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Select item 111316791.

Role of Nef in primate lentiviral immunopathogenesis

F. Kirchhoff, M. Schindler, A. Specht, N. Arhel, J. Münch

Cell Mol Life Sci. 2008 Sep; 65(17): 2621. Published online 2008 Apr 26. doi: 10.1007/s00018-008-8094-2

PMCID:: PMC11131679

Abstract Article PDF–1.2M

Select item 111045162.

Antigen-specific memory NK cell responses against HIV and influenza utilize the NKG2/HLA-E axis

Stephanie Jost, Olivier Lucar, Esther Lee, Taylor Yoder, Kyle Kroll, Sho Sugawara, Scott Smith, Rhianna Jones, George Tweet, Alexandra Werner, Phillip J. Tomezsko, Haley L. Dugan, Joshua Ghofrani, Philippe Rascle, Marcus Altfeld, Michaela Müller-Trutwin, Paul Goepfert, R. Keith Reeves

Sci Immunol. Author manuscript; available in PMC 2024 May 20.

Published in final edited form as: Sci Immunol. 2023 Dec 8; 8(90): eadi3974. Published online 2023 Dec 8. doi: 10.1126/sciimmunol.adi3974

PMCID:: PMC11104516

Abstract Article PDF–849K

Select item 106904373.

HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses

Zhansong Lin, Arman A. Bashirova, Mathias Viard, Lee Garner, Max Quastel, Maya Beiersdorfer, Wojciech K. Kasprzak, Marjan Akdag, Yuko Yuki, Pedro Ojeda, Sudipto Das, Thorkell Andresson, Vivek Naranbhai, Amir Horowitz, Andrew J. McMichael, Angelique Hoelzemer, Geraldine M. Gillespie, Wilfredo F. Garcia-Beltran, Mary Carrington

Nat Immunol. Author manuscript; available in PMC 2023 Dec 1.

Published in final edited form as: Nat Immunol. 2023 Jul; 24(7): 1087–1097. Published online 2023 Jun 1. doi: 10.1038/s41590-023-01523-z

PMCID:: PMC10690437

Abstract Article PDF–3.3M

Select item 106759464.

IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis

Hui Zheng, Xiaolin Guan, Xin Meng, Ying Tong, Yanchun Wang, Suhong Xie, Lin Guo, Renquan Lu

J Ovarian Res. 2023; 16: 229. Published online 2023 Nov 25. doi: 10.1186/s13048-023-01286-z

PMCID:: PMC10675946

Abstract Article PDF–1.6M

Select item 106114595.

Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells

Jagoda Siemaszko, Piotr Łacina, Donata Szymczak, Agnieszka Szeremet, Maciej Majcherek, Anna Czyż, Małgorzata Sobczyk-Kruszelnicka, Wojciech Fidyk, Iwona Solarska, Barbara Nasiłowska-Adamska, Patrycja Skowrońska, Maria Bieniaszewska, Agnieszka Tomaszewska, Grzegorz W. Basak, Sebastian Giebel, Tomasz Wróbel, Katarzyna Bogunia-Kubik

Front Immunol. 2023; 14: 1227897. Published online 2023 Oct 13. doi: 10.3389/fimmu.2023.1227897

PMCID:: PMC10611459

Abstract Article PDF–3.7M

Select item 104496406.

The complex HLA-E-nonapeptide in Behçet disease

Ángel Luís Castaño-Núñez, Marco-Antonio Montes-Cano, José-Raúl García-Lozano, Norberto Ortego-Centeno, Francisco José García-Hernández, Gerard Espinosa, Genaro Graña-Gil, Juan Sánchez-Bursón, María Rosa Juliá, Roser Solans, Ricardo Blanco, Ana-Celia Barnosi-Marín, Ricardo Gómez de la Torre, Patricia Fanlo, Mónica Rodríguez-Carballeira, Luis Rodríguez-Rodríguez, Teresa Camps, Santos Castañeda, Juan-Jose Alegre-Sancho, Javier Martín, María Francisca González-Escribano

Front Immunol. 2023; 14: 1080047. Published online 2023 Aug 10. doi: 10.3389/fimmu.2023.1080047

PMCID:: PMC10449640

Abstract Article PDF–527K

Select item 104125857.

