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Select item 109902771.

ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton

Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012

PMCID:: PMC10990277

Abstract Article PDF–3.9M

Select item 103459632.

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald

Clin Cancer Res. 2023 Jul 14; 29(14): 2686–2701. Published online 2023 Mar 28. doi: 10.1158/1078-0432.CCR-22-2535

PMCID:: PMC10345963

Abstract Article PDF–13M

Select item 96913583.

Elevated ITGA5 facilitates hyperactivated mTORC1-mediated progression of laryngeal squamous cell carcinoma via upregulation of EFNB2

Dapeng Li, Anjiang Sun, Liang Zhang, Zhao Ding, Fangzheng Yi, Xue Yang, Zixi Wang, Xu Chen, Weiwei Liu, Shixian Liu, Hailong Shen, Manli Miao, Ling Zhang, Ping Liu, Yuchen Liu, Shihong Su, Hailiang Huang, Can Huang, Zhongdong Hu, Hongbing Zhang, Xiaojun Zha, Yehai Liu

Theranostics. 2022; 12(17): 7431–7449. Published online 2022 Oct 24. doi: 10.7150/thno.76232

PMCID:: PMC9691358

Abstract Article PDF–5.4M

Select item 94339384.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

Select item 91714115.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 90846346.

EphrinB2 expression in prostate adenocarcinoma: Implications for targeted therapy

Chhavi Gupta, Akash Sali, Binyun Ma, Alexandra Jackovich, Sarmad Sadeghi, David Quinn, Parkash Gill, Inderbir Gill

Pathol Res Pract. Author manuscript; available in PMC 2022 May 9.

Published in final edited form as: Pathol Res Pract. 2020 Jun; 216(6): 152967. Published online 2020 Apr 19. doi: 10.1016/j.prp.2020.152967

PMCID:: PMC9084634

Abstract Article PDF–2.0M

Select item 88361627.

EphrinB2–EphB4 Signaling in Neurooncological Disease

Andras Piffko, Christian Uhl, Peter Vajkoczy, Marcus Czabanka, Thomas Broggini

Int J Mol Sci. 2022 Feb; 23(3): 1679. Published online 2022 Jan 31. doi: 10.3390/ijms23031679

PMCID:: PMC8836162

Abstract Article PDF–2.8M

Select item 85138538.

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari

PLoS Pathog. 2021 Oct; 17(10): e1009412. Published online 2021 Oct 1. doi: 10.1371/journal.ppat.1009412

PMCID:: PMC8513853

Abstract Article PDF–4.1M

Select item 82904249.

The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme

Shilpa Bhatia, Sanjana Bukkapatnam, Benjamin Van Court, Andy Phan, Ayman Oweida, Jacob Gadwa, Adam C. Mueller, Miles Piper, Laurel Darragh, Diemmy Nguyen, Ahmed Gilani, Michael Knitz, Thomas Bickett, Adam Green, Sujatha Venkataraman, Rajeev Vibhakar, Diana Cittelly, Sana D. Karam

Mol Carcinog. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: Mol Carcinog. 2020 Sep; 59(9): 1064–1075. Published online 2020 Jun 22. doi: 10.1002/mc.23237

PMCID:: PMC8290424

Abstract Article PDF–1.8M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 787993611.

Mutations in the G–H loop region of ephrin-B2 can enhance Nipah virus binding and infection

Junfa Yuan, Glenn Marsh, Dimple Khetawat, Christopher C. Broder, Lin-Fa Wang, Zhengli Shi

J Gen Virol. 2011 Sep; 92(Pt 9): 2142–2152. doi: 10.1099/vir.0.033787-0

PMCID:: PMC7879936

Abstract Article PDF–974K

Select item 787370112.

Global proteomics of Ubqln2-based murine models of ALS

Alexandra M. Whiteley, Miguel A. Prado, Stefanie A.H. de Poot, Joao A. Paulo, Marissa Ashton, Sara Dominguez, Martin Weber, Hai Ngu, John Szpyt, Mark P. Jedrychowski, Amy Easton, Steven P. Gygi, Thimo Kurz, Mervyn J. Monteiro, Eric J. Brown, Daniel Finley

J Biol Chem. 2021 Jan-Jun; 296: 100153. Published online 2020 Dec 10. doi: 10.1074/jbc.RA120.015960

PMCID:: PMC7873701

Abstract Article PDF–3.0M

Select item 749636513.

