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Select item 108622351.

PF4 activates the c-Mpl–Jak2 pathway in platelets

Richard J. Buka, Samantha J. Montague, Luis A. Moran, Eleyna M. Martin, Alexandre Slater, Steve P. Watson, Phillip L. R. Nicolson

Blood. 2024 Jan 4; 143(1): 64–69. Published online 2023 Oct 29. doi: 10.1182/blood.2023020872

PMCID:: PMC10862235

Abstract Article

Select item 107266952.

JAK2, CALR, and MPL Mutation Profiles in Colombian patients with BCR-ABL Negative Myeloproliferative Neoplasms

Ana Isabel Giraldo-Rincón, Sara Naranjo Molina, Natalia Gomez-Lopera, Daniel Aguirre Acevedo, Andrea Ucroz Benavidez, Kenny Gálvez Cárdenas, Francisco Cuellar Ambrosí, Jose Domingo Torres, Sigifredo Ospina, Katherine Palacio, Lina Gaviria Jaramillo, Carlos Mario Muñeton, Gonzalo Vasquez Palacio

Colomb Med (Cali) 2023 Jul-Sep; 54(3): e2035353. Published online 2023 Sep 30. doi: 10.25100/cm.v54i3.5353

PMCID:: PMC10726695

Abstract Article PDF–841K

Select item 95878763.

Study of CALR, MPL, and c-kit Gene Mutations in Thai Patients with JAK2 V617F Negative Myeloproliferative Neoplasms

Kriangpol Wiriyaukaradecha, Supanee Nimsanor, Nithiphut Tantirukdham, Jin Tongsom, Chakrit Bunyoo, Kamonwan Soonklang, Narongrit Sritana, Chirayu Auewarakul

Asian Pac J Cancer Prev. 2022 May; 23(5): 1671–1678. doi: 10.31557/APJCP.2022.23.5.1671

PMCID:: PMC9587876

Abstract Article PDF–667K

Select item 88438024.

Upregulation of endogenous thrombopoietin receptor (MPL) with in vivo passage of calreticulin (CALR) mutant Ba/F3 cells, highlighting MPL as the requisite cytokine receptor for CALR mediated transformation

Stefan A. Brooks, Daniel M. Kim, Sarah J. Morse, Quy H. Nguyen, Brianna M. Craver, Hew Yeng Lai, Angela G. Fleischman

Leuk Res. Author manuscript; available in PMC 2022 Feb 15.

Published in final edited form as: Leuk Res. 2019 Jul; 82: 11–14. Published online 2019 May 9. doi: 10.1016/j.leukres.2019.05.003

PMCID:: PMC8843802

Article PDF–784K

Select item 86301455.

MPL S505C enhances driver mutations at W515 in essential thrombocythemia

Leila N. Varghese, Gonzalo Carreño-Tarragona, Gabriel Levy, Xabier Gutiérrez-López de Ocáriz, Inmaculada Rapado, Joaquín Martínez-López, Rosa Ayala, Stefan N. Constantinescu

Blood Cancer J. 2021 Nov; 11(11): 188. Published online 2021 Nov 29. doi: 10.1038/s41408-021-00583-4

PMCID:: PMC8630145

Article PDF–817K

Select item 84090396.

CAMT-MPL: congenital amegakaryocytic thrombocytopenia caused by MPL mutations - heterogeneity of a monogenic disorder - a comprehensive analysis of 56 patients

Manuela Germeshausen, Matthias Ballmaier

Haematologica. 2021 Sep 1; 106(9): 2439–2448. Published online 2020 Jul 23. doi: 10.3324/haematol.2020.257972

PMCID:: PMC8409039

Abstract Article PDF–2.8M

Select item 83075617.

