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Select item 111795071.

KRAS, NRAS and BRAF Mutational Profile of Colorectal Cancer in a Series of Moroccan Patients

Sara El Zaitouni, Abdelilah Laraqui, Meriem Ghaouti, Asmae Benzekri, Fouad Kettani, Tahar Bajjou, Yassine Sekhsokh, Soukaina Benmokhtar, Meryem Jafari, Walid Baba, Mohamed Oukabli, Hicham El Annaz, Rachid Abi, Mohamed Rida Tagajdid, Safae El Kochri, Idriss Amine Lahlou, Rabii Ameziane El Hassani, Khalid Ennibi

Cancer Control. 2024 Jan-Dec; 31: 10732748241262179. Published online 2024 Jun 14. doi: 10.1177/10732748241262179

PMCID:: PMC11179507

Abstract Article PDF–582K

Select item 111416442.

Mechanism of co-operation of mutant IL-7Rα and mutant NRAS in acute lymphoblastic leukemia: role of MYC

Hila Winer, Wenqing Li, Gisele Rodrigues, Tim Gower, Thomas Joshua Meyer, Julie Hixon, Scott K. Durum

Haematologica. 2024 Jun 1; 109(6): 1726–1740. Published online 2023 Nov 30. doi: 10.3324/haematol.2023.283559

PMCID:: PMC11141644

Abstract Article PDF–4.7M

Select item 111357333.

Changes in cell morphology and function induced by the NRAS Q61R mutation in lymphatic endothelial cells

Shiho Yasue, Michio Ozeki, Akifumi Nozawa, Saori Endo, Hidenori Ohnishi

PLoS One. 2024; 19(5): e0289187. Published online 2024 May 29. doi: 10.1371/journal.pone.0289187

PMCID:: PMC11135733

Abstract Article PDF–2.1M

Select item 109945874.

Epidemiological and clinicopathological features of KRAS, NRAS, BRAF mutations and MSI in Chinese patients with stage I–III colorectal cancer

Weicheng Wang, Rui Wang, Xiao Han, Wei Zhang, Lijun Zhu, Yanhong Gu

Medicine (Baltimore) 2024 Apr 5; 103(14): e37693. Published online 2024 Apr 5. doi: 10.1097/MD.0000000000037693

PMCID:: PMC10994587

Abstract Article PDF–581K

Select item 108044835.

Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis

Haruhiko Takahashi, Manabu Natsumeda, Norikazu Hara, Akihide Koyama, Hiroshi Shimizu, Akinori Miyashita, Daiken Satake, Yoshihiro Mouri, Jun Tsukano, Keita Kawabe, Yoshihiro Tsukamoto, Masayasu Okada, Ryosuke Ogura, Akihiko Yuki, Hajime Umezu, Akiyoshi Kakita, Takeshi Ikeuchi, Makoto Oishi

Acta Neuropathol Commun. 2024; 12: 14. Published online 2024 Jan 22. doi: 10.1186/s40478-024-01723-0

PMCID:: PMC10804483

Abstract Article PDF–6.0M

Select item 106176736.

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg

Science. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021

PMCID:: PMC10617673

Abstract Article PDF–3.6M

Select item 105839597.

Anatomical resection improves relapse-free survival in colorectal liver metastases in patients with KRAS/NRAS/BRAF mutations or right-sided colon cancer: a retrospective cohort study

Wenju Chang, Yijiao Chen, Shizhao Zhou, Li Ren, Yuqiu Xu, Dexiang Zhu, Wentao Tang, Qinghai Ye, Xiaoying Wang, Jia Fan, Ye Wei, Jianmin Xu

Int J Surg. 2023 Oct; 109(10): 3070–3077. Published online 2023 Aug 1. doi: 10.1097/JS9.0000000000000562

PMCID:: PMC10583959

Abstract Article PDF–741K

Select item 104542878.

Clinical, Pathological and Molecular Insights on KRAS, NRAS, BRAF, PIK3CA and TP53 Mutations in Metastatic Colorectal Cancer Patients from Northeastern Romania

Vlad-Adrian Afrăsânie, Mihai-Vasile Marinca, Bogdan Gafton, Teodora Alexa-Stratulat, Alexandra Rusu, Eliza-Maria Froicu, Daniel Sur, Cristian Virgil Lungulescu, Larisa Popovici, Andrei-Vlad Lefter, Irina Afrăsânie, Anca-Viorica Ivanov, Lucian Miron, Cristina Rusu

Int J Mol Sci. 2023 Aug; 24(16): 12679. Published online 2023 Aug 11. doi: 10.3390/ijms241612679

PMCID:: PMC10454287

Abstract Article PDF–497K

Select item 102667829.

RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia

Jian-Gang Ren, Bowen Xing, Kaosheng Lv, Rachel A. O’Keefe, Mengfang Wu, Ruoxing Wang, Kaylyn M. Bauer, Arevik Ghazaryan, George M. Burslem, Jing Zhang, Ryan M. O’Connell, Vinodh Pillai, Elizabeth O. Hexner, Mark R. Philips, Wei Tong

J Clin Invest. 2023 Jun 15; 133(12): e165510. Published online 2023 Jun 15. doi: 10.1172/JCI165510

PMCID:: PMC10266782

Abstract Article PDF–2.8M

Select item 1024078210.

Correlation between KRAS and NRAS mutational status and clinicopathological features in 414 cases of metastatic colorectal cancer in Morocco: the largest North African case series

Youssef Mahdi, Mouna Khmou, Amine Souadka, Hajar El Agouri, Soumaya Ech-charif, Chaimaa Mounjid, Basma El Khannoussi

BMC Gastroenterol. 2023; 23: 193. Published online 2023 Jun 5. doi: 10.1186/s12876-023-02694-7

PMCID:: PMC10240782

Abstract Article PDF–910K

Select item 1023742211.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1012092512.

MicroRNA-708 emerges as a potential candidate to target undruggable NRAS

Jia Meng Pang, Po-Chen Chien, Ming-Chien Kao, Pei-Yun Chiu, Pin-Xu Chen, Yu-Ling Hsu, Chengyang Liu, Xiaowei Liang, Kai-Ti Lin

PLoS One. 2023; 18(4): e0284744. Published online 2023 Apr 21. doi: 10.1371/journal.pone.0284744

PMCID:: PMC10120925

Abstract Article PDF–2.5M

Select item 977255813.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 963180314.

NRAS^Q61R mutation in human endothelial cells causes vascular malformations

Elisa Boscolo, Patricia Pastura, Sandra Schrenk, Jillian Goines, Rachael Kang, Devin Pillis, Punam Malik, Timothy D. Le Cras

Angiogenesis. Author manuscript; available in PMC 2022 Nov 3.

Published in final edited form as: Angiogenesis. 2022 Aug; 25(3): 331–342. Published online 2022 Apr 7. doi: 10.1007/s10456-022-09836-7

PMCID:: PMC9631803

Abstract Article PDF–2.0M

Select item 962912115.

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

Wenjing Xiao, Jianqun Wang, Xiaojing Wang, Shuang Cai, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shikai Jin, Boling Yuan, Yi Zhou, Qilan Li, Qiangsong Tong, Liduan Zheng

Autophagy. 2022; 18(11): 2615–2635. Published online 2022 Mar 6. doi: 10.1080/15548627.2022.2044651

PMCID:: PMC9629121

Abstract Article PDF–8.1M

Select item 957818216.

Elevated NRAS expression during DCIS is a potential driver for progression to basal-like properties and local invasiveness

Ze-Yi Zheng, Hanan Elsarraj, Jonathan T. Lei, Yan Hong, Meenakshi Anurag, Long Feng, Hilda Kennedy, Yichao Shen, Flora Lo, Zifan Zhao, Bing Zhang, Xiang H.-F. Zhang, Ossama W. Tawfik, Fariba Behbod, Eric C. Chang

Breast Cancer Res. 2022; 24: 68. Published online 2022 Oct 18. doi: 10.1186/s13058-022-01565-5

PMCID:: PMC9578182

Abstract Article PDF–5.6M

Select item 947545317.

The N⁶-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2

Boyan Li, Rongrong Zhao, Wei Qiu, Ziwen Pan, Shulin Zhao, Yanhua Qi, Jiawei Qiu, Shouji Zhang, Qindong Guo, Yang Fan, Hao Xu, Ming Li, Gang Li, Hao Xue

Theranostics. 2022; 12(14): 6363–6379. Published online 2022 Aug 29. doi: 10.7150/thno.74600

PMCID:: PMC9475453

Abstract Article PDF–4.4M

Select item 937228118.

NOTCH4 mutation as predictive biomarker for immunotherapy benefits in NRAS wildtype melanoma

Hongxia Li, Qin Zhang, Qianqian Duan, Yuan Tan, Tingting Sun, Chuang Qi

Front Immunol. 2022; 13: 894110. Published online 2022 Jul 29. doi: 10.3389/fimmu.2022.894110

PMCID:: PMC9372281

Abstract Article PDF–1.4M

Select item 927928519.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 925596520.

Genomic landscape of lymphatic malformations: a case series and response to the PI3Kα inhibitor alpelisib in an N-of-1 clinical trial

Montaser F Shaheen, Julie Y Tse, Ethan S Sokol, Margaret Masterson, Pranshu Bansal, Ian Rabinowitz, Christy A Tarleton, Andrey S Dobroff, Tracey L Smith, Thèrése J Bocklage, Brian K Mannakee, Ryan N Gutenkunst, Joyce Bischoff, Scott A Ness, Gregory M Riedlinger, Roman Groisberg, Renata Pasqualini, Shridar Ganesan, Wadih Arap

eLife. 2022; 11: e74510. Published online 2022 Jul 5. doi: 10.7554/eLife.74510