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Select item 110678631.

CeLab, a Microfluidic Platform for the Study of Life History Traits, reveals Metformin and SGK-1 regulation of Longevity and Reproductive Span

Salman Sohrabi, Vanessa Cota, Coleen T. Murphy

Lab Chip. Author manuscript; available in PMC 2024 Jun 13.

Published in final edited form as: Lab Chip. 2023 Jun 13; 23(12): 2738–2757. Published online 2023 Jun 13. doi: 10.1039/d3lc00028a

PMCID:: PMC11067863

Abstract Article PDF–2.9M

Select item 110199322.

LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans

Taruna Pandey, Bingying Wang, Changnan Wang, Jenny Zu, Huichao Deng, Kang Shen, Goncalo Dias do Vale, Jeffrey G. McDonald, Dengke K. Ma

Cell Rep. Author manuscript; available in PMC 2024 Apr 16.

Published in final edited form as: Cell Rep. 2024 Mar 26; 43(3): 113899. Published online 2024 Mar 5. doi: 10.1016/j.celrep.2024.113899

PMCID:: PMC11019932

Abstract Article PDF–1.8M

Select item 107535863.

GRD-1/PTR-11, the C. elegans hedgehog/patched-like morphogen-receptor pair, modulates developmental rate

Sinclair W. Emans, Armen Yerevanian, Fasih M. Ahsan, Jen F. Rotti, Yifei Zhou, Lucydalila Cedillo, Alexander A. Soukas

Development. 2023 Dec 15; 150(24): dev201974. Published online 2023 Dec 11. doi: 10.1242/dev.201974

PMCID:: PMC10753586

Abstract Article

Select item 107028234.

Metabolic plasticity sustains the robustness of Caenorhabditis elegans embryogenesis

Siyu Chen, Xing Su, Jinglin Zhu, Long Xiao, Yulin Cong, Leilei Yang, Zhuo Du, Xun Huang

EMBO Rep. 2023 Dec; 24(12): e57440. Published online 2023 Oct 27. doi: 10.15252/embr.202357440

PMCID:: PMC10702823

Abstract Article PDF–9.5M

Select item 105503825.

SGK-1 mediated inhibition of iron import is a determinant of lifespan in C. elegans

Gang Wu, Ralf Baumeister, Thomas Heimbucher

MicroPubl Biol. 2023; 2023: 10.17912/micropub.biology.000970. Published online 2023 Sep 17. doi: 10.17912/micropub.biology.000970

PMCID:: PMC10550382

Abstract Article PDF–3.6M

Select item 94378486.

Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans

Murat Artan, Markus Hartl, Weiqiang Chen, Mario de Bono

J Biol Chem. 2022 Sep; 298(9): 102343. Published online 2022 Aug 3. doi: 10.1016/j.jbc.2022.102343

PMCID:: PMC9437848

Abstract Article PDF–2.0M

Select item 93713567.

The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan

İçten Meraş, Laëtitia Chotard, Thomas Liontis, Zakaria Ratemi, Benjamin Wiles, Jung Hwa Seo, Jeremy M. Van Raamsdonk, Christian E. Rocheleau

PLoS Genet. 2022 Aug; 18(8): e1010328. Published online 2022 Aug 1. doi: 10.1371/journal.pgen.1010328

PMCID:: PMC9371356

Abstract Article PDF–3.3M

Select item 92179328.

SIN-3 functions through multi-protein interaction to regulate apoptosis, autophagy, and longevity in Caenorhabditis elegans

Chandrika Konwar, Jayant Maini, Surbhi Kohli, Vani Brahmachari, Daman Saluja

Sci Rep. 2022; 12: 10560. Published online 2022 Jun 22. doi: 10.1038/s41598-022-13864-0

PMCID:: PMC9217932

Abstract Article PDF–2.6M

Select item 84425759.

Insulin/IGF-1 signaling and heat stress differentially regulate HSF1 activities in germline development

Stacey L. Edwards, Purevsuren Erdenebat, Allison C. Morphis, Lalit Kumar, Lai Wang, Tomasz Chamera, Constantin Georgescu, Jonathan D. Wren, Jian Li

Cell Rep. Author manuscript; available in PMC 2021 Sep 15.

Published in final edited form as: Cell Rep. 2021 Aug 31; 36(9): 109623. doi: 10.1016/j.celrep.2021.109623

PMCID:: PMC8442575

Abstract Article PDF–1.5M

Select item 799517610.

