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Select item 110290331.

Long-term proliferation of functional human NK cells, with conversion of CD56^dim NK cells to a CD56^bright phenotype, induced by carcinoma cells co-expressing 4-1BBL and IL-12

Alexander C. Dowell, Kimberley A. Oldham, Rupesh I. Bhatt, Steven P. Lee, Peter F. Searle

Cancer Immunol Immunother. 2012 May; 61(5): 615–628. Published online 2011 Oct 22. doi: 10.1007/s00262-011-1122-3

PMCID:: PMC11029033

Abstract Article PDF–1.0M

Select item 92633552.

Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB

Morten Aagaard Nielsen, Kristian Juul-Madsen, John Stegmayr, Chao Gao, Akul Y. Mehta, Stinne Ravn Greisen, Tue Wenzel Kragstrup, Malene Hvid, Thomas Vorup-Jensen, Richard D. Cummings, Hakon Leffler, Bent Winding Deleuran

Front Immunol. 2022; 13: 915890. Published online 2022 Jun 24. doi: 10.3389/fimmu.2022.915890

PMCID:: PMC9263355

Abstract Article PDF–4.1M

Select item 92316233.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 84575694.

TNFSF9 promotes metastasis of pancreatic cancer through Wnt/Snail signaling and M2 polarization of macrophages

Jiao Wu, Yunpeng Wang, Yichun Yang, Fuqiang Liu, Jun Chen, Zhongxiang Jiang, Zheng Jiang

Aging (Albany NY) 2021 Sep 15; 13(17): 21571–21586. Published online 2021 Sep 13. doi: 10.18632/aging.203497

PMCID:: PMC8457569

Abstract Article PDF–2.0M

Select item 82274245.

4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer

Alejandra G. Martinez-Perez, Jose J. Perez-Trujillo, Rodolfo Garza-Morales, Maria J. Loera-Arias, Odila Saucedo-Cardenas, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Roberto Montes-de-Oca-Luna

Int J Mol Sci. 2021 Jun; 22(12): 6210. Published online 2021 Jun 9. doi: 10.3390/ijms22126210

PMCID:: PMC8227424

Abstract Article PDF–561K

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79149037.

Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis

Khang Luu, Mugdha Vijay Patwardhan, Qun Zeng, Stina L. Wickström, Andreas Lundqvist, Herbert Schwarz

Cells. 2021 Feb; 10(2): 353. Published online 2021 Feb 9. doi: 10.3390/cells10020353

PMCID:: PMC7914903

Abstract Article PDF–1.4M

Select item 77849548.

CD137 ligand interacts with CD32a to trigger reverse CD137 ligand signaling

Qun Zeng, Ye Mon Soe, Yanting Lim, Radoslaw M. Sobota, Herbert Schwarz

Cell Mol Immunol. 2020 Nov; 17(11): 1188–1189. Published online 2020 Feb 19. doi: 10.1038/s41423-020-0370-6

PMCID:: PMC7784954

Article PDF–628K

Select item 67835069.

CD137L-DCs, Potent Immune-Stimulators—History, Characteristics, and Perspectives

Qun Zeng, Yubin Zhou, Herbert Schwarz

Front Immunol. 2019; 10: 2216. Published online 2019 Oct 2. doi: 10.3389/fimmu.2019.02216

PMCID:: PMC6783506

Abstract Article PDF–769K

Select item 636928910.

Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding

Aruna Bitra, Tzanko Doukov, Giuseppe Destito, Michael Croft, Dirk M. Zajonc

J Biol Chem. 2019 Feb 8; 294(6): 1831–1845. Published online 2018 Dec 13. doi: 10.1074/jbc.RA118.006297

PMCID:: PMC6369289

Abstract Article PDF–4.4M

Select item 602897411.

Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier

Aruna Bitra, Tzanko Doukov, Michael Croft, Dirk M. Zajonc

J Biol Chem. 2018 Jun 29; 293(26): 9958–9969. Published online 2018 May 2. doi: 10.1074/jbc.RA118.003176

PMCID:: PMC6028974

Abstract Article PDF–3.0M

Select item 558758512.

Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells

Yusuke Tsuda, Chizu Tanikawa, Takafumi Miyamoto, Makoto Hirata, Varalee Yodsurang, Yao-zhong Zhang, Seiya Imoto, Rui Yamaguchi, Satoru Miyano, Hiroshi Takayanagi, Hirotaka Kawano, Hidewaki Nakagawa, Sakae Tanaka, Koichi Matsuda

Sci Rep. 2017; 7: 10739. Published online 2017 Sep 6. doi: 10.1038/s41598-017-11208-x

PMCID:: PMC5587585

Abstract Article PDF–1.9M

Select item 553161113.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 494947714.

Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype

Zulkarnain Harfuddin, Bhushan Dharmadhikari, Siew Cheng Wong, Kaibo Duan, Michael Poidinger, Shaqireen Kwajah, Herbert Schwarz

Sci Rep. 2016; 6: 29712. Published online 2016 Jul 19. doi: 10.1038/srep29712

PMCID:: PMC4949477

Abstract Article PDF–1.8M

Select item 475277415.

Effector function of CTLs is increased by irradiated colorectal tumor cells that modulate OX-40L and 4-1BBL and is reversed following dual blockade

Anita Kumari, Charlie Garnett-Benson

BMC Res Notes. 2016; 9: 92. Published online 2016 Feb 13. doi: 10.1186/s13104-016-1914-9

PMCID:: PMC4752774

Abstract Article PDF–2.0M

Select item 461721116.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 400444417.

The Tumor Necrosis Family Member 4-1BBL Sustains Inflammation by Interacting with Mediators of Toll-Like Receptor Signaling

Jianhui Ma, Bo-Ram Bang, Jiawei Lu, So-Young Eun, Motoyuki Otsuka, Michael Croft, Peter Tobias, Jiahuai Han, Osamu Takeuchi, Shizuo Akira, Michael Karin, Hideo Yagita, Young Jun Kang

Sci Signal. Author manuscript; available in PMC 2014 Apr 29.

Published in final edited form as: Sci Signal. 2013 Oct 1; 6(295): ra87. Published online 2013 Oct 1. doi: 10.1126/scisignal.2004431

PMCID:: PMC4004444

Abstract Article PDF–1.4M

Select item 388775318.

Reverse Signaling through the Co-Stimulatory Ligand, CD137L, as a Critical Mediator of Sterile Inflammation

Sang Jun Park, Hye Jeong Kim, Jong Soo Lee, Hong Rae Cho, Byungsuk Kwon

Mol Cells. 2012 Jun 30; 33(6): 533–537. Published online 2012 Apr 20. doi: 10.1007/s10059-012-0077-3

PMCID:: PMC3887753

Abstract Article PDF–341K

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316916720.

Risk of Meningioma and Common Variation in Genes related to Innate Immunity

Preetha Rajaraman, Alina V. Brenner, Gila Neta, Ruth Pfeiffer, Sophia S. Wang, Meredith Yeager, Gilles Thomas, Howard A. Fine, Martha S. Linet, Nathaniel Rothman, Stephen J. Chanock, Peter D. Inskip

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2011 Sep 7.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 May; 19(5): 1356–1361. Published online 2010 Apr 20. doi: 10.1158/1055-9965.EPI-09-1151

PMCID:: PMC3169167

Abstract Article PDF–61K

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