EPH receptor B2 stimulates human monocyte adhesion and migration independently of its EphrinB ligands

Dianne Vreeken, Caroline Suzanne Bruikman, Stefan Martinus Leonardus Cox, Huayu Zhang, Reshma Lalai, Angela Koudijs, Anton Jan van Zonneveld, Gerard Kornelis Hovingh, Janine Maria van Gils

J Leukoc Biol. 2020 Sep; 108(3): 999–1011. Published online 2020 Apr 26. doi: 10.1002/JLB.2A0320-283RR

PMCID:: PMC7496365

Abstract Article PDF–6.4M

Select item 743212414.

Polymorphisms in the Angiogenesis-Related Genes EFNB2, MMP2 and JAG1 Are Associated with Survival of Colorectal Cancer Patients

Dominique Scherer, Heike Deutelmoser, Yesilda Balavarca, Reka Toth, Nina Habermann, Katharina Buck, Elisabeth Johanna Kap, Akke Botma, Petra Seibold, Lina Jansen, Justo Lorenzo Bermejo, Korbinian Weigl, Axel Benner, Michael Hoffmeister, Alexis Ulrich, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Cornelia M. Ulrich

Int J Mol Sci. 2020 Aug; 21(15): 5395. Published online 2020 Jul 29. doi: 10.3390/ijms21155395

PMCID:: PMC7432124

Abstract Article PDF–279K

Select item 716998315.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 699057916.

EphrinB2 overexpression enhances osteogenic differentiation of dental pulp stem cells partially through ephrinB2-mediated reverse signaling

Wen Wang, Changyong Yuan, Tengyu Geng, Yi Liu, Shaoyue Zhu, Chengfei Zhang, Zongxiang Liu, Penglai Wang

Stem Cell Res Ther. 2020; 11: 40. Published online 2020 Jan 29. doi: 10.1186/s13287-019-1540-2

PMCID:: PMC6990579

Abstract Article PDF–3.7M

Select item 688639017.

Inhibition of EphB4–Ephrin-B2 Signaling Enhances Response to Cetuximab-Radiation Therapy in Head and Neck Cancers

Shilpa Bhatia, Jaspreet Sharma, Sanjana Bukkapatnam, Ayman Oweida, Shelby Lennon, Andy Phan, Dallin Milner, Nomin Uyanga, Antonio Jimeno, David Raben, Hilary Somerset, Lynn Heasley, Sana D. Karam

Clin Cancer Res. Author manuscript; available in PMC 2019 Dec 2.

Published in final edited form as: Clin Cancer Res. 2018 Sep 15; 24(18): 4539–4550. Published online 2018 May 30. doi: 10.1158/1078-0432.CCR-18-0327

PMCID:: PMC6886390

Abstract Article PDF–1.5M

Select item 683120518.

Ephrin-B2 inhibits cell proliferation and motility in vitro and predicts longer metastasis-free survival in breast cancer

Zeljana Magic, Josefine Sandström, Gizeh Perez-Tenorio

Int J Oncol. 2019 Dec; 55(6): 1275–1286. Published online 2019 Oct 4. doi: 10.3892/ijo.2019.4892

PMCID:: PMC6831205

Abstract Article PDF–1.2M

Select item 678257419.

Specification of Distinct Dopaminergic Neural Pathways: Roles of the Eph Family Receptor EphB1 and Ligand Ephrin-B2

Yong Yue, David A. J. Widmer, Alycia K. Halladay, Douglas Pat Cerretti, George C. Wagner, Jean-Luc Dreyer, Renping Zhou

J Neurosci. 1999 Mar 15; 19(6): 2090–2101. doi: 10.1523/JNEUROSCI.19-06-02090.1999

PMCID:: PMC6782574

Abstract Article PDF–1.3M

Select item 672608820.

Interactions between Ephrin-B and Metabotropic Glutamate 1 Receptors in Brain Tissue and Cultured Neurons

L. Calò, V. Bruno, P. Spinsanti, G. Molinari, V. Korkhov, Z. Esposito, M. Patanè, D. Melchiorri, M. Freissmuth, F. Nicoletti

J Neurosci. 2005 Mar 2; 25(9): 2245–2254. doi: 10.1523/JNEUROSCI.4956-04.2005

PMCID:: PMC6726088

Abstract Article PDF–519K

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