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Select item 113681831.

Hyd/UBR5 defines a tumor suppressor pathway that links Polycomb repressive complex to regulated protein degradation in tissue growth control and tumorigenesis

Pei Wen, Huiyan Lei, Hua Deng, Su Deng, Carla Rodriguez Tirado, Meiling Wang, Ping Mu, Yonggang Zheng, Duojia Pan

Genes Dev. 2024 Jul 1; 38(13-14): 675–691. doi: 10.1101/gad.351856.124

PMCID:: PMC11368183

Abstract Article PDF–48M

Select item 112627932.

Drosophila medulla neuroblast termination via apoptosis, differentiation, and gliogenic switch is scheduled by the depletion of the neuroepithelial stem cell pool

Phuong-Khanh Nguyen, Louise Y Cheng

eLife. 2024; 13: e96876. Published online 2024 Jun 21. doi: 10.7554/eLife.96876

PMCID:: PMC11262793

Abstract Article PDF–6.6M

Select item 112475063.

Functional exploration of copy number alterations in a Drosophila model of triple-negative breast cancer

Jennifer E. L. Diaz, Vanessa Barcessat, Christian Bahamon, Chana Hecht, Tirtha K. Das, Ross L. Cagan

Dis Model Mech. 2024 Jul 1; 17(7): dmm050191. Published online 2024 Jul 3. doi: 10.1242/dmm.050191

PMCID:: PMC11247506

Abstract Article

Select item 111999554.

Modeling neurodegenerative and neurodevelopmental disorders in the Drosophila mushroom body

Aaron Stahl, Seth M. Tomchik

Learn Mem. 2024 May; 31(5): a053816. Published online 2024 May. doi: 10.1101/lm.053816.123

PMCID:: PMC11199955

Abstract Article PDF–937K

Select item 109457565.

Timed receptor tyrosine kinase signaling couples the central and a peripheral circadian clock in Drosophila

Javier Cavieres-Lepe, Emad Amini, Maia Zabel, Dick R. Nässel, Ralf Stanewsky, Christian Wegener, John Ewer

Proc Natl Acad Sci U S A. 2024 Mar 12; 121(11): e2308067121. Published online 2024 Mar 5. doi: 10.1073/pnas.2308067121

PMCID:: PMC10945756

Abstract Article PDF–5.4M

Select item 108350476.

miR-137 regulates PTP61F, affecting insulin signaling, metabolic homeostasis, and starvation resistance in Drosophila

Hana Saedi, Girma Waro, Lea Giacchetta, Susan Tsunoda

Proc Natl Acad Sci U S A. 2024 Jan 30; 121(5): e2319475121. Published online 2024 Jan 22. doi: 10.1073/pnas.2319475121

PMCID:: PMC10835047

Abstract Article PDF–3.0M

Select item 108029047.

A Conserved Mechanism for JNK-Mediated Loss of Notch Function in Advanced Prostate Cancer

Cheng-Wei Wang, Marie Clémot, Takao Hashimoto, Johnny A. Diaz, Lauren M. Goins, Andrew S. Goldstein, Raghavendra Nagaraj, Utpal Banerjee

Sci Signal. Author manuscript; available in PMC 2024 Jan 22.

Published in final edited form as: Sci Signal. 2023 Nov 7; 16(810): eabo5213. Published online 2023 Nov 7. doi: 10.1126/scisignal.abo5213

PMCID:: PMC10802904

Abstract Article PDF–2.8M

Select item 107845248.

Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila

Daewon Lee, Eunju Yoon, Su Jin Ham, Kunwoo Lee, Hansaem Jang, Daihn Woo, Da Hyun Lee, Sehyeon Kim, Sekyu Choi, Jongkyeong Chung

Nat Commun. 2024; 15: 468. Published online 2024 Jan 11. doi: 10.1038/s41467-024-44747-9

PMCID:: PMC10784524

Abstract Article PDF–4.8M

Select item 107027979.

Convergent insulin and TGF‐β signalling drives cancer cachexia by promoting aberrant fat body ECM accumulation in a Drosophila tumour model

Daniel Bakopoulos, Sofya Golenkina, Callum Dark, Elizabeth L Christie, Besaiz J Sánchez‐Sánchez, Brian M Stramer, Louise Y Cheng

EMBO Rep. 2023 Dec; 24(12): e57695. Published online 2023 Nov 28. doi: 10.15252/embr.202357695

PMCID:: PMC10702797

Abstract Article PDF–14M

Select item 1066276110.

Coordination of Pickpocket ion channel delivery and dendrite growth in Drosophila sensory neurons

Josephine W. Mitchell, Ipek Midillioglu, Ethan Schauer, Bei Wang, Chun Han, Jill Wildonger

PLoS Genet. 2023 Nov; 19(11): e1011025. Published online 2023 Nov 9. doi: 10.1371/journal.pgen.1011025

PMCID:: PMC10662761

Abstract Article PDF–5.6M

Select item 1062962011.