Clinical and Laboratory Features of JAK2 V617F, CALR, and MPL Mutations in Malaysian Patients with Classical Myeloproliferative Neoplasm (MPN)

Razan Hayati Zulkeflee, Zefarina Zulkafli, Muhammad Farid Johan, Azlan Husin, Md Asiful Islam, Rosline Hassan

Int J Environ Res Public Health. 2021 Jul; 18(14): 7582. Published online 2021 Jul 16. doi: 10.3390/ijerph18147582

PMCID:: PMC8307561

Abstract Article PDF–1.1M

Select item 82690768.

Thrombopoietin Contributes to Enhanced Platelet Activation in Patients with Type 1 Diabetes Mellitus

Ornella Bosco, Barbara Vizio, Gabriella Gruden, Martina Schiavello, Bartolomeo Lorenzati, Paolo Cavallo-Perin, Isabella Russo, Giuseppe Montrucchio, Enrico Lupia

Int J Mol Sci. 2021 Jul; 22(13): 7032. Published online 2021 Jun 29. doi: 10.3390/ijms22137032

PMCID:: PMC8269076

Abstract Article PDF–1.6M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 816151610.

An Asian-specific MPL genetic variant alters JAK–STAT signaling and influences platelet count in the population

Pengfei Sun, Wei Zhou, Yi Fu, Chloe Y Y Cheung, Yujun Dong, Min-Lee Yang, He Zhang, Jia Jia, Yong Huo, Cristen J Willer, Y Eugene Chen, Clara S Tang, Hung-Fat Tse, Karen S L Lam, Wei Gao, Ming Xu, Haiyi Yu, Pak Chung Sham, Yan Zhang, Santhi K Ganesh

Hum Mol Genet. 2021 May 1; 30(9): 836–842. Published online 2021 Mar 9. doi: 10.1093/hmg/ddab062

PMCID:: PMC8161516

Abstract Article PDF–273K

Select item 808577211.

Mechanism of mutant calreticulin-mediated activation of the thrombopoietin receptor in cancers

Arunkumar Venkatesan, Jie Geng, Malathi Kandarpa, Sanjeeva Joseph Wijeyesakere, Ashwini Bhide, Moshe Talpaz, Irina D. Pogozheva, Malini Raghavan

J Cell Biol. 2021 Jul 5; 220(7): e202009179. Published online 2021 Apr 28. doi: 10.1083/jcb.202009179

PMCID:: PMC8085772

Abstract Article PDF–7.3M

Select item 806989212.

Low JAK2 V617F Allele Burden in Ph-Negative Chronic Myeloproliferative Neoplasms Is Associated with Additional CALR or MPL Gene Mutations

Tatiana V. Makarik, Adhamjon O. Abdullaev, Elena E. Nikulina, Svetlana A. Treglazova, Elena E. Stepanova, Irina N. Subortseva, Alla M. Kovrigina, Anait L. Melikyan, Sergei M. Kulikov, Andrey B. Sudarikov

Genes (Basel) 2021 Apr; 12(4): 559. Published online 2021 Apr 12. doi: 10.3390/genes12040559

PMCID:: PMC8069892

Abstract Article PDF–4.4M

Select item 772765813.

The Genetic Basis of Primary Myelofibrosis and Its Clinical Relevance

Elisa Rumi, Chiara Trotti, Daniele Vanni, Ilaria Carola Casetti, Daniela Pietra, Emanuela Sant’Antonio

Int J Mol Sci. 2020 Dec; 21(23): 8885. Published online 2020 Nov 24. doi: 10.3390/ijms21238885

PMCID:: PMC7727658

Abstract Article PDF–582K

Select item 761383914.

Mutation profile in BCR-ABL1-negative myeloproliferative neoplasms: A single-center experience from India

Madhavi Maddali, Uday Prakash Kulkarni, Niveditha Ravindra, Arun Kumar Arunachalam, Arvind Venkatraman, Sharon Lionel, Marie Therese Manipadam, Anup J. Devasia, Anu Korula, N.A. Fouzia, Aby Abraham, Alok Srivastava, Biju George, Poonkuzhali Balasubramanian, Vikram Mathews

Hematol Oncol Stem Cell Ther. Author manuscript; available in PMC 2022 Nov 19.

