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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107028142.

The HACE1 E3 ligase mediates RAC1‐dependent control of mTOR signaling complexes

Busra Turgu, Amal El‐Naggar, Melanie Kogler, Luigi Tortola, Hai‐Feng Zhang, Mariam Hassan, Michael M Lizardo, Sonia HY Kung, Wan Lam, Josef M Penninger, Poul H Sorensen

EMBO Rep. 2023 Dec; 24(12): e56815. Published online 2023 Oct 17. doi: 10.15252/embr.202356815

PMCID:: PMC10702814

Abstract Article PDF–21M

Select item 79795423.

HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner

Busra Turgu, Fan Zhang, Amal El-Naggar, Gian Luca Negri, Melanie Kogler, Luigi Tortola, Fraser Johnson, Tony Ng, Amy Li, Donald Yapp, William Lockwood, Daniel Martinez, John M. Maris, Mads Daugaard, Josef M. Penninger, Christopher S. Hughes, Poul H. Sorensen

Oncogene. 2021; 40(11): 1988–2001. Published online 2021 Feb 18. doi: 10.1038/s41388-021-01680-1

PMCID:: PMC7979542

Abstract Article PDF–4.1M

Select item 79387704.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 76112025.

HACE1 prevents lung carcinogenesis via inhibition of RAC-family GTPases

Melanie Kogler, Luigi Tortola, Gian Luca Negri, Alexandra Leopoldi, Amal M. El-Naggar, Stefan Mereiter, Carlos Gomez Diaz, Roberto Nitsch, Davide Tortora, Anoop M. Kavirayani, Bianca V. Gapp, Shuan Rao, Iris Uribesalgo, David Hoffmann, Domagoj Cikes, Maria Novatchkova, David A. Williams, Jeffrey M. Trent, Fumiyo Ikeda, Mads Daugaard, Astrid Hagelkruys, Poul H. Sorensen, Josef M. Penninger

Cancer Res. Author manuscript; available in PMC 2021 Jul 12.

Published in final edited form as: Cancer Res. 2020 Jul 15; 80(14): 3009–3022. Published online 2020 May 4. doi: 10.1158/0008-5472.CAN-19-2270

PMCID:: PMC7611202

Abstract Article PDF–3.5M

Select item 58861166.

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

Dagmar E Ehrnhoefer, Amber L Southwell, Meenalochani Sivasubramanian, Xiaofan Qiu, Erika B Villanueva, Yuanyun Xie, Sabine Waltl, Lisa Anderson, Anita Fazeli, Lorenzo Casal, Boguslaw Felczak, Michelle Tsang, Michael R Hayden

Hum Mol Genet. 2018 Jan 15; 27(2): 239–253. Published online 2017 Nov 7. doi: 10.1093/hmg/ddx394

PMCID:: PMC5886116

Abstract Article PDF–886K

Select item 52958217.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 48931568.

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

Luigi Tortola, Roberto Nitsch, Mathieu J.M. Bertrand, Melanie Kogler, Younes Redouane, Ivona Kozieradzki, Iris Uribesalgo, Lilian M. Fennell, Mads Daugaard, Helene Klug, Gerald Wirnsberger, Reiner Wimmer, Thomas Perlot, Renu Sarao, Shuan Rao, Toshikatsu Hanada, Nozomi Takahashi, Elisabeth Kernbauer, Duygu Demiröz, Giulio Superti-Furga, Thomas Decker, Andrea Pichler, Fumiyo Ikeda, Guido Kroemer, Peter Vandenabeele, Poul H. Sorensen, Josef M. Penninger

Cell Rep. 2016 May 17; 15(7): 1481–1492. Published online 2016 May 5. doi: 10.1016/j.celrep.2016.04.032

Correction in:: Cell Rep. 2016 Sep 20; 16(12): 3414.

PMCID:: PMC4893156

Abstract Article

Select item 44667289.

Metformin increases degradation of phospholamban via autophagy in cardiomyocytes

Allen C. T. Teng, Tetsuaki Miyake, Shunichi Yokoe, Liyong Zhang, Luís Mário Rezende, Jr., Parveen Sharma, David H. MacLennan, Peter P. Liu, Anthony O. Gramolini

Proc Natl Acad Sci U S A. 2015 Jun 9; 112(23): 7165–7170. Published online 2015 May 26. doi: 10.1073/pnas.1508815112

PMCID:: PMC4466728

Abstract Article PDF–1.3M

Select item 438711310.

Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction

Naniye Cetinbas, Mads Daugaard, Andrew Mullen, Shamil Hajee, Barak Rotblat, Alejandra Lopez, Amy Li, Ralph J DeBerardinis, Poul H Sorensen

Oncogene. Author manuscript; available in PMC 2016 Jan 23.

Published in final edited form as: Oncogene. 2015 Jul 23; 34(30): 4005–4010. Published online 2014 Oct 6. doi: 10.1038/onc.2014.316

PMCID:: PMC4387113

Abstract Article PDF–542K

Select item 416649211.

Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression

Zhengzhao Liu, Peng Chen, Hong Gao, Yu Gu, Jiao Yang, Hong Peng, Xingxing Xu, Haifeng Wang, Meiqiang Yang, Xiaoying Liu, Libin Fan, Shiyao Chen, Jian Zhou, Yihong Sun, Kangchen Ruan, Shuqun Cheng, Masaaki Komatsu, Eileen White, Lin Li, Hongbin Ji, Daniel Finley, Ronggui Hu

Cancer Cell. Author manuscript; available in PMC 2015 Jul 14.

Published in final edited form as: Cancer Cell. 2014 Jul 14; 26(1): 106–120. doi: 10.1016/j.ccr.2014.05.015

PMCID:: PMC4166492

Abstract Article PDF–1.3M

Select item 396495512.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 395920913.

HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress

Liyong Zhang, Xin Chen, Parveen Sharma, Mark Moon, Alex D. Sheftel, Fayez Dawood, Mai P. Nghiem, Jun Wu, Ren-Ke Li, Anthony O. Gramolini, Poul H. Sorensen, Josef M. Penninger, John H. Brumell, Peter P. Liu

Nat Commun. 2014 Mar 11; 5: 3430. Published online 2014 Mar 11. doi: 10.1038/ncomms4430

PMCID:: PMC3959209

Abstract Article PDF–3.6M

Select item 393991914.

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response

Barak Rotblat, Amber L. Southwell, Dagmar E. Ehrnhoefer, Niels H. Skotte, Martina Metzler, Sonia Franciosi, Gabriel Leprivier, Syam Prakash Somasekharan, Adi Barokas, Yu Deng, Tiffany Tang, Joan Mathers, Naniye Cetinbas, Mads Daugaard, Brian Kwok, Liheng Li, Christopher J. Carnie, Dieter Fink, Roberto Nitsch, Jason D. Galpin, Christopher A. Ahern, Gerry Melino, Josef M. Penninger, Michael R. Hayden, Poul H. Sorensen

Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8): 3032–3037. Published online 2014 Feb 10. doi: 10.1073/pnas.1314421111

PMCID:: PMC3939919

Abstract Article PDF–1.0M

Select item 375904115.

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes

Mads Daugaard, Roberto Nitsch, Babak Razaghi, Lindsay McDonald, Ameer Jarrar, Stéphanie Torrino, Sonia Castillo-Lluva, Barak Rotblat, Liheng Li, Angeliki Malliri, Emmanuel Lemichez, Amel Mettouchi, Jason N. Berman, Josef M. Penninger, Poul H. Sorensen

Nat Commun. 2013 Jul 17; 4: 2180. Published online 2013 Jul 17. doi: 10.1038/ncomms3180

PMCID:: PMC3759041

Abstract Article PDF–1.9M

Select item 357241016.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 317805917.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253418.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 273662719.

HACE1: A Novel Repressor of RAR Transcriptional Activity

Jianhua Zhao, Zhenping Zhang, Zivjena Vucetic, Kenneth J. Soprano, Dianne Robert Soprano

J Cell Biochem. Author manuscript; available in PMC 2009 Sep 2.

Published in final edited form as: J Cell Biochem. 2009 Jun 1; 107(3): 482–493. doi: 10.1002/jcb.22146

PMCID:: PMC2736627

Abstract Article PDF–668K

Select item 141356820.

BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System

Susan Magdaleno, Patricia Jensen, Craig L Brumwell, Anna Seal, Karen Lehman, Andrew Asbury, Tony Cheung, Tommie Cornelius, Diana M Batten, Christopher Eden, Shannon M Norland, Dennis S Rice, Nilesh Dosooye, Sundeep Shakya, Perdeep Mehta, Tom Curran

PLoS Biol. 2006 Apr; 4(4): e86. Published online 2006 Mar 28. doi: 10.1371/journal.pbio.0040086

PMCID:: PMC1413568

Article PDF–99K

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