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Items: 1 to 20 of 45

1.
PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment
Junichiro Takano, Shinsuke Ito, Yixing Dong, Jafar Sharif, Yaeko Nakajima-Takagi, Taichi Umeyama, Yong-Woon Han, Kyoichi Isono, Takashi Kondo, Yusuke Iizuka, Tomohiro Miyai, Yoko Koseki, Mika Ikegaya, Mizuki Sakihara, Manabu Nakayama, Osamu Ohara, Yoshinori Hasegawa, Kosuke Hashimoto, Erik Arner, Robert J. Klose, Atsushi Iwama, Haruhiko Koseki, Tomokatsu Ikawa
Nat Commun. 2022; 13: 7159. Published online 2022 Nov 28. doi: 10.1038/s41467-022-34856-8
PMCID:
PMC9705430
AbstractArticlePDF–4.0M
2.
OFCD Syndrome and Extraembryonic Defects are Revealed by Conditional Mutation of the Polycomb-group Repressive Complex 1.1 (PRC1.1) Gene Bcor
Michelle Y. Hamline, Connie M. Corcoran, Joseph A. Wamstad, Isabelle Miletich, Jifan Feng, Jamie L. Lohr, Myriam Hemberger, Paul T. Sharpe, Micah D. Gearhart, Vivian J. Bardwell
Dev Biol. Author manuscript; available in PMC 2022 Oct 20.
Published in final edited form as: Dev Biol. 2020 Dec 1; 468(1-2): 110–132. Published online 2020 Jul 18. doi: 10.1016/j.ydbio.2020.06.013
PMCID:
PMC9583620
AbstractArticlePDF–4.9M
3.
Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with early-onset retinal degeneration
Maéva Langouët, Christine Jolicoeur, Awais Javed, Pierre Mattar, Micah D. Gearhart, Stephen P. Daiger, Mette Bertelsen, Lisbeth Tranebjærg, Nanna D. Rendtorff, Karen Grønskov, Catherine Jespersgaard, Rui Chen, Zixi Sun, Hui Li, Najmeh Alirezaie, Jacek Majewski, Vivian J. Bardwell, Ruifang Sui, Robert K. Koenekoop, Michel Cayouette
Sci Adv. 2022 Sep; 8(36): eabh2868. Published online 2022 Sep 7. doi: 10.1126/sciadv.abh2868
PMCID:
PMC9451151
AbstractArticlePDF–7.1M
4.
Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1–CoREST interactome during embryonic stem cell differentiation
Claire E. Barnes, David M. English, Megan Broderick, Mark O. Collins, Shaun M. Cowley
Mol Omics. 2022 Jan 17; 18(1): 31–44. Published online 2021 Oct 14. doi: 10.1039/d1mo00236h
PMCID:
PMC8763317
AbstractArticle
5.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
6.
Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice
Paolo Sportoletti, Daniele Sorcini, Anna G. Guzman, Jaime M. Reyes, Arianna Stella, Andrea Marra, Sara Sartori, Lorenzo Brunetti, Roberta Rossi, Beatrice Del Papa, Francesco Maria Adamo, Giulia Pianigiani, Camilla Betti, Annarita Scialdone, Valerio Guarente, Giulio Spinozzi, Valentina Tini, Maria Paola Martelli, Margaret A. Goodell, Brunangelo Falini
Leukemia. 2021; 35(7): 1949–1963. Published online 2020 Nov 6. doi: 10.1038/s41375-020-01075-3
PMCID:
PMC8257496
AbstractArticlePDF–2.4M
7.
TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation
Xiaochen Fan, V Pragathi Masamsetti, Jane QJ Sun, Kasper Engholm-Keller, Pierre Osteil, Joshua Studdert, Mark E Graham, Nicolas Fossat, Patrick PL Tam
eLife. 2021; 10: e62873. Published online 2021 Feb 8. doi: 10.7554/eLife.62873
PMCID:
PMC7968925
AbstractArticlePDF–4.0M
8.
BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity
Charles R. Schmidt, Nicholas J. Achille, Aravinda Kuntimaddi, Adam M. Boulton, Benjamin I. Leach, Shubin Zhang, Nancy J. Zeleznik-Le, John H. Bushweller
Blood Cancer Discov. 2020 Sep; 1(2): 162–177. Published online 2020 Jul 7. doi: 10.1158/2643-3230.BCD-20-0036
PMCID:
PMC7497807
AbstractArticlePDF–22M
9.
Functional loss of a noncanonical BCOR–PRC1.1 complex accelerates SHH-driven medulloblastoma formation
Lena M. Kutscher, Konstantin Okonechnikov, Nadja V. Batora, Jessica Clark, Patricia B.G. Silva, Mikaella Vouri, Sjoerd van Rijn, Laura Sieber, Britta Statz, Micah D. Gearhart, Ryo Shiraishi, Norman Mack, Brent A. Orr, Andrey Korshunov, Brian L. Gudenas, Kyle S. Smith, Audrey L. Mercier, Olivier Ayrault, Mikio Hoshino, Marcel Kool, Katja von Hoff, Norbert Graf, Gudrun Fleischhack, Vivian J. Bardwell, Stefan M. Pfister, Paul A. Northcott, Daisuke Kawauchi
Genes Dev. 2020 Sep 1; 34(17-18): 1161–1176. doi: 10.1101/gad.337584.120
PMCID:
PMC7462063
AbstractArticlePDF–8.2M
10.
KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis
Yusuke Isshiki, Yaeko Nakajima-Takagi, Motohiko Oshima, Kazumasa Aoyama, Mohamed Rizk, Shuhei Kurosawa, Atsunori Saraya, Takashi Kondo, Emiko Sakaida, Chiaki Nakaseko, Koutaro Yokote, Haruhiko Koseki, Atsushi Iwama
Blood Adv. 2019 Sep 10; 3(17): 2537–2549. Published online 2019 Aug 30. doi: 10.1182/bloodadvances.2018028522
PMCID:
PMC6737409
AbstractArticlePDF–1.7M
11.
Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background
Mianmian Yin, Yang Jo Chung, R. Coleman Lindsley, Robert L. Walker, Yuelin J. Zhu, Benjamin L. Ebert, Paul S. Meltzer, Peter D. Aplan
Blood. 2019 Jun 13; 133(24): 2610–2614. Prepublished online 2019 Apr 16. doi: 10.1182/blood.2018864173
PMCID:
PMC6566592
AbstractArticle
12.
BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors
Jessica A. Kotov, Dmitri I. Kotov, Jonathan L. Linehan, Vivian J. Bardwell, Micah D. Gearhart, Marc K. Jenkins
J Exp Med. 2019 Jun 3; 216(6): 1450–1464. Published online 2019 May 3. doi: 10.1084/jem.20182376
PMCID:
PMC6547868
AbstractArticlePDF–3.1M
13.
Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome
Shiro Tara, Yusuke Isshiki, Yaeko Nakajima-Takagi, Motohiko Oshima, Kazumasa Aoyama, Tomoyuki Tanaka, Daisuke Shinoda, Shuhei Koide, Atsunori Saraya, Satoru Miyagi, Ichiro Manabe, Hirotaka Matsui, Haruhiko Koseki, Vivian J. Bardwell, Atsushi Iwama
Blood. 2018 Dec 6; 132(23): 2470–2483. Prepublished online 2018 Sep 18. doi: 10.1182/blood-2018-01-827964
PMCID:
PMC6450057
AbstractArticle
14.
Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis
Madison J. Kelly, Joan So, Amy J. Rogers, Gareth Gregory, Jason Li, Magnus Zethoven, Micah D. Gearhart, Vivian J. Bardwell, Ricky W. Johnstone, Stephin J. Vervoort, Lev M. Kats
Nat Commun. 2019; 10: 1347. Published online 2019 Mar 22. doi: 10.1038/s41467-019-09250-6
PMCID:
PMC6430802
AbstractArticlePDF–3.2M
15.
Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells
Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch
Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262
PMCID:
PMC6244183
AbstractArticlePDF–753K
16.
Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders
Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba
Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.
Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594
PMCID:
PMC5645082
AbstractArticlePDF–2.3M
17.
Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies
Tomoyuki Tanaka, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Shiro Tara, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Sha Si, Ichiro Manabe, Masashi Sanada, Manabu Nakayama, Masayoshi Masuko, Hirohito Sone, Haruhiko Koseki, Atsushi Iwama
J Exp Med. 2017 Oct 2; 214(10): 2901–2913. doi: 10.1084/jem.20170167
PMCID:
PMC5626398
AbstractArticlePDF–2.1M
18.
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene
Marcus Lefebure, Richard W. Tothill, Elizabeth Kruse, Edwin D. Hawkins, Jake Shortt, Geoffrey M. Matthews, Gareth P. Gregory, Benjamin P. Martin, Madison J. Kelly, Izabela Todorovski, Maria A. Doyle, Richard Lupat, Jason Li, Jan Schroeder, Meaghan Wall, Stuart Craig, Gretchen Poortinga, Don Cameron, Megan Bywater, Lev Kats, Micah D. Gearhart, Vivian J. Bardwell, Ross A. Dickins, Ross D. Hannan, Anthony T. Papenfuss, Ricky W. Johnstone
Nat Commun. 2017; 8: 14581. Published online 2017 Mar 6. doi: 10.1038/ncomms14581
PMCID:
PMC5343491
AbstractArticlePDF–1.1M
19.
BCOR regulates myeloid cell proliferation and differentiation
Qi Cao, Micah D. Gearhart, Sigal Gery, Seyedmehdi Shojaee, Henry Yang, Haibo Sun, De-chen Lin, Jing-wen Bai, Monica Mead, Zhiqiang Zhao, Qi Chen, Wen-wen Chien, Serhan Alkan, Tamara Alpermann, Torsten Haferlach, Markus Müschen, Vivian J. Bardwell, H. Phillip Koeffler
Leukemia. Author manuscript; available in PMC 2016 Dec 1.
Published in final edited form as: Leukemia. 2016 May; 30(5): 1155–1165. Published online 2016 Feb 5. doi: 10.1038/leu.2016.2
PMCID:
PMC5131645
AbstractArticlePDF–2.9M
20.
Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos
Wei Cui, Xiangpeng Dai, Chelsea Marcho, Zhengbin Han, Kun Zhang, Kimberly D. Tremblay, Jesse Mager
Sci Rep. 2016; 6: 37396. Published online 2016 Nov 21. doi: 10.1038/srep37396
PMCID:
PMC5116644
AbstractArticlePDF–2.1M

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