Published in final edited form as: Hematol Oncol Stem Cell Ther. 2021 Mar 19; 15(2): 13–20. Published online 2021 Mar 19. doi: 10.1016/j.hemonc.2021.03.002

PMCID:: PMC7613839

Abstract Article PDF–595K

Select item 739528815.

Clinical acceleration of JAK2 p.V617F driven myeloproliferative disease due to a new uncommon homozygous MPL p.Y591D mutation

Jeremy Ong, Jane I. Lin, Helen Mitchell, Susan Morgan, Andrew C. Perkins

Haematologica. 2020 Aug; 105(8): e428–e431. doi: 10.3324/haematol.2020.250969

PMCID:: PMC7395288

Article PDF–477K

Select item 720250116.

c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis

Liang Li, Chenju Yi, WenJie Xia, Bihui Huang, Shichao Chen, Junyan Zhong, Xiaoyi Fang, Liuming Yang, Hongwu Xin, Shiying Silvia Zheng, Beng H Chong, Yingyun Fu, Chun Chen, Mo Yang

Aging (Albany NY) 2020 Apr 30; 12(8): 7397–7410. Published online 2020 Apr 27. doi: 10.18632/aging.103086

PMCID:: PMC7202501

Abstract Article PDF–1.4M

Select item 720218917.

The effects of mutational profiles on phenotypic presentation of myeloproliferative neoplasm subtypes in Bosnia: 18 year follow-up

Amina Kurtovic-Kozaric, Erna Islamagic, Hana Komic, Nurija Bilalovic, Izet Eminovic, Adnan Burekovic, Amna Uzunovic, Sabira Kurtovic

Bosn J Basic Med Sci. 2020 May; 20(2): 236–247. doi: 10.17305/bjbms.2019.4391

PMCID:: PMC7202189

Abstract Article PDF–2.6M

Select item 703094818.

Disease heterogeneity and personalized prognosis in myeloproliferative neoplasms

Jacob Grinfeld, Jyoti Nangalia, E Joanna Baxter, David C Wedge, Nicos Angelopoulos, Robert Cantrill, Anna L Godfrey, Elli Papaemmanuil, Gunes Gundem, Cathy MacLean, Julia Cook, Laura Mudie, Sarah O’Meara, Jon W Teague, Adam P Butler, Charlie E Massie, Nicholas Williams, Francesca L Nice, Christen L Andersen, Hans C Hasselbalch, Paola Guglielmelli, Mary Frances McMullin, Alessandro M Vannucchi, Claire N Harrison, Moritz Gerstung, Anthony R Green, Peter J Campbell

N Engl J Med. Author manuscript; available in PMC 2020 Feb 19.

Published in final edited form as: N Engl J Med. 2018 Oct 11; 379(15): 1416–1430. doi: 10.1056/NEJMoa1716614

PMCID:: PMC7030948

Abstract Article PDF–1.7M

Select item 699644419.

The Molecular Genetics of Myeloproliferative Neoplasms

Anna E. Marneth, Ann Mullally

Cold Spring Harb Perspect Med. 2020 Feb; 10(2): a034876. doi: 10.1101/cshperspect.a034876

PMCID:: PMC6996444

Abstract Article PDF–2.7M

Select item 697685720.

Clinical and Hematological Relevance of JAK2V617F, CALR, and MPL Mutations in Vietnamese Patients with Essential Thrombocythemia

Hoang Anh Vu, Tran Thi Thao, Cao Van Dong, Nguyen Lam Vuong, Ho Quoc Chuong, Phan Nguyen Thanh Van, Huynh Nghia, Nguyen Tan Binh, Phu Chi Dung, Phan Thi Xinh

Asian Pac J Cancer Prev. 2019; 20(9): 2775–2780. doi: 10.31557/APJCP.2019.20.9.2775

PMCID:: PMC6976857

Abstract Article PDF–404K

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