19. doi: 10.1016/j.ceca.2022.102638

PMCID:: PMC9588678

Abstract Article PDF–2.0M

Select item 950024510.

Decreased GZMB, NRP1, ITPR1, and SERPINB9 Transcripts Lead to Reduced Regulatory T Cells Suppressive Capacity in Generalized Vitiligo Patients

Prashant S. Giri, Ankit H. Bharti, Mitesh Dwivedi

J Immunol Res. 2022; 2022: 3426717. Published online 2022 Sep 15. doi: 10.1155/2022/3426717

PMCID:: PMC9500245

Abstract Article PDF–1.8M

Select item 933831311.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 923162312.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 916871513.

Binding of the erlin1/2 complex to the third intralumenal loop of IP₃R1 triggers its ubiquitin-proteasomal degradation

Xiaokong Gao, Caden G. Bonzerato, Richard J.H. Wojcikiewicz

J Biol Chem. 2022 Jun; 298(6): 102026. Published online 2022 May 11. doi: 10.1016/j.jbc.2022.102026

PMCID:: PMC9168715

Abstract Article PDF–4.4M

Select item 911973614.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 903755415.

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy

Bing-Ru Yan, Taoyingnan Li, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Yuhuan Zhou, Peter K. Kim, Brian Raught, John H. Brumell

Autophagy. 2022; 18(4): 829–840. Published online 2021 Aug 25. doi: 10.1080/15548627.2021.1960116

PMCID:: PMC9037554

Abstract Article PDF–4.1M

Select item 884374816.

IP3 receptor orchestrates maladaptive vascular responses in heart failure

Haikel Dridi, Gaetano Santulli, Jessica Gambardella, Stanislovas S. Jankauskas, Qi Yuan, Jingyi Yang, Steven Reiken, Xujun Wang, Anetta Wronska, Xiaoping Liu, Alain Lacampagne, Andrew R. Marks

J Clin Invest. 2022 Feb 15; 132(4): e152859. Published online 2022 Feb 15. doi: 10.1172/JCI152859

PMCID:: PMC8843748

Abstract Article PDF–1.6M

Select item 878411817.

Functional communication between IP₃R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE

Moaz Ahmad, Hwei Ling Ong, Hassan Saadi, Ga-Yeon Son, Zahra Shokatian, Lara E. Terry, Mohamed Trebak, David I. Yule, Indu Ambudkar

Proc Natl Acad Sci U S A. 2022 Jan 18; 119(3): e2114928118. Published online 2022 Jan 12. doi: 10.1073/pnas.2114928118

PMCID:: PMC8784118

Abstract Article PDF–3.4M

Select item 856242618.

A Novel De Novo Intronic Variant in ITPR1 Causes Gillespie Syndrome

Laura Keehan, Ming-Ming Jiang, Xiaohui Li, Ronit Marom, Hongzheng Dai, David Murdock, Pengfei Liu, Jill Hunter, Jason D. Heaney, Laurie Robak, Lisa Emrick, Tim Lotze, Lauren Blieden, Undiagnosed Diseases Network, Richard Alan Lewis, Alex V. Levin, Jenina Capasso, William Craigen, Jill A. Rosenfeld, Brendan Lee, Lindsay C. Burrage

Am J Med Genet A. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: Am J Med Genet A. 2021 Aug; 185(8): 2315–2324. Published online 2021 May 5. doi: 10.1002/ajmg.a.62232

PMCID:: PMC8562426

Abstract Article PDF–467K

Select item 855290719.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 830261920.

KRAP tethers IP₃ receptors to actin and licenses them to evoke cytosolic Ca²⁺ signals

Nagendra Babu Thillaiappan, Holly A. Smith, Peace Atakpa-Adaji, Colin W. Taylor

Nat Commun. 2021; 12: 4514. Published online 2021 Jul 23. doi: 10.1038/s41467-021-24739-9

PMCID:: PMC8302619

Abstract Article PDF–11M

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