High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation

Brooke D. Huisman, Ning Guan, Timo Rückert, Lee Garner, Nishant K. Singh, Andrew J. McMichael, Geraldine M. Gillespie, Chiara Romagnani, Michael E. Birnbaum

Nat Commun. 2023; 14: 4809. Published online 2023 Aug 9. doi: 10.1038/s41467-023-40220-1

Correction in:: Nat Commun. 2023; 14: 5264.

PMCID:: PMC10412585

Abstract Article PDF–1.2M

Select item 101655408.

Intracellular trafficking of HLA-E and its regulation

Wanlin He, Ester Gea-Mallorquí, Huw Colin-York, Marco Fritzsche, Geraldine M. Gillespie, Simon Brackenridge, Persephone Borrow, Andrew J. McMichael

J Exp Med. 2023 Aug 7; 220(8): e20221941. Published online 2023 May 4. doi: 10.1084/jem.20221941

PMCID:: PMC10165540

Abstract Article PDF–6.4M

Select item 99225729.

HLA-E*01:01 + HLA-E*01:01 genotype confers less susceptibility to COVID-19, while HLA-E*01:03 + HLA-E*01:03 genotype is associated with more severe disease

Ehteramolsadat Hosseini, Arefeh Minagar, Mehran Ghasemzadeh, Ali Arabkhazaeli, Alireza Ghasemzadeh

Hum Immunol. 2023 Apr; 84(4): 263–271. Published online 2023 Feb 13. doi: 10.1016/j.humimm.2023.02.002

PMCID:: PMC9922572

Abstract Article PDF–1.3M

Select item 947912210.

NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer

Bérengère Salomé, John P. Sfakianos, Daniel Ranti, Jorge Daza, Christine Bieber, Andrew Charap, Christian Hammer, Romain Banchereau, Adam M. Farkas, Dan Fu Ruan, Sudeh Izadmehr, Daniel Geanon, Geoffrey Kelly, Ronaldo M. de Real, Brian Lee, Kristin G. Beaumont, Sanjana Shroff, Yuanshuo A. Wang, Ying-chih Wang, Tin Htwe Thin, Monica Garcia-Barros, Everardo Hegewisch-Solloa, Emily M. Mace, Li Wang, Timothy O’Donnell, Diego Chowell, Ruben Fernandez-Rodriguez, Mihaela Skobe, Nicole Taylor, Seunghee Kim-Schulze, Robert P. Sebra, Doug Palmer, Eleanor Clancy-Thompson, Scott Hammond, Alice O. Kamphorst, Karl-Johan Malmberg, Emanuela Marcenaro, Pedro Romero, Rachel Brody, Mathias Viard, Yuko Yuki, Maureen Martin, Mary Carrington, Reza Mehrazin, Peter Wiklund, Ira Mellman, Sanjeev Mariathasan, Jun Zhu, Matthew D. Galsky, Nina Bhardwaj, Amir Horowitz

Cancer Cell. Author manuscript; available in PMC 2023 Sep 12.

Published in final edited form as: Cancer Cell. 2022 Sep 12; 40(9): 1027–1043.e9. doi: 10.1016/j.ccell.2022.08.005

PMCID:: PMC9479122

Abstract Article PDF–3.7M

Select item 935262111.

Evolution and molecular interactions of major histocompatibility complex (MHC)-G, -E and -F genes

Antonio Arnaiz-Villena, Fabio Suarez-Trujillo, Ignacio Juarez, Carmen Rodríguez-Sainz, José Palacio-Gruber, Christian Vaquero-Yuste, Marta Molina-Alejandre, Eduardo Fernández-Cruz, José Manuel Martin-Villa

Cell Mol Life Sci. 2022 Aug; 79(8): 464. Published online 2022 Aug 4. doi: 10.1007/s00018-022-04491-z

PMCID:: PMC9352621

Abstract Article PDF–2.5M

Select item 923162312.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 897583513.

Downregulated cytotoxic CD8⁺ T-cell identifies with the NKG2A-soluble HLA-E axis as a predictive biomarker and potential therapeutic target in keloids

Heng Xu, Zhu Zhu, Jian Hu, Jiawei Sun, Yan Wo, Xianshu Wang, Hongzhi Zou, Bin Li, Yixin Zhang

Cell Mol Immunol. 2022 Apr; 19(4): 527–539. Published online 2022 Jan 17. doi: 10.1038/s41423-021-00834-1

PMCID:: PMC8975835

Abstract Article PDF–5.4M

Select item 886504614.

