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Items: 1 to 20 of 74

1.
MLL-AF9 regulates transcriptional initiation in mixed lineage leukemic cells
Zimei Yang, Ge Zhang, Ruoyu Zhao, Tian Tian, Junhong Zhi, Gang Wei, Robert G. Roeder, Lili Jing, Ming Yu
J Biol Chem. 2024 Aug; 300(8): 107566. Published online 2024 Jul 11. doi: 10.1016/j.jbc.2024.107566
PMCID:
PMC11345648
AbstractArticlePDF–4.3M
2.
AF9 sustains glycolysis in colorectal cancer via H3K9ac‐mediated PCK2 and FBP1 transcription
Xuefeng He, Xinyang Zhong, Yi Fang, Zijuan Hu, Zhiyu Chen, Yaxian Wang, Huixia Huang, Senlin Zhao, Dawei Li, Ping Wei
Clin Transl Med. 2023 Aug; 13(8): e1352. Published online 2023 Aug 10. doi: 10.1002/ctm2.1352
PMCID:
PMC10413954
AbstractArticlePDF–15M
3.
Molecular Recognition of Methacryllysine and Crotonyllysine by the AF9 YEATS Domain
Nurgül Bilgin, Laust Moesgaard, Mohammad M. Rahman, Vildan A. Türkmen, Jacob Kongsted, Jasmin Mecinović
Int J Mol Sci. 2023 Apr; 24(8): 7002. Published online 2023 Apr 10. doi: 10.3390/ijms24087002
PMCID:
PMC10138300
AbstractArticlePDF–1.5M
4.
Assessment of community efforts to advance network-based prediction of protein–protein interactions
Xu-Wen Wang, Lorenzo Madeddu, Kerstin Spirohn, Leonardo Martini, Adriano Fazzone, Luca Becchetti, Thomas P. Wytock, István A. Kovács, Olivér M. Balogh, Bettina Benczik, Mátyás Pétervári, Bence Ágg, Péter Ferdinandy, Loan Vulliard, Jörg Menche, Stefania Colonnese, Manuela Petti, Gaetano Scarano, Francesca Cuomo, Tong Hao, Florent Laval, Luc Willems, Jean-Claude Twizere, Marc Vidal, Michael A. Calderwood, Enrico Petrillo, Albert-László Barabási, Edwin K. Silverman, Joseph Loscalzo, Paola Velardi, Yang-Yu Liu
Nat Commun. 2023; 14: 1582. Published online 2023 Mar 22. doi: 10.1038/s41467-023-37079-7
PMCID:
PMC10033937
AbstractArticlePDF–1.5M
5.
Negative Feedback Loop Mechanism between EAF1/2 and DBC1 in Regulating ELL Stability and Functions
Subham Basu, Arijit Nandy, Mahesh K. Barad, Sujay Pal, Debabrata Biswas
Mol Cell Biol. 2022 Oct; 42(10): e00151-22. Published online 2022 Aug 29. doi: 10.1128/mcb.00151-22
PMCID:
PMC9590304
AbstractArticlePDF–3.2M
6.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
7.
The intrinsically disordered proteins MLLT3 (AF9) and MLLT1 (ENL) – multimodal transcriptional switches with roles in normal hematopoiesis, MLL fusion leukemia, and kidney cancer
Ashish Kabra, John Bushweller
J Mol Biol. Author manuscript; available in PMC 2023 Jan 15.
Published in final edited form as: J Mol Biol. 2022 Jan 15; 434(1): 167117. Published online 2021 Jun 23. doi: 10.1016/j.jmb.2021.167117
PMCID:
PMC8695629
AbstractArticlePDF–1.3M
8.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
9.
A conserved acetylation switch enables pharmacological control of tubby-like protein stability
Evan M. Kerek, Kevin H. Yoon, Shu Y. Luo, Jerry Chen, Robert Valencia, Olivier Julien, Andrew J. Waskiewicz, Basil P. Hubbard
J Biol Chem. 2021 Jan-Jun; 296: 100073. Published online 2020 Nov 23. doi: 10.1074/jbc.RA120.015839
PMCID:
PMC7948452
AbstractArticlePDF–3.6M
10.
The miR-5694/AF9/Snail Axis Provides Metastatic Advantages and a Therapeutic Target in Basal-like Breast Cancer
Xin Tian, Hua Yu, Dong Li, Guojiang Jin, Shundong Dai, Pengchao Gong, Cuicui Kong, Xiongjun Wang
Mol Ther. 2021 Mar 3; 29(3): 1239–1257. Published online 2020 Nov 20. doi: 10.1016/j.ymthe.2020.11.022
PMCID:
PMC7934584
AbstractArticlePDF–4.3M
11.
Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis
Sierrah M. Grigsby, Ann Friedman, Jennifer Chase, Bridget Waas, James Ropa, Justin Serio, Chenxi Shen, Andrew G. Muntean, Ivan Maillard, Zaneta Nikolovska-Coleska
Cancers (Basel) 2021 Feb; 13(4): 642. Published online 2021 Feb 5. doi: 10.3390/cancers13040642
PMCID:
PMC7914713
AbstractArticlePDF–3.4M
12.
BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity
Charles R. Schmidt, Nicholas J. Achille, Aravinda Kuntimaddi, Adam M. Boulton, Benjamin I. Leach, Shubin Zhang, Nancy J. Zeleznik-Le, John H. Bushweller
Blood Cancer Discov. 2020 Sep; 1(2): 162–177. Published online 2020 Jul 7. doi: 10.1158/2643-3230.BCD-20-0036
PMCID:
PMC7497807
AbstractArticlePDF–22M
13.
Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation
Guochao Chen, Duo Wang, Bin Wu, Fuxiang Yan, Hongjuan Xue, Quanmeng Wang, Shu Quan, Yong Chen
Nat Commun. 2020; 11: 4206. Published online 2020 Aug 21. doi: 10.1038/s41467-020-18021-7
PMCID:
PMC7442819
AbstractArticlePDF–3.4M
14.
Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2
Jun Wu, Yuhua Xue, Xiang Gao, Qiang Zhou
Nucleic Acids Res. 2020 Jul 27; 48(13): 7321–7332. Published online 2020 Jun 1. doi: 10.1093/nar/gkaa461
PMCID:
PMC7367184
AbstractArticlePDF–3.8M
15.
MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment
Vincenzo Calvanese, Andrew T. Nguyen, Timothy J. Bolan, Anastasia Vavilina, Trent Su, Lydia K. Lee, Yanling Wang, Fides D. Lay, Mattias Magnusson, Gay M. Crooks, Siavash K. Kurdistani, Hanna K. A. Mikkola
Nature. Author manuscript; available in PMC 2020 Jun 8.
Published in final edited form as: Nature. 2019 Dec; 576(7786): 281–286. Published online 2019 Nov 27. doi: 10.1038/s41586-019-1790-2
PMCID:
PMC7278275
AbstractArticlePDF–7.0M
16.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
17.
DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes
Subham Basu, Mahesh Barad, Dipika Yadav, Arijit Nandy, Bidisha Mukherjee, Jit Sarkar, Partha Chakrabarti, Satinath Mukhopadhyay, Debabrata Biswas
Proc Natl Acad Sci U S A. 2020 Mar 24; 117(12): 6509–6520. Published online 2020 Mar 9. doi: 10.1073/pnas.1912375117
PMCID:
PMC7104407
AbstractArticlePDF–2.5M
18.
Characterization of Copy Number Variations in Oral Cavity Squamous Cell Carcinoma Reveals a Novel Role for MLLT3 in Cell Invasiveness
Chun‐I Wang, Huang‐Kai Kao, Ting‐Wen Chen, Yenlin Huang, Hsing‐Wen Cheng, Jui‐Shan Yi, Shao‐Yu Hung, Chi‐Sheng Wu, Yun‐Shien Lee, Kai‐Ping Chang
Oncologist. 2019 Dec; 24(12): e1388–e1400. Published online 2019 Jul 4. doi: 10.1634/theoncologist.2019-0063
PMCID:
PMC6975970
AbstractArticlePDF–1.9M
19.
MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
Xinyue Chen, Daniel B. Burkhardt, Amaleah A. Hartman, Xiao Hu, Anna E. Eastman, Chao Sun, Xujun Wang, Mei Zhong, Smita Krishnaswamy, Shangqin Guo
Nat Commun. 2019; 10: 5767. Published online 2019 Dec 18. doi: 10.1038/s41467-019-13666-5
Correction in:
Nat Commun. 2020; 11: 681.
PMCID:
PMC6920141
AbstractArticlePDF–2.6M
20.
FLT3N676K drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis
Axel Hyrenius-Wittsten, Mattias Pilheden, Antoni Falqués-Costa, Mia Eriksson, Helena Sturesson, Pauline Schneider, Priscilla Wander, Cristian Garcia-Ruiz, Jian Liu, Helena Ågerstam, Anne Hultquist, Henrik Lilljebjörn, Ronald W. Stam, Marcus Järås, Anna K. Hagström-Andersson
Leukemia. 2019; 33(9): 2310–2314. Published online 2019 Apr 5. doi: 10.1038/s41375-019-0465-1
PMCID:
PMC6756218
ArticlePDF–957K

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