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Items: 1 to 20 of 38

1.
IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events
Rina Fujiwara, Si-Nan Zhai, Dongming Liang, Aayushi P. Shah, Matthew Tracey, Xu-Kai Ma, Christopher J. Fields, María Saraí Mendoza-Figueroa, Michele C. Meline, Deirdre C. Tatomer, Li Yang, Jeremy E. Wilusz
Mol Cell. Author manuscript; available in PMC 2024 Dec 21.
Published in final edited form as: Mol Cell. 2023 Dec 21; 83(24): 4445–4460.e7. Published online 2023 Nov 22. doi: 10.1016/j.molcel.2023.10.035
PMCID:
PMC10841813
AbstractArticlePDF–3.4M
2.
Bi-allelic variants in INTS11 are associated with a complex neurological disorder
Burak Tepe, Erica L. Macke, Marcello Niceta, Monika Weisz Hubshman, Oguz Kanca, Laura Schultz-Rogers, Yuri A. Zarate, G. Bradley Schaefer, Jorge Luis Granadillo De Luque, Daniel J. Wegner, Benjamin Cogne, Brigitte Gilbert-Dussardier, Xavier Le Guillou, Eric J. Wagner, Lynn S. Pais, Jennifer E. Neil, Ganeshwaran H. Mochida, Christopher A. Walsh, Nurit Magal, Valerie Drasinover, Mordechai Shohat, Tanya Schwab, Chris Schmitz, Karl Clark, Anthony Fine, Brendan Lanpher, Ralitza Gavrilova, Pierre Blanc, Lydie Burglen, Alexandra Afenjar, Dora Steel, Manju A. Kurian, Prab Prabhakar, Sophie Gößwein, Nataliya Di Donato, Enrico S. Bertini, Undiagnosed Diseases Network, Michael F. Wangler, Shinya Yamamoto, Marco Tartaglia, Eric W. Klee, Hugo J. Bellen
Am J Hum Genet. 2023 May 4; 110(5): 774–789. Published online 2023 Apr 12. doi: 10.1016/j.ajhg.2023.03.012
PMCID:
PMC10183469
AbstractArticlePDF–3.1M
3.
Inositol hexakisphosphate is required for Integrator function
Min-Han Lin, Madeline K. Jensen, Nathan D. Elrod, Kai-Lieh Huang, Kevin A. Welle, Eric J. Wagner, Liang Tong
Nat Commun. 2022; 13: 5742. Published online 2022 Sep 30. doi: 10.1038/s41467-022-33506-3
PMCID:
PMC9525679
AbstractArticlePDF–2.7M
4.
Variant Polycomb complexes in Drosophila consistent with ancient functional diversity
Hyuckjoon Kang, Janel R. Cabrera, Barry M. Zee, Heather A. Kang, Jenny Marie Jobe, Maeve B. Hegarty, Aurelie E. Barry, Alexander Glotov, Yuri B. Schwartz, Mitzi I. Kuroda
Sci Adv. 2022 Sep; 8(36): eadd0103. Published online 2022 Sep 7. doi: 10.1126/sciadv.add0103
PMCID:
PMC9451159
AbstractArticlePDF–1.3M
5.
An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination
Oguz Kanca, Jonathan Zirin, Yanhui Hu, Burak Tepe, Debdeep Dutta, Wen-Wen Lin, Liwen Ma, Ming Ge, Zhongyuan Zuo, Lu-Ping Liu, Robert W Levis, Norbert Perrimon, Hugo J Bellen
eLife. 2022; 11: e76077. Published online 2022 Jun 20. doi: 10.7554/eLife.76077
PMCID:
PMC9239680
AbstractArticlePDF–1.2M
6.
Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes
Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis
G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349
PMCID:
PMC8664486
AbstractArticlePDF–3.1M
7.
Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination
Kai-Lieh Huang, David Jee, Chad B. Stein, Nathan D. Elrod, Telmo Henriques, Lauren G. Mascibroda, David Baillat, William K. Russell, Karen Adelman, Eric J. Wagner
Mol Cell. Author manuscript; available in PMC 2021 Oct 15.
Published in final edited form as: Mol Cell. 2020 Oct 15; 80(2): 345–358.e9. Published online 2020 Sep 22. doi: 10.1016/j.molcel.2020.08.016
PMCID:
PMC7660970
AbstractArticlePDF–3.3M
8.
CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans
Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang
Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119
PMCID:
PMC6961578
AbstractArticlePDF–3.6M
9.
The Integrator complex attenuates promoter-proximal transcription at protein-coding genes
Nathan D. Elrod, Telmo Henriques, Kai-Lieh Huang, Deirdre C. Tatomer, Jeremy E. Wilusz, Eric J. Wagner, Karen Adelman
Mol Cell. Author manuscript; available in PMC 2020 Dec 5.
Published in final edited form as: Mol Cell. 2019 Dec 5; 76(5): 738–752.e7. doi: 10.1016/j.molcel.2019.10.034
PMCID:
PMC6952639
AbstractArticlePDF–3.2M
10.