HLA-E and HLA-F Are Overexpressed in Glioblastoma and HLA-E Increased After Exposure to Ionizing Radiation

TOMAS HRBAC, ALENA KOPKOVA, FRANTISEK SIEGL, MAREK VECERA, MICHAELA RUCKOVA, TOMAS KAZDA, RADIM JANCALEK, MICHAL HENDRYCH, MARKETA HERMANOVA, VACLAV VYBIHAL, PAVEL FADRUS, MARTIN SMRCKA, FILIP SOKOL, VACLAV KUBES, RADIM LIPINA, ONDREJ SLABY, LEOS KREN, JIRI SANA

Cancer Genomics Proteomics. 2022 Mar-Apr; 19(2): 151–162. Published online 2022 Mar 3. doi: 10.21873/cgp.20311

PMCID:: PMC8865046

Abstract Article PDF–814K

Select item 885868615.

SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells

Quirin Hammer, Josefine Dunst, Wanda Christ, Francesca Picarazzi, Mareike Wendorff, Pouria Momayyezi, Oisín Huhn, Herman K. Netskar, Kimia T. Maleki, Marina García, Takuya Sekine, Ebba Sohlberg, Valerio Azzimato, Myriam Aouadi, Karolinska COVID-19 Study Group, Severe COVID-19 GWAS Group, Frauke Degenhardt, Andre Franke, Francesco Spallotta, Mattia Mori, Jakob Michaëlsson, Niklas K. Björkström, Timo Rückert, Chiara Romagnani, Amir Horowitz, Jonas Klingström, Hans-Gustaf Ljunggren, Karl-Johan Malmberg

Cell Rep. 2022 Mar 8; 38(10): 110503. Published online 2022 Feb 21. doi: 10.1016/j.celrep.2022.110503

PMCID:: PMC8858686

Abstract Article PDF–3.5M

Select item 851115616.

HLA-E circulating and genetic determinants in schizophrenia and bipolar disorder

Wahid Boukouaci, Mohamed Lajnef, Jean-Romain Richard, Ching-Lien Wu, Jihène Bouassida, Ismail Rafik, Marianne Foiselle, Céline Straczek, Esma Mezouad, Soumia Naamoune, Sofiane Salah, Mohamed Amin Bencharif, Arij Ben Chaaben, Caroline Barau, Philippe Le Corvoisier, Marion Leboyer, Ryad Tamouza

Sci Rep. 2021; 11: 20260. Published online 2021 Oct 12. doi: 10.1038/s41598-021-99732-9

PMCID:: PMC8511156

Abstract Article PDF–1.3M

Select item 824797717.

HLA‐E diversity unfolded: Identification and characterization of 170 novel HLA‐E alleles

Christin Paech, Viviane Albrecht, Kathrin Putke, Gerhard Schöfl, Bianca Schöne, Alexander H. Schmidt, Vinzenz Lange, Anja Klussmeier

HLA. 2021 May; 97(5): 389–398. Published online 2021 Feb 16. doi: 10.1111/tan.14195

PMCID:: PMC8247977

Abstract Article PDF–2.1M

Select item 816503018.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 809227519.

Extent of Cytomegalovirus Replication in the Human Host Depends on Variations of the HLA-E/UL40 Axis

Hannes Vietzen, Timo Rückert, Svenja Hartenberger, Claudia Honsig, Peter Jaksch, Silvana Geleff, Quirin Hammer, Chiara Romagnani, Maia Segura-Wang, Elisabeth Puchhammer-Stöckl

mBio. 2021 Mar-Apr; 12(2): e02996-20. Published online 2021 Mar 16. doi: 10.1128/mBio.02996-20

PMCID:: PMC8092275

Abstract Article PDF–1.8M

Select item 756368120.

Human Amnion Epithelial Cells Impair T Cell Proliferation: The Role of HLA-G and HLA-E Molecules

Fabio Morandi, Danilo Marimpietri, Andre Görgens, Alessia Gallo, Raghuraman Chittor Srinivasan, Samir El-Andaloussi, Roberto Gramignoli

Cells. 2020 Sep; 9(9): 2123. Published online 2020 Sep 19. doi: 10.3390/cells9092123

PMCID:: PMC7563681

Abstract Article PDF–1.9M

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