EPIC: Software Toolkit for Elution Profile-Based Inference of Protein Complexes

Lucas ZhongMing Hu, Florian Goebels, June H. Tan, Eric Wolf, Uros Kuzmanov, Cuihong Wan, Sadhna Phanse, Changjiang Xu, Mike Schertzberg, Andrew G. Fraser, Gary D. Bader, Andrew Emili

Nat Methods. Author manuscript; available in PMC 2021 Mar 26.

Published in final edited form as: Nat Methods. 2019 Aug; 16(8): 737–742. Published online 2019 Jul 15. doi: 10.1038/s41592-019-0461-4

PMCID:: PMC7995176

Abstract Article PDF–1.0M

Select item 787461711.

Toxic stress-specific cytoprotective responses regulate learned behavioral decisions in C. elegans

Gábor Hajdú, Eszter Gecse, István Taisz, István Móra, Csaba Sőti

BMC Biol. 2021; 19: 26. Published online 2021 Feb 9. doi: 10.1186/s12915-021-00956-y

PMCID:: PMC7874617

Abstract Article PDF–2.8M

Select item 746966512.

TORC2-SGK-1 signaling integrates external signals to regulate autophagic turnover of mitochondria via mtROS

Thomas Heimbucher, Wenjing Qi, Ralf Baumeister

Autophagy. 2020; 16(6): 1154–1156. Published online 2020 Apr 15. doi: 10.1080/15548627.2020.1749368

PMCID:: PMC7469665

Abstract Article PDF–611K

Select item 738224813.

Bacteria-derived metabolite, methylglyoxal, modulates the longevity of C. elegans through TORC2/SGK-1/DAF-16 signaling

Min-Gi Shin, Jae-Woong Lee, Jun-Seok Han, Bora Lee, Jin-Hyuck Jeong, So-Hyun Park, Jong-Hwan Kim, Sumi Jang, Mooncheol Park, Seon-Young Kim, Seokho Kim, Yong Ryoul Yang, Jeong-Yoon Kim, Kwang-Lae Hoe, Chankyu Park, Kwang-Pyo Lee, Ki-Sun Kwon, Eun-Soo Kwon

Proc Natl Acad Sci U S A. 2020 Jul 21; 117(29): 17142–17150. Published online 2020 Jul 7. doi: 10.1073/pnas.1915719117

PMCID:: PMC7382248

Abstract Article PDF–2.3M

Select item 694365314.

Exploring Target Genes Involved in the Effect of Quercetin on the Response to Oxidative Stress in Caenorhabditis elegans

Begoña Ayuda-Durán, Susana González-Manzano, Antonio Miranda-Vizuete, Eva Sánchez-Hernández, Marta R. Romero, Montserrat Dueñas, Celestino Santos-Buelga, Ana M. González-Paramás

Antioxidants (Basel) 2019 Dec; 8(12): 585. Published online 2019 Nov 25. doi: 10.3390/antiox8120585

PMCID:: PMC6943653

Abstract Article PDF–3.6M

Select item 682736815.

Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules

Elisabeth A. Marnik, J. Heath Fuqua, Catherine S. Sharp, Jesse D. Rochester, Emily L. Xu, Sarah E. Holbrook, Dustin L. Updike

Genetics. 2019 Nov; 213(3): 923–939. Published online 2019 Sep 10. doi: 10.1534/genetics.119.302670

PMCID:: PMC6827368

Abstract Article PDF–4.0M

Select item 673553916.

Suppressing the dark side of autophagy

Ben Zhou, Alexander A. Soukas

Autophagy. 2019; 15(10): 1852–1853. Published online 2019 Jul 18. doi: 10.1080/15548627.2019.1644077

PMCID:: PMC6735539

Abstract Article PDF–758K

Select item 661088117.

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

Ben Zhou, Johannes Kreuzer, Caroline Kumsta, Lianfeng Wu, Kimberli J. Kamer, Lucydalila Cedillo, Yuyao Zhang, Sainan Li, Michael C. Kacergis, Christopher M. Webster, Geza Fejes-Toth, Aniko Naray-Fejes-Toth, Sudeshna Das, Malene Hansen, Wilhelm Haas, Alexander A. Soukas

Cell. Author manuscript; available in PMC 2020 Apr 4.

Published in final edited form as: Cell. 2019 Apr 4; 177(2): 299–314.e16. Published online 2019 Mar 28. doi: 10.1016/j.cell.2019.02.013