The Integrator complex cleaves nascent mRNAs to attenuate transcription
Deirdre C. Tatomer, Nathan D. Elrod, Dongming Liang, Mei-Sheng Xiao, Jeffrey Z. Jiang, Michael Jonathan, Kai-Lieh Huang, Eric J. Wagner, Sara Cherry, Jeremy E. Wilusz
Genes Dev. 2019 Nov 1; 33(21-22): 1525–1538. doi: 10.1101/gad.330167.119
PMCID:
PMC6824465
AbstractArticlePDF–4.0M
11.
Biogenesis of RNase P RNA from an intron requires co-assembly with cognate protein subunits
Geeta Palsule, Venkat Gopalan, Amanda Simcox
Nucleic Acids Res. 2019 Sep 19; 47(16): 8746–8754. Published online 2019 Jul 9. doi: 10.1093/nar/gkz572
Correction in:
Nucleic Acids Res. 2019 Dec 2; 47(21): 11480.
PMCID:
PMC6797745
AbstractArticlePDF–1.7M
12.
Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module
Todd R Albrecht, Sergey P Shevtsov, Yixuan Wu, Lauren G Mascibroda, Natoya J Peart, Kai-Lieh Huang, Iain A Sawyer, Liang Tong, Miroslav Dundr, Eric J Wagner
Nucleic Acids Res. 2018 May 4; 46(8): 4241–4255. Published online 2018 Feb 20. doi: 10.1093/nar/gky100
PMCID:
PMC5934644
AbstractArticlePDF–9.0M
13.
Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species
Piero Sanfilippo, Jiayu Wen, Eric C. Lai
Genome Biol. 2017; 18: 229. Published online 2017 Nov 30. doi: 10.1186/s13059-017-1358-0
PMCID:
PMC5707805
AbstractArticlePDF–3.2M
14.
Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster
Xiaochuan Liu, Jaime Freitas, Dinghai Zheng, Marta S. Oliveira, Mainul Hoque, Torcato Martins, Telmo Henriques, Bin Tian, Alexandra Moreira
RNA. 2017 Dec; 23(12): 1807–1816. doi: 10.1261/rna.062661.117
PMCID:
PMC5689002
AbstractArticlePDF–4.0M
15.
mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster
Gildas Lepennetier, Francesco Catania
G3 (Bethesda) 2016 Jun; 6(6): 1617–1626. Published online 2016 Mar 28. doi: 10.1534/g3.116.029231
PMCID:
PMC4889658
AbstractArticlePDF–1.5M
16.
Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes
Sadhna Phanse, Cuihong Wan, Blake Borgeson, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Bezginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, W. Brent Derry, Elisabeth R. Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili
Data Brief. 2016 Mar; 6: 715–721. Published online 2015 Dec 12. doi: 10.1016/j.dib.2015.11.062
PMCID:
PMC4738005
AbstractArticlePDF–205K
17.
Suppressor of sable [Su(s)] and Wdr82 down-regulate RNA from heat-shock-inducible repetitive elements by a mechanism that involves transcription termination
Paul Brewer-Jensen, Carrie B. Wilson, John Abernethy, Lonna Mollison, Samantha Card, Lillie L. Searles
RNA. 2016 Jan; 22(1): 139–154. doi: 10.1261/rna.048819.114
PMCID:
PMC4691828
AbstractArticlePDF–586K
18.
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders
Madeline A. Crosby, L. Sian Gramates, Gilberto dos Santos, Beverley B. Matthews, Susan E. St. Pierre, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, David B. Emmert, Susan M. Russo, William M. Gelbart, the FlyBase Consortium
G3 (Bethesda) 2015 Aug; 5(8): 1737–1749. Published online 2015 Jun 24. doi: 10.1534/g3.115.018937
PMCID:
PMC4528330
AbstractArticlePDF–2.2M
19.
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data
Beverley B. Matthews, Gilberto dos Santos, Madeline A. Crosby, David B. Emmert, Susan E. St. Pierre, L. Sian Gramates, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, Victor Strelets, Susan M. Russo, William M. Gelbart, the FlyBase Consortium
G3 (Bethesda) 2015 Aug; 5(8): 1721–1736. Published online 2015 Jun 24. doi: 10.1534/g3.115.018929
PMCID:
PMC4528329
AbstractArticlePDF–4.9M
20.
The Release 6 reference sequence of the Drosophila melanogaster genome
Roger A. Hoskins, Joseph W. Carlson, Kenneth H. Wan, Soo Park, Ivonne Mendez, Samuel E. Galle, Benjamin W. Booth, Barret D. Pfeiffer, Reed A. George, Robert Svirskas, Martin Krzywinski, Jacqueline Schein, Maria Carmela Accardo, Elisabetta Damia, Giovanni Messina, María Méndez-Lago, Beatriz de Pablos, Olga V. Demakova, Evgeniya N. Andreyeva, Lidiya V. Boldyreva, Marco Marra, A. Bernardo Carvalho, Patrizio Dimitri, Alfredo Villasante, Igor F. Zhimulev, Gerald M. Rubin, Gary H. Karpen, Susan E. Celniker
Genome Res. 2015 Mar; 25(3): 445–458. doi: 10.1101/gr.185579.114
PMCID:
PMC4352887
AbstractArticlePDF–1022K

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