Diet-induced glial insulin resistance impairs the clearance of neuronal debris in Drosophila brain

Mroj Alassaf, Akhila Rajan

PLoS Biol. 2023 Nov; 21(11): e3002359. Published online 2023 Nov 7. doi: 10.1371/journal.pbio.3002359

PMCID:: PMC10629620

Abstract Article PDF–3.4M

Select item 1057242212.

PolyQ-Expansion Causes Mitochondria Fragmentation Independent of Huntingtin and Is Distinct from Traumatic Brain Injury (TBI)/Mechanical Stress-Mediated Fragmentation Which Results from Cell Death

Kelsey Swinter, Dania Salah, Rasika Rathnayake, Shermali Gunawardena

Cells. 2023 Oct; 12(19): 2406. Published online 2023 Oct 5. doi: 10.3390/cells12192406

PMCID:: PMC10572422

Abstract Article PDF–12M

Select item 1056136713.

Single‐cell RNA sequencing identifies eggplant as a regulator of germ cell development in Drosophila

Zhipeng Sun, Todd G Nystul, Guohua Zhong

EMBO Rep. 2023 Oct; 24(10): e56475. Published online 2023 Aug 21. doi: 10.15252/embr.202256475

PMCID:: PMC10561367

Abstract Article PDF–8.7M

Select item 1055383514.

Spatial regulation of Drosophila ovarian Follicle Stem Cell division rates and cell cycle transitions

David Melamed, Aaron Choi, Amy Reilein, Simon Tavaré, Daniel Kalderon

PLoS Genet. 2023 Sep; 19(9): e1010965. Published online 2023 Sep 25. doi: 10.1371/journal.pgen.1010965

Correction in:: PLoS Genet. 2023 Nov; 19(11): e1011040.

PMCID:: PMC10553835

Abstract Article PDF–4.5M

Select item 1049510915.

Fat body-specific reduction of CTPS alleviates HFD-induced obesity

Jingnan Liu, Yuanbing Zhang, Qiao-Qi Wang, Youfang Zhou, Ji-Long Liu

eLife. 2023; 12: e85293. Published online 2023 Sep 11. doi: 10.7554/eLife.85293

PMCID:: PMC10495109

Abstract Article PDF–13M

Select item 1034162716.

PLA2G12A as a Novel Biomarker for Colorectal Cancer with Prognostic Relevance

Eva Parisi, Ivan Hidalgo, Robert Montal, Ona Pallisé, Jordi Tarragona, Anabel Sorolla, Anna Novell, Kyra Campbell, Maria Alba Sorolla, Andreu Casali, Antonieta Salud

Int J Mol Sci. 2023 Jul; 24(13): 10889. Published online 2023 Jun 30. doi: 10.3390/ijms241310889

PMCID:: PMC10341627

Abstract Article PDF–3.4M

Select item 1020495717.

TORC1 regulation of dendrite regrowth after pruning is linked to actin and exocytosis

Neeraja Sanal, Lorena Keding, Ulrike Gigengack, Esther Michalke, Sebastian Rumpf

PLoS Genet. 2023 May; 19(5): e1010526. Published online 2023 May 11. doi: 10.1371/journal.pgen.1010526

PMCID:: PMC10204957

Abstract Article PDF–4.4M

Select item 1011838518.

Pooled genome-wide CRISPR activation screening for rapamycin resistance genes in Drosophila cells

Baolong Xia, Raghuvir Viswanatha, Yanhui Hu, Stephanie E Mohr, Norbert Perrimon

eLife. 2023; 12: e85542. Published online 2023 Apr 20. doi: 10.7554/eLife.85542

PMCID:: PMC10118385

Abstract Article PDF–11M

Select item 1006797219.

A PI3K-calcium-Nox axis primes leukocyte Nrf2 to boost immune resilience and limit collateral damage

Giuliana D. Clemente, Helen Weavers

J Cell Biol. 2023 Jun 5; 222(6): e202203062. Published online 2023 Mar 30. doi: 10.1083/jcb.202203062

PMCID:: PMC10067972

Abstract Article PDF–6.6M

Select item 954524220.

Vitamin B6 rescues insulin resistance and glucose‐induced DNA damage caused by reduced activity of Drosophila PI3K

Elisa Mascolo, Francesco Liguori, Chiara Merigliano, Ludovica Schiano, Eleonora Gnocchini, Eleonora Pilesi, Cinzia Volonté, Martino L. Di Salvo, Roberto Contestabile, Angela Tramonti, Fiammetta Vernì

J Cell Physiol. 2022 Sep; 237(9): 3578–3586. Published online 2022 Jun 9. doi: 10.1002/jcp.30812