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Select item 107941511.

Na_v1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis

Wenyu Fu, Dmytro Vasylyev, Yufei Bi, Mingshuang Zhang, Guodong Sun, Asya Khleborodova, Guiwu Huang, Libo Zhao, Renpeng Zhou, Yonggang Li, Shujun Liu, Xianyi Cai, Wenjun He, Min Cui, Xiangli Zhao, Aubryanna Hettinghouse, Julia Good, Ellen Kim, Eric Strauss, Philipp Leucht, Ran Schwarzkopf, Edward X. Guo, Jonathan Samuels, Wenhuo Hu, Mukundan Attur, Stephen G. Waxman, Chuan-ju Liu

Nature. 2024; 625(7995): 557–565. Published online 2024 Jan 3. doi: 10.1038/s41586-023-06888-7

PMCID:: PMC10794151

Abstract Article PDF–85M

Select item 107693502.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders

Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz

Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700

PMCID:: PMC10769350

Abstract Article PDF–11M

Select item 104107613.

Identification and targeting of a unique Na_V1.7 domain driving chronic pain

Kimberly Gomez, Harrison J. Stratton, Paz Duran, Santiago Loya, Cheng Tang, Aida Calderon-Rivera, Liberty François-Moutal, May Khanna, Cynthia L. Madura, Shizhen Luo, Bryan McKiver, Edward Choi, Dongzhi Ran, Lisa Boinon, Samantha Perez-Miller, M. Imad Damaj, Aubin Moutal, Rajesh Khanna

Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2217800120. Published online 2023 Jul 27. doi: 10.1073/pnas.2217800120

PMCID:: PMC10410761

Abstract Article PDF–18M

Select item 101713594.

Na_v 1.7 gain-of-function mutation I228M triggers age-dependent nociceptive insensitivity and C-LTMR dysregulation

Nivanthika K. Wimalasena, Daniel G. Taub, Jaehoon Shim, Sara Hakim, Riki Kawaguchi, Lubin Chen, Mahmoud El-Rifai, Daniel H. Geschwind, Sulayman D. Dib-Hajj, Stephen G. Waxman, Clifford J. Woolf

Exp Neurol. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Exp Neurol. 2023 Jun; 364: 114393. Published online 2023 Mar 30. doi: 10.1016/j.expneurol.2023.114393

PMCID:: PMC10171359

Abstract Article PDF–1.9M

Select item 101479235.

Pain-causing stinging nettle toxins target TMEM233 to modulate Na_V1.7 function

Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter

Nat Commun. 2023; 14: 2442. Published online 2023 Apr 28. doi: 10.1038/s41467-023-37963-2

PMCID:: PMC10147923

Abstract Article PDF–3.8M

Select item 95865476.

Na_v1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice

Steven J Middleton, Irene Perini, Andreas C Themistocleous, Greg A Weir, Kirsty McCann, Allison M Barry, Andrew Marshall, Michael Lee, Leah M Mayo, Manon Bohic, Georgios Baskozos, India Morrison, Line S Löken, Sarah McIntyre, Saad S Nagi, Roland Staud, Isac Sehlstedt, Richard D Johnson, Johan Wessberg, John N Wood, Christopher G Woods, Aziz Moqrich, Håkan Olausson, David L Bennett

Brain. 2022 Oct; 145(10): 3637–3653. Published online 2021 Dec 27. doi: 10.1093/brain/awab482

PMCID:: PMC9586547

Abstract Article PDF–1.9M

Select item 95368427.

Selective optogenetic activation of Na_V1.7–expressing afferents in Na_V1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli

Toyoaki Maruta, Kotaro Hidaka, Satoshi Kouroki, Tomohiro Koshida, Mio Kurogi, Yohko Kage, Seiya Mizuno, Tetsuro Shirasaka, Toshihiko Yanagita, Satoru Takahashi, Ryu Takeya, Isao Tsuneyoshi

PLoS One. 2022; 17(10): e0275751. Published online 2022 Oct 6. doi: 10.1371/journal.pone.0275751

PMCID:: PMC9536842

Abstract Article PDF–1.4M

Select item 84974398.

Dissecting the precise nature of itch-evoked scratching

Nivanthika K. Wimalasena, George Milner, Ricardo Silva, Cliff Vuong, Zihe Zhang, Diana M. Bautista, Clifford J. Woolf

Neuron. Author manuscript; available in PMC 2021 Oct 8.

Published in final edited form as: Neuron. 2021 Oct 6; 109(19): 3075–3087.e2. Published online 2021 Aug 18. doi: 10.1016/j.neuron.2021.07.020

PMCID:: PMC8497439

Abstract Article PDF–1.4M

Select item 81193019.

Two independent mouse lines carrying the Nav1.7-I228M gain-of-function variant display DRG neuron hyperexcitability but a minimal pain phenotype

Lubin Chen, Nivanthika K. Wimalasena, Jaehoon Shim, Chongyang Han, Seong-il Lee, Rafael Gonzalez-Cano, Mark Estacion, Catharina G. Faber, Giuseppe Lauria, Sulayman D. Dib-Hajj, Clifford J. Woolf, Stephen G. Waxman

Pain. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Pain. 2021 Jun 1; 162(6): 1758–1770. doi: 10.1097/j.pain.0000000000002171

PMCID:: PMC8119301

Article PDF–1.3M

Select item 793877010.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 771370611.

Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans

R. Brian Roome, Farin B. Bourojeni, Bishakha Mona, Shima Rastegar-Pouyani, Raphael Blain, Annie Dumouchel, Charleen Salesse, W. Scott Thompson, Megan Brookbank, Yorick Gitton, Lino Tessarollo, Martyn Goulding, Jane E. Johnson, Marie Kmita, Alain Chédotal, Artur Kania

Cell Rep. Author manuscript; available in PMC 2020 Dec 3.

Published in final edited form as: Cell Rep. 2020 Nov 24; 33(8): 108425. doi: 10.1016/j.celrep.2020.108425

PMCID:: PMC7713706

Abstract Article PDF–4.9M

Select item 703092612.

Sensory neuron–derived Na_V1.7 contributes to dorsal horn neuron excitability

Sascha R. A. Alles, Filipe Nascimento, Rafael Luján, Ana P. Luiz, Queensta Millet, M. Ali Bangash, Sonia Santana-Varela, Xuelong Zhou, James J. Cox, Andrei L. Okorokov, Marco Beato, Jing Zhao, John N. Wood

Sci Adv. 2020 Feb; 6(8): eaax4568. Published online 2020 Feb 19. doi: 10.1126/sciadv.aax4568

PMCID:: PMC7030926

Abstract Article PDF–3.0M

Select item 692874313.

3’-O-Methylorobol Inhibits the Voltage-Gated Sodium Channel Nav1.7 with Anti-Itch Efficacy in A Histamine-Dependent Itch Mouse Model

Fan Zhang, Ying Wu, Shuwen Xue, Shuangyan Wang, Chunlei Zhang, Zhengyu Cao

Int J Mol Sci. 2019 Dec; 20(23): 6058. Published online 2019 Dec 1. doi: 10.3390/ijms20236058

PMCID:: PMC6928743

Abstract Article PDF–3.4M

Select item 671140414.

Synergistic regulation of serotonin and opioid signaling contribute to pain insensitivity in Na_v1.7 knockout mice

Jörg Isensee, Leonhardt Krahé, Katharina Moeller, Vanessa Pereira, Jane E. Sexton, Xiaohui Sun, Edward Emery, John N. Wood, Tim Hucho

Sci Signal. Author manuscript; available in PMC 2019 Aug 14.

Published in final edited form as: Sci Signal. 2017 Jan 10; 10(461): eaah4874. Published online 2017 Jan 10. doi: 10.1126/scisignal.aah4874

PMCID:: PMC6711404

Abstract Article PDF–3.1M

Select item 669277015.

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics

Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea

Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253

PMCID:: PMC6692770

Abstract Article PDF–7.7M

Select item 668750616.

ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons

An-Jing Ren, Kai Wang, Huan Zhang, Anjun Liu, Xianhua Ma, Qing Liang, Dongmei Cao, John N. Wood, David Z. He, Yu-Qiang Ding, Wen-Jun Yuan, Zhifang Xie, Weiping J. Zhang

Nat Commun. Author manuscript; available in PMC 2019 Aug 8.

Published in final edited form as: Nat Commun. 2014 Nov 5; 5: 4984. Published online 2014 Nov 5. doi: 10.1038/ncomms5984

PMCID:: PMC6687506

Abstract Article PDF–3.4M

Select item 662101717.

Early Development of Electrical Excitability in the Mouse Enteric Nervous System

Marlene M. Hao, Alan E. Lomax, Sonja J. McKeown, Christopher A. Reid, Heather M. Young, Joel C. Bornstein

J Neurosci. 2012 Aug 8; 32(32): 10949–10960. doi: 10.1523/JNEUROSCI.1426-12.2012

PMCID:: PMC6621017

Abstract Article PDF–2.3M

Select item 662101518.

Sodium Channel Na_v1.7 Is Essential for Lowering Heat Pain Threshold after Burn Injury

Shannon D. Shields, Xiaoyang Cheng, Nurcan Üçeyler, Claudia Sommer, Sulayman D. Dib-Hajj, Stephen G. Waxman

J Neurosci. 2012 Aug 8; 32(32): 10819–10832. doi: 10.1523/JNEUROSCI.0304-12.2012

PMCID:: PMC6621015

Abstract Article PDF–2.2M

Select item 661550019.

Depolarized Inactivation Overcomes Impaired Activation to Produce DRG Neuron Hyperexcitability in a Na_v1.7 Mutation in a Patient with Distal Limb Pain

Jianying Huang, Yang Yang, Sulayman D. Dib-Hajj, Michael van Es, Peng Zhao, Jody Salomon, Joost P.H. Drenth, Stephen G. Waxman

J Neurosci. 2014 Sep 10; 34(37): 12328–12340. doi: 10.1523/JNEUROSCI.2773-14.2014

PMCID:: PMC6615500

Abstract Article PDF–2.8M

Select item 659965420.

The role of Na_v1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes

Ruo-Xiao Cheng, Yu Feng, Di Liu, Zhi-Hong Wang, Jiang-Tao Zhang, Li-Hua Chen, Cun-Jin Su, Bing Wang, Ya Huang, Ru-Rong Ji, Ji Hu, Tong Liu

Theranostics. 2019; 9(15): 4287–4307. Published online 2019 May 31. doi: 10.7150/thno.36077

PMCID:: PMC6599654

Abstract Article PDF–3.0M

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